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Human Essential Fatty Acid Deficiency: Treatment By Topical Application Of Linoleic Acid.

Paul R. Skolnik, William H. Eaglstein, Vincent A. Ziboh
Published 1977 · Medicine
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An essential fatty acid (EFA) deficiency developed in a 19-year-old man who was being maintained on a long-term regimen of fat-free, intravenous hyperalimentation fluids. The EFA deficiency was reversed after 21 days by daily, topical application of linoleic acid to the patient's skin. The ratio of eicosatrienoic acid (20:3, n-9) to eicosatetraenoic acid (20:4, n-6) decreased to normal levels in the skin and serum with clinical improvement of the EFA deficiency syndrome. The cutaneous manifestations (scalp dermatitis, alopecia, and depigmentation of hair) were reversed with continued, topical application of safflower oil, which contains 60% to 70% linoleic acid.

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Emily L Guo (2017)
Dermatologic Problems in the Intensive Care Unit: Part IV
Rita S. Berman (1986)
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Ashley Nieves (2014)
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Blanca R. Del Pozzo-Magaña (2019)
Biological significance of essential fatty acids.
Undurti N. Das (2006)
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Munkhbayar Semchin (2008)
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Sakkat Kim (2016)
Early docosahexaenoic and arachidonic acid supplementation in extremely-low-birth-weight infants
Daniel T Robinson (2016)
Telogen effluvium.
Shannon Harrison (2002)
Principles of Paediatric Dermatological Therapy
Dennis P. West (2011)
Potential of essential fatty acid deficiency with extremely low fat diet in lipoprotein lipase deficiency during pregnancy: A case report
Elaine C Tsai (2004)
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Debasis Bagchi (2015)
Evaluation of moisturizing and irritation potential of sacha inchi oil.
Wichuda Soimee (2019)
The empiric use of palm kernel oil in neonatal skin care: Justifiable or not?
Andreas Chiabi (2011)
Disorders of Hair
Andrew G. Messenger (2010)
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