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The Plasticity Of Denervated And Reinnervated Laryngeal Muscle: Focus On Single-fiber Myosin Heavy-chain Isoform Expression.

Y. Z. Wu, M. Baker, J. Marie, R. Crumley, V. Caiozzo
Published 2004 · Biology, Medicine

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No studies have examined the effects of denervation on the single-fiber distribution of myosin heavy-chain (MyHC) isoforms in laryngeal muscle. The fast type IIB MyHC isoform represents the largest proportion of the myosin pool in the posterior cricoarytenoid (PCA) and the thyroarytenoid (TA) muscles. However, the fast type IIB MyHC isoform is distributed differently at the single-fiber level. Hence, we hypothesized that denervation would result in markedly different patterns of MyHC isoform expression at the single-fiber level. To test this hypothesis, we assigned animals to the following 3 groups: (1) control group; (2) denervation group; or (3) reinnervation group. Animals were killed 7, 14, 30, 90, and 180 days after denervation or reinnervation. Subsequently, the distribution of MyHC isoforms were electrophoretically determined in approximately 7200 single fibers. There were 4 key findings to emerge from this study: (1) The MyHC isoform profile of the PCA muscle, at both the whole-muscle and single-fiber level, is more malleable than that of the TA muscle. (2) In the PCA and TA muscles, denervation produced some similar changes, resulting in a large increase in the pool of fibers coexpressing fast type IIX and IIB MyHC isoforms. (3) Reinnervation of the TA muscle produced significant alterations in the single-fiber distribution of MyHC isoforms while having little effect on the whole-muscle MyHC isoform composition. (4) Since the transitions in MyHC isoform expression associated with denervation were limited primarily to fast type IIB to fast type IIX, we postulate that only minor reductions in muscle function would result (as defined by maximum shortening velocity and the force-velocity relationship).
This paper references
10.1249/00003677-199101000-00008
The plasticity of skeletal muscle: effects of neuromuscular activity.
R. Roy (1991)
Single fiber MyHC isoform
YZ Wu (2004)
10.1177/000348949510400310
Atypical Myosin Heavy Chain in Rat Laryngeal Muscle
J. DelGaudio (1995)
10.1152/ajpcell.1998.275.1.C68
Quantification of myosin heavy chain mRNA in somatic and branchial arch muscles using competitive PCR.
H. H. Jung (1998)
10.1097/00005537-199909000-00030
Myosin Heavy Chain Composition in Human Laryngeal Muscles
A. Shiotani (1999)
10.1113/jphysiol.1994.sp020254
Unloaded shortening velocity and myosin heavy chain and alkali light chain isoform composition in rat skeletal muscle fibres.
R. Bottinelli (1994)
10.1016/S0194-5998(98)70380-8
A New Concept in Laryngeal Muscle: Multiple Myosin Isoform Types in Single Muscle Fibers of the Lateral Cricoarytenoid
Y. Z. Wu (1998)
10.1097/00005537-199808000-00023
Myosin heavy chain composition in rat laryngeal muscles after denervation
A. Shiotani (1998)
10.1002/mus.10271
Plasticity of skeletal muscle phenotype: Mechanical consequences
V. Caiozzo (2002)
10.1152/JAPPL.2000.88.2.682
Role of denervation in modulating IIb MHC gene expression in response to T(3) plus unloading state.
N. A. di Maso (2000)
Myosin heavy chain composition in human laryngeal muscle
A Shiotani (1999)
Perspectives for cervical anatomy of the phrenic nerve roots in rabbits: perspectives for laryngeal reinnervation
JP Marie (1999)
10.1177/000348949710601212
Changes in Myosin Expression in Denervated Laryngeal Muscle
J. DelGaudio (1997)
10.1001/ARCHOTOL.126.7.857
New perspectives about human laryngeal muscle: single-fiber analyses and interspecies comparisons.
Y. Z. Wu (2000)
10.1007/3540528806_3
Cellular and molecular diversities of mammalian skeletal muscle fibers.
D. Pette (1990)
10.1177/019459988209000414
Regeneration of the Recurrent Laryngeal Nerve
R. Crumley (1982)
10.3109/00016489309130245
Misdirected reinnervation in the feline intrinsic laryngeal muscles after long-term denervation.
M. Nomoto (1993)
10.1177/000348949910800518
Cervical Anatomy of Phrenic Nerve Roots in the Rabbit
J. Marie (1999)
10.1001/ARCHOTOL.126.7.865
Are hybrid fibers a common motif of canine laryngeal muscles? Single-fiber analyses of myosin heavy-chain isoform composition.
Y. Z. Wu (2000)
10.1111/J.1432-1033.1990.TB19379.X
Myosin heavy chain isoform composition in striated muscle after denervation and self-reinnervation.
A. Jakubiec-Puka (1990)
10.1113/jphysiol.1960.sp006395
Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses
A. Buller (1960)
10.1113/jphysiol.1991.sp018617
Force‐velocity relations and myosin heavy chain isoform compositions of skinned fibres from rat skeletal muscle.
R. Bottinelli (1991)
10.1016/0006-8993(91)91632-B
Synapse formation by autonomic nerves in the previously denervated neuromuscular junctions of the feline intrinsic laryngeal muscles
M. Nomoto (1991)
Interactions between motoneurons and muscles in respect of the characteristics spped of their responses
AJ Buller (1960)
10.1016/0092-8674(92)90319-8
The synaptic vesicle protein SV2 is a novel type of transmembrane transporter
M. Feany (1992)
10.1249/00003677-199600240-00013
Thyroid Hormone: Modulation of Muscle Structure, Function, and Adaptive Responses to Mechanical Loading
V. J. Caiozzo (1996)
10.1097/00005768-199605001-01101
Changes in myosin mRNA and protein expression in denervated rat soleus and tibialis anterior.
K. Huey (1996)
10.1001/ARCHOTOL.126.7.874
Single-fiber myosin heavy-chain isoform composition of rodent laryngeal muscle: modulation by thyroid hormone.
Y. Z. Wu (2000)
10.1177/000348949910801013
Experimental Reinnervation of a Strap Muscle with a Few Roots of the Phrenic Nerve in Rabbits
J. Marie (1999)
10.1152/ajpcell.1999.276.5.C1069
An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle.
M. T. Wheeler (1999)
A new concept in laryngeal muscle: multiple myosin isoforms in single fibers of the lateral cricoarytenoid
YZ Wu (1998)
10.1152/JAPPL.1998.85.6.2237
Novel transitions in MHC isoforms: separate and combined effects of thyroid hormone and mechanical unloading.
V. Caiozzo (1998)
10.1097/00005537-200103000-00017
Modulation of Myosin Heavy Chains in Rat Laryngeal Muscle
A. Shiotani (2001)



This paper is referenced by
Muscle Growth and Development in Intrauterine Growth Restricted Pigs
H. Zhu (2015)
10.1371/journal.pone.0077233
Reinnervation of Bilateral Posterior Cricoarytenoid Muscles Using the Left Phrenic Nerve in Patients with Bilateral Vocal Fold Paralysis
Meng Li (2013)
10.1001/ARCHOTOL.130.9.1056
Effects of denervation on cell cycle control in laryngeal muscle.
V. Caiozzo (2004)
10.1354/vp.43-6-881
Myosin Heavy Chain Composition in Normal and Atrophic Equine Laryngeal Muscle
C. Adreani (2006)
10.1017/S0022215112001788
Tacrolimus enhances the recovery of normal laryngeal muscle fibre distribution after reinnervation.
P. Gorphe (2012)
10.1007/s00405-010-1355-3
Laryngeal transplantation in minipigs: vascular, myologic and functional outcomes
M. Birchall (2010)
10.1007/s00405-015-3664-z
Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation
Xiao-xia Qiu (2015)
10.3109/00016489.2013.860657
Changes in electrical response function and myosin heavy chain isoforms following denervation and reinnervation of bilateral posterior cricoarytenoid muscles in dogs
J. Li (2014)
10.1002/lary.23698
The impact of nimodipine administration combined with nerve‐muscle pedicle implantation on long‐term denervated rat thyroarytenoid muscle
Kohei Nishimoto (2013)
10.1007/978-1-4614-4466-4_11
Laryngeal Muscle Response to Neuromuscular Diseases and Specific Pathologies
Joseph C. Stemple (2012)
10.1007/978-1-4614-4466-4
Craniofacial Muscles
L. McLoon (2013)
10.1002/cphy.c130009
Mechanisms modulating skeletal muscle phenotype.
B. Blaauw (2013)
10.1177/000348940711600903
Myosin Heavy Chain Composition and Fiber Size of the Cricopharyngeus Muscle in Patients with Achalasia and Normal Subjects
Melinda V Davis (2007)
10.1152/physrev.00031.2010
Fiber types in mammalian skeletal muscles.
S. Schiaffino (2011)
10.1007/978-1-4614-4466-4_17
Comparison of the Craniofacial Muscles: A Unifying Hypothesis
Linda K McLoon (2012)
10.1016/J.JCOMDIS.2010.04.006
Quantitative PCR analysis of laryngeal muscle fiber types
Douglas van Daele (2010)
10.1044/1092-4388(2006/049)
Proteomic profiling of rat thyroarytenoid muscle.
Nathan V Welham (2006)
10.1177/0145561319874721
Evaluation of Diffusional Characteristics and Microstructure in Unilateral Vocal Fold Paralysis Using Diffusion Tensor Imaging.
Jie Cai (2019)
10.1002/mus.26460
Functional electrical stimulation following nerve injury in a large animal model
M. Cercone (2019)
10.1016/j.jcomdis.2010.04.006
Quantitative PCR analysis of laryngeal muscle fiber types.
D. V. Van Daele (2010)
10.1097/MLG.0b013e318173e188
Characterization of Laryngeal Muscle Stem Cell Survival and Proliferation
Patrick C. Walz (2008)
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