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A Novel Electrogenerated Chemiluminescence Reaction Scheme Using Core‐Shell Luminol‐Based SiO2 Nanoparticles As A Regulator And Its Analytical Application

L. Zhang, Xingwang Zheng, Z. Guo
Published 2007 · Chemistry

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A novel core-shell luminol-based SiO2 nanoparticle was synthesized by two step micro-emulsion method. While these nanoparticles were used as electrogenerated chemiluminescence (ECL) reagent, the electrochemical (EC) reaction as well as the subsequent chemiluminescence (CL) reaction not only could be separated spatially, but also presented high efficiency for analytical purpose. In this case, the core-shell luminol-based SiO2 nanoparticles offered more potential to avoid the contradiction between the EC and the CL reaction conditions. A new ECL method based on the nanoparticle was developed, and isoniazid was selected as a model analyte to illustrate the characteristics of this new ECL method. Under the selected conditions, the proposed ECL response to isoniazid concentration was linear in the range of 1.0×10−10 to 1.0×10−6 g/mL with 2×10−11 g/mL detection limit.
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