MODIFICATION OF GUDDEN METHOD FOR STUDY OF CEREBRAL LOCALIZATION

In recent anatomic studies of the central nervous system experimental methods for investigation of localization and interconnections of different regions have been extensively employed. Such problems may in some instances be solved by application of the Marchi technic. Usually, however, the retrograde cell changes must be studied, either early chromatolysis or the late changes, consisting of atrophy and loss of cells. In studying the problem of localization within the olivocerebellar connections, I found that none of these methods proved satisfactory. In order to find, if possible, a more suitable method, I therefore undertook a systematic investigation of the retrograde changes in the cells of the inferior olive following lesions of the cerebellum. A modification of Gudden's method was chosen which gives more definite and exact results than those previously mentioned, and, at the same time, avoids for the most part the drawbacks of the original method. A report on the