Online citations, reference lists, and bibliographies.
← Back to Search

Enhancement Of Colony‐stimulating‐factor–dependent Clonal Growth Of Murine Macrophage Progenitors And Their Phagocytic Activity By Retinoic Acid

R. Goldman
Published 1985 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
The effect of retinoic acid (RA) on the colony‐stimulating‐factor‐dependent clonal growth of myeloid progenitors was assessed in semisolid agar cultures of mouse bone marrow cells using L‐cell‐conditioned medium that gave rise to macrophage colonies, granulocyte colonies, and mixed macrophage‐granulocyte colonies and clusters. RA was found to enhance the overall formation of myeloid colonies (about 50%) and clusters in 7‐day cultures. The increase was due to an enhanced formation of macrophage colonies (70–250%) and clusters which reached a maximal value at about 3 μM RA. In 4‐day cultures, the effect of RA on macrophage colony formation was biphasic with a maximal enhancement at 10 nM. RA suppressed granulocyte‐colony formation in macrophages at all stages of differentiation and/or maturation in culture. The Fc‐receptor‐mediated erythrophagocytosis as well as the phagocytosis of heat‐killed yeast cells (HK‐yeast) and starch particles increased by RA treatment in a dose‐dependent manner, reaching an increase of 100–200% of the activity expressed in the absence of RA. Peritoneal exudate macrophages likewise physiological and pharmacological concentrations of RA. Expression of an RA‐mediated increase in phagocytic activity required a prolonged incubation with RA (> 19 hr). The data suggest that RA may be of physiological relevance in the regulation of proliferation and function of hemopoietic cells. Therapeutic doses of RA may potentiate macrophage proliferation and function, elements that are crucial at all phases of the various defense mechanisms that the organism possesses.
This paper references
Retinoids as regulators of macrophage function.
J. Rhodes (1980)
Interferon-induced changes in the monocyte membrane: inhibition by retinol and retinoic acid.
J. Rhodes (1982)
Effects of retinoids on induction of differentiation of cultured mouse myeloid leukemia cells.
K. Takenaga (1980)
Retinoic acid promotion of papilloma formation in mouse skin.
H. Hennings (1982)
Studies on colony formation in vitro by mouse bone marrow cells . I. Continuous cluster formation and relation of clusters to colonies
D. Metcalf (1969)
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.
T. R. Breitman (1980)
Retinoic acid enhances growth of human early erythroid progenitor cells in vitro.
D. Douer (1982)
Complement and Fc receptor‐mediated phagocytosis of normal and stimulated mouse peritoneal macrophages
Z. Bar-Shavit (1979)
Stimulation of cell proliferation by vitamin A derivatives on murine sarcoma virus-transformed mouse cells in serum-free culture.
A. Hiragun (1983)
Identification and characterization of the monoblast in mononuclear phagocyte colonies grown in vitro
T. J. Goud (1975)
Induction of differentiation of cultured human promyelocytic leukemia cells by retinoids.
Y. Honma (1980)
Complement (C3)‐Receptor‐Mediated Phagocytosis of Agarose Beads by Mouse Macrophages
E. Johnson (1983)
High-pressure liquid chromatographic determination of 13-cis-retinoic acid and all-trans-retinoic acid in human plasma.
C. Frolik (1978)
Inhibition of differentiation and proliferation of colony-stimulating factor-induced clonal growth of normal human marrow cells in vitro by retinoic acid.
E. Bradley (1983)
The nature of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐stimulated hemopoiesis, colony stimulating factor (CSF) requirement for colony formation, and the effect of TPA on [125I]CSF‐1 binding to macrophages
L. Guilbert (1983)
C. Feldherr (1968)
Stimulation of macrophage plasminogen activator activity by colony‐stimulating factors
J. Hamilton (1980)
Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro.
R. Stuart (1980)
Purification and properties of colony-stimulating factor from mouse lung-conditioned medium.
A. Burgess (1977)
Induction of differentiation of the human histiocytic lymphoma cell line U-937 by retinoic acid and cyclic adenosine 3':5'-monophosphate-inducing agents.
I. Olsson (1982)
The Function of Vitamin A: Current Concepts 1
M. Zile (1983)
Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.
R. Lotan (1980)
Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy
R. Tushinski (1982)
Effect of retinoic acid on the proliferation and phagocytic capability of murine macrophage‐like cell lines
R. Goldman (1984)
Stimulation of sialidase activity during cell differentiation of human promyelocytic leukemia cell line HL-60.
N. Nojiri (1982)
Glycosyltransferase activities and the differentiation of human promyelocytic (HL60) cells by retinoic acid and a phorbol ester.
J. Durham (1983)
Regulation of myelopoiesis in vitro: partial replacement of colony-stimulating factors by tumor-promoting phorbol esters.
R. Stuart (1981)
Clonal analysis of proliferation and differentiation of paired daughter cells: action of granulocyte-macrophage colony-stimulating factor on granulocyte-macrophage precursors.
D. Metcalf (1980)
1,25-Dihydroxyvitamin D3 and the regulation of the differentiation and function of macrophages and granulocytes.
E. Shezen (1985)
Chemotactic activity of bone marrow-derived macrophages changes with time in culture.
W. Falk (1981)
Induction of a high phagocytic capability in P388D1, a macrophage-like tumor cell line, by 1 alpha, 25-dihydroxyvitamin D3.
R. Goldman (1984)
Retinoic acid. Inhibition of the clonal growth of human myeloid leukemia cells.
D. Douer (1982)
Retinoic acid enhances colony-stimulating factor-induced clonal growth of normal human myeloid progenitor cells in vitro.
D. Douer (1982)
Yeast Mannans inhibit binding and phagocytosis of zymosan by mouse peritoneal macrophages
SJ Sung (1983)
Analysis of colonies developing in vitro from mouse bone marrow cells stimulated by kidney feeder layers or leukemic serum
D. Metcalf (1967)
Retinoids specifically enhance the number of epidermal growth factor receptors
A. Jetten (1980)
Dissociation of bactericidal activity from other functions of activated macrophages in exudates induced by thioglycolate medium.
G. Spitalny (1981)
Surface properties of bacillus Calmette-Guerin-activated mouse macrophages. Reduced expression of mannose-specific endocytosis, Fc receptors, and antigen F4/80 accompanies induction of Ia
R. A. Ezekowitz (1981)
A macrophage receptor for (mannose/glucosamine)-glycoproteins of potential importance in phagocytic activity.
G. Warr (1980)
Formation of vinculin plaques precedes other cytoskeletal changes during retinoic acid-induced teratocarcinoma cell differentiation.
E. Lehtonen (1983)
Terminal Differentiation of Human Promyelocytic Leukemic Cells in Primary Culture in Response to Retinoic Acid
T. R. Breitman (1981)
Expression of a mannosyl-fucosyl receptor for endocytosis on cultured primary macrophages and their hybrids
P. Stahl (1982)
Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan
R. Ezekowitz (1984)
Complement (C3)‐Receptor‐Mediated Phagocytosis of Agarose Beads by Mouse Macrophages
E. Johnson (1983)
Enhancement in 'apparent' membrane microviscosity during differentiation of embryonal carcinoma cells induced by retinoids.
A. Jetten (1982)
Retinoic acid: an endogenous compound of human blood. Unequivocal demonstration of endogenous retinoic acid in normal physiological conditions.
M. G. De Ruyter (1979)
Effect of retinoic acid on the acylation of phospholipids in granulocytes in vitro.
J. Tou (1983)

