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Synthesis Of Triazole‐Epothilones By Using Cu2O Nanoparticles To Catalyze 1,3‐Dipolar Cycloaddition

Xiyan Duan, Y. Zhang, Yahui Ding, J. Lin, X. Kong, Q. Zhang, C. Dong, G. Luo, Y. Chen
Published 2012 · Chemistry

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We report the total synthesis of a triazole-epothilone analogue 1. The key step to generate the macrocyclic ring and the triazole ring was to apply Cu2O nanoparticles (Cu2O-NPs) to catalyze the 1,3-dipolar cycloaddition. The conformation of 1 and its bioactivity in MCF cancer cell lines were investigated.
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