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Iron Status Following Trauma, Excluding Burns
D. Walsh, K. Pattanapanyasat, P. Lamchiagdhase, P. Siritongtaworn, P. Thavichaigarn, N. Jiarakul, C. Chuntrasakul, C. Komoltri, C. Dheeradhada, F. Pearce, W. Wiesmann, H. Webster
Published 1996 · Medicine
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Serum concentration of iron, transferrin saturation and total iron binding capacity (TIBC) were measured on days 1, 2, 3, 5, 7, 10 and 13 in 36 Thai patients with trauma (burns excluded) to determine temporal changes in iron metabolism. Throughout the study profound hypo‐ferraemia was observed in association with decreased transferrin saturation. TIBC, in contrast, did not differ significantly from that in controls. These findings confirm previous reports which describe altered iron metabolism in association with an adverse event, a response known as ‘stress hypoferraemia’, and extends these observations to non‐burned patients with trauma. The degree of hypoferraemia in patients in this study was not related to sepsis, Injury Severity Score, volume of blood transfused or surgery, suggesting that hypoferraemia following trauma is an independent event. The recognition of rapid and prolonged iron sequestration provides insight into the clinical condition of patients with trauma.
This paper references
Blood substitutes and infection
B. Otto (1992)
Effects of accidental trauma on cytokine and endotoxin production.
A. Botha (1994)
Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury
T. J. Donnelly (1994)
Enhancement of Escherichia coli infection and endotoxic activity by hemoglobin and ferric ammonium citrate.
G. H. Bornside (1970)
Acute hypoferraemia following fractures.
D. Zdravkovic (1986)
A systematic study of host defense processes in badly injured patients.
H. Polk (1986)
Perspectives in iron metabolism.
C. Finch (1982)
Effects of Bacteria Endotoxin on Plasma Iron
R. Kampschmidt (1962)
The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.
S. Baker (1974)
Effect of induced fever on serum iron and ferritin concentrations in man
Rj Elin (1977)
Iron depletion: a defense against intracellular infection and neoplasia.
E. Weinberg (1992)
Rapid drop in serum iron concentration as a host defense mechanism. A review of experimental and clinical evidence.
Ballantyne Gh (1984)
Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma.
T. Byrd (1993)
Sepsis syndrome: a valid clinical entity
R. Bone (1989)
Nitric oxide: pathophysiological mechanisms.
S. Gross (1995)
Pathogenesis of peritonitis. 3. Local adjuvant action of hemoglobin in experimental E. coli peritonitis.
Simmons Rl (1968)
Enhancement of bacterial infection by ferric iron: kinetics, mechanisms, and surgical significance.
H. Polk (1971)
Iron up-modulates the expression of transferrin receptors during monocyte-macrophage maturation.
U. Testa (1989)
Differential regulation of iron regulatory element-binding protein(s) in cell extracts of activated lymphocytes versus monocytes-macrophages.
U. Testa (1991)
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C. V. van Iperen (2001)
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J. Wizorek (2003)
Electron paramagnetic resonance analysis of transferrin-bound iron in animal models of blunt trauma.
N. Gorbunov (2003)
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D. Walsh (2005)
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Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism.
A. Jacob (1997)
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