Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

Quantitative Characterization Of Sphere‐templated Porous Biomaterials

A. Marshall, B. Ratner
Published 2005 · Materials Science

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Three-dimensional (3-D) porous hydrogels were fabricated by polymerizing 2-hydroxyethyl methacrylate around templates of random close-packed poly(methyl methacrylate) microspheres with nominal diameter of 5 or 15 μm. The templates were leached out to create networks of interconnected spherical pores. Applications for sphere-templated porous biomaterials include scaffolds for tissue engineering and spatial control of wound healing. This study describes an approach to characterizing pore structure and predicting permeability of sphere-templated porous hydrogels. The materials were embedded in resin, and 1-μm-plane sections were digitally analyzed with fluorescence microscopy. The porosity and pore size distribution were determined from stereological interpretation, and we present novel techniques for obtaining the pore throat size distribution, the number of pore throats per pore, and the tortuosity. A simple apparatus is also introduced for measurement of the hydraulic permeability. Permeability predictions based on quantitative microscopy measurements and on stereology were found to agree closely with permeability measurements. The aptness of the Kozeny equation for spherically pored materials is also investigated. © 2005 American Institute of Chemical Engineers AIChE J, 2005
This paper references



This paper is referenced by
10.1177/0885328211431857
Long-term biocompatibility and osseointegration of electron beam melted, free-form–fabricated solid and porous titanium alloy: Experimental studies in sheep
A. Palmquist (2013)
10.1002/jbm.a.32798
Epidermal and dermal integration into sphere-templated porous poly(2-hydroxyethyl methacrylate) implants in mice.
Y. Fukano (2010)
10.1088/1748-6041/6/1/015007
The effect of pore size on tissue ingrowth and neovascularization in porous bioceramics of controlled architecture in vivo.
B. Feng (2011)
10.1007/S10853-007-2419-7
Implantable photonic crystal for reflection-based optical sensing of biodegradation
M. Fujishima (2008)
10.1177/193229681100500505
Glucose Sensor Membranes for Mitigating the Foreign Body Response
Ahyeon Koh (2011)
10.1161/ATVBAHA.109.194233
VEGF Induces Differentiation of Functional Endothelium From Human Embryonic Stem Cells: Implications for Tissue Engineering
M. Nourse (2010)
10.1002/bit.23027
Marrow‐Derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness
S. Peyton (2011)
10.1002/jbm.b.31765
Presence of pores and hydrogel composition influence tensile properties of scaffolds fabricated from well-defined sphere templates.
Stephanie M Lanasa (2011)
10.1155/2013/681050
Application and performance of 3D printing in nanobiomaterials
W. Liu (2013)
10.1177/0731684411431857
Long-term biocompatibility and osseointegration of electron beam melted, free-form–fabricated solid and porous titanium alloy: Experimental studies in sheep
A. Palmquist (2013)
10.1002/JBM.A.31661
Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration.
A. Stachowiak (2008)
10.1016/j.biomaterials.2014.07.013
A tough, precision-porous hydrogel scaffold: ophthalmologic applications.
Wenqi Teng (2014)
10.1016/J.IJSOLSTR.2014.06.027
Modeling of metallic foam morphology using the Representative Volume Element approach: Development and experimental validation
C. Simoneau (2014)
Matériaux poreux à base de polyuréthane pour l’ingénierie tissulaire
G. Lutzweiler (2019)
10.1002/mame.201600044
Self-Cleaning, Thermoresponsive P (NIPAAm-co-AMPS) Double Network Membranes for Implanted Glucose Biosensors.
Ruochong Fei (2016)
10.4172/2157-7552.S1-001
Comparative Characterisation of 3-D Hydroxyapatite Scaffolds Developed Via Replication of Synthetic Polymer Foams and Natural Marine Sponges
E. Cunningham (2011)
10.1016/J.BIOMATERIALS.2006.11.033
Photo-patterning of porous hydrogels for tissue engineering.
S. Bryant (2007)
10.1002/jbm.a.32214
Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model.
B. Beckstead (2009)
10.1002/adma.201701115
Inverse Opal Scaffolds and Their Biomedical Applications.
Y. Zhang (2017)
10.3390/pharmaceutics12070602
The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation
G. Lutzweiler (2020)
10.1089/ten.TEC.2014.0454
Pore Interconnectivity Influences Growth Factor-Mediated Vascularization in Sphere-Templated Hydrogels.
Sami I. Somo (2015)
10.1021/BK-2013-1135.CH015
Biomaterial-induced angiogenesis to address peripheral vascular disease
Dale J Terasaki (2013)
10.1080/00268976.2019.1654140
Characterising the throat diameter of through-pores in network structures using a percolation criterion
K. W. Wang (2019)
Application and Performance of 3 D Printing in Nanobiomaterials
W. Liu (2015)
Development of biomaterial porous scaffolds for dendritic cell modulation and mRNA delivery
Ruying Chen (2017)
10.1002/jbm.a.33125
Quantifying the effect of pore size and surface treatment on epidermal incorporation into percutaneously implanted sphere-templated porous biomaterials in mice.
R. Underwood (2011)
10.1021/am4040653
Self-cleaning membrane to extend the lifetime of an implanted glucose biosensor.
A. Abraham (2013)
10.1007/s10439-014-1192-4
Functional Augmentation of Naturally-Derived Materials for Tissue Regeneration
A. B. Allen (2014)
10.1149/ma2007-02/32/1508
Electrochemical measurements of diffusion through cardiac muscle tissue engineering scaffolds
Kavita M. Jeerage (2007)
10.2174/0929867326666190903113004
Natural Polymers Based Hydrogels for Cell Culture Applications.
G. José (2019)
10.1002/ADFM.201601146
Multi-Material Tissue Engineering Scaffold with Hierarchical Pore Architecture.
K. Morgan (2016)
10.1088/1758-5090/aa7077
Fabrication of biomimetic bone grafts with multi-material 3D printing.
Nicholas A. Sears (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar