Online citations, reference lists, and bibliographies.
← Back to Search

Formation Of Microparticulate Protein Powder Using A Supercritical Fluid Antisolvent

S. Yeo, G. B. Lim, P. G. Debendetti, H. Bernstein
Published 1993 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Gas antisolvent (GAS) expansion of dimethylsulfoxide (DMSO) and N,N‐dimethylformamide (DMFA) solutions with supercritical carbon dioxide was used to produce biologically active powders of insulin. Powders with 90% of the particles smaller than 4 μm and 10% smaller than 1 μm were obtained under all conditions tested when the process was operated continuously, with small liquid droplets sprayed into a flowing supercritical continuum. Slow pressurization of the stagnant protein solution resulted in larger particles. In vivo tests on rats revealed no differences between the biological activity of processed and unprocessed insulin, GAS processing of organic solution appears to be a reliable and effective method for the production of dry, biologically active microparticulate powders of peptides and proteins. © 1993 John Wiley & Sons, Inc.
This paper references
SIZING MATERIALS BY CRUSHING AND GRINDING
L. Hixon (1990)
10.1002/AIC.690360615
Solvent expansion and solute solubility predictions in gas-expanded liquids
C. Chang (1990)
10.1021/BK-1989-0406.CH022
Gas Antisolvent Recrystallization: New Process To Recrystallize Compounds Insoluble in Supercritical Fluids
P. Gallagher (1989)
10.1016/0021-8502(91)90013-8
Particle formation with supercritical fluids—a review
J. Tom (1991)
10.1126/SCIENCE.2218494
New methods of drug delivery.
R. Langer (1990)
10.1002/AIC.690350902
Phase equilibria for supercritical fluid process design
J. Brennecke (1989)
10.1002/AIC.690371002
Molecular thermodynamics of solubilities in gas antisolvent crystallization
D. Dixon (1991)
10.1002/AIC.690340813
Enzyme‐caytalyzed oxidation of cholesterol in supercritical carbon dioxide
T. Randolph (1988)
10.1126/science.239.4838.387
Enzymatic Oxidation of Cholesterol Aggregates in Supercritical Carbon Dioxide
T. Randolph (1988)
10.1002/JPS.2600530912
CONTROLLED CRYSTALLIZATION OF HYDROCORTISONE BY ULTRASONIC IRRADIATION.
R. Cohn (1964)
10.1021/cen-v069n045.p026
New University Aims To Bolster Hong Kong's Industrial Growth: Set up to combat effects of brain drain as colony faces reintegration into China, institution has strong support of industry and the community
J. Haggin (1991)
10.1002/AIC.690321214
Diffusion and mass transfer in supercritical fluids
P. Debenedetti (1986)
10.1002/JPS.3030390807
Studies on pharmaceutical powders and the state of subdivision. IV. The application of spray-drying techniques to pharmaceutical powders.
S. Riegelman (1950)
10.1073/PNAS.85.9.2979
Cholesterol aggregation and interaction with cholesterol oxidase in supercritical carbon dioxide.
T. Randolph (1988)
10.1021/BP00011A004
Formation of Bioerodible Polymeric Microspheres and Microparticles by Rapid Expansion of Supercritical Solutions
J. Tom (1991)



This paper is referenced by
10.1021/CG0155090
Depressurization of an Expanded Liquid Organic Solution (DELOS): A New Procedure for Obtaining Submicron- or Micron-Sized Crystalline Particles
N. Ventosa (2001)
10.1016/J.COLSURFA.2004.11.038
Droplet mass transfer, intradroplet nucleation and submicron particle production in two-phase flow of solvent-supercritical antisolvent emulsion
S. Dukhin (2005)
10.1016/J.SUPFLU.2005.12.001
Supercritical antisolvent precipitation of atenolol: The influence of the organic solvent and of the processing approach
I. Kikic (2006)
10.1016/0032-3861(95)97881-F
Semicrystalline microfibrils and hollow fibres by precipitation with a compressed-fluid antisolvent
G. Luna-Bárcenas (1995)
10.1002/admi.202000950
Antisolvents in Perovskite Solar Cells: Importance, Issues, and Alternatives
S. Ghosh (2020)
10.3390/pharmaceutics11120629
Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems
Paroma Chakravarty (2019)
10.1023/A:1011949805156
Supercritical Fluid Processing of Materials from Aqueous Solutions: The Application of SEDS to Lactose as a Model Substance
S. Palakodaty (2004)
10.1002/BIT.1079
Production of different morphologies of biocompatible polymeric materials by supercritical CO(2) antisolvent techniques.
N. Elvassore (2001)
A nanoparticle engineering process: spray-freezing into liquid to enhance the dissolution of poorly water soluble drugs
Jiahui Hu (2003)
10.1016/J.POWTEC.2004.07.002
Particle encapsulation with polymers via in situ polymerization in supercritical CO2
B. Yue (2004)
10.1016/J.VACCINE.2007.05.064
Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs.
M. Amidi (2007)
Preparation of nanoparticles consisting of methacrylic polymers and drugs by an aerosol flow reactor method
Hannele Eerikäinen (2005)
10.1016/0168-3659(93)90166-3
Application of supercritical fluids for the production of sustained delivery devices
P. Debenedetti (1993)
10.1023/A:1012112503590
Long-Term and High-Temperature Storage of Supercritically-Processed Microparticulate Protein Powders
M. Winters (2004)
10.1080/03602549909351647
Polymer Processing with Supercritical Fluids: An Overview
M. Lora (1999)
10.1016/S0032-5910(98)00207-1
Supercritical antisolvent precipitation of nanoparticles of a zinc oxide precursor
E. Reverchon (1999)
10.1016/S0928-0987(00)00108-1
Supercritical fluid processing of proteins. I: lysozyme precipitation from organic solution.
S. Moshashaée (2000)
Particle production by supercritical antisolvent processing techniques
Markku Rantakylä (2004)
10.1016/J.SUPFLU.2008.06.002
Spherical microparticles production by supercritical antisolvent precipitation: Interpretation of results
E. Reverchon (2008)
Development of a Transdermal Delivery System for Progesterone using Supercritical Carbon Dioxide
James R. Falconer (2012)
10.4155/TDE.10.82
Design of submicron and nanoparticle delivery systems using supercritical carbon dioxide-mediated processes: an overview.
A. S. Zarena (2011)
10.3929/ETHZ-A-004433773
Gas antisolvent recrystallization of specialty chemicals
G. Muhrer (2002)
10.1021/JE010202Q
High-Pressure Vapor−Liquid Equilibrium for the Binary Systems Carbon Dioxide + Dimethyl Sulfoxide and Carbon Dioxide + Dichloromethane
A. Gonzalez (2002)
10.1016/S0032-5910(02)00102-X
Extraction and precipitation particle coating using supercritical CO2
Yulu Wang (2002)
10.14356/KONA.2002010
Dry Powders for Pulmonary Delivery of Peptides and Proteins
H. Okamoto (2002)
10.1016/0032-9592(95)87043-1
Potentials and Prospects for Application of Supercritical Fluid Technology in Bioprocessing
A. Jarzȩbski (1995)
10.1007/978-1-4615-2674-2_6
Supercritical fluids : fundamentals and applications
P. Debenedetti (1994)
10.1080/02726359708906772
COMPARISON OF NASAL INSULIN POWDERS PREPARED BY SUPERCRITICAL FLUID AND FREEZE-DRYING TECHNIQUES
H. Zia (1997)
10.1039/A906486I
Polymer synthesis and processing using supercritical carbon dioxide
A. Cooper (2000)
10.1016/S0896-8446(02)00094-3
Recrystallization of sulfathiazole and chlorpropamide using the supercritical fluid antisolvent process
Sang-Do Yeo (2003)
10.1016/J.SUPFLU.2004.07.007
Effect of the phase behaviour of the solvent–antisolvent systems on the gas–antisolvent-crystallisation of paracetamol
A. Weber (2005)
10.1016/J.ADDR.2006.07.010
Particle engineering techniques for inhaled biopharmaceuticals.
S. Shoyele (2006)
See more
Semantic Scholar Logo Some data provided by SemanticScholar