Online citations, reference lists, and bibliographies.

Autism Prevalence Trends Over Time In Denmark: Changes In Prevalence And Age At Diagnosis.

E. Parner, D. Schendel, P. Thorsen
Published 2008 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
OBJECTIVE To examine the effect of changing age at diagnosis on the diagnosed prevalence of autism among different birth cohorts. DESIGN Population-based cohort study. SETTING Children were identified in the Danish Medical Birth Registry and psychiatric outcomes were obtained via linkage with the Danish National Psychiatric Register. PARTICIPANTS All children born in Denmark from January 1, 1994, through December 31, 1999 (N = 407 458). MAIN OUTCOME MEASURES The age-specific prevalence, hazard ratio, and relative risk by age. RESULTS Statistically significant shifts in age at diagnosis were observed for autism spectrum disorder; children diagnosed before age 9 years in the cohorts born between January 1, 1994, and December 31, 1995, between January 1, 1996, and December 31, 1997, and between January 1, 1998, and December 31, 1999, were on average diagnosed at ages 5.9 (95% confidence interval [CI], 5.8-6.0), 5.8 (95% CI, 5.7-5.9), and 5.3 (95% CI, 5.2-5.4) years, respectively. The relative risk comparing the 1996-1997 birth cohort with the 1994-1995 birth cohort at age 3 years was 1.20 (95% CI, 0.86-1.67), which decreased to 1.10 (95% CI, 1.00-1.20) at age 11 years. Similarly, the relative risk comparing the 1998-1999 birth cohort with the 1994-1995 birth cohort at age 3 years was 1.69 (95% CI, 1.24-2.31), which decreased to 1.23 (95% CI, 1.11-1.37) at age 11 years. Similar results were observed for childhood autism. CONCLUSIONS Shifts in age at diagnosis inflated the observed prevalence of autism in young children in the more recent cohorts compared with the oldest cohort. This study supports the argument that the apparent increase in autism in recent years is at least in part attributable to decreases in the age at diagnosis over time.
This paper references
Factors associated with age at diagnosis among children with autism spectrum disorders. Pediatrics
DS Mandell (2005)
10.1038/ncpneuro0731
Diagnosis of autism spectrum disorders in the first 3 years of life
R. Landa (2008)
10.1542/peds.108.5.1155
Prevalence of autism in a United States population: the Brick Township, New Jersey, investigation.
J. Bertrand (2001)
10.1023/A:1015453830880
The Changing Prevalence of Autism in California
L. Croen (2002)
10.1176/appi.ajp.162.6.1133
Pervasive developmental disorders in preschool children: confirmation of high prevalence.
S. Chakrabarti (2005)
10.1097/chi.0b013e31804a7f3b
The autism epidemic: fact or artifact?
A. Wazana (2007)
10.1542/peds.2005-1516
The Contribution of Diagnostic Substitution to the Growing Administrative Prevalence of Autism in US Special Education
P. Shattuck (2006)
10.1017/S0033291704002387
The incidence and prevalence of pervasive developmental disorders: a Danish population-based study.
M. Lauritsen (2004)
10.1001/archpedi.159.1.37
The incidence of autism in Olmsted County, Minnesota, 1976-1997: results from a population-based study.
W. Barbaresi (2005)
The Danish Medical Birth Registry.
L. Knudsen (1998)
10.1136/adc.88.8.666
Prevalence of autism and parentally reported triggers in a north east London population
R. Lingam (2003)
10.1001/jama.289.1.49
Prevalence of autism in a US metropolitan area.
M. Yeargin-Allsopp (2003)
10.1001/archpedi.157.7.622
Analysis of prevalence trends of autism spectrum disorder in Minnesota.
J. Gurney (2003)
10.1542/peds.2004-1958
National Autism Prevalence Trends From United States Special Education Data
C. Newschaffer (2005)
10.1542/peds.2005-0185
Factors Associated With Age of Diagnosis Among Children With Autism Spectrum Disorders
D. Mandell (2005)
10.1002/sim.1203
Flexible parametric proportional-hazards and proportional-odds models for censored survival data, with application to prognostic modelling and estimation of treatment effects.
P. Royston (2002)
Epidemiology of autistic disorder and other pervasive developmental disorders.
E. Fombonne (2005)
The Danish Psychiatric Central Register.
P. Munk-jørgensen (1997)
10.1001/jama.285.9.1183
Time trends in autism and in MMR immunization coverage in California.
L. Dales (2001)
10.1037/e566462006-001
Prevalence of four developmental disabilities among children aged 8 years--Metropolitan Atlanta Developmental Disabilities Surveillance Program, 1996 and 2000.
Tanya Karapurkar Bhasin (2006)
10.1176/appi.ps.56.1.56
Trends in diagnosis rates for autism and ADHD at hospital discharge in the context of other psychiatric diagnoses.
D. Mandell (2005)
10.1002/EBCH.1949
Vaccines for measles, mumps and rubella in children.
V. Demicheli (2005)
10.1001/archpedi.161.2.193
Time trends in reported diagnoses of childhood neuropsychiatric disorders: a Danish cohort study.
H. Atladóttir (2007)
Prevalence of autism spectrum disorders--autism and developmental disabilities monitoring network, 14 sites, United States, 2002.
Jon Baio (2007)



