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Pulmonary Hypertension.

S. Shah
Published 2012 · Medicine

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Pulmonary hypertension (PH), defined as elevated pulmonary artery pressure, is common in the general population and associated with increased mortality. Accordingly, physicians commonly encounter patients with dyspnea, exercise intolerance, and/or right heart failure who have elevated pulmonary artery systolic pressure (PASP) on echocardiography. Although pulmonary arterial vasodilators may often be considered in this setting, these drugs have been predominantly tested in the subset of PH patients with pulmonary arterial hypertension (PAH). Elevated PASP alone is not sufficient for the diagnosis of PAH, and secondary causes of PASP elevation, most commonly left heart disease, are far more prevalent than isolated PAH. Treatment of this more common group of patients with PH due to left heart disease is challenging because there are few evidence-based treatment options, and pulmonary vasodilator therapy may lead to worsening symptoms. Therefore, improving symptoms and avoiding adverse outcomes in patients with PH requires the following: (1) understanding the optimal use of echocardiography for the diagnosis of PH; (2) recognizing the utility and proper interpretation of invasive hemodynamic testing prior to starting pulmonary vasodilator therapy; (3) differentiating PAH from pulmonary venous hypertension due to left heart disease; and (4) understanding the appropriate treatment strategies for PH and resultant right heart failure.
This paper references
10.1016/J.JACC.2007.07.078
Long-term use of sildenafil in the therapeutic management of heart failure.
M. Guazzi (2007)
Mortality inadultswith sickle cell diseaseandpulmonary hypertension
A Mehari (2012)
GualandroSF.Pulmonaryhypertensiondiagnosedbyright heart catheterisation in sickle cell disease
GH Fonseca (2012)
10.1056/NEJMOA032274
Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism.
V. Pengo (2004)
Diagnosis and differentialassessmentofpulmonaryarterialhypertension
RJ Barst (2004)
10.1016/j.amjcard.2010.02.039
Prevalence and risk factors of pulmonary hypertension in patients with elevated pulmonary venous pressure and preserved ejection fraction.
Calvin C. Leung (2010)
Guidelines for the echocardiographicassessmentof therightheart inadults
LaiWW RudskiLG (2010)
10.1016/j.rmed.2010.05.009
Categorization and impact of pulmonary hypertension in patients with advanced COPD.
M. Cuttica (2010)
10.1016/j.healun.2013.01.314
Survival in Pulmonary Arterial Hypertension Patients Awaiting Transplant
Mardi Gomberg‐Maitland (2013)
10.1161/CIRCULATIONAHA.106.674028
Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications.
H. C. Champion (2009)
Right ventricular function in cardiovascular disease : part I
F Haddad (2008)
10.7326/0003-4819-115-5-343
Survival in patients with primary pulmonary hypertension. Results from a national prospective registry.
G. D'Alonzo (1991)
10.1161/CIRCULATIONAHA.107.653584
Right Ventricular Function in Cardiovascular Disease, Part II: Pathophysiology, Clinical Importance, and Management of Right Ventricular Failure
F. Haddad (2008)
Updated clinicalclassificationofpulmonaryhypertension
IM Robbins (2009)
10.1161/CIRCULATIONAHA.107.653576
Right Ventricular Function in Cardiovascular Disease, Part I: Anatomy, Physiology, Aging, and Functional Assessment of the Right Ventricle
F. Haddad (2008)
10.1016/j.ahj.2012.01.024
Current practice for determining pulmonary capillary wedge pressure predisposes to serious errors in the classification of patients with pulmonary hypertension.
J. Ryan (2012)
10.1164/rccm.200912-1820OC
Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension.
A. Campo (2010)
10.1161/CIRCULATIONAHA.110.983866
Pulmonary Hypertension in Heart Failure With Preserved Ejection FractionClinical Perspective
M. Guazzi (2011)
Pulmonaryhypertension in hemolytic disorders
GladwinMT MachadoRF (2010)
10.1001/jama.2012.358
Mortality in adults with sickle cell disease and pulmonary hypertension.
A. Mehari (2012)
10.1016/J.REPCE.2011.10.006
Guidelines for the diagnosis and treatment of pulmonary hypertension
N. Galiè (2012)
Accuracy of noninvasivelydeterminedpulmonaryarterysystolicpressure
JM Testani (2010)
10.1161/CIRCHEARTFAILURE.110.958801
Clinical Characteristics of Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction
T. Thenappan (2011)
10.1161/CIRCULATIONAHA.108.838698
Age-Associated Increases in Pulmonary Artery Systolic Pressure in the General Population
C. Lam (2009)
10.1016/j.jacc.2009.04.008
Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension.
M. Hoeper (2009)
10.1161/CIRCULATIONAHA.107.719500
Association of Serum Creatinine With Abnormal Hemodynamics and Mortality in Pulmonary Arterial Hypertension
S. Shah (2008)
10.1378/chest.11-0344
Limitations inherent to the simplified Bernoulli equation explain the inaccuracy of Doppler echocardiographic estimates of pulmonary artery pressures in patients with pulmonary hypertension.
A. Giardini (2011)
Right ventricular function in cardiovascular disease : part II
F Haddad (2008)
10.1016/S0145-4145(08)01041-1
Elevated Pulmonary Artery Pressure by Doppler Echocardiography Predicts Hospitalization for Heart Failure and Mortality in Ambulatory Stable Coronary Artery Disease: The Heart and Soul Study
M. Cheitlin (2008)
10.1007/s00408-011-9293-4
Echocardiographic Evidence of Pulmonary Hypertension is Associated with Increased 1-year Mortality in Patients Admitted with Chronic Obstructive Pulmonary Disease
A. C. Stone (2011)
10.1016/S0046-8177(85)80215-X
Pulmonary vascular disease and hypertension after valve surgery for mitral stenosis.
A. F. Tryka (1985)
10.1002/UOG.122
Applying the right statistics: analyses of measurement studies.
J. Bland (2003)
10.1016/j.cardfail.2010.01.003
Pulmonary hypertension in heart failure.
M. Guglin (2010)
10.1016/j.accreview.2004.10.043
Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the Endothelin-A Receptor Antagonist Trial in heart failure (EARTH): Randomised, double-blind, placebo-controlled trial ☆
I. Anand (2004)
10.1097/00000542-196908000-00024
Pulmonary hypertension.
S. Gaine (2000)
10.1161/CIRCULATIONAHA.109.933275
Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival
J. Testani (2010)
Pulmonaryhypertensiondiagnosedbyright heart catheterisation in sickle cell disease
GH Fonseca (2012)
10.1016/J.YPED.2011.10.023
A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease
J. A. Stockman (2013)
10.1183/09031936.00139009
Guidelines for the diagnosis and treatment of pulmonary hypertension
N. Galié (2009)
10.1056/NEJM200406103502418
Pulmonary hypertension as a risk factor for death in patients with sickle cell disease.
E. Klings (2004)
10.1161/CIRCULATIONAHA.107.723007
Diagnosis and treatment of secondary (non-category 1) pulmonary hypertension.
S. Rich (2008)
10.1016/j.amjcard.2009.06.048
Frequency and impact of pulmonary hypertension in patients with obstructive sleep apnea syndrome.
O. Minai (2009)
10.1016/S0002-8703(97)70105-4
A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST).
R. Califf (1997)
10.1055/s-0033-1356490
Pulmonary hypertension associated with left heart disease.
Yochai Adir (2013)
prehensive invasive and noninvasive approach to the right ventriclepulmonary circulation unit
HC Champion (2009)
etal.Guidelines for the echocardiographicassessmentof therightheart inadults
RudskiLG (2010)
10.1016/j.jacc.2009.04.011
Diagnosis and assessment of pulmonary arterial hypertension.
D. Badesch (2009)
Accuracy of noninvasivelydeterminedpulmonaryarterysystolicpressure.Am
JM Testani (2010)
10.1016/j.amjcard.2007.11.010
Usefulness of noninvasive estimate of pulmonary vascular resistance to predict mortality, heart failure, and adverse cardiovascular events in Patients With stable coronary artery disease (from the Heart and Soul Study).
Ramin Farzaneh-Far (2008)
10.1161/CIRCULATIONAHA.106.626226
Sildenafil Improves Exercise Hemodynamics and Oxygen Uptake in Patients With Systolic Heart Failure
G. Lewis (2007)
10.1016/J.JACC.2006.07.061
Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers.
M. Hoeper (2006)
Tricuspidannular displacement predicts survival in pulmonary hypertension
ForfiaPR (2006)
10.1016/j.ejheart.2004.10.021
Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure
Juan F. Delgado (2005)
10.1378/chest.08-2784
Misclassification of pulmonary hypertension due to reliance on pulmonary capillary wedge pressure rather than left ventricular end-diastolic pressure.
S. Halpern (2009)
10.1378/chest.08-2008
Association of the metabolic syndrome with pulmonary venous hypertension.
Ivan R. Robbins (2009)
Sildena - fil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure
GD Lewis (2007)
ACCF / AHA 2009 expert consensus document on pulmonary hypertension
VV McLaughlin
10.1378/chest.10-1269
Inaccuracy of Doppler echocardiographic estimates of pulmonary artery pressures in patients with pulmonary hypertension: implications for clinical practice.
J. Rich (2011)
10.1161/01.CIR.0000024254.18659.22
Clinical correlates and reference intervals for pulmonary artery systolic pressure among echocardiographically normal subjects.
R. Milani (2002)
10.1164/RCCM.200604-547OC
Tricuspid annular displacement predicts survival in pulmonary hypertension.
P. Forfia (2006)
10.1016/S8756-3452(08)70399-2
Pulmonary Arterial Hypertension in France: Results from a National Registry
K. L. Lewis (2007)
Incidence of chronic thromboembolicpulmonaryhypertensionafter pulmonary embolism
V Pengo (2004)
10.1164/rccm.200811-1691OC
Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension.
M. Fisher (2009)
10.1093/EURHEARTJ/EHM567
Right coronary artery flow impairment in patients with pulmonary hypertension.
S. A. van Wolferen (2008)
ACCF/AHA Expert Consensus Document
Vallerie V. McLaughlin (2009)
10.1159/000146076
Pulmonary Hypertension in Chronic Renal Failure Patients
S. Abdelwhab (2008)



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