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High-Performance Liquid Chromatography Assay For Moxifloxacin In Bulk, Pharmaceutical Formulations And Serum: Application To In-Vitro Metal Interactions

N. Sultana, M. S. Arayne, Mahwish Akhtar, Sana Shamim, Somia Gul, M. M. Khan
Published 2010 · Chemistry

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acid was delivered at a flow rate of 1 mL min -1 . The eluents was monitored using UV detector at 290 nm. The proposed method is specific, accurate (99.39-102.67%), precise (intra-day variation 0.04-0.86% and inter-day variation 0.12-0.94%) and linearity (R 2 > 0.999) within the desired range 0.39-25 gm L -1 concentration. The detection and quantification limit was 0.002-0.51 gm L -1 and 0.01-0.555 gm L -1 ,r espectively. The analysis of variance (ANOVA) and student’s t-test were applied to verify the results. The anticipated method is applicable to routine analysis of MOX in pharmaceutical formulations and human serum samples. It is also applied on interaction of MOX with several essential and trace metals as well as interaction with antacids.
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