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Sorting And Recycling Of Cell Surface Receptors And Endocytosed Ligands: The Asialoglycoprotein And Transferrin Receptors

A. Ciechanover, A. Schwartz, H. Lodish
Published 1983 · Biology, Medicine

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With few exceptions, receptor‐mediated endocytosis of specific ligands is mediated through clustering of receptor‐ligand complexes in coated pits on the cell surface, followed by internalizalion of the complex into endocytic vesicles. During this process, ligand‐receptor dissociation occurs, most probably in a low pH prelysosomal compartment. In most cases the ligand is ultimately directed to the lysosomes, wherein it is degraded, while the receptor recycles to the cell surface.
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