Online citations, reference lists, and bibliographies.
← Back to Search

Timing And Topography Of Cerebral Blood Flow, Aura, And Headache During Migraine Attacks

J. Olesen, L. Friberg, T. Olsen, H. Iversen, N. Lassen, A. Andersen, A. Karle
Published 1990 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Ten years of study has resulted in considerable but fragmented knowledge about regional cerebral blood flow in migraine with aura (classic migraine). In the present study, the number of repeatedly studied patients (n = 63) was large enough to determine statistically significant sequences of events and statistically significant spatial relations. The first observable event was a decrease of regional cerebral blood flow posteriorly in one cerebral hemisphere. Further development of this pathological process was accompanied by the aura symptoms. Thereafter headache occurred while regional cerebral blood flow remained decreased. During the headache phase, regional cerebral blood flow gradually changed from abnormally low to abnormally high without apparent change in headache. In some patients headache disappeared while regional cerebral blood flow remained increased. Although regional cerebral blood flow reduction and aura symptoms in the great majority of patients were unilateral, one‐third had bilateral headache. Unilateral headache usually localized to the side on which regional cerebral blood flow was reduced and from which the aura symptoms originated (i.e., aura symptoms were perceived to occur contralaterally but presumably originated in the hypoperfused hemisphere). Our results suggest a simple model for migraine attacks: A pathological disturbance in one cerebral hemisphere causes the aura symptoms and after a time delay, it also causes the headache by stimulating local vascular nociceptors. Bilateral headache caused by a unilateral cerebral disturbance may be explained by recent neuroanatomical and neurophysiological findings.
This paper references
10.1212/WNL.10.6.555
The tentorial nerves and localization of intracranial pain in man
W. Feindel (1960)
10.1016/0006-8993(83)90928-9
The cells of origin of cat trigeminothalamic projections: Especially in the caudal medulla
Y. Shigenaga (1983)
10.1002/CNE.902230105
Trigeminal projections to supratentorial pial and dural blood vessels in cats demonstrated by horseradish peroxidase histochemistry
M. Mayberg (1984)
10.1016/0022-510X(66)90025-6
Personal observations on the spectral march of migraine.
E. Hare (1966)
Trigeminal nerve pathways to the cerebral arteries in monkeys.
G. Ruskell (1987)
10.1111/J.1526-4610.1986.HED2605216.X
Observations on Prodromes of Classic Migraine in a Headache Clinic Population
D. Bana (1986)
10.1046/j.1468-2982.1988.0801001.x
Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study
Fulvio Sorge (1988)
10.1001/ARCHNEUR.1966.00470160022003
Some clinical aspects of migraine. A prospective survey of 500 patients.
J. Lance (1966)
10.1002/ANA.410140512
Regulation of regional cerebral blood flow during and between migraine attacks
M. Lauritzen (1983)
10.1002/ANA.410090406
Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine
J. Olesen (1981)
10.1111/j.1600-0404.1987.tb05452.x
Subcutaneous blood flow in the temporal region of migraine patients
K. Jensen (1987)
10.1093/BRAIN/110.4.917
Focal ischaemia caused by instability of cerebrovascular tone during attacks of hemiplegic migraine. A regional cerebral blood flow study.
L. Friberg (1987)
10.1002/CNE.902250204
Co‐localization of retrogradely transported wheat germ agglutinin and the putative neurotransmitter substance P within trigeminal ganglion cells projecting to cat middle cerebral artery
L. Y. Liu-Chen (1984)
10.1093/BRAIN/107.2.447
Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography.
M. Lauritzen (1984)
10.1001/ARCHNEUR.1987.00520140028013
Ischemia May Be the Primary Cause of the Neurologic Deficits in Classic Migraine
D. Kronborg (1990)
10.1136/JNNP.44.9.846
Asymmetry of the aura and pain in migraine.
R. Peatfield (1981)
10.1001/ARCHNEUR.1988.00520260040017
Delayed hyperemia following hypoperfusion in classic migraine. Single photon emission computed tomographic demonstration.
A. Andersen (1988)
10.1002/ANA.410130609
Changes in regional cerebral blood flow during the course of classic migraine attacks
Martin Lauritzen (1983)
10.1001/ARCHNEURPSYC.1940.02280070051003
DURAL HEADACHE AND INNERVATION OF THE DURA MATER
W. Penfield (1940)
10.1136/jnnp.23.1.23
OBSERVATIONS ON 500 CASES OF MIGRAINE AND ALLIED VASCULAR HEADACHE
G. Selby (1960)
A multidetector scintillation camera with 254 channels.
E. Sveinsdottir (1977)
10.1001/ARCHSURG.1940.01210040002001
EXPERIMENTAL STUDIES ON HEADACHE: PAIN-SENSITIVE STRUCTURES OF THE HEAD AND THEIR SIGNIFICANCE IN HEADACHE
B. S. Ray (1940)
10.1038/jcbfm.1988.8
Brain Stem Terminations of the Trigeminal and Upper Spinal Ganglia Innervation of the Cerebrovascular System: WGA-HRP Transganglionic Study
M. Arbab (1988)
10.1016/0304-3959(86)90244-7
Activation of trigeminal brain-stem nociceptive neurons by dural artery stimulation
K. Davis (1986)
10.1523/JNEUROSCI.06-08-02200.1986
Pattern of intracranial and extracranial projections of trigeminal ganglion cells
T. O’Connor (1986)
10.1016/0304-3959(89)90072-9
Pain perception in a man with total corpus callosum transection
B. Stein (1989)
10.1111/j.1600-0404.1986.tb03290.x
Classic migraine
K. Jensen (1986)
10.1001/JAMA.1972.03200040039008
The migrainous scintillating scotoma.
C. Aring (1972)
10.1093/OXFORDJOURNALS.QJMED.A067039
HEMIPLEGIC MIGRAINE, A CLINICAL STUDY.
P. Bradshaw (1965)
10.7326/0003-4819-32-2-350_1
Headache and other head pain
H. Wolff (1972)
10.1016/0304-3959(89)90078-X
Substance P and peripheral inflammatory hyperalgesia
M. Nakamura-Craig (1989)
10.1111/j.1600-0404.1985.tb00915.x
Temporal muscle blood flow in common migraine
K. Jensen (1985)
10.1159/000115790
Classic migraine--clinical findings in 164 patients.
G. C. Manzoni (1985)
10.1016/0006-8993(86)90777-8
Response of brainstem trigeminal neurons to electrical stimulation of the dura
A. Strassman (1986)



This paper is referenced by
10.1016/S0161-6420(93)31468-5
Occult Retinal and Choroidal Vascular Disease: The Value of Timed and Directed Fluorescein Angiography
J. Rizzo (1993)
10.5348/IJCRI-2014-03-478-CR-9
Prolonged aphasia and perfusion computed tomography abnormalities in migraine with aura
A. Angermaier (2014)
10.1016/0028-3908(94)00153-J
Comparison of the effects of sumatriptan and the NK1 antagonist CP-99,994 on plasma extravasation in dura mater and c-fos mRNA expression in trigeminal nucleus caudalis of rats
S. Shepheard (1995)
10.1097/00004647-199605000-00018
Autoregulation in the Middle Meningeal Artery
J. Michalíček (1996)
10.1111/j.1526-4610.2009.01367.x
Pseudotumor Cerebri in Childhood Hepatitis E Virus Infection
R. Thapa (2009)
10.1002/ccd.20931
Patent foramen ovale and migraine
M. Post (2007)
10.1111/j.1476-5381.2011.01633.x
Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine
E. Moore (2012)
10.1111/j.1468-2982.2009.01973.x
Tonabersat, A Novel Gap-Junction Modulator for the Prevention of Migraine
S. Silberstein (2009)
Migraine – pathophysiology of pain
V. Vuković (2009)
10.1007/s10072-012-1103-0
Reduction in retinal nerve fiber layer thickness in migraine patients
S. Gipponi (2012)
10.2217/FNL.15.45
The role of cortical spreading depression in migraine
Doğa Vurallı (2015)
10.1111/j.1468-2982.2009.01949.x
Posterior hypoperfusion in migraine without aura?
P. Tfelt-Hansen (2010)
10.1177/1120672119899900
Vascular changes with optical coherence tomography angiography during aura of migraine: A case report.
Pınar Bingöl Kızıltunç (2020)
10.1007/s10787-009-8058-7
Therapeutic transcranial magnetic stimulation in migraine and its implications for a neuroinflammatory hypothesis
A. McComas (2009)
10.2174/1389202910607010001
The Molecular Genetics of Migraine: Toward the Identification of Responsible Genes
F. Gianfrancesco (2006)
10.2174/1874205X00903010064
Migraine: An Overview
S. Salomone (2009)
10.1111/j.1468-2982.2009.02015.x
History of migraine with aura and cortical spreading depression from 1941 and onwards
P. Tfelt-Hansen (2010)
10.1016/j.pharmthera.2010.12.001
Potential mechanisms of prospective antimigraine drugs: a focus on vascular (side) effects.
K. Chan (2011)
10.1155/2009/424192
Pediatric Migraine
U. H. Shah (2009)
Clinical Characteristics and Pathophysiological Mechanisms of Familial Migraine with and without Aura
M. Kallela (2000)
10.1016/S0306-4522(98)00366-2
Release of substance P, calcitonin gene-related peptide and prostaglandin E2 from rat dura mater encephali following electrical and chemical stimulation in vitro
A. Ebersberger (1999)
10.1179/174313208X341049
Migraine and stroke: current perspectives
Debra G Elliott (2008)
10.1007/978-3-0348-8131-9
Migraine: A Neuroinflammatory Disease?
M. J. Parnham (2002)
ANTIPSYCHOTICS FOR MIGRAINE PROPHYLAXIS : AN INITIAL LOOK AT QUETIAPINE Based on
S. Abu-shakra (2002)
10.18203/2349-3259.IJCT20160475
The efficiency of pulsed electromagnetic field in refractory migraine headaches: a randomized, single-blinded, placebo-controlled, parallel group
B. Hatef (2016)
PREVALENCE OF DIFFERENT TYPES OF HEADACHE IN URBAN AND RURAL AREAS OF THE PUNJAB PROVINCE OF PAKISTAN
Aamir Mushtaq (2014)
10.3344/kjp.2017.30.3.176
Intravenous caffeine citrate vs. magnesium sulfate for reducing pain in patients with acute migraine headache; a prospective quasi-experimental study
Alireza Baratloo (2017)
10.1046/j.1468-2982.1994.1402107.x
Improved Description of the Migraine Aura by a Diagnostic Aura Diary
M. Russell (1994)
10.1016/S0022-510X(96)00258-4
Pattern reversal visual evoked potentials in classic and common migraine
K. Shibata (1997)
10.1046/j.1526-4610.2003.03014.x
Prolonged Cortical Electrical Depression and Diffuse Vasospasm Without Ischemia in a Case of Severe Hemiplegic Migraine During Pregnancy
P. González-Alegre (2003)
10.1111/j.1526-4610.2011.01892.x
One Hundred Years of Migraine Research: Major Clinical and Scientific Observations From 1910 to 2010
P. Tfelt-Hansen (2011)
PROFILÁTICO DAS ENXAQUECAS PROFILÁTICO DAS ENXAQUECAS PROFILÁTICO DAS ENXAQUECAS PROFILÁTICO DAS ENXAQUECAS PROFILÁTICO DAS ENXAQUECAS
A. Krymchantowski (1999)
See more
Semantic Scholar Logo Some data provided by SemanticScholar