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Comparison Of The Gastrointestinal Anatomy, Physiology, And Biochemistry Of Humans And Commonly Used Laboratory Animals
Published 1995 · Chemistry, Biology, Medicine
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In addition to metabolic differences, the anatomical, physiological, and biochemical differences in the gastrointestinal (G.I.) tract of the human and common laboratory animals can cause significant variation in drug absorption from the oral route. Among the physiological factors, pH, bile, pancreatic juice, and mucus and fluid volume and content can modify dissolution rates, solubility, transit times, and membrane transport of drug molecules. The microbial content of the G.I. tract can significantly affect the reductive metabolism and enterohepatic circulation of drugs and colonic delivery of formulations. The transit time of dosage forms can be significantly different between species due to different dimensions and propulsive activities of the G.I. tract. The lipid/protein composition of the enterocyte membrane along the G.I. tract can alter binding and passive, active, and carrier‐mediated transport of drugs. The location and number of Peyer's patches can also be important in the absorption of large molecules and particulate matter.
This paper references
Transit of solids through the human colon: regional quantification in the unprepared bowel.
M. Proano (1990)
A comparison of brush-border membranes prepared from rabbit small intestine by procedures involving Ca2+ and Mg2+ precipitation.
H. Aubry (1986)
Functional and structural characteristics of the jejunum and ileum in the dog and the rat.
J. W. Robinson (1977)
Alternative Approaches to Oral Controlled Drug Delivery: Bioadhesives and In-Situ Systems
K. Park (1984)
Transit of pharmaceutical dosage forms through the small intestine.
S. Davis (1986)
Lipid components of two different regions of an intestinal epithelial cell membrane of mouse.
Kawai Koichi (1974)
On the preparation and some properties of closed membrane vesicles from hog duodenal and jejunal brush border.
D. Louvard (1973)
Physiological implications of microbial digestion in the large intestine of mammals: relation to dietary factors.
C. E. Stevens (1978)
Regional differences in the lipid composition and fluidity of rat colonic brush-border membranes.
T. Brasitus (1985)
A comparison of small intestinal transit time between the rat and the guinea-pig.
G. Pettersson (1976)
A Qualitative and Quantitative Morphologic Study of Peyer's Patches of the Mouse
K. Abe (1977)
[Comparative anatomo-surgical study on the biliary and pancreatic excretory apparatus of the most common experimental animals].
A. Farinon (1975)
Alterations in the physical state and composition of brush border membrane lipids of rat enterocytes during differentiation.
T. Brasitus (1985)
Membrane fluidity and lipid composition of rat small intestinal brush-border membranes during postnatal maturation.
C. Hübner (1988)
OBSERVATIONS ON THE FLORA OF THE ALIMENTARY TRACT OF ANIMALS AND FACTORS AFFECTING ITS COMPOSITION.
H. W. Smith (1965)
Targeting in the gastrointestinal tract: new approaches.
W. Ritschel (1991)
Studies on the brush border membrane on mouse duodenum: lipids.
T. Billington (1978)
INTESTINAL TRANSPORT OF ANTIBODIES IN THE NEWBORN RAT
R. Rodewald (1973)
Rate-limiting steps in oral absorption of a leucotriene D4 antagonist in the beagle dog.
T. Kararli (1992)
Canine Peyer's patches: macroscopic, light microscopic, scanning electron microscopic and immunohistochemical investigations.
H. HogenEsch (1987)
Structure-function relationships in intestinal brush border membranes.
P. Proulx (1991)
Animal models for oral drug absorption
J. Dressman (1991)
CHAPTER 3 – Anatomy, Physiology, and Biochemistry of the Rabbit
Carlos Kozma (1974)
Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection.
A. Allen (1980)
Ultrastructure and alkaline phosphatase activity of the dome epithelium of canine Peyer's patches.
H. HogenEsch (1990)
Gastrointestinal absorption of drugs.
Kararli Tt (1989)
Plasma membrane and mucosal glycosphingolipids in the rat intestine.
G. Forstner (1973)
Morphologic characteristics of the epithelial surface of aggregated lymphoid follicles (Peyer's patches) in the small intestine of newborn gnotobiotic calves and pigs.
A. Torres-Medina (1981)
A double isotope technique for the evaluation of drug action on gastric evacuation and small bowel propulsion studied in the rat
F. Nilsson (1973)
Comparative morphology of the stomach of some laboratory mammals
N. G. Ghoshal (1989)
Bile secretion and bile composition in the freely moving, unanaesthetized rat with a permanent biliary drainage: influence of food intake on bile flow.
R. Vonk (1978)
Measurement of gastric pH during digestion of a solid meal in dogs.
I. Yamada (1990)
Lipid composition and fluidity of rat enterocyte basolateral membranes. Regional differences.
T. Brasitus (1984)
Intestinal brush border revisited.
R. Holmes (1989)
Liver function and gastric acid secretion in parkinsonian patients under prolonged treatment with L-dopa and a peripheral decarboxylase inhibitor.
M. Streifler (1976)
Microvillus membrane vesicles from pig small intestine. Purity and lipid composition.
K. Christiansen (1981)
Biochemical pharmacology of the intestinal flora.
P. Goldman (1978)
Scanning electron microscope observations of mammalian intestinal villi, intervillus floor and crypt tubules
A. Taylor (1971)
Number, size, and distribution of Peyer's patches in the human small intestine
J. S. Cornes (1965)
Structural features of and cholesterol distribution in M-cell membranes in guinea pig, rat, and mouse Peyer's patches.
J. Madara (1984)
Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles.
R. L. Owen (1974)
The epithelial surface of the monkey gastrointestinal tract. A scanning electron-microscopic study.
J. Burke (1976)
Morphology of the Intestinal Mucosa
K. Carr (1984)
Lipid fluidity and composition of intestinal microvillus membranes isolated from rats of different ages.
T. Brasitus (1984)
Rabbit small intestinal brush border membrane preparation and lipid composition.
H. Hauser (1980)
Unprepared human colon does not discriminate between solids and liquids.
M. Proano (1991)
Peyer's patches and the early development of B lymphocytes.
J. Reynolds (1987)
Postnatal development and lymphocyte production of jejunal and ileal Peyer's patches in normal and gnotobiotic pigs.
R. Pabst (1988)
Lipid dynamics and lipid-protein interactions in rat enterocyte basolateral and microvillus membranes.
T. Brasitus (1980)
Interaction of drugs with bile components. I. Effects of bile salts on the dissolution behavior of indomethacin and phenylbutazone.
S. Miyazaki (1979)
Gastric emptying and secretion in the rhesus monkey.
A. Dubois (1977)
Intestinal membrane lipid composition and fluidity during development in the rat.
S. Schwarz (1985)
Peyer's patches: morphologic studies.
W. Faulk (1970)
Intestinal bacteria and the hydrolysis of glycosidic bonds.
G. Hawksworth (1971)
Some biological issues in oral, controlled drug delivery
P. Gruber (1987)
CHAPTER 10 – The Significance of the Gut Flora in Safety Testing of Food Additives
B. Drasar (1970)
Colon-specific drug delivery
D. Friend (1991)
Polygraphic study of periodic breathing and hypersomnolence in a patient with severe hypothyroidism.
T. Yamamoto (1977)
Glycosphingolipids and ceramide distribution in brush border and basolateral membranes of the rat mature intestinal cells [proceedings].
Bouhours Jf (1978)
Lipid composition and membrane fluidity in the small intestine of the developing rabbit.
S. Schwarz (1984)
Osmolality of blood and intestinal contents in the pig, guinea pig, and Ascaris lumbricoides.
R. Harpur (1965)
Gastrointestinal pH measurement in rats: influence of the microbial flora, diet and fasting
F. Ward (1987)
The extrahepatic biliary tract in common domestic and laboratory animals
F. Mann (1920)
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Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system.
Shun-Ying Jin (2006)
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Nadia Abder Rahman Ali Ghazal (2005)
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R. Mahato (2003)
Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations.
C. O'Driscoll (2008)
Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers.
Timothy K. Tippin (2008)
Histoplanimetrical study on the relationship between the cell kinetics of villous columnar epithelial cells and the proliferation of indigenous bacteria in rat small intestine.
Wang-Mei Qi (2009)
Surface area assessment of the murine intestinal tract as a prerequisite for oral dose translation from mouse to man
C. Casteleyn (2010)
Animal Model Systems Suitable for Controlled Release Modeling
S. C. Sutton (2011)
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Câmpus de Araraquara (2014)
Microencapsulation of probiotics for gastrointestinal delivery.
M. Cook (2012)
Contribution of in vivo models of thrombosis to the discovery and development of novel antithrombotic agents.
R. Leadley (2000)
Development of the Enteric Nervous System in a Porcine Model of Early Life Stress: Implications for Long-Term Intestinal Disease Susceptibility.
Julia Elise Medland (2015)
Nivalenol Has a Greater Impact than Deoxynivalenol on Pig Jejunum Mucosa in Vitro on Explants and in Vivo on Intestinal Loops
Sophal Cheat (2015)
Forces Driving Chaperone Action
P. Koldewey (2016)
Characterizing Intestinal Glucose Absorption in Mammalian Pig and Aquatic Species Tilapia and Trout
Marina Subramaniam (2019)
DESIGN AND SYNTHESIS OF STIMULI-RESPONSIVE POLYMERIC NANOGELS TOWARDS THERAPEUTIC TRANSLATION
Mallory R Gordon (2018)
Assessing the effects of silver nanoparticles on monolayers of differentiated Caco-2 cells, as a model of intestinal barrier.
L. Vila (2018)
Dissecting the role of milk components on gut microbiota composition
E. A. Maga (2013)
The Effect of a Drug‐delivery System Consisting of Soybean Phosphatidyl Choline and Medium‐chain Monoacylglycerol on the Intestinal Permeability of Hexarelin in the Rat
U. Fagerholm (1998)
Bioaccessibility and relative oral bioavailability of cobalt and nickel in residential soil and dust affected by metal grinding operations.
M. Suh (2019)
Characteristics of digestive processes in Atlantic salmon (Salmo salar). Enzyme pH optima, chyme pH, and enzyme activities
Å. Krogdahl (2015)
The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract
Yanzhuo Kong (2020)
An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non‐genotoxic initiating events
D. Proctor (2018)
Delivery strategies to enhance oral vaccination against enteric infections.
Christopher J. H. Davitt (2015)
Study of Fucoidan Digestibility via an in Vitro Digestion System
Y. Cao (2015)
A novel oral dosage formulation of the ginsenoside aglycone protopanaxadiol exhibits therapeutic activity against a hormone-insensitive model of prostate cancer
Alain G. Musende (2012)
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M. Christiansen (2015)
Gender-Related Differences in Mycophenolate Mofetil-Induced Gastrointestinal Toxicity in Rats
S. Stern (2007)
Drug Absorption and Routes of Administration
A. Florence (1998)
Impaired bioavailability of rifampicin in presence of isoniazid from fixed dose combination (FDC) formulation.
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