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Reactions In Droplets In Microfluidic Channels.

Helen Song, Delai L Chen, R. Ismagilov
Published 2006 · Chemistry, Medicine

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Fundamental and applied research in chemistry and biology benefits from opportunities provided by droplet-based microfluidic systems. These systems enable the miniaturization of reactions by compartmentalizing reactions in droplets of femoliter to microliter volumes. Compartmentalization in droplets provides rapid mixing of reagents, control of the timing of reactions on timescales from milliseconds to months, control of interfacial properties, and the ability to synthesize and transport solid reagents and products. Droplet-based microfluidics can help to enhance and accelerate chemical and biochemical screening, protein crystallization, enzymatic kinetics, and assays. Moreover, the control provided by droplets in microfluidic devices can lead to new scientific methods and insights.
This paper references
Lab Chip
K S Huang (2006)
10.1002/ELPS.200500109
Droplet fusion by alternating current (AC) field electrocoalescence in microchannels
M. Chabert (2005)
Chem. Rev
K S Lam (1997)
Angew. Chem. Angew. Chem. Int. Ed
B Zheng (2004)
10.1016/J.CEJ.2003.11.019
Novel microreactors for functional polymer beads
T. Nisisako (2004)
10.1136/pgmj.12.123.32-b
Toxicology
(1860)
10.1109/43.969439
Scheduling of microfluidic operations for reconfigurabletwo-dimensional electrowetting arrays
J. Ding (2001)
10.1073/pnas.0409333102
Dynamic microcompartmentation in synthetic cells
M. Long (2005)
10.1038/nrd1985
Lab-on-a-chip: microfluidics in drug discovery
P. Dittrich (2006)
Acc. Chem. Res
J C Mcdonald (2002)
10.1103/PHYSREVLETT.95.208304
Droplet traffic at a simple junction at low capillary numbers.
W. Engl (2005)
Angew. Chem. Angew. Chem. Int. Ed
T Dwars (2005)
10.1039/B102818A
The intensification of rapid reactions in multiphase systems using slug flow in capillaries.
J. R. Burns (2001)
J. Appl. Phys
H Moon (2002)
Appl. Phys. Lett
M Y He (2005)
10.1126/SCIENCE.285.5424.83
Microfabrication inside capillaries using multiphase laminar flow patterning
Kenis (1999)
Angew. Chem. Angew. Chem. Int. Ed. Angew. Chem. Int. Ed
S Q Xu (2005)
10.1002/ANIE.200590085
Erratum: Generation of monodisperse particles by using microfluidics - Control over size, shape, and composition (Angewandte Chemie - International Edition (2005) 44 (724-728) DOI: 10.1002/anie.200462226)
Shengqing Xu (2005)
10.1093/CLINCHEM/17.1.42
Origin of the lag phase of continuous-flow analysis curves.
R. Thiers (1971)
10.1021/AC049071X
Reagent-loaded cartridges for valveless and automated fluid delivery in microfluidic devices.
V. Linder (2005)
10.1021/CR960013O
Spatially Addressable Combinatorial Libraries.
M. Pirrung (1997)
Angew. Chem. Int. Ed
C S Peyratout (2004)
10.1002/ADMA.200400590
Formation of Arrayed Droplets by Soft Lithography and Two-Phase Fluid Flow, and Application in Protein Crystallization.
B. Zheng (2004)
Ind. Eng. Chem. Res
S Sugiura (2002)
10.1073/PNAS.90.23.10922
Complex synthetic chemical libraries indexed with molecular tags.
M. Ohlmeyer (1993)
Langmuir
B G De Geest (2005)
10.1016/J.CBPA.2005.02.002
High-throughput screens and selections of enzyme-encoding genes.
A. Aharoni (2005)
Phys. Fluids
M Muradoglu (2005)
Chem. Eng. J
T Henkel (2004)
10.1021/LA051527Y
Synthesis of monodisperse biodegradable microgels in microfluidic devices.
B. D. De Geest (2005)
10.1038/NMAT1267
Self-assembly of polymeric microspheres of complex internal structures
M. Fiałkowski (2004)
10.1063/1.1997280
Electro-generation of single femtoliter- and picoliter-volume aqueous droplets in microfluidic systems
Mingyan He (2005)
10.1063/1.1308534
Electrowetting-based actuation of liquid droplets for microfluidic applications
M. Pollack (2000)
Appl. Microbiol. Biotechnol
J M Köhler (2005)
J. Am. Chem. Soc
D L Chen (2005)
10.1016/J.COLSURFA.2004.11.021
Preparation of monodisperse poly(divinylbenzene) macrobeads via a drop breaking and polymerization method
Seong-Heun Cho (2005)
J. Appl. Crystallogr
M K Yadav (2005)
Langmuir
J H Xu (2006)
10.1002/ANIE.200462857
A microfluidic approach for screening submicroliter volumes against multiple reagents by using preformed arrays of nanoliter plugs in a three-phase liquid/liquid/gas flow.
B. Zheng (2005)
10.1002/ADMA.200502431
Synthesis of Monodisperse Bicolored Janus Particles with Electrical Anisotropy Using a Microfluidic Co‐Flow System
T. Nisisako (2006)
10.1016/0001-8686(93)80039-E
Water in oil colloïdal droplets used as microreactors
Marie-Paule Pileni (1993)
Colloid Chemistry II. Vol. 227
K. Landfester (2003)
10.1103/REVMODPHYS.77.977
Microfluidics: Fluid physics at the nanoliter scale
T. Squires (2005)
10.1016/S0924-4247(01)00734-8
Electrowetting and electrowetting-on-dielectric for microscale liquid handling
J. Lee (2002)
10.1021/JA0635682
Microfluidic production of biopolymer microcapsules with controlled morphology.
H. Zhang (2006)
10.1063/1.1812380
The generation of highly monodisperse droplets through the breakup of hydrodynamically focused microthread in a microfluidic device
Q. Xu (2004)
Lab Chip
K Martin (2003)
Kagaku Kogaku Ronbunshu
S Sugiura (2004)
10.1021/IE0490536
Internal Circulation within the Liquid Slugs of a Liquid-Liquid Slug-Flow Capillary Microreactor
M. N. Kashid (2005)
J. S. Go, Lab Chip
S Abraham (2006)
IEEE Trans. Comput- Aided Des. Integr. Circuits Syst
H Ding (2001)
10.1038/nrd817
Encoding microcarriers: present and future technologies
K. Braeckmans (2002)
Chem. Rev
M C Pirrung (1997)
Adv. Synth. Catal
B Ahmed (2006)
J. Fluid Mech
F P Bretherton (1961)
10.1021/AC050031I
Contamination-free continuous flow microfluidic polymerase chain reaction for quantitative and clinical applications.
K. Dorfman (2005)
10.1093/CLINCHEM/10.10.918
MULTIPLE AUTOMATIC SEQUENTIAL ANALYSIS.
L. Skeggs (1964)
10.1038/nature05062
Control and detection of chemical reactions in microfluidic systems
A. deMello (2006)
10.1016/S0003-2670(00)84463-3
Experimental comparison of flow-injection analysis and air-segmented continuous flow analysis
C. Patton (1986)
Ind. Eng. Chem. Res
N De Mas (2003)
10.1021/AC0204146
Continuous segmented-flow polymerase chain reaction for high-throughput miniaturized DNA amplification.
M. Curcio (2003)
Lab Chip
J T Cabral (2006)
10.1007/S11746-004-965-9
Production of monodispersed water-in-oil emulsions using polymer microchannels
H. Liu (2004)
Lab Chip
V Cristini (2004)
10.1021/AC048754+
Digital microfluidics with in-line sample purification for proteomics analyses with MALDI-MS.
A. Wheeler (2005)
J. Fluid Mech
C Queguiner (1997)
10.1002/ELPS.200500173
Microfluidic flow focusing: Drop size and scaling in pressure versus flow‐rate‐driven pumping
T. Ward (2005)
10.1039/B606424H
Manipulating the generation of Ca-alginate microspheres using microfluidic channels as a carrier of gold nanoparticles.
K. Huang (2006)
10.1002/ANGE.200300568
Maßgeschneiderte Polyelektrolyt‐Mikrokapseln: von Multischichten zu smarten Kapseln
Claire Peyratout (2004)
ChemBioChem
P S Dittrich (2005)
J. Am. Chem. Soc
C J Gerdts (2004)
Clin. Chem
B Rocks (1982)
Phys. Rev. E
P Guillot (2005)
10.1021/IE0201415
Preparation of Monodispersed Polymeric Microspheres over 50 μm Employing Microchannel Emulsification
S. Sugiura (2002)
10.1205/026387699526106
Development of a Microreactor for Chemical Production
J. Burns (1999)
10.1126/SCIENCE.1109164
Monodisperse Double Emulsions Generated from a Microcapillary Device
A. Utada (2005)
J. Appl. Crystallogr
A Mcpherson (2000)
10.1063/1.1825059
Giant magnetoresistance monitoring of magnetic picodroplets in an integrated microfluidic system
Nikola Pekas (2004)
10.1021/LA0482406
Micromixing of miscible liquids in segmented gas-liquid flow.
A. Guenther (2005)
10.1017/S0022112097006587
Axisymmetric motion of capsules through cylindrical channels
C. Quéguiner (1997)
Anal. Chim. Acta
J D Tice (2004)
10.1021/LA047368K
Controlled synthesis of nonspherical microparticles using microfluidics.
D. Dendukuri (2005)
Langmuir
A Günther (2005)
J. Am. Chem. Soc
E Quevedo (2005)
Lab Chip
D N Adamson (2006)
J. Am. Chem. Soc
J P Rolland (2004)
10.1252/KAKORONBUNSHU.30.129
Effect of Physical Properties on Droplet Formation in Microchannel Emulsification
S. Sugiura (2004)
10.1021/AC060748L
Microfluidic and optical systems for the on-demand generation and manipulation of single femtoliter-volume aqueous droplets.
Robert M. Lorenz (2006)
10.1039/B301258C
Generation of larger numbers of separated microbial populations by cultivation in segmented-flow microdevices.
K. Martin (2003)
Appl. Phys. Lett
S L Anna (2003)
Appl. Phys. Lett
N Pekas (2004)
Phys. Fluids
R O Grigoriev (2005)
The Kinematics of Mixing: Stretching
J. M. Ottino (1989)
10.1039/B403378G
Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system.
I. Shestopalov (2004)
Nat. Phys
P Garstecki (2005)
10.1007/s00253-005-0176-6
Chip devices for miniaturized biotechnology
J. Köhler (2005)
Nucleic Acids Res
C W Wei (2005)
Curr. Opin. Chem. Biol
P Watts (2003)
10.1021/LA030090W
Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers
Joshua D. Tice (2003)
10.1016/J.ACA.2003.12.030
Droplet-based microfluidic lab-on-a-chip for glucose detection
V. Srinivasan (2004)
Lab Chip
P Garstecki (2006)
10.1073/PNAS.0408236101
A vesicle bioreactor as a step toward an artificial cell assembly.
V. Noireaux (2004)
Microfluidics Angewandte Chemie
10.1021/JA057720W
Microgram-scale testing of reaction conditions in solution using nanoliter plugs in microfluidics with detection by MALDI-MS.
T. Hatakeyama (2006)
10.1073/PNAS.0507171102
High-speed microfluidic differential manometer for cellular-scale hydrodynamics.
M. Abkarian (2006)
Langmuir
E Lorenceau (2005)
10.1002/ANGE.200501365
Reaktionen in micellaren Systemen
T. Dwars (2005)
10.1002/ANIE.200300577
Chemistry in microstructured reactors.
K. Jaehnisch (2004)
Reviews 7354 www.angewandte.org
R F Ismagilov (2006)
Anal. Chem
N H Finkel (2004)
10.1021/CR9600114
The “One-Bead-One-Compound” Combinatorial Library Method
K. Lam (1997)
10.1021/JA051381P
High-temperature microfluidic synthesis of CdSe nanocrystals in nanoliter droplets.
E. Chan (2005)
10.1103/PHYSREVLETT.92.054503
Geometrically mediated breakup of drops in microfluidic devices.
D. Link (2004)
10.1021/JA040811T
Solvent Resistant Photocurable “Liquid Teflon” for Microfluidic Device Fabrication [J. Am. Chem. Soc. 2004, 126, 2322−2323].
J. Rolland (2004)
10.1016/S0959-440X(00)00131-7
High-throughput protein crystallization.
R. Stevens (2000)
Anal. Chem. Anal. Chem. Anal. Chem
M Curcio (2003)
10.1021/LA050105L
Continuous fabrication of biocatalyst immobilized microparticles using photopolymerization and immiscible liquids in microfluidic systems.
W. J. Jeong (2005)
10.1179/174328408x369933
Biomaterials
R. Misra (2008)
J. Am. Chem. Soc
J L Steinbacher (2006)
Anal. Chem
K K Stewart (1983)
10.1021/AC0498112
Electrowetting-based microfluidics for analysis of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry.
A. Wheeler (2004)
Anal. Chem
K Handique (2000)
10.1021/LA060759+
Microfluidic assembly of homogeneous and Janus colloid-filled hydrogel granules.
R. F. Shepherd (2006)
Langmuir
S Okushima (2004)
10.1002/ANGE.200200550
Mikrobläschen als Kontrastmittel für die diagnostische Ultraschall-Bildgebung: die Schlüsselrolle von Perfluorverbindungen†
E. Schutt (2003)
Anal. Chem
R M Lorenz (2006)
Clin. Chem
L T Skeggs (1964)
Annu. Rev. Mater. Sci
Y N Xia (1998)
10.1103/PHYSREVLETT.94.234502
Nonlinear dynamics of a flow-focusing bubble generator: an inverted dripping faucet.
P. Garstecki (2005)
Proc. Natl. Acad. Sci. USA 1983
I Giaever
10.1021/AC049061W
Controlling nonspecific protein adsorption in a plug-based microfluidic system by controlling interfacial chemistry using fluorous-phase surfactants.
L. Roach (2005)
Angew. Chem. Int. Ed
C J Gerdts (2006)
10.1021/LA0471137
Microfluidic platform for the generation of organic-phase microreactors.
Zuzanna T. Cygan (2005)
Chem. Eng. Technol
Y Onal (2005)
10.1063/1.1537519
Formation of dispersions using “flow focusing” in microchannels
S. Anna (2003)
10.1021/ES060031F
Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan, China.
M. K. So (2006)
10.1021/CC0498940
High-throughput microcoil NMR of compound libraries using zero-dispersion segmented flow analysis.
R. Kautz (2005)
10.1039/b108740c
Droplet formation in a microchannel network.
T. Nisisako (2002)
J. Am. Oil Chem. Soc
H J Liu (2004)
Phys. Fluids
T Cubaud (2004)
10.1088/0953-8984/17/28/R01
Electrowetting: from basics to applications
F. Mugele (2005)
J. Am. Chem. Soc
C L Hansen (2006)
10.1103/PHYSREVLETT.97.024503
Flowing crystals: nonequilibrium structure of foam.
P. Garstecki (2006)
The Kinematics of Mixing: Stretching, Chaos, and Transport
J. Ottino (1989)
Rev. Mod. Phys
T M Squires (2005)
Lab Chip
M Zourob (2006)
10.1002/ANIE.200453974
A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip X-ray diffraction.
B. Zheng (2004)
10.1021/AC990571D
Handling of Picoliter Liquid Samples in a Poly(dimethylsiloxane)-Based Microfluidic Device
K. Hosokawa (1999)
Curr. Opin. Chem. Biol
A Aharoni (2005)
10.1002/CEAT.200500008
Sample pulse broadening in taylor flow microchannels for screening applications
W. Salman (2005)
10.1098/RSPA.1934.0169
The formation of emulsions in definable fields of flow
G. I. Taylor (1934)
10.1063/1.1504171
Low voltage electrowetting-on-dielectric
H. Moon (2002)
Anal. Chem
D C Duffy (1998)
10.1016/0039-9140(81)80019-7
Flow-injection analysis: A review of its early history.
K. Stewart (1981)
10.1103/PHYSREVLETT.87.274501
Perfectly monodisperse microbubbling by capillary flow focusing.
A. Gañán-Calvo (2001)
10.1016/J.TOX.2006.01.029
Perfluorooctanoic acid: relationship between repeated inhalation exposures and plasma PFOA concentration in the rat.
P. Hinderliter (2006)
10.1056/NEJM199609123351101
Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress Syndrome
C. L. Leach (1996)
10.1021/AC050008X
Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow.
J. El-Ali (2005)
10.1021/JA060882N
Janus and ternary particles generated by microfluidic synthesis: design, synthesis, and self-assembly.
Z. Nie (2006)
Anal. Chem
J S Marcus (2006)
10.1021/AC00260A001
Flow injection analysis. New tool for old assays. New approach to analytical measurements
K. Stewart (1983)
10.1002/ANIE.200462226
Generation of monodisperse particles by using microfluidics: control over size, shape, and composition.
Shengqing Xu (2005)
10.1002/ADMA.200304890
Generation of Uniform Colloidal Assemblies in Soft Microfluidic Devices
Gi-Ra Yi (2003)
10.1039/B513195B
A micro-reactor for preparing uniform molecularly imprinted polymer beads
M. Zourob (2006)
10.1021/AC0346959
Cylindrical compact thermal-cycling device for continuous-flow polymerase chain reaction.
Nokyoung Park (2003)
10.1021/AC035196A
Concentrating solutes and nanoparticles within individual aqueous microdroplets.
Mingyan He (2004)
Adv. Mater
B Xu (1999)
Chem. Eng. J
T Nisisako (2004)
10.1039/B510841A
Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up.
P. Garstecki (2006)
10.1126/SCIENCE.1112615
Droplet Control for Microfluidics
M. Joanicot (2005)
Langmuir
S Daniel (2005)
10.1063/1.1630378
Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels.
Helen Song (2003)
10.1021/IE020717Q
Microfabricated Multiphase Reactors for the Selective Direct Fluorination of Aromatics
N. Mas (2003)
Phys. Rev. Lett
D R Link (2004)
Anal. Chem
M Y He (2004)
Catal. Today
L Kiwi-Minsker (2005)
10.1103/PHYSREVLETT.91.054501
Optical manipulation of microscale fluid flow.
Nicolas Garnier (2003)
Appl. Phys. Lett
Q Y Xu (2004)
10.1016/J.SBI.2005.08.009
Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization.
B. Zheng (2005)
10.1039/B516317J
Electronic drop sensing in microfluidic devices: automated operation of a nanoliter viscometer.
N. Srivastava (2006)
Lab Chip
G Cristobal (2006)
Lab Chip
M G Pollack (2002)
10.1002/ANIE.200300568
Tailor-made polyelectrolyte microcapsules: from multilayers to smart containers.
Claire Peyratout (2004)
J. Micromech. Microeng
B J Adzima (2006)
10.1002/ADMA.200401738
An Axisymmetric Flow‐Focusing Microfluidic Device
Shoji Takeuchi (2005)
10.1017/S0022112061000160
The motion of long bubbles in tubes
F. Bretherton (1961)
Chem. Eng. Commun
J R Burns (2002)
10.1063/1.1813871
Transport of bubbles in square microchannels
T. Cubaud (2002)
10.1039/B517178D
Timing controllable electrofusion device for aqueous droplet-based microreactors.
Wei-heong Tan (2006)
Appl. Phys. Lett
P Garstecki (2004)
J. Am. Chem. Soc
H Zhang (2006)
10.1006/JCIS.2001.7893
Dilational Rheology of Mixed β-Casein/Tween 20 and β-Casein (f114-169)/Tween 20 Films at Oil-Water Interface
J. Girardet (2001)
Appl. Phys. Lett
G Cristobal (2006)
Angew. Chem. Angew. Chem. Int. Ed
E G Schutt (2003)
10.1080/00986440214585
A Microreactor for the Nitration of Benzene and Toluene
J. Burns (2002)
Angew. Chem. Angew. Chem. Int. Ed
S L Poe (2006)
10.1017/S0022112061000159
Deposition of a viscous fluid on the wall of a tube
G. I. Taylor (1961)
10.1039/B518006F
Microfluidics assisted synthesis of well-defined spherical polymeric microcapsules and their utilization as potential encapsulants.
S. Abraham (2006)
Lab Chip
N Srivastava (2006)
Tetrahedron
J A Gladysz (2002)
10.1021/AC000064S
Nanoliter liquid metering in microchannels using hydrophobic patterns
Handique (2000)
Compendium of chemical terminology. IUPAC recommendations
A. D. McNaught (1997)
10.1039/B604993A
Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices.
David N Adamson (2006)
10.1073/pnas.262485199
A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion
C. Hansen (2002)
Langmuir
S A Khan (2004)
Chem. Eng. Technol
M Günther (2005)
10.1002/ANIE.200503925
Solving the clogging problem: precipitate-forming reactions in flow.
S. Poe (2006)
10.1016/J.ACA.2003.11.024
Effects of viscosity on droplet formation and mixing in microfluidic channels
Joshua D. Tice (2004)
10.1021/JA037166V
Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets.
B. Zheng (2003)
Nat. Rev. Drug Discovery
S Dittrich (2006)
Appl. Phys. Lett
H Song (2003)
10.1016/J.CEJ.2003.11.025
Digital reaction technology by micro segmented flow—components, concepts and applications
J. Köhler (2004)
10.1021/JA056641H
Controlled microfluidic encapsulation of cells, proteins, and microbeads in lipid vesicles.
Yung-Chieh Tan (2006)
10.1021/AC0495743
Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays.
B. Zheng (2004)
10.1107/S002188980502649X
In situ data collection and structure refinement from microcapillary protein crystallization.
M. K. Yadav (2005)
Clin. Chem
R E Thiers (1971)
10.1126/SCIENCE.1066238
Chaotic Mixer for Microchannels
A. Stroock (2002)
10.1039/B511976F
Microfluidic approach for rapid multicomponent interfacial tensiometry.
J. Cabral (2006)
10.1126/SCIENCE.6828872
Cell growth on liquid microcarriers.
C. Keese (1983)
10.1103/PHYSREVLETT.96.144501
Monodisperse drop formation in square microchannels.
O. Ozen (2006)
Nat. Rev. Drug Discovery
K Braeckmans (2002)
10.1073/PNAS.80.1.219
Behavior of cells at fluid interfaces.
I. Giaever (1983)
10.1039/B412712A
Planar chip device for PCR and hybridization with surface acoustic wave pump.
Z. Guttenberg (2005)
Biosens. Bioelectron
A Grodrian (2004)
Proc. Natl. Acad. Sci. USA 2006
M Abkarian
Annu. Rev. Fluid Mech
H A Stone (2004)
Phys. Rev. Lett
J B Knight (1998)
10.1063/1.2164911
Dielectrophoretic manipulation of drops for high-speed microfluidic sorting devices
K. Ahn (2006)
10.1002/CEAT.200500147
Application of a capillary microreactor for selective hydrogenation of α,β-unsaturated aldehydes in aqueous multiphase catalysis
Y. Önal (2005)
10.1063/1.2221929
Microfluidic bypass for efficient passive regulation of droplet traffic at a junction
G. Cristobal (2006)
Proc. Natl. Acad. Sci. USA 2005
M S Long
J. Am. Chem. Soc
Y.-C Tan (2006)
Proc. Natl. Acad. Sci
M H J Ohlmeyer (1993)
J. Am. Chem. Soc
B Zheng (2003)
Chem. Soc. Rev
P Watts (2005)
10.1021/AC050827H
Mixing crowded biological solutions in milliseconds.
Albert K. Liau (2005)
J. Colloid Interface Sci
S Sugiura (2000)
10.1093/nar/gni078
Using a microfluidic device for 1 μl DNA microarray hybridization in 500 s
Cheng-Wey Wei (2005)
10.1073/PNAS.0504712102
Space- and time-resolved spectrophotometry in microsystems.
N. Damean (2005)
10.1038/NPHYS176
Oscillations with uniquely long periods in a microfluidic bubble generator
P. Garstecki (2005)
J. Comb. Chem
R A Kautz (2005)
10.1109/TCAD.2004.828115
Behavioral modeling and performance evaluation of microelectrofluidics-based PCR systems using SystemC
T. Zhang (2004)
10.1016/J.AB.2003.10.005
In vitro compartmentalization by double emulsions: sorting and gene enrichment by fluorescence activated cell sorting.
K. Bernath (2004)
Angew. Chem. Angew. Chem. Int. Ed. Electrophoresis
D R Link (2005)
Langmuir
R F Shepherd (2006)
Lab Chip
A Günther (2004)
10.1126/SCIENCE.291.5506.1023
Surface-directed liquid flow inside microchannels.
B. Zhao (2001)
Lab Chip
L H Hung (2006)
Colloid Chemistry II. Vol. 227
K. Landfester (2003)
10.1039/B313866F
The application of micro reactors for organic synthesis.
P. Watts (2005)
10.1002/ELPS.200406113
Wall coating for capillary electrophoresis on microchips
V. Dolnik (2004)
Chem. Eng. Technol
W Salman (2005)
Langmuir
J D Tice (2003)
Lab Chip
Z Guttenberg (2005)
10.1021/BK-1991-0448.CH009
Competitive Adsorption and Protein—Surfactant Interactions in Oil-in-Water Emulsions
E. Dickinson (1991)
Anal. Chem
M Tokeshi (2002)
10.1021/AC0480850
Selective encapsulation of single cells and subcellular organelles into picoliter- and femtoliter-volume droplets.
Mingyan He (2005)
10.1016/S0167-7799(01)01910-2
Protein microarray technology.
D. Stoll (2002)
10.1006/JCIS.2000.6843
Preparation of Monodispersed Solid Lipid Microspheres Using a Microchannel Emulsification Technique.
Sugiura (2000)
10.1063/1.1946902
Design for mixing using bubbles in branched microfluidic channels
P. Garstecki (2005)
10.1002/ANIE.200503540
Electric control of droplets in microfluidic devices.
D. Link (2006)
Appl. Phys. Lett
K T Kotz (2004)
10.1007/3-540-44484-X_1
Generation, Characterization, and Modeling of Polymer Micro- and Nano-Particles
J. U. Otaigbe (2001)
10.1103/PHYSREVLETT.86.4163
Dynamic pattern formation in a vesicle-generating microfluidic device.
T. Thorsen (2001)
10.1021/JA0576637
A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination.
C. Hansen (2006)
10.1039/B510843H
Mixing with bubbles: a practical technology for use with portable microfluidic devices.
P. Garstecki (2006)
10.1002/(SICI)1522-2683(20000101)21:1<27::AID-ELPS27>3.0.CO;2-C
Fabrication of microfluidic systems in poly(dimethylsiloxane)
J. C. Mcdonald (2000)
J. Micromech. Microeng
K Handique (2001)
10.1002/CEAT.200407122
Formation of Monomeric and Novolak Azo Dyes in Nanofluid Segments by Use of a Double Injector Chip Reactor
P. M. Günther (2005)
10.1063/1.1796526
Formation of monodisperse bubbles in a microfluidic flow-focusing device
P. Garstecki (2004)
Adv. Mater
S Takeuchi (2005)
J. Fluid Mech
G I Taylor (1961)
10.1063/1.1850374
Chaotic mixing in thermocapillary-driven microdroplets
R. Grigoriev (2005)
10.1039/B110474H
Electrowetting-based actuation of droplets for integrated microfluidics.
M. Pollack (2002)
10.1021/ac980656z
Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane).
D. C. Duffy (1998)
Lab Chip
J R Burns (2001)
10.1021/CR980040+
Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry.
F. Guillier (2000)
10.1021/JA042494W
Polymer particles with various shapes and morphologies produced in continuous microfluidic reactors.
Z. Nie (2005)
Reviews 7356 www.angewandte.org
R F Ismagilov (2006)
10.1021/JA0529945
Interfacial polymerization within a simplified microfluidic device: capturing capsules.
E. Quevedo (2005)
10.1103/PHYSREVLETT.80.3863
Hydrodynamic Focusing on a Silicon Chip: Mixing Nanoliters in Microseconds
J. Knight (1998)
10.1039/B403982C
Transport and reaction in microscale segmented gas-liquid flow.
A. Guenther (2004)
10.1038/NMAT1270
Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors
Jeffrey R. Millman (2005)
J. Phys. Condens. Matter
F Mugele (2005)
Langmuir
V Barbier (2006)
Adv. Colloid Interface Sci
M P Pileni (1993)
Phys. Rev. Lett
N Garnier (2003)
10.1073/PNAS.0503287102
Permeation-driven flow in poly(dimethylsiloxane) microfluidic devices.
G. Randall (2005)
10.1039/B513908B
Alternating droplet generation and controlled dynamic droplet fusion in microfluidic device for CdS nanoparticle synthesis.
Lung-Hsin Hung (2006)
10.1063/1.2214461
A numerical study of two-phase Stokes flow in an axisymmetric flow-focusing device
M. J. Jensen (2006)
IEEE Trans. Comput- Aided Des. Integr. Circuits Syst
T H Zhang (2004)
10.1002/ADSC.200505480
Enhancement of Reaction Rates by Segmented Fluid Flow in Capillary Scale Reactors
B. Ahmed (2006)
Anal. Chem
V Linder (2005)
Langmuir
Z T Cygan (2005)
Chem. Eng. Res. Des
J R Burns (1999)
10.1038/438930a
Colloid science: Non-spherical bubbles
A. Subramaniam (2005)
10.1063/1.1781735
On-chip manipulation of levitated femtodroplets
I. Lyuksyutov (2004)
10.1021/AC040165G
Development of a microchip-based bioassay system using cultured cells.
M. Goto (2005)
10.1002/ELPS.200305648
Surface modification in microchip electrophoresis
D. Belder (2003)
J. Food Sci
S E Euston (1995)
10.1039/B602702D
On-line laser Raman spectroscopic probing of droplets engineered in microfluidic devices.
G. Cristobal (2006)
J. Am. Chem. Soc
T Hatakeyama (2006)
10.1021/LA0480336
Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices.
Shingo Okushima (2004)
10.1021/LA020698P
Electrowetting-Induced Droplet Movement in an Immiscible Medium
J. S. Kuo (2003)
Anal. Chem
A Liau (2005)
Chem. Eng. J
J M Köhler (2004)
10.1007/3-540-36412-9_4
Miniemulsions for nanoparticle synthesis
K. Landfester (2003)
10.1107/S0021889800001254
In situ X‐ray crystallography
A. McPherson (2000)
Angew. Chem. Angew. Chem. Int. Ed
H Song (2003)
10.1021/JA052279V
Using microfluidics to observe the effect of mixing on nucleation of protein crystals.
Delai L Chen (2005)
10.1109/JMEMS.2002.807467
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
S. K. Cho (2003)
Anal. Chem
K Hosokawa (1999)
10.1038/nature05058
The origins and the future of microfluidics
G. Whitesides (2006)
Environ. Sci. Technol
M K So (2006)
10.1007/BF01969584
Transport phenomena
V. S. Vaidhyanathan (2005)
Langmuir
D Dendukuri (2005)
Adv. Mater
T Nisisako (2006)
J. Micromech. Microeng
H J Oh (2006)
10.1038/nbt871
Integrated nanoliter systems
J. Hong (2003)
10.1021/JA0354566
Millisecond kinetics on a microfluidic chip using nanoliters of reagents.
Helen Song (2003)
10.1002/ANGE.200300577
Chemie in Mikrostrukturreaktoren
K. Jaehnisch (2004)
Appl. Phys. Lett
K Ahn (2006)
10.1016/S0142-9612(98)00071-4
Fluorinated materials for in vivo oxygen transport (blood substitutes), diagnosis and drug delivery.
J. Riess (1998)
Lab Chip
T Nisisako (2002)
10.1002/cbic.200400321
A New Embedded Process for Compartmentalized Cell‐Free Protein Expression and On‐line Detection in Microfluidic Devices
P. Dittrich (2005)
10.1007/b100117
Microemulsion polymerizations and reactions
P. Y. Chow (2005)
Chem. Eng. Sci
M T Kreutzer (2005)
Proc. Natl. Acad. Sci. USA 2004
V Noireaux
Phys. Fluids
M J Jensen (2006)
10.1088/0960-1317/11/5/316
Mathematical modeling of drop mixing in a slit-type microchannel
K. Handique (2001)
Anal. Chem
A R Wheeler (2005)
10.1098/rspa.1953.0139
Dispersion of soluble matter in solvent flowing slowly through a tube
G. I. Taylor (1953)
10.1016/J.BIOS.2003.12.021
Segmented flow generation by chip reactors for highly parallelized cell cultivation.
A. Grodrian (2004)
10.1016/J.CEJ.2004.01.021
Chip modules for generation and manipulation of fluid segments for micro serial flow processes
T. Henkel (2004)
10.1088/0960-1317/16/2/013
Hydrodynamic micro-encapsulation of aqueous fluids and cells via 'on the fly' photopolymerization
H. J. Oh (2006)
Proc. Natl. Acad. Sci. USA 2004
C L Hansen
Catal. Today
G Dummann (2003)
Philos. Trans. R. Soc. London Ser. A
M R Bringer (2004)
10.1021/LA050797D
Generation of polymerosomes from double-emulsions.
E. Lorenceau (2005)
10.1021/AC0513865
Parallel picoliter rt-PCR assays using microfluidics.
J. Marcus (2006)
10.1038/nature04163
Controlled microfluidic interfaces
J. Atencia (2004)
10.1039/b108739h
Chemical reactions in microdroplets by electrostatic manipulation of droplets in liquid media.
T. Taniguchi (2002)
Anal. Chem
H Song (2006)
10.1126/SCIENCE.282.5388.484
An integrated nanoliter DNA analysis device.
M. Burns (1998)
Nat. Mater
M Fialkowski (2005)
10.1103/PHYSREVLETT.90.144505
Ordered and disordered patterns in two-phase flows in microchannels.
R. Dreyfus (2003)
Phys. Rev. Lett
P Garstecki (2005)
10.1063/1.2218058
Electrocoalescence of drops synchronized by size-dependent flow in microfluidic channels
K. Ahn (2006)
10.1016/J.CES.2005.03.022
Multiphase monolith reactors: Chemical reaction engineering of segmented flow in microchannels
M. Kreutzer (2005)
10.1038/426515A
On-chip manipulation of free droplets
O. Velev (2003)
Lab Chip
T Taniguchi (2002)
Angew. Chem. Int. Ed
B Zheng (2005)
10.1002/(SICI)1521-4095(199910)11:14<1186::AID-ADMA1186>3.0.CO;2-K
Making Negative Poisson's Ratio Microstructures by Soft Lithography**
Bing Xu (1999)
Langmuir
J S Kuo (2003)
10.1021/AC011111Z
Continuous-flow chemical processing on a microchip by combining microunit operations and a multiphase flow network.
M. Tokeshi (2002)
10.1038/4462
Exploring the new world of the genome with DNA microarrays
P. Brown (1999)
10.1002/ANIE.200200550
Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals.
E. Schutt (2003)
10.1126/SCIENCE.1067595
Micro/Nano Encapsulation via Electrified Coaxial Liquid Jets
I. Loscertales (2002)
Anal. Chem
M Goto (2005)
Curr. Opin. Struct. Biol
R C Stevens (2000)
Anal. Chem
J El-Ali (2005)
10.1063/1.1992514
Mixing in a drop moving through a serpentine channel: A computational study
M. Muradoglu (2005)
Proc. Natl. Acad. Sci. USA 2005
N Damean
Sens. Actuators A
J Lee (2002)
10.1016/S0040-4020(02)00222-3
Fluorous chemistry: From biphasic catalysis to a parallel chemical universe and beyond
J. Gladysz (2002)
Phys. Rev. Lett
A M Ganan-Calvo (2001)
Angew. Chem. Angew. Chem. Int. Ed. J. Am. Chem. Soc
B K H Yen (2005)
Anal. Chem
L S Roach (2005)
10.1093/CLINCHEM/28.3.409
FLow-injection analysis: a new approach to quantitative measurements in clinical chemistry.
B. Rocks (1982)
10.1021/AR010110Q
Poly(dimethylsiloxane) as a material for fabricating microfluidic devices.
J. C. Mcdonald (2002)
10.1039/B403280M
Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting.
Yung-Chieh Tan (2004)
Chem. Rev
F Guillier (2000)
10.1126/SCIENCE.283.5409.1892
Chemical transformations in individual ultrasmall biomimetic containers.
D. T. Chiu (1999)
10.1016/S1367-5931(03)00050-4
Microfluidic combinatorial chemistry.
P. Watts (2003)
10.1126/SCIENCE.1099343
Designing Optimal Micromixers
J. Ottino (2004)
10.1016/S0920-5861(03)00056-7
The capillary-microreactor: a new reactor concept for the intensification of heat and mass transfer in liquid–liquid reactions
Gerrit Dummann (2003)
10.1016/S0076-6879(03)68004-3
Robotics for automated crystal formation and analysis.
M. Weselak (2003)
J. Microelectromech. Syst
S K Cho (2003)
10.1098/rsta.2003.1364
Microfluidic systems for chemical kinetics that rely on chaotic mixing in droplets
Michelle R. Bringer (2004)
Angew. Chem. Angew. Chem. Int. Ed
K Jähnisch (2004)
Lab Chip
I Shestopalov (2004)
10.1017/S0022112084001233
Stirring by chaotic advection
H. Aref (1984)
Anal. Biochem
K Bernath (2004)
Phys. Rev. Lett
W Engl (2005)
10.1002/ANIE.200500792
A microfabricated gas-liquid segmented flow reactor for high-temperature synthesis: the case of CdSe quantum dots.
B. Yen (2005)
10.1039/B403226H
Theory and numerical simulation of droplet dynamics in complex flows--a review.
V. Cristini (2004)
10.1021/LA046886S
Vibration-actuated drop motion on surfaces for batch microfluidic processes.
S. Daniel (2005)
10.1038/374321A0
The consequences of imperfect mixing in autocatalytic chemical and biological systems
I. Epstein (1995)
10.1088/0960-1317/16/8/010
Pressure drops for droplet flows in microfluidic channels
Brian J. Adzima (2006)
Phys. Rev. Lett
R Dreyfus (2003)
10.1021/LA0605743
Controllable preparation of monodisperse O/W and W/O emulsions in the same microfluidic device.
J. Xu (2006)
10.1063/1.2164393
Generation of monodisperse gel emulsions in a microfluidic device
C. Priest (2006)
10.1073/PNAS.0405847101
Systematic investigation of protein phase behavior with a microfluidic formulator.
C. Hansen (2004)
Analyst
S E Barnes (2006)
Nat. Mater
J R Millman (2005)
Appl. Phys. Lett
I F Lyuksyutov (2004)
Adv. Mater
G R Yi (2003)
Curr. Opin. Struct. Biol
B Zheng (2005)
10.1126/SCIENCE.1074868
Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles
A. Dinsmore (2002)
J. Am. Chem. Soc
Z H Nie (2006)
Lab Chip
W H Tan (2006)
Phys. Rev. Lett
T Thorsen (2001)
10.1146/ANNUREV.FLUID.36.050802.122124
Engineering Flows in Small Devices: Microfluidics Toward a Lab-on-a-Chip
H. Stone (2004)
10.1126/SCIENCE.1096956
A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions
J. Kobayashi (2004)
Langmuir
M Seo (2005)
10.1002/ANIE.200501365
Reactions in micellar systems.
T. Dwars (2005)
Appl. Phys. Lett
C Priest (2006)
Talanta
K K Stewart (1981)
10.1039/B603693G
Raman spectroscopic monitoring of droplet polymerization in a microfluidic device.
S. E. Barnes (2006)
Nat. Genet
P O Brown (1999)
10.1126/science.1118919
Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics
C. Lee (2005)
10.1021/JA0612403
Rapid self-assembly of core-shell organosilicon microcapsules within a microfluidic device.
Jeremy L. Steinbacher (2006)
10.1021/AC0416463
Barcoding the microworld.
Nancy H. Finkel (2004)
10.1021/LA0499012
Microfluidic synthesis of colloidal silica.
S. Khan (2004)
10.1021/LA050070P
Microfluidics: from dynamic lattices to periodic arrays of polymer disks.
Minseok Seo (2005)
J. Am. Chem. Soc
H Song (2003)
Anal. Chem
B Zheng (2004)
Trends Biotechnol
M F Templin (2002)
N. Engl. J. Med
C L Leach (1996)
10.1016/J.CATTOD.2005.09.011
Microstructured reactors for catalytic reactions
L. Kiwi-Minsker (2005)
10.6013/jbrewsocjapan1988.86.425
基礎講座 電気泳動(Electrophoresis)
大房 健 (2005)
Adv. Mater
B Zheng (2004)
Anal. Chim. Acta
V Srinivasan (2004)
Nat. Biotechnol
J W Hong (2003)
Phys. Rev. Lett
O Ozen (2006)
Proc. Natl. Acad. Sci. USA 2002
C L Hansen
10.1103/PHYSREVE.72.066301
Stability of parallel flows in a microchannel after a T junction.
P. Guillot (2005)
10.1021/JA031689L
A synthetic reaction network: chemical amplification using nonequilibrium autocatalytic reactions coupled in time.
Cory J. Gerdts (2004)
Langmuir
W J Jeong (2005)
Proc. Natl. Acad. Sci. USA 2005
G C Randall
Ind. Eng. Chem. Res
M N Kashid (2005)
Appl. Phys. Lett
M G Pollack (2000)
Anal. Chim. Acta
C J Patton (1986)
10.1021/LA053289C
Stable modification of PDMS surface properties by plasma polymerization: application to the formation of double emulsions in microfluidic systems.
V. Barbier (2006)
J. Colloid Interface Sci
J M Girardet (2001)
10.1111/J.1365-2621.1995.TB06307.X
Competitive Adsorption Between Sodium Caseinate and Oil‐Soluble and Water‐Soluble Surfactants in Oil‐in‐Water Emulsions
S. E. Euston (1995)
10.1126/SCIENCE.1109173
Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat
Frederick K Balagaddé (2005)
10.1002/ANIE.200390203
A microfluidic system for controlling reaction networks in time.
Helen Song (2003)



This paper is referenced by
10.1088/1742-6596/796/1/012039
Experimental characterization of a silicone oil-in-water droplet generator based on a micro T-junction
B. Rostami (2017)
10.3390/polym12040776
512-Channel Geometric Droplet-Splitting Microfluidic Device by Injection of Premixed Emulsion for Microsphere Production
Chul Min Suwon Kim (2020)
10.1038/srep03321
Mapping three-dimensional temperature in microfluidic chip
J. Wu (2013)
10.1002/ECJ.11944
Review of Microfluidic Devices for On-Chip Chemical Sensing
T. Watanabe (2017)
10.1016/J.MOLSTRUC.2018.06.084
Effects of junction angle and gas pressure on polymer nanosphere preparation from microbubbles bursted in a combined microfluidic device with thin capillaries
I. Kucuk (2018)
10.1039/c8cc01786g
CO2-Triggered microreactions in liquid marbles.
X. Luo (2018)
10.1002/elps.201100078
Sequential microfluidic droplet processing for rapid DNA extraction
X. Pan (2011)
10.1021/ac201658s
Theoretical design and analysis of multivolume digital assays with wide dynamic range validated experimentally with microfluidic digital PCR.
J. Kreutz (2011)
10.1021/la200473h
Breakup of double emulsion droplets in a tapered nozzle.
Jiang Li (2011)
10.1007/S00033-013-0396-Z
Stokes flow in a two-dimensional micro-device combined by a cross-slot and a microfluidic four-roll mill
J. Guan (2015)
10.1002/CITE.201700030
Stofftransport in einer Flüssig/Flüssig‐Pfropfenströmung im Mikrokapillarreaktor
C. Heckmann (2017)
10.1063/5.0002929
Measurement of fluid viscosity based on droplet microfluidics
W. Zeng (2020)
10.1080/00397911.2010.517611
Clean and Efficient Benzylic C-H Oxidation Using a Microflow System
Xiaoming Lv (2011)
10.1002/anie.201604378
Solid-to-Liquid Charge Transfer for Generating Droplets with Tunable Charge.
Yajuan Sun (2016)
10.1155/2012/935325
Optofluidics for Lab-on-a-Chip
E. P. Chiou (2012)
10.1016/J.SNA.2011.09.019
Valve-based microfluidic droplet micromixer and mercury (II) ion detection
Zhi-xiao Guo (2011)
10.1039/C2RA20074K
Synthesis of hierarchically porous zeolite A crystals with uniform particle size in a droplet microreactor
Phan Huy Hoang (2012)
10.1021/nn302043q
In vitro biosynthesis of metal nanoparticles in microdroplets.
Kyoung G. Lee (2012)
10.1016/J.SUPFLU.2011.11.029
Supercritical microfluidics: Opportunities in flow-through chemistry and materials science
S. Marre (2012)
10.1016/J.CHEMOLAB.2011.03.005
Lab-on-a-chip technologies for massive parallel data generation in the life sciences: A review
Sebastian Johannes Trietsch (2011)
10.1016/J.APPLTHERMALENG.2014.11.084
3D numerical simulation of droplet passive breakup in a micro-channel T-junction using the Volume-Of-Fluid method
Bin Chen (2015)
Silicon Nanoribbon FET Sensors : Fabrication, Surface Modification and Microfluidic Integration
Roodabeh Afrasiabi (2016)
10.1002/CHIN.200706277
Reactions in Droplets in Microfluidic Channels
Helen Song (2007)
10.3390/mi11020201
Review on Microbubbles and Microdroplets Flowing through Microfluidic Geometrical Elements
Ana T S Cerdeira (2020)
10.1016/j.ab.2019.113466
Quantitative protein detection using single molecule imaging enzyme-linked immunosorbent assay (iELISA).
Cheng-cheng Wu (2019)
10.4018/978-1-5225-7138-4.CH005
Immiscible Two-Phase Parallel Microflow and Its Applications in Fabricating Micro- and Nanomaterials
Y. Li (2019)
10.1016/J.APSUSC.2018.02.055
High-throughput controllable generation of droplet arrays with low consumption
Yinyin Lin (2018)
10.1039/c8lc00916c
Microfluidic screening of antibiotic susceptibility at a single-cell level shows the inoculum effect of cefotaxime on E. coli.
W. Postek (2018)
10.1002/elsc.201400074
Droplet‐based microfluidics for microtoxicological studies
J. Cao (2015)
10.1246/CL.2012.562
New Synthetic Opportunities in Miniaturized Flow Reactors with Inductive Heating
A. Kirschning (2012)
10.1021/ac300019m
FT-IR Spectroscopic Imaging of Reactions in Multiphase Flow in Microfluidic Channels
K. Chan (2012)
10.1021/ja808697e
Laterally mobile, functionalized self-assembled monolayers at the fluorous-aqueous interface in a plug-based microfluidic system: characterization and testing with membrane protein crystallization.
J. Kreutz (2009)
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