This paper is referenced by
Impaired T lymphocyte immune response in vitamin A depleted rats and chicks.
A. Friedman (1989)
Granulocyte-macrophage colony-stimulating factor: pleiotropic cytokine with potential clinical usefulness.
C. Ruef (1990)
Characteristics of the β-glucan receptor of murine macrophages
R. Goldman (1988)
Modulation of transglutaminase activity in mononuclear phagocytes and macrophage-like tumor cell lines by differentiation agents.
R. Goldman (1987)
Opposing effects of dexamethasone on the clonal growth of granulocyte and macrophage progenitor cells and on the phagocytic capability of mononuclear phagocytes at different stages of differentiation
E. Shezen (1985)
Control of lipoprotein lipase secretion in mouse macrophages.
R. Goldman (1989)
Vitamin A and Immunity
A. Friedman (1993)
Bacterial lipopolysaccharide suppresses the expression of lipoprotein lipase in murine macrophages: a process independent of tumor necrosis factor or interleukin 1.
O. Sopher (1987)
Inducible Production of Human Macrophage Growth Factor
J. Csejtey (2005)
Decreased resistance and immune response to Escherichia coli infection in chicks with low or high intakes of vitamin A.
A. Friedman (1991)
Control of Lipoprotein Lipase Secretion by Macrophages: Effect of Macrophage Differentiation Agents
R. Goldman (1990)
Semantic Scholar Logo Some data provided by SemanticScholar