Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Solid–liquid Equilibria Of Multicomponent Lipid Mixtures Under CO2 Pressure: Measurement And Thermodynamic Modeling

K. Vezzù, A. Bertucco, F. P. Lucien
Published 2008 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Share
A method for evaluating solid–liquid equilibria of mixtures of lipids and carbon dioxide (CO2) under pressure is developed and presented in this article. Experimental measurements by high-pressure differential scanning calorimetry (DSC) are performed to determine solid–liquid transition temperatures as a function of composition. These data are used to develop a simplified approach for thermodynamic modeling, that is, correlation and prediction, of the solid–liquid equilibria. The model requires fewer pure component properties in comparison with cubic equations of state: the solid-state fugacity is determined with reference to the subcooled liquid state whereas regular solution theory is applied for the calculation of liquid-phase activity coefficients. Application of the model is demonstrated for mixtures of ceramide 3A and cholesterol in compressed CO2 in the range of pressure from 0.1 to 6.1 MPa. A satisfactory correlation of solid–liquid equilibria is obtained for binary systems consisting of either the lipid mixture or one lipid in compressed CO2. With the fitted binary interactions parameters, the eutectic temperature of the ternary mixture is predicted to within 1°C of the experimental value in the range of pressure considered. The proposed evaluation method looks sufficiently accurate for representing multiphase equilibria of lipid mixtures in compressed CO2 and has direct application to gas-assisted micronization processes such as PGSS (Particles from Gas-Saturated Solution). © 2008 American Institute of Chemical Engineers AIChE J, 2008
This paper references
10.1016/0896-8446(92)90025-F
Multiphase equilibria of binary and ternary mixtures involving solid phase(s) at supercritical-fluid conditions
D. Zhang (1992)
10.1021/BK-1989-0406.CH009
Four-Phase (Solid—Solid—Liquid—Gas) Equilibrium of Two Ternary Organic Systems with Carbon Dioxide
Gary L. White (1989)
10.1021/JE0503857
Evaluation of the Vaporization, Fusion, and Sublimation Enthalpies of the 1-Alkanols: The Vaporization Enthalpy of 1-, 6-, 7-, and 9-Heptadecanol, 1-Octadecanol, 1-Eicosanol, 1-Docosanol, 1-Hexacosanol, and Cholesterol at T ) 298.15 K by Correlation Gas Chromatography
G. Nichols (2006)
10.1016/J.SUPFLU.2006.10.003
Measurement and thermodynamic modeling of solid–liquid–gas equilibrium of some organic compounds in the presence of CO2
E. Bertakis (2007)
10.1016/J.ADDR.2003.12.002
Solid lipid nanoparticles for parenteral drug delivery.
S. Wissing (2004)
Investigations on the occlusive properties of solid lipid nanoparticles (SLN).
S. Wissing (2001)
10.1039/B517540B
Structural organisation and phase behaviour of a stratum corneum lipid analogue: ceramide 3A.
P. Garidel (2006)
10.1016/S0009-3084(97)00050-9
Structure of stratum corneum lipids characterized by FT-Raman spectroscopy and DSC. III. Mixtures of ceramides and cholesterol.
M. Wegener (1997)
10.1016/S0896-8446(99)00048-0
Solubilities of solid mixtures in supercritical carbon dioxide: a review
F. P. Lucien (2000)
10.1111/1523-1747.EP12340135
Optimization of physiological lipid mixtures for barrier repair.
M. Man MQ (1996)
10.1016/J.CHEMPHYSLIP.2006.09.001
Phase behaviour of stearic acid-stearonitrile mixtures. A thermodynamic study in bulk and at the air-water interface.
A. C. Teixeira (2006)
10.1016/S0378-3812(00)00437-4
Comparison of different methods for determination of the S–L–G equilibrium curve of a solid component in the presence of a compressed gas
Klementina Fukné-Kokot (2000)
10.1016/S0896-8446(01)00064-X
Particle design using supercritical fluids: Literature and patent survey
Jennifer Jung (2001)
10.1016/J.FLUID.2004.12.012
Influence of the aromatic ring substituents on phase equilibria of vanillins in binary systems with CO2
M. Škerget (2005)
10.1016/S0896-8446(01)00123-1
Phase equilibria of organic solid solutes and supercritical fluids with respect to the RESS process
A. Diefenbacher (2002)
10.1016/J.SUPFLU.2005.11.016
Effect of high-pressure gases on phase behaviour of solid lipids
S. Spilimbergo (2006)
10.1016/S0378-3812(03)00180-8
The effect of gas pressure on the melting behavior of compounds
K. Fischer (2003)
10.1016/S0169-409X(01)00105-3
Solid lipid nanoparticles: production, characterization and applications.
W. Mehnert (2001)
10.1016/S0009-3084(02)00027-0
Interaction among molecules in mixtures of ceramide/stearic acid, ceramide/cholesterol and ceramide/stearic acid/cholesterol.
Noboru Ohta (2002)
10.1021/IE970376U
A Thermodynamic Analysis of Three-Phase Equilibria in Binary and Ternary Systems for Applications in Rapid Expansion of a Supercritical Solution (RESS), Particles from Gas-Saturated Solutions (PGSS), and Supercritical Antisolvent (SAS)
Ireneo Kikic and (1997)
10.1016/0378-3812(90)85145-Z
Solubilities and selectivities in supercritical fluid mixtures near critical end points
R. Lemert (1990)
10.1007/BF02560841
Die thermodynamischen Eigenschaften von Kohlendioxid
U. Sievers (1984)
10.1016/S0009-3084(97)00049-2
Structure of stratum corneum lipids characterized by FT-Raman spectroscopy and DSC. II. Mixtures of ceramides and saturated fatty acids.
R. Neubert (1997)
10.1016/S0040-6031(98)00402-X
Design improvements in adiabatic calorimetry: The heat capacity of cholesterol between 10 and 425 K
J. C. Miltenburg (1998)
10.1021/IE030278A
Thermodynamic Analysis of Micronization Processes from Gas-Saturated Solution
N. Elvassore (2003)
10.1081/DDC-120030422
Nanoparticle Engineering Processes for Enhancing the Dissolution Rates of Poorly Water Soluble Drugs
Jiahui Hu (2004)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar