Online citations, reference lists, and bibliographies.

Exercise For Women Receiving Adjuvant Therapy For Breast Cancer.

A. Furmaniak, M. Menig, M. Markes
Published 2016 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND A huge clinical research database on adjuvant cancer treatment has verified improvements in breast cancer outcomes such as recurrence and mortality rates. On the other hand, adjuvant and neoadjuvant therapy with chemotherapy and radiotherapy impacts on quality of life due to substantial short- and long-term side effects. A number of studies have evaluated the effect of exercise interventions on those side effects. This is an updated version of the original Cochrane review published in 2006. The original review identified some benefits of physical activity on physical fitness and the resulting capacity for performing activities of daily life. It also identified a lack of evidence for other outcomes, providing clear justification for an updated review. OBJECTIVES To assess the effect of aerobic or resistance exercise interventions during adjuvant treatment for breast cancer on treatment-related side effects such as physical deterioration, fatigue, diminished quality of life, depression, and cognitive dysfunction. SEARCH METHODS We carried out an updated search in the Cochrane Breast Cancer Group Specialised Register (30 March 2015), the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 2, 2015), MEDLINE (1966 to 30 March 2015), and EMBASE (1966 to 30 March 2015). We did not update the original searches in CINAHL (1982 to 2004), SPORTDiscus (1975 to 2004), PsycINFO (1872 to 2003), SIGLE (1880 to 2004), and ProQuest Digital Dissertations (1861 to 2004). We searched the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) and ClinicalTrials.gov for ongoing trials on 30 March 2015. We screened references in relevant reviews and published clinical trials. SELECTION CRITERIA We included randomised controlled trials that examined aerobic or resistance exercise or both in women undergoing adjuvant treatment for breast cancer. Published and unpublished trials were eligible. DATA COLLECTION AND ANALYSIS Two review authors independently performed data extraction, assessed trials, and graded the methodological quality using Cochrane's 'Risk of bias' tool. Any disagreements were resolved through discussion or by consulting the third review author. We entered data into Review Manager for analysis. For outcomes assessed with a variety of instruments, we used the standardised mean difference (SMD) as a summary statistic for meta-analysis; for those assessed with the same instrument, we used the mean difference (MD). MAIN RESULTS For this 2015 update we included a total of 32 studies with 2626 randomised women, 8 studies from the original search and 24 studies from the updated search. We found evidence that physical exercise during adjuvant treatment for breast cancer probably improves physical fitness (SMD 0.42, 95% confidence interval (CI) 0.25 to 0.59; 15 studies; 1310 women; moderate-quality evidence) and slightly reduces fatigue (SMD -0.28, 95% CI -0.41 to -0.16; 19 studies; 1698 women; moderate-quality evidence). Exercise may lead to little or no improvement in health-related quality of life (MD 1.10, 95% CI -5.28 to 7.48; 1 study; 68 women; low-quality evidence), a slight improvement in cancer site-specific quality of life (MD 4.24, 95% CI -1.81 to 10.29; 4 studies; 262 women; low-quality evidence), and an improvement in cognitive function (MD -11.55, 95% CI -22.06 to -1.05; 2 studies; 213 women; low-quality evidence). Exercise probably leads to little or no difference in cancer-specific quality of life (SMD 0.12, 95% CI 0.00 to 0.25; 12 studies; 1012 women; moderate-quality evidence) and little or no difference in depression (SMD -0.15, 95% CI -0.30 to 0.01; 5 studies; 674 women; moderate-quality evidence). Evidence for other outcomes ranged from low to moderate quality. Seven trials reported a very small number of adverse events. AUTHORS' CONCLUSIONS Exercise during adjuvant treatment for breast cancer can be regarded as a supportive self care intervention that probably results in less fatigue, improved physical fitness, and little or no difference in cancer-specific quality of life and depression. Exercise may also slightly improve cancer site-specific quality of life and cognitive function, while it may result in little or no difference in health-related quality of life. This review is based on trials with a considerable degree of clinical heterogeneity regarding adjuvant cancer treatments and exercise interventions. Due to the difficulty of blinding exercise trials, all included trials were at high risk for performance bias. Furthermore, the majority of trials were at high risk for detection bias, largely due to most outcomes being self reported.The findings of the updated review have enabled us to make a more precise conclusion that both aerobic and resistance exercise can be regarded as beneficial for individuals with adjuvant therapy-related side effects. Further research is required to determine the optimal type, intensity, and timing of an exercise intervention. Furthermore, long-term evaluation is required due to possible long-term side effects of adjuvant treatment.
This paper references
10.1016/S0025-7125(03)00101-9
Advances in breast cancer detection and management.
L. Newman (2003)
10.1007/s00520-005-0851-2
Exercise barrier and task self-efficacy in breast cancer patients during treatment
L. Rogers (2005)
10.1200/JCO.2003.01.119
Cognitive function, fatigue, and menopausal symptoms in women receiving adjuvant chemotherapy for breast cancer.
N. Tchen (2003)
10.1123/JSEP.33.2.235
Reduced barriers mediated physical activity maintenance among breast cancer survivors.
L. Rogers (2011)
10.1007/s11764-011-0205-7
Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan
L. Sprod (2011)
10.1200/JCO.2003.04.093
Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes.
K. Courneya (2003)
10.1200/JCO.2012.41.8525
Efficacy of cognitive behavioral therapy and physical exercise in alleviating treatment-induced menopausal symptoms in patients with breast cancer: results of a randomized, controlled, multicenter trial.
S. Duijts (2012)
10.1002/SIM.1186
Quantifying heterogeneity in a meta-analysis.
J. Higgins (2002)
10.1016/J.EJON.2004.03.007
A pilot study of a supervised group exercise programme as a rehabilitation treatment for women with breast cancer receiving adjuvant treatment.
A. Campbell (2005)
10.1002/(SICI)1097-0142(19990515)85:10<2273::AID-CNCR24>3.0.CO;2-B
Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy
F. Dimeo (1999)
10.1053/J.SONCN.2003.09.002
Chemotherapy-related cognitive dysfunction in breast cancer.
J. O'Shaughnessy (2003)
Daily walking during adjuvant chemotherapy for patients with breast and colorectal cancer - a randomized pilot study
Minna Malin (2013)
10.1080/02841860510029905
The effect of physiotherapy on shoulder function in patients surgically treated for breast cancer: A randomized study
Mette Cathrine Lauridsen (2005)
10.1037/0033-2909.86.2.420
Intraclass correlations: uses in assessing rater reliability.
P. Shrout (1979)
10.1002/PON.1021
A pilot study of yoga for breast cancer survivors: physical and psychological benefits.
S. N. Culos-Reed (2006)
10.1007/s10549-010-1126-2
Multimodal exercise improves quality of life of women being treated for breast cancer, but at what cost? Randomized trial with economic evaluation
T. Haines (2010)
10.1177/1534735407306214
Effects of an Integrated Yoga Program in Modulating Psychological Stress and Radiation-Induced Genotoxic Stress in Breast Cancer Patients Undergoing Radiotherapy
B. Banerjee (2007)
10.1200/JCO.2006.24.18_SUPPL.8504
A randomized controlled pilot of home-based exercise (HBEX) versus standard care (SC) among breast (BC) and prostate cancer (PC) patients receiving radiation therapy (RTH).
K. Mustian (2006)
10.1188/08.ONF.830-835
Nausea at the end of adjuvant cancer treatment in relation to exercise during treatment in patients with breast cancer.
J. Lee (2008)
10.1097/00005768-200105000-00006
Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy.
A. Schwartz (2001)
10.1249/01.MSS.0000093622.41587.B6
Exercise in cancer survivors: an overview of research.
K. Courneya (2003)
10.3816/CBC.2003.S.018
Current status and future directions in breast cancer therapy.
C. Hudis (2003)
10.1111/j.1526-4637.2012.01481.x
Effectiveness of water physical therapy on pain, pressure pain sensitivity, and myofascial trigger points in breast cancer survivors: a randomized, controlled clinical trial.
I. Cantarero-Villanueva (2012)
10.1188/07.ONF.627-633
Exercise effects on bone mineral density in women with breast cancer receiving adjuvant chemotherapy.
A. Schwartz (2007)
10.3816/CBC.2008.n.005
Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.
W. Demark-Wahnefried (2008)
10.1097/NCC.0b013e3181e4588d
Effects of a 6-Week Walking Program on Taiwanese Women Newly Diagnosed With Early-Stage Breast Cancer
Y. Wang (2011)
Exercise during prostate cancer treatment : effects on functional status and symptoms
M Tillery (2007)
10.1002/pon.1503
Restorative yoga for women with breast cancer: findings from a randomized pilot study.
S. Danhauer (2009)
10.1097/01893697-200523010-00004
Effects of Aerobic Exercise Training on Peak Aerobic Capacity, Fatigue, and Psychological Factors During Radiation for Breast Cancer
J. Drouin (2005)
10.1188/03.ONF.E40-E47
Delayed chemotherapy-induced nausea in women treated for breast cancer.
S. Dibble (2003)
Introduction: acute leukemia: recent advances.
C. Bloomfield (1997)
10.1007/s00520-009-0587-5
Yoga of Awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial
J. Carson (2009)
ACSM's exercise management for persons with chronic diseasesand disabilities
J. Durstine (2003)
10.1186/s12885-015-1069-4
Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
J. Meneses-Echávez (2015)
ACSM's Guidelines for Exercise Testing and Prescription
L. Pescatello (1995)
10.1186/1471-2407-10-673
Design of the Physical exercise during Adjuvant Chemotherapy Effectiveness Study (PACES):A randomized controlled trial to evaluate effectiveness and cost-effectiveness of physical exercise in improving physical fitness and reducing fatigue
H. van Waart (2010)
10.1200/JCO.2006.06.6027
Randomized controlled trial of yoga among a multiethnic sample of breast cancer patients: effects on quality of life.
A. Moadel (2007)
10.1007/s12160-011-9324-7
A Randomized Trial of a Telephone-Delivered Exercise Intervention for Non-urban Dwelling Women Newly Diagnosed with Breast Cancer: Exercise for Health
E. Eakin (2012)
10.1055/s-0029-1213544
Auswirkungen einer 3-monatigen Krafttrainingsintervention auf die kognitiven Fähigkeiten von Mammakarzinompatientinnen während der Chemotherapie
Freerk Theeagnus Baumann (2009)
10.1016/J.PEC.2006.02.006
Randomized pilot test of a lifestyle physical activity intervention for breast cancer survivors.
K. Basen-Engquist (2006)
10.1177/030089160108700308
Radiotherapy-related Fatigue: How to Assess and how to Treat the Symptom. A Commentary
B. Jereczek-Fossa (2001)
10.1002/cncr.24551
Impact of a walking intervention on cardiorespiratory fitness, self‐reported physical function, and pain in patients undergoing treatment for solid tumors
K. Griffith (2009)
10.1188/05.ONF.807-815
Social cognitive theory and physical activity during breast cancer treatment.
L. Rogers (2005)
10.1200/JCO.2007.12.7357
Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors.
J. Ligibel (2008)
10.1097/00006199-198911000-00007
Effects of Aerobic Interval Training on Cancer Patients' Functional Capacity
M. G. MacVicar (1989)
10.1590/S1516-31802007000100005
The effects of an individualized exercise intervention on body composition in breast cancer patients undergoing treatment.
C. Battaglini (2007)
10.1111/j.1745-7599.2010.00573.x
Effect of Iyengar yoga practice on fatigue and diurnal salivary cortisol concentration in breast cancer survivors
Jacquelyn L. Banasik (2011)
10.1136/bmj.a1655
Developing and evaluating complex interventions: the new Medical Research Council guidance
P. Craig (2008)
10.1002/PON.594
Exercise participation after diagnosis of breast cancer: trends and effects on mood and quality of life.
B. Pinto (2002)
10.1046/J.1523-5394.2001.009003119.X
Fatigue and quality of life outcomes of exercise during cancer treatment.
V. Mock (2001)
10.3810/psm.2002.08.402
Exercise for Breast Cancer Survivors
K. Courneya (2002)
10.1002/(SICI)1099-1611(199905/06)8:3<191::AID-PON355>3.0.CO;2-T
Exercise in the rehabilitation of breast cancer survivors.
B. Pinto (1999)
10.1158/1055-9965.EPI-07-0413
Six-Month Follow-up of Patient-Rated Outcomes in a Randomized Controlled Trial of Exercise Training during Breast Cancer Chemotherapy
K. Courneya (2007)
10.1111/j.1365-2648.2010.05492.x
Effects of a home-based walking program on perceived symptom and mood status in postoperative breast cancer women receiving adjuvant chemotherapy.
Chyn-Yng Yang (2011)
10.1016/j.ejon.2009.09.005
The effect of symptom clusters on functional status and quality of life in women with breast cancer.
M. Dodd (2010)
10.1007/s00520-012-1549-x
Water versus land-based multimodal exercise program effects on body composition in breast cancer survivors: a controlled clinical trial
C. Fernández-Lao (2012)
10.1007/s10549-012-2331-y
Exercise for health: a randomized, controlled trial evaluating the impact of a pragmatic, translational exercise intervention on the quality of life, function and treatment-related side effects following breast cancer
S. Hayes (2012)
10.1158/1055-9965.EPI-10-0521
Hemoglobin and Aerobic Fitness Changes with Supervised Exercise Training in Breast Cancer Patients Receiving Chemotherapy
L. Dolan (2010)
10.1901/JABA.2008.26-20
Feasibility of an Exercise Program for Puerto Rican Women who are Breast Cancer Survivors
Ana L. Mulero Portela (2008)
10.1200/jco.2013.31.15_suppl.e20623
Iyengar yoga compared to exercise in women with stage I-III breast cancer: Feasibility of therapeutic interventions during adjuvant cytotoxic or endocrine therapy.
Florian Wiedemann (2013)
10.1136/bmj.39094.648553.AE
Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial
N. Mutrie (2007)
10.1200/JCO.1990.8.8.1327
Weight change in women treated with adjuvant therapy or observed following mastectomy for node-positive breast cancer.
J. Camoriano (1990)
10.1016/J.EJCA.2012.02.025
AOS8 Effectiveness of an education-combining exercise programme for chemotherapy-related fatigue in women with breast cancer
Jinpitcha Mamom (2012)
10.1097/00005768-199806000-00032
ACSM Position Stand: The Recommended Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in Healthy Adults
M. Pollock (1998)
10.1016/j.jsams.2012.08.012
Improving muscular endurance with the MVe Fitness Chair™ in breast cancer survivors: a feasibility and efficacy study.
Eric A Martin (2013)
10.1002/PON.658
The group psychotherapy and home-based physical exercise (group-hope) trial in cancer survivors: physical fitness and quality of life outcomes.
K. Courneya (2003)
10.1097/01893697-200624030-00003
Random Control Clinical Trail on Effect of Aerobic Exercise Training on Weight Management During Radiation Treatment for Breast Cancer*
Jacqueline S. Droitin (2006)
10.1200/JCO.2006.07.9988
Randomized controlled trial of the effects of print materials and step pedometers on physical activity and quality of life in breast cancer survivors.
J. Vallance (2007)
10.1093/annonc/mds342
Psychological effect of exercise in women with breast cancer receiving adjuvant therapy: what is the optimal dose needed?
M. Carayol (2013)
10.1158/1055-9965.EPI-08-0531
Randomized Controlled Trial of Aerobic Exercise on Insulin and Insulin-like Growth Factors in Breast Cancer Survivors: The Yale Exercise and Survivorship Study
M. Irwin (2009)
Evaluating the benefits of exercise for women receiving adjuvant therapy for breast cancer: research challenges.
Carolyn Ingram (2010)
10.1097/00007632-199710150-00001
Method guidelines for systematic reviews in the Cochrane Collaboration Back Review Group for Spinal Disorders.
M. V. van Tulder (1997)
10.1089/acm.2010.0653
Impact of relaxation training according to Yoga In Daily Life® system on self-esteem after breast cancer surgery.
Tine Kovačič (2011)
Published by John Wiley & Sons Ltd
Omid Azizi Farzan Modarresi (2015)
10.7326/0003-4819-134-8-200104170-00012
The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
D. Altman (2001)
10.1300/J015V25N02_08
Exercise: Complementary therapy for breast cancer rehabilitation.
K. M. Mustian (2002)
10.1142/S0192415X06003618
Effects of chan-chuang qigong on improving symptom and psychological distress in chemotherapy patients.
Tsoy-Ing Lee (2006)
10.1016/S0272-7358(99)00032-X
Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory.
P. Salmon (2001)
10.1634/theoncologist.2012-0278
Impact of a home-based walking intervention on outcomes of sleep quality, emotional distress, and fatigue in patients undergoing treatment for solid tumors.
J. Wenzel (2013)
10.1186/s12889-015-1751-0
Can physical activity help to maintain cognitive functioning and psychosocial well-being among breast cancer patients treated with chemotherapy? A randomised controlled trial: study protocol
Kajal Gokal (2015)
10.1023/A:1008978611274
Fatigue mediates the effects of exercise on quality of life
A. Schwartz (2004)
10.1007/978-3-642-72137-3_7
Anticipatory Nausea and Vomiting in the Era of 5-HT3 Antiemetics
G. Morrow (1998)
10.1002/cncr.11227
Physical activity levels before and after a diagnosis of breast carcinoma
M. Irwin (2003)
10.1046/J.1523-5394.2002.106006.X
Adherence to moderate-intensity exercise during breast cancer therapy.
M. Pickett (2002)
10.1177/1054773810379402
Nutritional Symptom and Body Composition Outcomes of Aerobic Exercise in Women With Breast Cancer
C. Denysschen (2011)
10.3138/9781487595777-005
A commentary
John Galsworthy
10.1002/14651858.CD008465.pub2
Exercise interventions on health-related quality of life for people with cancer during active treatment.
S. Mishra (2012)
10.1177/0193945910379004
Intervention Components Promoting Adherence to Strength Training Exercise in Breast Cancer Survivors With Bone Loss
Rita McGuire (2011)
10.4137/BCBCR.S9221
Bootcamp During Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial
R. Rao (2012)
10.1097/NCC.0b013e3181ddc58c
A Randomized Controlled Trial of Home-Based Exercise for Cancer-Related Fatigue in Women During and After Chemotherapy With or Without Radiation Therapy
M. Dodd (2010)
10.1200/JCO.2014.32.15_SUPPL.9535
Physical activity during cancer treatment (PACT) study: Short- and long-term effects on fatigue of an 18-week exercise intervention during adjuvant chemotherapy in patients with breast or colon cancer.
Anne M May (2014)
10.1371/journal.pone.0099111
Choosing Important Health Outcomes for Comparative Effectiveness Research: A Systematic Review
E. Gargon (2014)
10.1055/S-2008-1038853
Supportive Effekte eines moderaten Ausdauertrainings während der zytotoxischen/endokrinen Therapie von Mammakarzinompatientinnen – Ergebnisse einer Pilotstudie
N. Köhler (2008)
10.1136/bjsm.34.3.160
Exercise for cancer patients: a new challenge in sports medicine
F. Dimeo (2000)
Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial.
A. Fairey (2003)
10.1159/000327505
12-Week Resistance Training with Breast Cancer Patients during Chemotherapy: Effects on Cognitive Abilities
F. Baumann (2011)
Effects of yoga on natural killer cell counts in early breast cancer patients undergoing conventional treatment. Comment to: recreational music-making modulates natural killer cell activity, cytokines, and mood states in corporate employees Masatada Wachi, Masahiro Koyama, Masanori Utsuyama, Barry B
R. M. Rao (2008)
10.1111/J.1365-2648.2007.04293.X
Using a conceptual model in nursing research--mitigating fatigue in cancer patients.
V. Mock (2007)
10.1007/s00520-015-2884-5
Effects of a self-managed home-based walking intervention on psychosocial health outcomes for breast cancer patients receiving chemotherapy: a randomised controlled trial
Kajal Gokal (2015)
10.1046/J.1523-5394.2000.82007.X
Cancer-related fatigue. Suffering a different fatigue.
S. Holley (2000)
10.1007/s00520-014-2567-7
Adherence to prescribed exercise time and intensity declines as the exercise program proceeds: findings from women under treatment for breast cancer
Hsiang-Ping Huang (2014)
[Exercise and breast cancer].
Pekka Latikka (1997)
10.1007/s12160-008-9019-x
Analyzing Theoretical Mechanisms of Physical Activity Behavior Change in Breast Cancer Survivors: Results from the Activity Promotion (ACTION) Trial
J. Vallance (2008)
10.1503/cmaj.1031000
Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy
P. Truong (2004)
Effect of aerobic exercise on body weight and composition in patients with breast cancer on adjuvant chemotherapy.
M. Winningham (1989)
10.1097/01893697-199715010-00028
A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy.
V. Mock (1994)
10.1188/02.ONF.949-956
Pain and fatigue management: results of a nursing randomized clinical trial.
B. Given (2002)
10.1152/JAPPLPHYSIOL.00566.2004
Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors.
A. Fairey (2005)
10.7326/0003-4819-141-10-200411160-00009
Better Reporting of Harms in Randomized Trials: An Extension of the CONSORT Statement
J. Ioannidis (2004)
10.1002/ijc.29383
Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: A randomized controlled trial
M. Schmidt (2015)
10.1200/JCO.2006.08.2024
Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial.
K. Courneya (2007)
Coping with cancer
A. Weisman (1979)
10.1002/pon.3082
Evaluation of a social cognitive theory-based email intervention designed to influence the physical activity of survivors of breast cancer.
Andrew G. Hatchett (2013)
10.1200/JCO.2003.04.069
Effect of upper extremity exercise on secondary lymphedema in breast cancer patients: a pilot study.
D. McKenzie (2003)
10.1200/JCO.2001.19.9.2381
Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy.
W. Demark-Wahnefried (2001)
10.1016/j.cct.2011.03.015
Design and implementation of the Exercise for Health trial -- a pragmatic exercise intervention for women with breast cancer.
S. Hayes (2011)
10.1007/s11764-012-0233-y
Five-year follow-up of participants in a randomised controlled trial showing benefits from exercise for breast cancer survivors during adjuvant treatment. Are there lasting effects?
