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Development Of Self‐Emulsifying Drug Delivery Systems (SEDDS) For Oral Bioavailability Enhancement Of Poorly Soluble Drugs

D. Fatouros, A. Müllertz
Published 2013 · Chemistry

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10.1007/s11095-006-9054-x
Use of a Dynamic in Vitro Lipolysis Model to Rationalize Oral Formulation Development for Poor Water Soluble Drugs: Correlation with in Vivo Data and the Relationship to Intra-Enterocyte Processes in Rats
A. Dahan (2006)
10.1113/jphysiol.1968.sp008411
A relation between the chain length of fatty acids and the slowing of gastric emptying.
J. N. Hunt (1968)
10.1002/JPS.2600830336
Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation.
J. Kovarik (1994)
10.1023/A:1020311127328
Structured Triglyceride Vehicles for Oral Delivery of Halofantrine: Examination of Intestinal Lymphatic Transport and Bioavailability in Conscious Rats
R. Holm (2004)
10.1002/JPS.20039
Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine.
C. H. Porter (2004)
10.2165/00003495-200262100-00005
Food-Drug Interactions
L. Schmidt (2012)
10.1002/jps.2600561123
Solubilization and rate of dissolution of drugs in the presence of physiologic concentrations of lysolecithin.
T. R. Bates (1967)
10.1081/DDC-120028718
Enhanced Oral Bioavailability of a Poorly Water Soluble Drug PNU‐91325 by Supersaturatable Formulations
Ping Gao (2004)
10.1016/0021-9797(75)90035-1
Entropy-induced dispersion of bulk liquids
H. Reiss (1975)
10.1016/S0378-5173(00)00337-9
Improved bioavailability of vitamin E with a self emulsifying formulation.
T. Julianto (2000)
10.1023/A:1019858428449
Solubilization of Drugs by Physiological Mixtures of Bile Salts
T. Wiedmann (2004)
10.1016/0016-5085(93)90908-U
Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans.
F. Carrière (1993)
10.1023/A:1018987928936
Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound
S. Charman (2004)
10.1016/0009-8981(86)90044-6
Analysis of conjugated and unconjugated bile acids in serum and jejunal fluid of normal subjects.
A. Tangerman (1986)
10.3109/10611869808997871
Drug delivery systems for cyclosporine: achievements and complications.
B. A. Klyashchitsky (1998)
10.1023/A:1016062224568
Estimation of the Increase in Solubility of Drugs as a Function of Bile Salt Concentration
S. D. Mithani (2004)
10.1002/JPS.10501
Excipient effects on in vitro cytotoxicity of a novel paclitaxel self-emulsifying drug delivery system.
Neslihan Gursoy (2003)
10.1517/17425247.3.1.97
Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs
Ping Gao (2006)
10.1002/jps.2600550906
Solubilizing properties of bile salt solutions. II. Effect of inorganic electrolyte, lipids, and a mixed bile salt system on solubilization of glutethimide, griseofulvin, and hexestrol.
T. R. Bates (1966)
10.1016/S0169-409X(96)00492-9
Uptake of drugs into the intestinal lymphatics after oral administration
C. H. Porter (1997)
10.1023/A:1015939307478
In Vivo Model for Ciclosporin Intestinal Absorption in Lipid Vehicles
J. Reymond (1988)
10.1016/S0006-3495(89)82714-6
Vesicle-micelle transition of phosphatidylcholine and octyl glucoside elucidated by cryo-transmission electron microscopy.
P. K. Vinson (1989)
10.1016/0378-5173(94)90271-2
Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs
N. Shah (1994)
10.1016/S0378-5173(98)00054-4
Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
Shui-Mei Khoo (1998)
10.1016/S0378-5173(97)00248-2
Formulation and physical characterization of water-in-oil microemulsions containing long- versus medium-chain glycerides
P. P. Constantinides (1997)
10.1016/j.jconrel.2005.10.002
A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption.
Ji-Yeon Hong (2006)
10.1016/J.IJPHARM.2003.10.036
Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility.
P. C. de Smidt (2004)
10.1016/S0378-5173(99)00345-2
Effect of cellulose polymers on supersaturation and in vitro membrane transport of hydrocortisone acetate.
S. Raghavan (2000)
10.1023/A:1016268311867
Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects
P. Constantinides (2004)
10.1002/jps.2600770409
Physicochemical basis of increased bioavailability of a poorly water-soluble drug following oral administration as organic solutions.
