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EXISTENCE OF RESERVOIR IN THE STRATUM CORNEUM. EXPERIMENTAL PROOF.
C. F. Vickers
Published 1963 · Medicine
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A new concept of the function of the stratum corneum in percutaneous transfer is presented. Topically applied steroids forced into this layer by occlusion for a few hours with Saran Wrap remain for up to two weeks. Their presence can be demonstrated by the development of a physiological marker— vasoconstriction—after repeated occlusion with Saran. The reservoir is in the stratum corneum, as material injected intradermally does not produce a reservoir, no reservoir is demonstrable on skin stripped of the stratum corneum, and a reservoir established on unstripped skin can be destroyed by stripping the area.
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