← Back to Search
Sorting And Recycling Of Cell Surface Receptors And Endocytosed Ligands: The Asialoglycoprotein And Transferrin Receptors
A. Ciechanover, A. Schwartz, H. Lodish
Published 1983 · Biology, Medicine
Download PDFAnalyze on Scholarcy
With few exceptions, receptor‐mediated endocytosis of specific ligands is mediated through clustering of receptor‐ligand complexes in coated pits on the cell surface, followed by internalizalion of the complex into endocytic vesicles. During this process, ligand‐receptor dissociation occurs, most probably in a low pH prelysosomal compartment. In most cases the ligand is ultimately directed to the lysosomes, wherein it is degraded, while the receptor recycles to the cell surface.
This paper references
Penetration of semliki forest virus from acidic prelysosomal vacuoles
M. Marsh (1983)
Cell surface distribution and intracellular fate of asialoglycoproteins: a morphological and biochemical study of isolated rat hepatocytes and monolayer cultures
PL Zeitlin (1982)
Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.
A. Schwartz (1982)
Subcellular membrane topology and turnover of a rat hepatic binding protein specific for asialoglycoproteins.
T. Tanabe (1979)
Clathrin-coated vesicles contain an ATP-dependent proton pump.
M. Forgac (1983)
Characterization of the asialoglycoprotein receptor in a continuous hepatoma line.
A. Schwartz (1981)
Journey to the center of the cell: role of the receptosome.
I. Pastan (1981)
Mannose-specific endocytosis receptor of alveolar macrophages: demonstration of two functionally distinct intracellular pools of receptor and their roles in receptor recycling
C. Tietze (1982)
Recycling of the asialoglycoprotein receptor: biochemical and immunocytochemical evidence.
A. Schwartz (1982)
Recycling of cell-surface receptors: observations from the LDL receptor system.
M. Brown (1982)
Evidence for recycling of insulin receptors in isolated rat adipocytes.
S. Marshall (1981)
Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis
H. Geuze (1983)
Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody.
C. Enns (1981)
Carbohydrate-specific receptors of the liver.
G. Ashwell (1982)
Uptake and degradation of 125I-labelled asialo-fetuin by isolated rat hepatocytes.
H. Tolleshaug (1977)
Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization
F. Maxfield (1978)
Identification of transferrin receptors in reticulocytes.
F. V. van Bockxmeer (1977)
pH and the recycling of transferrin during receptor-mediated endocytosis.
A. Dautry-Varsat (1983)
Galactose-specific recognition system of mammalian liver: receptor distribution on the hepatocyte cell surface
D. A. Wall (1981)
Rapid acidification of endocytic vesicles containing α2-macroglobulin
B. Tycko (1982)
Receptor-mediated endocytosis of hormones in cultured cells.
I. Pastan (1981)
Micropinocytosis of transferrin by developing red cells: an electron-microscopic study utilizing ferritin-conjugated transferrin and ferritin-conjugated antibodies to transferrin.
A. Sullivan (1976)
Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells.
M. Willingham (1983)
Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.
J. Goldstein (1974)
Coated pits, coated vesicles, and receptor-mediated endocytosis
J. Goldstein (1979)
Transferrin recycling in reticulocytes: pH and iron are important determinants of ligand binding and processing.
C. Harding (1983)
Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin.
I. Trowbridge (1981)
Regulation of HeLa cell transferrin receptors.
J. H. Ward (1982)
Use of colloidal gold particles in double-labeling immunoelectron microscopy of ultrathin frozen tissue sections.
H. Geuze (1981)
Intracellular polypeptide hormone receptors. Characterization of insulin binding sites in Golgi fractions from the liver of female rats.
B. Posner (1978)
An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver. I. Distribution of 125I-ligands among the liver cell types
A. Hubbard (1979)
The reticulocyte plasma membrane pathway of iron uptake as determined by the mechanism of alpha, alpha'-dipyridyl inhibition.
M. Nuñez (1983)
Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling
P. Stahl (1980)
Kinetic analysis of chemotactic peptide receptor modulation
S. Zigmond (1982)
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
S. K. Basu (1981)
Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.
S. K. Basu (1978)
Immunocytochemical localization of the receptor for asialoglycoprotein in rat liver cells
H. Geuze (1982)
The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors
A. Ciechanover (1983)
Receptor-mediated endocytosis of transferrin in K562 cells.
R. Klausner (1983)
The plasma-to-cell cycle of transferrin.
J. H. Jandl (1963)
An ATP-driven proton pump in clathrin-coated vesicles.
D. K. Stone (1983)
Rapid acidification of endocytic vesicles containing asialoglycoprotein in cells of a human hepatoma line
B. Tycko (1983)
Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling
A. González-Noriega (1980)
Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.
R. Klausner (1983)
Intracellular dissociation of receptor-bound asialoglycoproteins in cultured hepatocytes. A pH-mediated nonlysosomal event.
J. Harford (1983)
Chloroquine reduces the number of asialo-glycoprotein receptors in the hepatocyte plasma membrane.
H. Tolleshaug (1979)
The isolation and properties of a rabbit liver binding protein specific for asialoglycoproteins.
R. L. Hudgin (1974)
Transferrin binding and iron uptake in mouse hepatocytes.
E. S. Cole (1983)
Difficulties in the quantification of asialoglycoprotein receptors on the rat hepatocyte.
A. Schwartz (1980)
Iron transport and storage proteins.
P. Aisen (1980)
Galactose and N-acetylgalactosamine-specific endocytosis of glycopeptides by isolated rat hepatocytes
J. Baenziger (1980)
Functional segregation of hepatic receptors for asialoglycoproteins during endocytosis.
R. Stockert (1980)
Stimulation of DNA synthesis in cultures of mouse spleen cell suspensions by bovine transferrin.
A. Vogt (1969)
Identification and quantification of the rat hepatocyte asialoglycoprotein receptor.
A. Schwartz (1981)
Studies on a mammalian hepatic binding protein specific for asialoglycoproteins. Evidence for receptor recycling in isolated rat hepatocytes.
C. Steer (1980)
Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.
A. Ciechanover (1983)
Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.
B. Knowles (1980)
Internalization and subcellular localization of transferrin and transferrin receptors in HeLa cells.
J. E. Lamb (1983)
Recycling receptors: The round-trip itinerary of migrant membrane proteins
M. Brown (1983)
Primary amines inhibit recycling of α2M receptors in fibroblasts
F. Leuven (1980)
Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.
J. van Renswoude (1982)
Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.
S. Ohkuma (1978)
Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.
M. Karin (1981)
Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts
F. Maxfield (1982)
This paper is referenced by
Ligand-decorated polysaccharide nanocarriers for targeting therapeutics to hepatocytes
Sabyasachi Maiti (2017)
Endothelial Cell Regulation of Coagulation
D. Stern (1998)
Possible mechanism of ineffective erythropoiesis by an altered transferrin receptor cycle in erythroleukemia
K. Muta (1988)
A Convenient Method For hTfR1 Inclusion Body Purification
M. Shao (2015)
Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
Sven Burgdorf (2008)
Synthesis and characterization of chitosan derivatives carrying galactose residues
Can Zhang (2005)
Genetic Investigation of MHC-Independent Missing-Self Recognition by Mouse NK Cells Using an In Vivo Bone Marrow Transplantation Model
P. Chen (2015)
Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells
J. Rodriguez (2011)
Molecular Dissection of the Human Transferrin Receptor
C. Schneider (1985)
Endothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties
C. Esposito (1989)
Endocytosis in plants
D. Robinson (1990)
Acidification and protein traffic.
O. A. Weisz (2003)
The Human Hyaluronan Receptor for Endocytosis (HARE/Stabilin-2) Is a Systemic Clearance Receptor for Heparin*
E. N. Harris (2008)
Recycling of the Yeast a-Factor Receptor
L. Chen (2000)
Live-cell imaging elucidates cellular interactions of gene nanocarriers for cancer therapy
F. M. Mickler (2013)
This information is current as Transplantation Model Using an In Vivo Bone Marrow Missing-Self Recognition by Mouse NK Cells Genetic Investigation of MHC-Independent Makrigiannis
J. Carlyle (2015)
permine grafted galactosylated chitosan for improved nanoparticle mediated ene delivery
U. Alex (2011)
Assessing the transport of receptor-mediated drug-delivery devices across cellular monolayers
E. Brewer (2014)
The Use of chitosan in The Formation of Silver Nanoparticles, Chitosanic Nanoparticles and Fibrous Structures
A. Abdelgawad (2013)
Chloroquine allows the secretion of internalized 125I‐epidermal growth factor from fibroblasts
E. Wakshull (1985)
Nonpalmitoylated Human Asialoglycoprotein Receptors Recycle Constitutively but Are Defective in Coated Pit-mediated Endocytosis, Dissociation, and Delivery of Ligand to Lysosomes*
J. Yik (2002)
Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.
I. Kim (2003)
Preparation and characterization of galactosylated chitosan coated BSA microspheres containing 5-fluorouracil
C. Zhang (2008)
Tumor necrosis factor production and receptor expression by a human malignant glioma cell line, D54-MG
J. Bethea (1990)
Non-stoichiometric Relationship between Clathrin Heavy and Light Chains Revealed by Quantitative Comparative Proteomics of Clathrin-coated Vesicles from Brain and Liver*S
M. Girard (2005)
Glycopolymer micelles with reducible ionic cores for hepatocytes-targeting delivery of DOX.
Y. Wang (2013)
Enhancing Glioblastoma-Specific Penetration by Functionalization of Nanoparticles with an Iron-Mimic Peptide Targeting Transferrin/Transferrin Receptor Complex.
Ting Kang (2015)
Secretory Component: The Receptor That Mediates External Secretion of Polymeric Immunoglobulins
D. Ahnen (1986)
Endothelium and Regulation of Coagulation
D. Stern (1991)
Rate transition and regulatory coupling in endocytosis of interferon‐α and tumor necrosis factor‐α in human epithelial tumor cells
S. Vuk-Pavlović (1992)
Crosstalk between Rab GTPases and cell junctions.
D. Mruk (2005)
Biochemical characterization and subcellular localization of human copper transporter 1 ( hCTR 1 )
Adriana E M Klomp ()See more