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High-Performance Liquid Chromatography Assay For Moxifloxacin In Bulk, Pharmaceutical Formulations And Serum: Application To In-Vitro Metal Interactions
N. Sultana, M. S. Arayne, Mahwish Akhtar, Sana Shamim, Somia Gul, M. M. Khan
Published 2010 · Chemistry
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acid was delivered at a flow rate of 1 mL min -1 . The eluents was monitored using UV detector at 290 nm. The proposed method is specific, accurate (99.39-102.67%), precise (intra-day variation 0.04-0.86% and inter-day variation 0.12-0.94%) and linearity (R 2 > 0.999) within the desired range 0.39-25 gm L -1 concentration. The detection and quantification limit was 0.002-0.51 gm L -1 and 0.01-0.555 gm L -1 ,r espectively. The analysis of variance (ANOVA) and student’s t-test were applied to verify the results. The anticipated method is applicable to routine analysis of MOX in pharmaceutical formulations and human serum samples. It is also applied on interaction of MOX with several essential and trace metals as well as interaction with antacids.
This paper references
Role of Mg2+ in Chromomycin A3 – DNA Interaction: A Molecular Modeling Study
S. Chakrabarti (2000)
The fluoroquinolone antibacterials: past, present and future perspectives.
P. Appelbaum (2000)
Protonation equilibrium and lipophilicity of moxifloxacin.
M. Langlois (2005)
Determination of moxifloxacin in growth media by high-performance liquid chromatography.
B. Ba (2001)
Determination of moxifloxacin in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry.
K. Vishwanathan (2002)
Effects of Iron Supplements on the Oral Bioavailability of Moxifloxacin, a Novel 8-Methoxyfluoroquinolone, in Humans
H. Stass (2001)
Interaction study of moxifloxacin with Cu(II) ion using square-wave voltammetry and its application in the determination in tablets
M. A. G. Trindade (2006)
The interactions of metal ions with quinolone antibacterial agents
I. Turel (2002)
Synthesis, characterization, and crystal structure of a copper(II) complex with quinolone family member (ciprofloxacin): bis(1)-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazin-1ylquinoline-3-carboxylate) copper(II) chloride hexahydrate
I. Turel (1994)
Pharmacodynamics of moxifloxacin against a high inoculum of Escherichia coli in an in vitro infection model.
R. Singh (2009)
Synthesis, crystal structure, and characterization of mixed-ligand complex of copper(I) with drug of norfloxacin and triphenyl phosphine: [Cu(PPh3)2(H-Norf)]ClO4
Z. Chen (2001)
Differential Pulse Polarographic Determination of Moxifloxacin Hydrochloride in Pharmaceuticals and Biological Fluids
R. İnam (2007)
The Merck index
S. Budavari (1998)
High-performance liquid chromatography assay for moxifloxacin: pharmacokinetics in human plasma.
S. T. Ulu (2007)
Transition metal complexes with the quinolone antibacterial agent pipemidic acid: Synthesis, characterization and biological activity
E. K. Efthimiadou (2007)
Determination of moxifloxacin in tablets and human urine by square-wave adsorptive voltammetry
M. A. G. Trindade (2005)
MAGNESIUM, CALCIUM AND BARIUM PERCHLORATE COMPLEXES OF CIPROFLOXACIN AND NORFLOXACIN
Jamil Ai-Mustafa (2002)
Mononuclear dioxomolybdenum(VI) complexes with the quinolones enrofloxacin and sparfloxacin: synthesis, structure, antibacterial activity and interaction with DNA
E. K. Efthimiadou (2008)
Optimization of separation and determination of moxifloxacin and its related substances by RP-HPLC.
P. Djurdjević (2009)
Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: Structure-activity relationship.
E. K. Efthimiadou (2008)
Validated spectrophotometric methods for the estimation of moxifloxacin in bulk and pharmaceutical formulations.
S. Motwani (2007)
Simultaneous Determination of Cefepime and the Quinolones Garenoxacin, Moxifloxacin and Levofloxacin in Human Urine by HPLC-UV
J. A. González (2005)
Synthesis and X-ray structural characterization of an iron(III) complex of the fluoroquinolone antimicrobial ciprofloxacin, [Fe(CIP)(NTA)]3·5H2O (NTANitrilotriacetato)
S. C. Wallis (1995)
Validation of chromatographic methods
M. E. Swartz (1998)
Synthesis, characterization, antibacterial activity, and interaction with DNA of the vanadyl-enrofloxacin complex.
E. K. Efthimiadou (2007)
Application of a validated stability-indicating densitometric thin-layer chromatographic method to stress degradation studies on moxifloxacin.
S. Motwani (2007)
Spectroscopic studies on the interaction of ofloxacin with metals
S. Sagdinc (2004)
Overview of the fluoroquinolones focus on moxifloxacin
V. Andriole (2002)
Review of the scientific basis for establishing the essentiality of trace elements
W. Mertz (2007)
The interaction of moxifloxacin and warfarin in three elderly patients.
K. O'Connor (2003)
Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives.
M. V. de Almeida (2007)
Synthesis, crystal structure, and characterization of three novel compounds of the quinolone family member (norfloxacin)
I. Turel (1996)
7 - Validation of HPLC Methods in Pharmaceutical Analysis
A. Lister (2005)
Nickel-quinolones interaction. Part 1 - Nickel(II) complexes with the antibacterial drug sparfloxacin: structure and biological properties.
Kalliopi C. Skyrianou (2009)
Mononuclear metal complexes with ciprofloxacin: Synthesis, characterization and DNA-binding properties.
G. Psomas (2008)
Complexes of Ni(II) and Cu(II) with ofloxacin. Crystal structure of a new Cu(II) ofloxacin complex.
B. Macías (2001)
Determination of moxifloxacin (BAY 12-8039) in plasma and lung tissue by high-performance liquid chromatography with ultraviolet detection using a fully automated extraction method with a new polymeric cartridge.
T. Lemoine (2000)
2D molecular square grid with strong blue fluorescent emission: a complex of norfloxacin with zinc(II).
Z. Chen (2001)
Simultaneous Quantification of Linezolid, Rifampicin, Levofloxacin, and Moxifloxacin in Human Plasma Using High-Performance Liquid Chromatography With UV
L. Baietto (2009)
Copper(II) complexes of the fluoroquinolone antimicrobial ciprofloxacin. Synthesis, X-ray structural characterization, and potentiometric study.
S. C. Wallis (1996)
The Inorganic Chemistry of Biological Processes
M. Hughes (1972)
Structural identification and characterization of impurities in moxifloxacin.
Y. Kumar (2004)
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M. A. Wahed (2014)
SIMPLE RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MOXIFLOXACIN HYDROCHLORIDE AND PREDNISOLONE ACETATE IN EYE DROPS
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Utility of Oxidation-Reduction Reaction for Determination of Gemifloxacin Mesylate and Moxifloxacin HCl in Pure Form and in Pharmaceutical Formulations using N-Bromosuccinimide
R. E. Sheikh (2013)
Simultaneous determination of moxifloxacin and ofloxacin in physiological fluids using high performance liquid chromatography with ultraviolet detection.
F. Khan (2016)
Validated UV-Visible Spectrophotometric method for simultaneous estimation of Cefixime and Moxifloxacin in Pharmaceutical Dosage Form -
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K. P. Patel (2013)
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF BROMFENAC SODIUM AND MOXIFLOXACIN IN THEIR COMBINED DOSAGE FORM
P. Pradhan (2014)
Stability indicating HPLC method for the simultaneous determination of moxifloxacin and prednisolone in pharmaceutical formulations
Syed Naeem Razzaq (2012)
S Synthesis , Characterization , Spectrofluorometric and Antibacterial Activity Studies of Moxifloxacin-Zirconium Complex
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Biological activities of some Fluoroquinolones-metal complexes
C. A. Akinremi (2012)
Development and Validation of a Liquid Chromatographic Method for the Determination of Leflunomide: Application to in vitro Drug Metal Interactions
N. Sultana (2011)
Simultaneous determination of glipizide and glimepride by Rp-Hplc in dosage formulations and in human serum
N. Sultana (2011)
Spectrophotometric Determination of Gemifloxacin Mesylate, Moxifloxacin Hydrochloride, and Enrofloxacin in Pharmaceutical Formulations Using Acid Dyes
A. A. Gouda (2014)
Nanoemulsion Based Vehicle for Effective Ocular Delivery of Moxifloxacin Using Experimental Design and Pharmacokinetic Study in Rabbits
Jigar Shah (2019)
M. M. A. Al Omari (2014)
Selective and Sensitive Chromatographic Methods for Determination of a Co-Formulated Binary Mixture in Antibacterial Eye Drops and Aqueous Humor in the Presence of Their Degradation Products and Potential Impurities.
M. A. Hegazy (2020)
Fragmentation of Moxifloxacin and Its Analogs by Electrospray Ionization Time-of-Flight Mass Spectrometry
Ze-Qin Guo (2014)
SIMPLE RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF MOXIFLOXACIN HYDROCHLORIDE AND BROMOFENAC SODIUM IN EYE DROPS
Haritha G. Reddy (2013)
Simultaneous determination of dexamethasone and moxifloxacin in pharmaceutical formulations using stability indicating HPLC method
Syed Naeem Razzaq (2017)
Photodegradation of norfloxacin in aqueous and organic solvents: A kinetic study
I. Ahmad (2015)
Photodegradation of Moxifloxacin in Aqueous and Organic Solvents: A Kinetic Study
I. Ahmad (2014)
RP-HPLC Method for Determination of Several NSAIDs and Their Combination Drugs
P. N. Patel (2013)
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND MOXIFLOXACIN HYDROCHLORIDE IN COMBINED TABLET DOSAGE FORM
Mehul D. Patel (2013)
Effect of Febrile Condition and Ketoprofen Co-administration on Pharmacokinetics of Moxifloxacin Following Intravenous Administration in Sheep
K. A. Sadariya (2014)
Monitoring of Pregabalin in Pharmaceutical Formulations and HumanSerum Using UV and RP-HPLC Techniques: Application to DissolutionTest Method
M. SaeedArayne (2014)
Simultaneous HPLC method development and validation of moxifloxacin hydrochloride and bromofenac sodium in pharmaceutical formulation
Shine Sudev (2015)