N. Mutrie (2012)
10.1002/cncr.22267
Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer
J. Drouin (2006)
10.1055/s-0031-1271697
Exercise training and cytokines in breast cancer survivors.
A. Gómez (2011)
10.1093/annonc/mdu374
Randomized, controlled trial of resistance training in breast cancer patients receiving adjuvant radiotherapy: results on cancer-related fatigue and quality of life.
K. Steindorf (2014)
10.1016/j.ejon.2010.01.027
Women's perceptions of home-based exercise performed during adjuvant chemotherapy for breast cancer.
C. Ingram (2010)
10.1016/j.apmr.2012.09.008
The effectiveness of a deep water aquatic exercise program in cancer-related fatigue in breast cancer survivors: a randomized controlled trial.
I. Cantarero-Villanueva (2013)
10.1016/S1521-690X(03)00046-0
Adjuvant endocrine therapy.
L. Rutqvist (2004)
The effect of aerobic exercise on patient reports of nausea.
Winningham Ml (1988)
10.1097/00002820-200603000-00012
The Influences of Chan-Chuang Qi-Gong Therapy on Complete Blood Cell Counts in Breast Cancer Patients Treated With Chemotherapy
Mei-Ling Yeh (2006)
10.1111/J.1365-2354.2006.00739.X
Effects of an integrated yoga programme on chemotherapy-induced nausea and emesis in breast cancer patients.
R. Raghavendra (2007)
10.13189/NH.2014.020602
Heading off Peripheral Neuropathy with Exercise: The Hope Study
C. Visovsky (2014)
10.1016/S0959-8049(11)71128-5
3055 POSTER Effectivenes of Brief Exercise Orientation Program on Breast Cancer Induced Fatigue
A. Gomes (2011)
10.5114/wo.2013.34453
Exercise tolerance in breast cancer patients during radiotherapy after aerobic training
P. Milecki (2013)
10.1093/OXFORDJOURNALS.JNCIMONOGRAPHS.A003451
Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer.
A. Partridge (2001)
10.1016/J.BBI.2005.04.001
Effect of exercise training on C-reactive protein in postmenopausal breast cancer survivors: A randomized controlled trial
A. Fairey (2005)
10.1097/00002820-200603000-00013
Cardiopulmonary Responses and Adherence to Exercise in Women Newly Diagnosed With Breast Cancer Undergoing Adjuvant Therapy
C. Kim (2006)
The effect of aerobic exercise on self-esteem and depressive and anxiety symptoms among breast cancer survivors.
M. Segar (1998)
10.1038/bjc.2013.750
Interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review
L. Bourke (2014)
Analysing and Presenting Results
P. Macaskill (2010)
Effects of home-based exercise training on vo2 in breast cancer patients under adjuvant or neoadjuvant chemotherapy (sapa).
Thibault Cornette (2015)
EFFECT OF COMBINATION EXERCISE TRAINING ON SEX HORMONE BINDING GLOBULIN IN POSTMENOPAUSAL WOMEN WITH BREAST CANCER
R. Nuri (2012)
10.1093/annonc/mdn292
Anthracycline-trastuzumab regimens for HER2/neu-overexpressing breast cancer: current experience and future strategies.
D. Rayson (2008)
10.1155/2016/5931816
Iyengar-Yoga Compared to Exercise as a Therapeutic Intervention during (Neo)adjuvant Therapy in Women with Stage I–III Breast Cancer: Health-Related Quality of Life, Mindfulness, Spirituality, Life Satisfaction, and Cancer-Related Fatigue
Désirée Lötzke (2016)
10.1097/00003677-200104000-00004
Exercise Interventions During Cancer Treatment: Biopsychosocial Outcomes
K. Courneya (2001)
10.1007/s00198-009-1083-y
The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: a 24-month randomized controlled trial
N. Waltman (2009)
10.1016/j.ctim.2008.05.005
Anxiolytic effects of a yoga program in early breast cancer patients undergoing conventional treatment: a randomized controlled trial.
M. R. Rao (2009)
Home-based exercise to alleviate fatigue and improve functional capacity among breast cancer survivors.
H. Yuen (2007)
10.1093/JNCI/DJH210
National Institutes of Health State-of-the-Science Conference Statement: Symptom management in cancer: pain, depression, and fatigue, July 15-17, 2002.
Daniel L. Patrick (2004)
10.1136/bmjsem-2015-000021
The challenge of preserving cardiorespiratory fitness in physically inactive patients with colon or breast cancer during adjuvant chemotherapy: a randomised feasibility study
T. Møller (2015)
10.1016/j.clbc.2011.03.013
Effects of Tai Chi Chuan on insulin and cytokine levels in a randomized controlled pilot study on breast cancer survivors.
M. Janelsins (2011)
10.1590/S0100-879X2008000800012
Effect of exercise on the caloric intake of breast cancer patients undergoing treatment.
C. Battaglini (2008)
10.1007/s12160-007-9009-4
Barriers to Supervised Exercise Training in a Randomized Controlled Trial of Breast Cancer Patients Receiving Chemotherapy
K. Courneya (2008)
10.1207/S15327558IJBM1303_10
Exercise beliefs of breast cancer survivors before and after participation in a randomized controlled trial
K. Courneya (2006)
10.1016/S0197-2456(02)00266-0
Leading the Way in Exercise and Diet (Project LEAD): intervening to improve function among older breast and prostate cancer survivors.
W. Demark-Wahnefried (2003)
10.1097/00002820-200208000-00004
Fatigue in Patients With Breast Cancer Receiving Adjuvant Chemotherapy: A Review of the Literature
N. de Jong (2002)
10.1123/JPAH.8.7.955
Feasibility of institutional registry-based recruitment for enrolling newly diagnosed breast cancer patients in an exercise trial.
Lisa A Cadmus Bertram (2011)
10.1016/S0002-8223(97)00133-8
Weight gain in women diagnosed with breast cancer.
W. Demark-Wahnefried (1997)
10.1136/bmj.327.7414.557
Measuring inconsistency in meta-analyses
J. Higgins (2003)
10.3810/psm.2000.05.896
Coping With Cancer
Kerry S. Courneya (2000)
10.1158/1055-9965.EPI-04-0736
Safety and Efficacy of Weight Training in Recent Breast Cancer Survivors to Alter Body Composition, Insulin, and Insulin-Like Growth Factor Axis Proteins
K. Schmitz (2005)
10.1158/1538-7445.AM2012-2
Abstract 2: FGFR3 as a therapeutic target in squamous cell lung carcinoma
R. Liao (2012)
10.1007/s10552-009-9358-3
Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors
J. Ligibel (2009)
10.2147/IJWH.S55552
Benefits, risks, and safety of external beam radiation therapy for breast cancer
L. Brown (2015)
10.1590/S1517-86922006000300009
The effects of resistance training on muscular strength and fatigue levels in breast cancer patients
C. Battaglini (2006)
10.1097/00005768-200212000-00001
Effects of exercise on physiological and psychological variables in cancer survivors.
T. R. Burnham (2002)
10.1007/s11764-009-0088-z
Adherence to a randomized controlled trial of aerobic exercise in breast cancer survivors: the Yale exercise and survivorship study
Rebecca Latka (2009)
10.1200/JCO.2006.05.7224
Lifestyle intervention development study to improve physical function in older adults with cancer: outcomes from Project LEAD.
W. Demark-Wahnefried (2006)
10.1046/j.1523-5394.2000.82007.x
Cancer-Related Fatigue
Sandra Holley ph d (2001)
10.1188/12.ONF.91-97
Timing and sustainability of an exercise intervention in women with breast cancer during and after cancer treatment.
Fang-Yu Chou (2012)
10.1111/j.1471-6712.2009.00714.x
The effect of designed exercise programme on quality of life in women with breast cancer receiving chemotherapy.
Aghabarari Maryam (2010)
10.1080/1612197X.2010.9671932
The Effect of a Cognitive Behavioral Exercise Intervention on Clinical Depression in a Multiethnic Sample of Women With Breast Cancer: A Randomized Controlled Trial
Frank M. Perna (2010)
10.1188/08.ONF.E90-E99
Patterns of Fatigue and Effect of Exercise in Patients Receiving Chemotherapy for Breast Cancer
Horng-Shiuann Wu (2008)
Psychosocial aspects of breast cancer treatment.
D. Spiegel (1997)
Fatigue and Physical Functioning During Breast Cancer Treatment
Victoria Mock (2011)
10.1111/1467-9280.t01-1-01430
Fitness Effects on the Cognitive Function of Older Adults
S. Colcombe (2003)
Exercise during prostate cancer treatment : effects on functional status and symptoms
M Tillery (2007)
10.1038/oby.2009.18
Exercise improves body fat, lean mass, and bone mass in breast cancer survivors.
M. Irwin (2009)
Effects of exercise vs bisphosphonates on bone mineral density in breast cancer patients receiving chemotherapy.
K. Swenson (2009)
Erratum: "The effects of an individualized exercise intervention on body composition in breast cancer patients undergoing treatment" (Sao Paulo Medical Journal (2007) vol. 125 (1) (22-8))
C. Battaglini (2007)
10.1186/1471-2407-10-272
Physical Activity during Cancer Treatment (PACT) Study: design of a randomised clinical trial
M. Velthuis (2010)
10.1186/s12916-015-0362-z
Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial
N. Travier (2015)
10.4103/0973-1482.137985
The effect of aerobic exercise on quality of life among breast cancer survivors: a randomized controlled trial.
A. Murtezani (2014)
10.1200/JCO.2005.23.16_SUPPL.8138
Results of Project LEAD (Leading the Way in Exercise and Diet) - A trial testing an intervention of telephone-counseling and mailed materials in improving physical functioning among older breast and prostate cancer survivors
W. Demark-Wahnefried (2005)
10.1002/cncr.26702
Yoga for persistent fatigue in breast cancer survivors
J. Bower (2012)
The effects of exercise training on maximum aerobic capacity, resting heart rate, blood pressure and anthropometric variables of postmenopausal women with breast cancer
N. Rahnama (2010)
10.1186/1471-2407-13-162
Randomized controlled trial to evaluate the effects of progressive resistance training compared to progressive muscle relaxation in breast cancer patients undergoing adjuvant radiotherapy: the BEST study
K. Potthoff (2012)
10.1016/j.cct.2012.10.006
Progressive resistance versus relaxation training for breast cancer patients during adjuvant chemotherapy: design and rationale of a randomized controlled trial (BEATE study).
M. Schmidt (2013)
10.1186/1479-5868-5-52
Understanding breast cancer patients' preference for two types of exercise training during chemotherapy in an unblinded randomized controlled trial
K. Courneya (2008)
10.1002/pon.1525
Exercise and quality of life during and after treatment for breast cancer: results of two randomized controlled trials.
Lisa A Cadmus (2009)
10.1111/j.1547-5069.2009.01247.x
An exercise intervention for breast cancer survivors with bone loss.
Janice J. Twiss (2009)
10.1684/BDC.2012.1610
Mise en place d'une étude pilote de sensibilisation au réentraînement à l'activité physique dans deux populations sélectionnées atteintes d'un cancer du sein
Julie Charbonnier (2012)
10.1200/JCO.2001.19.3.657
Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial.
R. Segal (2001)
10.1136/bmj.309.6964.1286
Systematic Reviews: Identifying relevant studies for systematic reviews
K. Dickersin (1994)
10.2307/2529310
The measurement of observer agreement for categorical data.
J. Landis (1977)
10.1016/j.ctim.2009.06.004
Effects of yoga program on quality of life and affect in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial.
H. Vadiraja (2009)
10.1186/1472-6874-9-15
Cognitive behavioral therapy and physical exercise for climacteric symptoms in breast cancer patients experiencing treatment-induced menopause: design of a multicenter trial
S. Duijts (2009)
10.1002/cncr.23446
Recruiting and retaining breast cancer survivors into a randomized controlled exercise trial
M. Irwin (2008)
10.1111/ecc.12068
Effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in breast cancer patients.
M. Ergun (2013)
10.1053/J.SEMINONCOL.2003.09.008
The impact of adjuvant therapy for breast cancer on cognitive function: current evidence and directions for research.
H. Rugo (2003)
10.1016/J.EJON.2006.03.005
A pilot study of the effects of programmed aerobic exercise on the severity of fatigue in cancer patients during external radiotherapy.
M. Aghili (2007)
Effects of a home-based walking training program on cardiorespiratory fitness in breast cancer patients receiving adjuvant chemotherapy: a pilot study.
F. Vincent (2013)
10.4040/jkan.2006.36.7.1111
[Effects of aerobic exercise using a flex-band on physical functions & body image in women undergoing radiation therapy after a mastectomy].
H. So (2006)
Effects of exercise on fatigue, physical functioning, and emotional distress during radiation therapy for breast cancer.
V. Mock (1997)
10.1136/bmjopen-2013-003556
At cancer diagnosis: a ‘window of opportunity’ for behavioural change towards physical activity. A randomised feasibility study in patients with colon and breast cancer
T. Møller (2013)
10.1097/00002820-200507000-00011
Dance and Movement Program Improves Quality‐of‐Life Measures in Breast Cancer Survivors
Susan L Sandel (2005)
10.1188/10.ONF.321-330
Physical activity in women receiving chemotherapy for breast cancer: adherence to a walking intervention.
Karen K Swenson (2010)
10.1249/MSS.0B013E3181586B41
Maintenance of physical activity in breast cancer survivors after a randomized trial.
J. Vallance (2008)
10.1097/01893697-201028010-00003
Exploring Wellness Coaching and Traditional Group Support for Breast Cancer Survivors: A Pilot Study
Mary L Galantino (2010)
10.1002/14651858.CD006145.pub3
Exercise for the management of cancer-related fatigue in adults.
Fiona Cramp (2012)
10.1007/s00520-008-0434-0
Maintenance of effects of a home-based physical activity program among breast cancer survivors
B. Pinto (2008)
10.1002/pon.1465
Home-based exercise among cancer survivors: adherence and its predictors.
B. Pinto (2009)
10.1136/bmj.b3410
Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial
L. Adamsen (2009)
10.1186/1479-5868-8-115
Validity of the international physical activity questionnaire short form (IPAQ-SF): A systematic review
P. Lee (2011)
10.1123/JSEP.28.3.269
Mediators of a Randomized Controlled Physical Activity Intervention for Breast Cancer Survivors
C. Rabin (2006)
10.1002/PON.863
Exercise manages fatigue during breast cancer treatment: a randomized controlled trial.
V. Mock (2005)
10.1055/S-2005-865848
Combined aerobic and resistance training in breast cancer survivors: A randomized, controlled pilot trial.
F. Herrero (2006)
10.1002/cncr.23379
Moderators of the effects of exercise training in breast cancer patients receiving chemotherapy
K. Courneya (2008)
10.1188/13.ONF.E374-E381
Effects of Nia exercise in women receiving radiation therapy for breast cancer.
D. Reis (2013)
10.6004/jnccn.2003.0029
Cancer-related fatigue. Clinical practice guidelines in oncology.
V. Mock (2003)
10.1007/s10552-012-0104-x
Effects of an exercise and hypocaloric healthy eating program on biomarkers associated with long-term prognosis after early-stage breast cancer: a randomized controlled trial
E. Scott (2012)
10.3109/0284186X.2013.781673
Safety and efficacy of aerobic training in operable breast cancer patients receiving neoadjuvant chemotherapy: A phase II randomized trial
W. Hornsby (2014)
10.1007/s10549-008-9987-3
Predictors of follow-up exercise behavior 6 months after a randomized trial of exercise training during breast cancer chemotherapy
K. Courneya (2008)
10.1097/00002820-200411000-00006
Exploring Social Cognitive Theory Constructs for Promoting Exercise Among Breast Cancer Patients
L. Rogers (2004)
10.1249/MSS.0b013e318168da45
Predictors of supervised exercise adherence during breast cancer chemotherapy.
K. Courneya (2008)
10.1155/2014/271828
Effects of Scheduled Exercise on Cancer-Related Fatigue in Women with Early Breast Cancer
A. M. L. Husebø (2014)
10.1200/jco.2006.24.18_suppl.590
The impact of an exercise intervention on body composition, fat distribution, and weight in breast cancer survivors.
Jennifer Ligibel (2006)
10.1249/MSS.0b013e31822cb5f2
A study of exercise modality and physical self-esteem in breast cancer survivors.
R. Musanti (2012)
10.1016/j.ejon.2014.07.004
Effects of supervised exercise on motivational outcomes in breast cancer survivors at 5-year follow-up.
L. Trinh (2014)
10.1016/S0140-6736(03)12838-3
Under-reporting of clinical trials is unethical
G. Antes (2003)
10.1002/PON.618
Psychological and fitness changes associated with exercise participation among women with breast cancer.
B. Pinto (2003)



This paper is referenced by
10.1158/1055-9965.EPI-15-1061
The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis
J. Meneses-Echávez (2016)
10.1016/j.annonc.2019.10.014
Transferring effective interventions for cancer-related fatigue from the adjuvant to the advanced cancer session: does it work?
Anne M May (2020)
10.1188/16.CJON.E132-E138
Improving Awareness, Identification, and Management of Sarcopenic Obesity in Cancer Survivors: An Evidence-Based Toolbox.
S. Lindsey (2016)
10.1186/s12916-015-0362-z
Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial
N. Travier (2015)
10.1016/J.AMP.2016.03.016
Cancer du sein, activité physique adaptée et qualité de vie
Sophie Lantheaume (2017)
10.1007/s00520-016-3327-7
Prevalence of unmet needs and correlated factors in advanced-stage cancer patients receiving rehabilitation
Takaaki Hasegawa (2016)
10.1002/14651858.CD012864
Physical activity and exercise interventions for disease‐related physical and mental health during and following treatment in people with non‐advanced colorectal cancer
Maresa McGettigan (2017)
Implementation of an Exercise Program in Breast Cancer Rehabilitation to Improve Shoulder Outcomes: A Pilot Study
Dragana Ceprnja (2015)
10.1016/j.jgo.2017.07.001
Assessment and management of radiotherapy induced toxicity in older patients.
A. O'Donovan (2017)
10.1186/s12885-015-1069-4
Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis
J. Meneses-Echávez (2015)
10.1002/14651858.CD011006.PUB3
ضدافسردگیها برای درمان افسردگی در افراد مبتلا به سرطان
Giovanni Ostuzzi (2018)
10.1080/08870446.2013.843682
Postsurgical physical activity and fatigue-related daily interference in women with non-metastatic breast cancer
J. Stagl (2014)
10.1007/s12282-014-0521-7
Meta-analysis of the effects of exercise intervention on quality of life in breast cancer survivors
Yingchun Zeng (2014)
Surveillance of the adult cancer survivor.
Jason Wilbur (2015)
10.32635/2176-9745.RBC.2019V65N2.360
Ganho Ponderal durante o Tratamento Oncológico Sistêmico para Câncer de Mama: Mudanças na Ingestão Alimentar e na Atividade Física
Marco Aurélio da Silva Ribeiro-Sousa (2019)
10.1007/s00520-014-2567-7
Adherence to prescribed exercise time and intensity declines as the exercise program proceeds: findings from women under treatment for breast cancer
Hsiang-Ping Huang (2014)
10.1002/pon.3727
Population-, intervention- and methodology-related characteristics of clinical trials impact exercise efficacy during adjuvant therapy for breast cancer: a meta-regression analysis.
M. Carayol (2015)
10.1590/S1516-89132015060286
Godoy & Godoy Compression Sleeve in the Treatment of Arm Lymphedema: New Concepts for Materials
José Maria Pereira de Godoy (2015)
10.1016/j.breast.2019.01.006
Non-pharmacological therapies for depressive symptoms in breast cancer patients: Systematic review and meta-analysis of randomized clinical trials.
Liliana Coutiño-Escamilla (2019)
The Role of Kinesiologists and the Promotion of Physical Activity and Exercise in the Canadian Health Care System
Glen Bergeron (2014)
10.1002/14651858.CD012988
Exercise therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast cancer
K. Roberts (2018)
10.1158/1055-9965.EPI-15-0812
Exploring the Feasibility of a Broad-Reach Physical Activity Behavior Change Intervention for Women Receiving Chemotherapy for Breast Cancer: A Randomized Trial
J. Vallance (2015)
10.1016/j.bulcan.2019.11.017
Activités physiques et cancers : des bénéfices prouvés pendant et après les traitements
G. Ninot (2020)
10.1016/j.ctim.2018.10.018
Aerobic physical activity and salivary cortisol levels among women with a history of breast cancer.
Mike Lambert (2019)
10.1016/j.clinbiomech.2017.12.011
Quantification of upper limb electromyographic measures and dysfunction of breast cancer survivors during performance of functional dynamic tasks
Rebecca L. Brookham (2018)
10.1016/j.jpainsymman.2019.09.010
Exercise training for improving patient-reported outcomes in patients with advanced-stage cancer: a systematic review and meta-analysis.
Y. Chen (2019)
10.1016/j.breast.2017.02.002
The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life: A systematic review and meta-analysis.
Andrea Lipsett (2017)
10.4048/jbc.2015.18.1.87
Effects of a 4-Week Multimodal Rehabilitation Program on Quality of Life, Cardiopulmonary Function, and Fatigue in Breast Cancer Patients
Junghwa Do (2015)
10.1016/j.jelekin.2015.07.002
Comparison of humeral rotation co-activation of breast cancer population and healthy shoulders.
Rebecca L. Brookham (2016)
10.1093/ptj/pzz090
The Effect of Exercise on Cancer-Related Cognitive Impairment and Applications for Physical Therapy: Systematic Review of Randomized Controlled Trials.
K. Campbell (2020)
10.1186/1479-5868-11-80
Determinants of exercise adherence and maintenance among cancer survivors: a systematic review
C. Kampshoff (2014)
10.1055/a-1018-2426
Leitlinienreport zur S3-Leitlinie Magenkarzinom – „Diagnostik und Therapie der Adenokarzinome des Magens und ösophagogastralen Übergangs“: Version 2.0 – August 2019 – AWMF-Registernummer: 032/009OL
M. Moehler (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar