Online citations, reference lists, and bibliographies.

Association Between Blood Pressure Control And Risk Of Recurrent Intracerebral Hemorrhage.

A. Biffi, C. Anderson, T. Battey, A. Ayres, S. Greenberg, A. Viswanathan, J. Rosand
Published 2015 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
IMPORTANCE Intracerebral hemorrhage (ICH) is the most severe form of stroke. Survivors are at high risk of recurrence, death, and worsening functional disability. OBJECTIVE To investigate the association between blood pressure (BP) after index ICH and risk of recurrent ICH. DESIGN, SETTING, AND PARTICIPANTS Single-site, tertiary care referral center observational study of 1145 of 2197 consecutive patients with ICH presenting from July 1994 to December 2013. A total of 1145 patients with ICH survived at least 90 days and were followed up through December 2013 (median follow-up of 36.8 months [minimum, 9.8 months]). EXPOSURES Blood pressure measurements at 3, 6, 9, and 12 months, and every 6 months thereafter, obtained from medical personnel (inpatient hospital or outpatient clinic medical or nursing staff) or via patient self-report. Exposure was characterized in 3 ways: (1) recorded systolic and diastolic measurements; (2) classification as adequate or inadequate BP control based on American Heart Association/American Stroke Association recommendations; and (3) stage of hypertension based on Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure 7 criteria. MAIN OUTCOMES AND MEASURES Recurrent ICH and its location within the brain (lobar vs nonlobar). RESULTS There were 102 recurrent ICH events among 505 survivors of lobar ICH and 44 recurrent ICH events among 640 survivors of nonlobar ICH. During follow-up adequate BP control was achieved on at least 1 measurement by 625 patients (54.6% of total [range, 49.2%-58.7%]) and consistently (ie, at all available time points) by 495 patients (43.2% of total [range, 34.5%-51.0%]). The event rate for lobar ICH was 84 per 1000 person-years among patients with inadequate BP control compared with 49 per 1000 person-years among patients with adequate BP control. For nonlobar ICH the event rate was 52 per 1000 person-years with inadequate BP control compared with 27 per 1000 person-years for patients with adequate BP control. In analyses modeling BP control as a time-varying variable, inadequate BP control was associated with higher risk of recurrence of both lobar ICH (hazard ratio [HR], 3.53 [95% CI, 1.65-7.54]) and nonlobar ICH (HR, 4.23 [95% CI, 1.02-17.52]). Systolic BP during follow-up was associated with increased risk of both lobar ICH recurrence (HR, 1.33 per 10-mm Hg increase [95% CI, 1.02-1.76]) and nonlobar ICH recurrence (HR, 1.54 [95% CI, 1.03-2.30]). Diastolic BP was associated with increased risk of nonlobar ICH recurrence (HR, 1.21 per 10-mm Hg increase [95% CI, 1.01-1.47]) but not with lobar ICH recurrence (HR, 1.36 [95% CI, 0.90-2.10]). CONCLUSIONS AND RELEVANCE In this observational single-center cohort study of ICH survivors, reported BP measurements suggesting inadequate BP control during follow-up were associated with higher risk of both lobar and nonlobar ICH recurrence. These data suggest that randomized clinical trials are needed to address the benefits and risks of stricter BP control in ICH survivors.
This paper references
evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC
PA James (2014)
10.1161/01.STR.31.10.2307
Orthostatic Hypotension as a Risk Factor for Stroke: The Atherosclerosis Risk in Communities (ARIC) Study, 1987–1996
M. Eigenbrodt (2000)
10.1001/jamainternmed.2014.3279
Observational modeling of strict vs conventional blood pressure control in patients with chronic kidney disease.
C. Kovesdy (2014)
Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
A V Chobanian
10.2337/dc13-0189
Aggressive Blood Pressure Control Increases Coronary Heart Disease Risk Among Diabetic Patients
Wenhui Zhao (2013)
10.1056/NEJMsa1406751
Cost-effectiveness of hypertension therapy according to 2014 guidelines.
A. Moran (2015)
Guidelines for themanagement of spontaneous intracerebral hemorrhage in adults :
J Broderick (2007)
10.1161/STROKEAHA.112.658369
Different Impacts of Blood Pressure Variability on the Progression of Cerebral Microbleeds and White Matter Lesions
W. Liu (2012)
10.1007/s11606-011-1660-6
Impact of Diastolic and Systolic Blood Pressure on Mortality: Implications for the Definition of “Normal”
Mph Brent C. Taylor PhD (2011)
10.5580/21b3
[Intracerebral hemorrhage].
N. Yasui (2006)
10.1161/01.HYP.0000107251.49515.C2
Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.
A. Chobanian (2003)
CASISP Study Group. Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions. Stroke
W Liu (2015)
10.1136/jnnp-2014-307856
Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial
H. Arima (2014)
10.1007/S11906-009-0057-Y
Blood pressure control in the elderly: Can you have too much of a good thing?
D. Hyman (2009)
10.1212/WNL.0b013e3181eee40f
Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy
A. Biffi (2010)
10.1002/ana.22134
Variants at APOE influence risk of deep and lobar intracerebral hemorrhage
A. Biffi (2010)
10.1161/STROKEAHA.112.663047
Poor Long-Term Blood Pressure Control After Intracerebral Hemorrhage
D. Zahuranec (2012)
10.1136/jnnp-2011-300371
The association between cerebral amyloid angiopathy and intracerebral haemorrhage: systematic review and meta-analysis
N. Samarasekera (2011)
10.1001/jama.2013.284427
2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).
P. James (2014)
10.1001/JAMA.289.19.2560
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.
A. Chobanian (2003)
National High Blood Pressure Education Program.
C. Lenfant (1986)
Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working G
J. Broderick (2007)
10.1097/01.hjh.0000226212.34055.86
Lower target blood pressures are safe and effective for the prevention of recurrent stroke: the PROGRESS trial
H. Arima (2006)
10.1161/STROKEAHA.109.563932
Effects of Perindopril-Based Lowering of Blood Pressure on Intracerebral Hemorrhage Related to Amyloid Angiopathy: The PROGRESS Trial
H. Arima (2010)
10.1136/jnnp-2013-306476
Long-term prognosis after intracerebral haemorrhage: systematic review and meta-analysis
M. T. C. Poon (2013)



This paper is referenced by
10.1016/B978-0-323-42973-3.00036-6
36 – Cerebrovascular Disease
Philip B Gorelick (2018)
10.30629/2658-7947-2019-24-6-29-38
Амилоидный ангиит и прогрессирующий корковый поверхностный сидероз как агрессивные фенотипы церебральной амилоидной ангиопатии: принципы рационального ведения пациентов
А. А. Кулеш (2020)
10.1093/brain/awx220
Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke
Chia-Ling Phuah (2017)
10.1007/s00115-019-0680-z
Fahreignung bei Hirngefäßerkrankungen
Prof. Dr. P. Marx (2019)
10.1016/j.wneu.2017.06.015
Antiplatelet Resumption after Antiplatelet-Related Intracerebral Hemorrhage: A Retrospective Hospital-Based Study.
Kay-Cheong Teo (2017)
10.1212/WNL.0000000000009321
Cortical superficial siderosis progression in cerebral amyloid angiopathy
Thanakit Pongpitakmetha (2020)
10.1186/s41984-020-00084-9
The puzzle of spontaneous versus traumatic intracranial hemorrhages
Gabriel Alexander Quiñones-Ossa (2020)
10.1161/HYPERTENSIONAHA.120.15073
Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study
Rodica E. Petrea (2020)
10.1212/WNL.0000000000009814
Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes
M. Georgakis (2020)
10.1055/S-0043-108908
Management von schwerwiegenden intrazerebralen Blutungen unter Antikoagulation
J. Kuramatsu (2017)
10.1080/14737175.2018.1480938
Cerebral amyloid angiopathy: diagnosis and potential therapies
Stewart A Weber (2018)
10.1016/j.ijcard.2016.10.085
Measuring the effects of CVD interventions and studies across socioeconomic groups: A brief review.
E. Callander (2017)
10.1093/BRAIN/AWW199
Delayed seizures after intracerebral haemorrhage.
A. Biffi (2016)
10.1371/journal.pone.0208477
Correction: Oscillometric central blood pressure and central systolic loading in stroke patients: Short-term reproducibility and effects of posture and fasting state
A. Mitchelmore (2018)
10.1161/STROKEAHA.118.023128
Ambient Pollutants and Spontaneous Intracerebral Hemorrhage in Greater Boston
E. Wilker (2018)
10.1177/1747493019828555
Management of oral anticoagulation after intracerebral hemorrhage
J. Kuramatsu (2019)
10.1007/s00115-019-0777-4
Intrazerebrale Blutung: „hot topics“
M. Sprügel (2019)
CADASIL : a pure model for studying cerebral small vessel disease
M. Panahi (2019)
10.1007/978-981-10-1427-7
Stroke Revisited: Hemorrhagic Stroke
S. Lee (2018)
10.1055/s-0038-1627454
Anticoagulants Resumption after Warfarin-Related Intracerebral Haemorrhage: The Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy).
L. Poli (2018)
10.1016/j.amjms.2017.08.005
Assessing Mobile Health Capacity and Task Shifting Strategies to Improve Hypertension Among Ghanaian Stroke Survivors☆,☆☆
Michelle Nichols (2017)
10.1212/WNL.0000000000004235
Long-term antithrombotic treatment in intracranial hemorrhage survivors with atrial fibrillation
Eleni Korompoki (2017)
10.1016/J.PRANEU.2016.10.001
Diagnostic et prise en charge d’une angiopathie amyloïde cérébrale sporadique
Jean Capron (2016)
10.1097/TA.0000000000001144
Low baseline (pre-injury) blood pressure predicts inpatient mortality in elderly trauma patients: A bi-institutional study
Jordan David Bohnen (2016)
10.1186/s42466-019-0043-z
Position paper: ability to drive in cerebrovascular diseases
Peter Marx (2019)
10.1016/j.jns.2017.07.015
Hemorrhage recurrence risk factors in cerebral amyloid angiopathy: Comparative analysis of the overall small vessel disease severity score versus individual neuroimaging markers
G. Boulouis (2017)
10.3389/fphar.2018.01169
Assessing the Pharmacological and Therapeutic Efficacy of Traditional Chinese Medicine Liangxue Tongyu Prescription for Intracerebral Hemorrhagic Stroke in Neurological Disease Models
X. Li (2018)
10.1001/jamaneurol.2016.0955
Risk Factors Associated With Early vs Delayed Dementia After Intracerebral Hemorrhage.
A. Biffi (2016)
10.1111/micc.12499
LncRNA-FENDRR mediates VEGFA to promote the apoptosis of brain microvascular endothelial cells via regulating miR-126 in mice with hypertensive intracerebral hemorrhage.
Baizhuo Dong (2018)
10.1111/add.13235
Is it time for a more ambitious research agenda for decreasing alcohol-related harm among young adults?
K. Bradley (2016)
10.1016/j.jstrokecerebrovasdis.2016.08.033
One-Year Rates and Determinants of Poststroke Systolic Blood Pressure Control among Ghanaians.
F. Sarfo (2017)
10.1038/s41598-020-67250-9
Circulating TIMP-1 is associated with hematoma volume in patients with spontaneous intracranial hemorrhage
Manuel Navarro-Oviedo (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar