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EXISTENCE OF RESERVOIR IN THE STRATUM CORNEUM. EXPERIMENTAL PROOF.

C. F. Vickers
Published 1963 · Medicine

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A new concept of the function of the stratum corneum in percutaneous transfer is presented. Topically applied steroids forced into this layer by occlusion for a few hours with Saran Wrap remain for up to two weeks. Their presence can be demonstrated by the development of a physiological marker— vasoconstriction—after repeated occlusion with Saran. The reservoir is in the stratum corneum, as material injected intradermally does not produce a reservoir, no reservoir is demonstrable on skin stripped of the stratum corneum, and a reservoir established on unstripped skin can be destroyed by stripping the area.
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This paper is referenced by
10.1111/j.1365-2133.1971.tb14053.x
THE IN VITRO PENETRATION OF FLUOCINONIDE THROUGH HUMAN SKIN FROM DIFFERENT VOLUMES OF DMSO
M. F. Coldman (1971)
10.1111/j.1365-2133.1991.tb00597.x
Absorption of hydrocortisone from the skin reservoir in atopic dermatitis
M. Turpeinen (1991)
10.1016/j.pharma.2015.06.002
Perspectives and strategies of alternative methods used in the risk assessment of personal care products.
Paul Quantin (2015)
10.1111/bjd.13240
Interactions between the stratum corneum and topically applied products: regulatory, instrumental and formulation issues with focus on moisturizers
M. Lodén (2014)
10.2336/NISHINIHONHIFU.68.656
Pathogenesis of Psoriasis Vulgaris (the third part): —therapies for psoriasis—@@@—乾癬の治療—
Takane Suda (2006)
10.1038/JID.1965.141
Relative potency of percutaneously absorbed corticosteroids in the suppression of pituitary-adrenal function.
R. Scoggins (1965)
10.1001/JAMA.1965.03090100042010
Topical Pharmacology and Toxicology of Dimethyl Sulfoxide—Part 1
A. Kligman (1965)
10.1111/1523-1747.EP12701619
Mechanism of percutaneous absorption. V. Percutaneous absorption of solvent deposited solids.
R. Scheuplein (1974)
10.1111/1523-1747.EP12496487
Environmental temperature and the percutaneous absorption of a cholinesterase inhibitor, VX.
F. Craig (1977)
10.1016/j.det.2015.05.004
Skin-Directed Therapies in Cutaneous T-Cell Lymphoma.
Cuong V Nguyen (2015)
10.1159/000096172
Topical Bioavailability of Triamcinolone Acetonide: Effect of Occlusion
C. Pellanda (2006)
10.1002/JPS.2600570603
Effect of topical vehicle composition on the in vitro release of fluocinolone acetonide and its acetate ester.
B. Poulsen (1968)
10.1080/09553009314550651
UV-radiation Protecting Efficacy of Thiols, Studied with UVA-induced Binding of 8-MOP and CPZ to Rat Epidermal Biomacromolecules in Vivo
L. T. V. Broeke (1993)
10.3109/9780849375903-3
DRUGS USED FOR SKIN DISEASES
N. Kitson (1998)
10.1046/J.1523-1747.2003.12131.X
Determination of the effect of lipophilicity on the in vitro permeability and tissue reservoir characteristics of topically applied solutes in human skin layers.
S. E. Cross (2003)
10.1016/j.tvjl.2012.11.004
The effects of formulation on the penetration and retention of budesonide in canine skin in vitro.
Liisa A. Ahlstrom (2013)
10.1001/ARCHDERM.1966.01600290120022
Hexachlorophene deposition in human stratum corneum. Enhancement by dimethylacetamide, dimethylsulfoxide, and methylethylether.
R. Stoughton (1966)
10.2336/NISHINIHONHIFU.38.65
Betamethasone 17-Benzoateの皮膚吸収
勲 白川 (1976)
10.1007/978-3-642-70025-5_2
Wirkstoffaufnahme durch die Haut
J. Ring (1985)
10.1111/j.1467-2494.1986.tb00437.x
Distribution and dissociation of benzoyl peroxide in cutaneous tissue after application on skin in the hairless rat
J. Wepierre (1986)
10.1111/j.1365-2133.1980.tb07658.x
Treatment of psoriasis and atopic dermatitis with halcinonide cream applied once and three times daily
T. Fredriksson (1980)
10.1002/CPHY.CP090119
Permeability of the skin.
R. Scheuplein (1971)
10.1111/j.1440-0960.1964.tb01351.x
THE EFFECTS OF BETAMETHASONE‐17‐VALERATE ON THE SKIN ON NORMAL WHITE RATS
H. Stringer (1964)
10.1038/JID.1965.65
AN IN VITRO STUDY OF THE RELATIVE MOISTURE OCCLUSIVE PROPERTIES OF SEVERAL TOPICAL VEHICLES AND SARAN WRAP.
R. E. Dempski (1965)
10.3109/09546639009089038
Therapeutic implications of corticosteroid formulations
W. A. Vloten (1990)
10.1016/0378-5173(91)90053-Q
Transdermal permeability and skin accumulation of amino acids
A. Ruland (1991)
10.1021/JS980025K
Enhanced skin permeation of sex hormones with novel topical spray vehicles.
T. M. Morgan (1998)
10.1155/2010/284230
Modelling formation of a drug reservoir in the stratum corneum and its impact on drug monitoring using reverse iontophoresis.
Yvonne Paulley (2010)
10.3390/ijms18112475
Effect of Different Skin Penetration Promoters in Halobetasol Propionate Permeation and Retention in Human Skin
Paulina Carvajal-Vidal (2017)
10.1016/0002-9343(86)90341-4
Influence of skin site on bioavailability of nitroglycerin ointment in congestive heart failure.
G. Moe (1986)
The influence of solubility, protein binding, and percutaneous absorption on reservoir formation in skin
S. R. Miselnicky (1988)
10.1111/j.1365-4632.2005.02482.x
Effect of topical corticosteroid application frequency on histamine‐induced wheals
Sharma K Narasimha (2005)
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