This paper is referenced by
10.1016/j.annepidem.2011.12.006
Parental age and autism spectrum disorders.
Erik T Parner (2012)
10.1016/j.dhjo.2009.10.008
Changes in autism spectrum disorder prevalence in 4 areas of the United States.
Catherine E. Rice (2010)
10.7554/eLife.02917
Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
Jan Sundquist (2014)
10.1542/peds.2017-4161
The Prevalence of Parent-Reported Autism Spectrum Disorder Among US Children
M. Kogan (2018)
10.1111/JSSR.12521
Religion and Disability: Variation in Religious Service Attendance Rates for Children with Chronic Health Conditions
Andrew L. Whitehead (2018)
10.1016/j.bbi.2011.09.003
Amniotic fluid chemokines and autism spectrum disorders: An exploratory study utilizing a Danish Historic Birth Cohort
Morsi Abdallah (2012)
10.1111/j.1365-3016.2012.01296.x
Using maternally reported data to investigate the association between early childhood infection and autism spectrum disorder: the importance of data source.
Hjördís Ósk Atladóttir (2012)
10.1016/j.juro.2011.03.070
Age at cryptorchidism diagnosis and orchiopexy in Denmark: a population based study of 508,964 boys born from 1995 to 2009.
Morten Søndergaard Jensen (2011)
10.1093/ije/dyw073
Parental age and attention-deficit/hyperactivity disorder (ADHD).
Susanne Hvolgaard Mikkelsen (2017)
10.1007/s10995-012-1004-0
Parent-Reported Prevalence of Autism Spectrum Disorders in US-Born Children: An Assessment of Changes within Birth Cohorts from the 2003 to the 2007 National Survey of Children’s Health
Laura A Schieve (2012)
10.3109/15622975.2011.639803
Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders
Morsi W. Abdallah (2013)
10.1007/s10803-014-2053-6
Time Trends Over 16 Years in Incidence-Rates of Autism Spectrum Disorders Across the Lifespan Based on Nationwide Danish Register Data
Christina Mohr Jensen (2014)
10.1007/s10803-016-2980-5
Urban and Education Disparity for Autism Spectrum Disorders in Taiwan Birth Cohort Study
For-Wey Lung (2017)
A Sibling Case-Control Study of Maternal Prenatal Body Mass Index as a Risk Factor For Autism Spectrum Disorder
Ruth Ann Hendrix (2011)
Reliability and Validity of Autism Diagnostic Interview-Revised,
Japanese Version (2013)
Dorsal anterior cingulate cortex glutamate concentrations and their relationships in adults with autism spectrum disorder
Jennifer Eileen Siegel-Ramsay (2018)
10.1016/B978-0-12-800228-5.00001-7
Overview of the Role of Environmental Factors in Neurodevelopmental Disorders
Pamela J. Lein (2015)
10.1007/s10803-013-1856-1
The changing prevalence of autism in three regions of Canada
Hélène Ouellette-Kuntz (2014)
10.1093/humrep/dez298
Infertility treatment and autism risk using the Modified Checklist for Autism in Toddlers (M-CHAT).
Sonia L Robinson (2020)
Troubles du spectre autistique, migration et concept d’ethnicité
Juliette Neyton (2015)
10.1007/s10803-010-1132-6
Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design
Katja M. Lampi (2011)
10.1007/s10803-018-3850-0
Dietary Patterns and Anthropometric Measures of Indian Children with Autism Spectrum Disorder
Seema Siddiqi (2019)
10.1542/peds.2009-1522
Prevalence of Parent-Reported Diagnosis of Autism Spectrum Disorder Among Children in the US, 2007
M. Kogan (2009)
10.1007/s10803-015-2497-3
Stoppage in Autism Spectrum Disorders
Therese Koops Grønborg (2015)
Screening for Autism Spectrum Disorders in Children below the age of 5 years A draft report for the UK National Screening Committee
Martin Allaby (2011)
10.1007/978-981-13-2194-8_11
Neurodevelopmental Disorders in the Hamamatsu Birth Cohort for Mothers and Children (HBC Study)
Kenji Tsuchiya (2019)
10.1179/147683010X12611460763922
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders
P. Whiteley (2010)
10.1016/J.RASD.2010.01.003
Unpacking the complex nature of the autism epidemic
Helen Leonard (2010)
10.1542/peds.2010-2943
Early Diagnoses of Autism Spectrum Disorders in Massachusetts Birth Cohorts, 2001–2005
Susan E. Manning (2011)
10.1007/978-3-030-30402-7_1
Overview and Introduction to Autism Spectrum Disorder (ASD).
Nader Al-Dewik (2020)
10.1007/s10803-013-1785-z
Early Signs of Autism in Toddlers: A Follow-Up Study in the Danish National Birth Cohort
Sanne Lemcke (2013)
Increasing autism prevalence in metropolitan
Walter M. Zahorodny (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar