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(S)‐ And (R)‐S‐Methyl‐S‐Phenyl Sulfoximine

M. Harmata
Published 2008 · Chemistry

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[60933-65-5] [33903-50-3] C7H9NOS (MW 155.22) InChI = 1S/C7H9NOS/c1-10(8,9)7-5-3-2-4-6-7/h2-6,8H,1H3/t10-/m1/s1 InChIKey = YFYIDTVGWCYSEO-SNVBAGLBSA-N InChI = 1S/C7H9NOS/c1-10(8,9)7-5-3-2-4-6-7/h2-6,8H,1H3/t10-/m0/s1 InChIKey = YFYIDTVGWCYSEO-JTQLQIEISA-N Physical Data: R-isomer: [α]D −28.5±3, c = 1 in acetonitrile; S-isomer: [α]/D +28.5±3°, c = 1 in acetonitrile; (racemate: bp 103–106 °C, mp 31–33 °C, picrate mp 171–173 °C, HCl salt mp 141–142 °C). Solubility: polar organic solvents. Form supplied in: solid or oil. Purification: chiral chromatography of racemate; crystallization of camphorsulfonic acids salts during resolution; distillation. Handling, Storage, and Precautions: sulfoximines are quite stable, only slightly less stable than sulfones. Loss of stereochemical integrity requires bond breaking and is thus essentially impossible even under extremes of heat possible in various reactions.
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