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National Patterns In Antidepressant Medication Treatment.

Mark Olfson, Steven C Marcus
Published 2009 · Medicine
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CONTEXT Antidepressants have recently become the most commonly prescribed class of medications in the United States. OBJECTIVE To compare sociodemographic and clinical patterns of antidepressant medication treatment in the United States between 1996 and 2005. DESIGN Analysis of antidepressant use data from the 1996 (n = 18 993) and 2005 (n = 28 445) Medical Expenditure Panel Surveys. SETTING Households in the United States. PARTICIPANTS Respondents aged 6 years or older who reported receiving at least 1 antidepressant prescription during that calendar year. MAIN OUTCOME MEASURES Rate of antidepressant use and adjusted rate ratios (ARRs) of year effect on rate of antidepressant use adjusted for age, sex, race/ethnicity, annual family income, self-perceived mental health, and insurance status. RESULTS The rate of antidepressant treatment increased from 5.84% (95% confidence interval [CI], 5.47-6.23) in 1996 to 10.12% (9.58-10.69) in 2005 (ARR, 1.68; 95% CI, 1.55-1.81), or from 13.3 to 27.0 million persons. Significant increases in antidepressant use were evident across all sociodemographic groups examined, except African Americans (ARR, 1.13; 95% CI, 0.89-1.44), who had comparatively low rates of use in both years (1996, 3.61%; 2005, 4.51%). Although antidepressant treatment increased for Hispanics (ARR, 1.75; 95% CI, 1.60-1.90), it remained comparatively low (1996, 3.72%; 2005, 5.21%). Among antidepressant users, the percentage of patients treated for depression did not significantly change (1996, 26.25% vs 2005, 26.85%; ARR, 0.95; 95% CI, 0.83-1.07), although the percentage of patients receiving antipsychotic medications (5.46% vs 8.86%; ARR, 1.77; 95% CI, 1.31-2.38) increased and those undergoing psychotherapy declined (31.50% vs 19.87%; ARR, 0.65; 95% CI, 0.56-0.72). CONCLUSIONS From 1996 to 2005, there was a marked and broad expansion in antidepressant treatment in the United States, with persisting low rates of treatment among racial/ethnic minorities. During this period, individuals treated with antidepressants became more likely to also receive treatment with antipsychotic medications and less likely to undergo psychotherapy.
This paper references
Prescription drugs and the changing patterns of treatment for mental disorders, 1996-2001.
Samuel H. Zuvekas (2005)
Prevalence and treatment of mental disorders, 1990 to 2003.
Ronald C. Kessler (2005)
The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD.
Christopher D. Schneck (2008)
Trends in use of antidepressants, lithium, and anticonvulsants in Kaiser Permanente-insured youths, 1994-2003.
Enid M. Hunkeler (2005)
Goodman and Gilman's The Pharmacological Basis of Therapeutics
Marcel J. Casavant (2002)
Economic grand rounds: financial disincentives for the provision of psychotherapy.
Joyce C. West (2003)
Depression treatment during outpatient visits by U.S. children and adolescents.
Jun Ma (2005)
National Ambulatory Medical Care Survey: 2005 summary.
Donald K Cherry (2002)
On modelling response propensity for dwelling unit (DU) level non-response adjustment in the Medical Expenditure Panel Survey (MEPS).
Lap-Ming Wun (2007)
Design and Methods of the Medical Expenditure Panel Survey Household Component
Joseph L. Cohen (1997)
Treatment preferences among depressed primary care patients
Megan Dwight-Johnson (2007)
Effectiveness of adjunctive antidepressant treatment for bipolar depression.
Gary S. Sachs (2007)
Sample Design of the Medical Expenditure Panel Survey Household Component, 1998–2007
TM Ezzati-Rice (2008)
Consensus statement on social anxiety disorder from the International Consensus Group on Depression and Anxiety.
James C. Ballenger (1998)
The Carter Center Mental Health Program: Addressing the Public Health Crisis in the Field of Mental Health Through Policy Change and Stigma Reduction
Rebecca G. Palpant (2006)
RNST (2002)
Impact of antidepressant drug adherence on comorbid medication use and resource utilization.
Wayne J. Katon (2005)
Provider and patient characteristics associated with antidepressant nonadherence: the impact of provider specialty.
Kara Zivin Bambauer (2007)
Patterns of adult psychotherapy in psychiatric practice.
Joshua E. Wilk (2006)
Ethnicity/race and the diagnosis of depression and use of antidepressants by adults in the United States.
David A Sclar (2008)
Increasing use of new prescription drugs: a case study.
Sandra M. Foote (2000)
The impact of survey attrition on health insurance coverage estimates in a National Longitudinal Health Care Survey
Steven B. Cohen (2006)
New Data Show Declines In Antidepressant Prescribing
Jim Rosack (2005)
Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression.
A. John Rush (2006)
National Trends in Ethnic Disparities in Mental Health Care
Carlos Blanco (2007)
Increase in Antidepressant Medication in the US Adult Population between 1990 and 2003
Ramin Mojtabai (2008)
Management of fibromyalgia syndrome.
Don L. Goldenberg (1989)
Risk perception research and the black box warning for SSRIs in children.
Randall D. Marshall (2006)
Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration
Irving Kirsch (2008)
Trends in psychotropic medication use among U.S. adults.
Ryne Paulose-Ram (2007)
Depressive symptoms and antidepressant use in a random community sample of ethnically diverse, urban elder persons.
Michael F Grunebaum (2008)
Racial variation in antidepressant treatment in a Medicaid population.
Catherine A. Melfi (2000)
National estimates of antidepressant medication use among U.S. children, 1997-2002.
Benedetto Vitiello (2006)
FDA Public Healt (2008)
The Acceptability of Treatment for Depression Among African-American, Hispanic, and White Primary Care Patients
Lisa A. Cooper (2003)
Racial differences in attitudes toward professional mental health care and in the use of services.
Chamberlain C. Diala (2000)
Income, Poverty, and Health Insurance Coverage in the United States: 2004
Carmen DeNavas-Walt (2005)
Design and estimation strategies in the Medical Expenditure Panel Survey for investigating trends in health care expenditures
T Ezzati-Rice (2004)
The Expert Consensus Guideline Series. Treatment of depression in women.
Lori L. Altshuler (2001)
Changes in the prevalence of major depression and comorbid substance use disorders in the United States between 1991-1992 and 2001-2002.
Wilson M Compton (2006)
Estimation procedures in the 1996 Medical Expenditure Panel Survey Household Component.
Cohen Sb (1999)
Prescribing trends in psychotropic medications: primary care, psychiatry, and other medical specialties.
Harold A. Pincus (1998)
Safety and tolerability of emerging pharmacological treatments for bipolar disorder.
David L. Dunner (2005)
Selective publication of antidepressant trials and its influence on apparent efficacy.
Erick H Turner (2008)
Safety and tolerability of emerging pharmacological treatments for
DL Dunner (2005)
Americans' attitudes toward mental health treatment seeking: 1990-2003.
Ramin Mojtabai (2007)
Is the prevalence of mental disorders a good measure of the need for services?
David Mechanic (2003)
Suicidality in children and adolescents being treated with antidepressant medications
J Rosack (2007)
Patients' preferences in the treatment of depressive disorder in primary care.
Digna J. F. van Schaik (2004)
A decade of direct-to-consumer advertising of prescription drugs.
Julie M. Donohue (2007)
The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).
Ronald C. Kessler (2003)
Impact of the FDA black box warning on physician antidepressant prescribing and practice patterns: opening Pandora's suicide box.
Timothy W. Lineberry (2007)
National trends in psychotherapy by office-based psychiatrists.
Ramin Mojtabai (2008)
Improving medication management of depression in health plans.
Constance M. Horgan (2008)
Testing for statistical discrimination by race/ethnicity in panel data for depression treatment in primary care.
Thomas McGuire (2008)
Measuring trends in mental health care disparities, 2000 2004.
Benjamin Lê Cook (2007)
Treatment of bipolar depression: an update.
Konstantinos N Fountoulakis (2008)
Overuse of Antidepressant Drugs for the Treatment of Depression
Jon N Jureidini (2006)
Changing Perceptions of Depression: Ten- Year Trends From the General Social Survey
M.P.H. Kate H. Blumner (2009)

This paper is referenced by
Initial prescription of antipsychotics and antidepressants in general practice and specialist care in Norway.
Svein Reidar Kjosavik (2011)
Antidepressants work, sort of--our system of care does not.
Ronald William Pies (2010)
Clinical Characteristics and Outpatient Mental Health Service Use of Transition-Age Youth in the USA
Kathleen J. Pottick (2013)
Antidepressant use in persons aged 12 and over: United States, 2005-2008.
Laura A. Pratt (2011)
Prescribing and Prescribers of Psychotropic Drugs in Norway. A population based pharmacoepidemiological study
Svein Reidar Kjosavik (2012)
Adjustment Disorders: Diagnostic and Treatment Issues
Patricia Casey (2013)
The prospective association between obesity and major depression in the general population: does single or recurrent episode matter?
Yeshambel T. Nigatu (2015)
The Costs Associated with Antidepressant Use in Depression and Anxiety in Community-Living Older Adults
Helen-Maria Vasiliadis (2013)
Prevalence and determinants of gastrointestinal symptoms in the Dutch community
Merel M. Tielemans (2013)
Economic factors in of patients’ nonadherence to antidepressant treatment
Haekyung Jeon-Slaughter (2012)
Provision of Health Services: Mental Health Care
Jon Cylus (2018)
The Use and Misuse of Psychiatric Drugs: An Evidence-Based Critique
Joel Paris (2010)
Beliefs of people taking antidepressants about the causes of their own depression.
John Read (2015)
STAR*D: A Tale and Trail of Bias
H. Edmund Pigott (2011)
Talking Circles for Adolescent Girls in an Urban High School: A Restorative Practices Program for Building Friendships and Developing Emotional Literacy Skills
Martha Ann Schumacher (2012)
Utilizing Consumer Health Posts for Pharmacovigilance: Identifying Underlying Factors Associated with Patients’ Attitudes Towards Antidepressants
Maryam Zolnoori (2017)
Association of Focused Medication Review With Optimization of Psychotropic Drug Prescribing
Rory Sheehan (2018)
Pitfalls in Geriatric Prescribing: Antidepressants and Extreme Sedation
Hirofumi Namiki (2019)
Autism risk following antidepressant medication during pregnancy
Alexander Viktorin (2017)
Adjustment disorder: A diagnosis whose time has come.
Rahel Bachem (2018)
Antidepressant drug use and subdural hematoma risk.
David Gaist (2019)
Differential effect of an anticholinergic antidepressant on sleep-dependent memory consolidation.
Monique Goerke (2014)
Prevalence of mood-altering and opioid medication use among spine surgery candidates and relationship with hospital cost
Mohammad Sami Walid (2010)
Trends in prescriptions and costs of drugs for mental disorders in England, 1998-2010.
S. Ilyas (2012)
Psychopharmaka und Diabetes
Claudia Ress (2011)
Does heterogeneity of depression diagnosis harm those with severe mood disorders?
Rebekah Snyder (2013)
Changing prevalence and treatment of depression among older people over two decades.
Antony Arthur (2019)
Psychotropic drug and polypharmacy use among adolescents and young adults: Findings from the Finnish 1981 Nationwide Birth Cohort Study
David Gyllenberg (2012)
Combining Antidepressants with Beta-Blockers: Evidence of a Clinically Significant CYP2D6 Drug Interaction.
Jaekyu Shin (2020)
The Infernal Alternatives of Corporate Pharmaceutical Research: Abandoning Psychiatry
Joseph Dumit (2018)
The DSM, Big Pharma, and Clinical Practice Guidelines: Protecting Patient Autonomy and Informed Consent
Lisa Cosgrove (2011)
Association of Antidepressant Medications With Incident Type 2 Diabetes Among Medicaid-Insured Youths
Mehmet Burcu (2017)
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