A. T. Serajuddin (1988)
10.1002/JPS.20068
Comparative bioavailability study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone.
C. Tuleu (2004)
10.1016/J.ADDR.2007.10.010
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.
C. Pouton (2008)
10.1002/JPS.10554
Probing drug solubilization patterns in the gastrointestinal tract after administration of lipid-based delivery systems: a phase diagram approach.
Greg A Kossena (2004)
10.1211/jpp.58.6.0011
Examination of the impact of a range of Pluronic surfactants on the in‐vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone
L. Sek (2006)
10.1023/A:1014407421366
Forecasting the Oral Absorption Behavior of Poorly Soluble Weak Bases Using Solubility and Dissolution Studies in Biorelevant Media
Edmund S. Kostewicz (2004)
10.1002/jemt.1060100111
Controlled environment vitrification system: an improved sample preparation technique.
J. Bellare (1988)
10.1016/J.EJPS.2004.11.007
In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media.
V. H. Sunesen (2005)
10.1016/J.EJPS.2007.01.007
Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state.
M. Grove (2007)
10.1023/A:1025718513246
Intestinal Lymphatic Transport of Halofantrine Occurs After Oral Administration of a Unit-Dose Lipid-Based Formulation to Fasted Dogs
Shui-Mei Khoo (2004)
10.1017/S0033583500004297
Cryo-electron microscopy of vitrified specimens.
J. Dubochet (1988)
10.1016/S0378-5173(00)00614-1
Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment.
T. R. Kommuru (2001)
10.1023/A:1018923912135
Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion Formulation
E. A. Mueller (2004)
10.1016/0378-5173(82)90128-4
Study of the influence of sodium taurocholate (STC) and sodium glycocholate (SGC) on the mass transfer of certain drugs. Digoxin
M. Kassem (1982)
10.1016/S0169-409X(96)00490-5
Formulation of self-emulsifying drug delivery systems
C. Pouton (1997)
10.1211/jpp.58.9.0004
Preparation and evaluation of self‐microemulsifying drug delivery systems (SMEDDS) containing atorvastatin
Hai-rong Shen (2006)
10.1023/A:1018922517162
Influence of a Fat-Rich Meal on the Pharmacokinetics of a New Oral Formulation of Cyclosporine in a Crossover Comparison with the Market Formulation
E. A. Mueller (2004)
10.1016/J.EJPS.2006.02.005
Bioavailability of seocalcitol II: development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides.
M. Grove (2006)
10.1007/s11095-005-8192-x
The Effects of Food on the Dissolution of Poorly Soluble Drugs in Human and in Model Small Intestinal Fluids
E. M. Persson (2005)
10.1016/j.ejpb.2008.01.022
In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks.
D. Fatouros (2008)
10.1023/A:1011984216775
Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage Forms
J. Dressman (2004)
10.1016/S0928-0987(00)00181-0
In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs.
J. Dressman (2000)
10.1002/JPS.20260
Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drug.
Greg A Kossena (2005)
10.1016/S0939-6411(00)00089-8
Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs.
T. Gershanik (2000)
10.1002/JPS.20673
Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds.
F. S. Nielsen (2007)
10.1007/s11095-007-9304-6
Structural Development of Self Nano Emulsifying Drug Delivery Systems (SNEDDS) During In Vitro Lipid Digestion Monitored by Small-angle X-ray Scattering
Dimitrios G. Fatouros (2007)
10.1016/J.EJPS.2003.08.005
Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine.
J. Odeberg (2003)
10.1023/B:PHAM.0000036914.22132.cc
Susceptibility to Lipase-Mediated Digestion Reduces the Oral Bioavailability of Danazol After Administration as a Medium-Chain Lipid-Based Microemulsion Formulation
C. H. Porter (2004)
10.1016/J.IJPHARM.2004.05.015
Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations.
S. P. Yap (2004)
10.1080/03639040802244318
A Systematic Dilution Study of Self-Microemulsifying Drug Delivery Systems in Artificial Intestinal Fluid Using Dynamic Laser Light Backscattering
Céline Ditner (2009)
10.1021/LA00005A025
Viscosity, microstructure, and interparticle potential of AOT/H2O/n-decane inverse microemulsions
J. Bergenholtz (1995)
10.1002/jps.2600611113
Micelle formation and testosterone solubilization by sodium glycocholate.
Leo Martis (1972)
10.1002/JPS.20824
Quality by design: understanding the product variability of a self-nanoemulsified drug delivery system of cyclosporine A.
A. Zidan (2007)
10.1016/0928-0987(94)00078-E
Preparation and in vitro evaluation of tetrandrine-entrapped albumin microspheres as an inhaled drug delivery system
Xian Ming Zeng (1995)
10.1002/JPS.10511
Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability.
Ping Gao (2003)
10.1016/S0928-0987(01)00169-5
A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium.
N. H. Zangenberg (2001)
10.1021/JS970300N
Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor.
D. Hauss (1998)
10.1016/0378-5173(94)00222-Q
An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy
D. Craig (1995)
10.1016/S0928-0987(01)00182-8
A dynamic in vitro lipolysis model. II: Evaluation of the model.
N. H. Zangenberg (2001)
10.1016/S0169-409X(01)00151-X
Intestinal lymphatic drug transport: an update.
C. J. Porter (2001)
10.1016/0378-5173(80)90086-1
Solubilization of diazepam in bile salts and in sodium cholate-lecithin-water phases
M. Rosoff (1980)
10.1021/bi00457a006
Medium-chain versus long-chain triacylglycerol emulsion hydrolysis by lipoprotein lipase and hepatic lipase: implications for the mechanisms of lipase action.
R. Deckelbaum (1990)
10.1016/S0378-5173(00)00591-3
Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: binding, effects on barrier function and cytotoxicity.
T. Gershanik (2000)
10.1002/(SICI)1520-6017(200004)89:4<429::AID-JPS1>3.0.CO;2-J
Intestinal permeation enhancers.
B. Aungst (2000)
10.1194/JLR.R200012-JLR200
The triglyceride lipases of the pancreas Published, JLR Papers in Press, October 1, 2002. DOI 10.1194/jlr.R200012-JLR200
M. Lowe (2002)
10.1002/jps.22122
Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity.
Karen Kleberg (2010)
10.1023/A:1011910801212
Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs
E. Galia (2004)
10.1016/J.IJPHARM.2003.12.028
Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs.
B. Kang (2004)
10.1021/LA950505G
A Study of the Microstructure of a Four-Component Nonionic Microemulsion by Cryo-TEM, NMR, SAXS, and SANS
O. Regev (1996)
10.1126/science.432636
Watching fat digestion.
J. Patton (1979)
10.1016/S0006-3495(91)82169-5
Intermediate structures in the cholate-phosphatidylcholine vesicle-micelle transition
A. Walter (1991)
10.1002/JPS.10158
Examination of the solubilization of drugs by bile salt micelles.
T. Wiedmann (2002)
10.1016/S0188-0128(99)00034-2
Comparative bioavailability evaluation of two cyclosporine oral formulations in healthy Mexican volunteers.
J. González-Llaven (1999)
10.1016/J.EJPB.2007.01.017
The effect of different lipid based formulations on the oral absorption of lipophilic drugs: the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats.
A. Dahan (2007)
10.1016/J.EJPS.2007.02.009
Morphological observations on a lipid-based drug delivery system during in vitro digestion.
D. Fatouros (2007)
10.1023/A:1007576713216
A Comparison of the Solubility of Danazol in Human and Simulated Gastrointestinal Fluids
B. L. Pedersen (2004)
10.1016/S0169-409X(01)00178-8
The drug efflux-metabolism alliance: biochemical aspects.
L. Benet (2001)
The pharmacokinetics of Sandimmun Neoral: a new oral formulation of cyclosporine.
D. Holt (1994)
10.1016/J.EJPB.2005.12.005
Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system.
Wei Wu (2006)
10.1016/J.IJPHARM.2006.09.060
Quality by design: understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box-Behnken design and desirability function.
A. Zidan (2007)
10.1002/jps.2600590512
Inhibition of sulfathiazole crystal growth by polyvinylpyrrolidone.
A. Simonelli (1970)
10.1016/S0169-409X(01)00182-X
In vitro assessment of oral lipid based formulations.
C. J. Porter (2001)
10.1007/s11095-008-9641-0
Lipid-based Formulations for Danazol Containing a Digestible Surfactant, Labrafil M2125CS: In Vivo Bioavailability and Dynamic In Vitro Lipolysis
A. Larsen (2008)



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