Online citations, reference lists, and bibliographies.
← Back to Search

Activation And Proliferation Signals In Murine Macrophages: Stimulation Of Glucose Uptake By Hemopoietic Growth Factors And Other Agents

J. Hamilton, G. Vairo, S. Lingelbach
Published 1988 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Purified colony‐stimulating factor (CSF‐1) (or macrophage colony stimulating factor [M‐CSF]) stimulated the glucose uptake of murine bone marrow‐derived macrophages (BMM) and resident peritoneal macrophages (RPM) as measured by 3H‐2‐deoxyglucose (2‐DOG) uptake. Similar concentrations of CSF‐1 stimulated the 2‐DOG uptake and DNA synthesis in BMM. Other purified hemopoietic growth factors, granulocyte‐macrophage CSF (GM‐CSF) and interleukin‐3 (IL‐3) (or multi‐CSF), and the tumor promoter, 12‐O‐tetrade‐canoyl‐phorbol‐13‐acetate (TPA), even though differing in their mitogenic capabilities on BMM, were also stimulators of 2‐DOG uptake in BMM and RPM. The nonmitogenic agents, lipopolysaccharide (LPS) and concanavalin A (Con A), were also active. The inhibition by cytochalasin B and by high concentrations of D‐glucose suggest that the basal and stimulated 2‐DOG uptake occurred via a carrier‐facilitated D‐glucose transport system. The responses of the two macrophage populations to the hemopoietic growth factors and to the other agents were quite similar, suggesting that events that are important for the induction of DNA synthesis are not tightly coupled to the earlier rise in glucose uptake. For the BMM, the ability of a particular agent to stimulate glucose uptake did not parallel its ability to promote cell survival. However, stimulation of glucose uptake could still be a necessary but insufficient early macrophage response for cell survival and subsequent DNA synthesis.
This paper references
The roles of transport and phosphorylation in nutrient uptake in cultured animal cells.
R. Wohlhueter (1980)
Changes in glycolytic enzyme levels and isozyme expression in human lymphocytes during blast transformation.
M. Kester (1977)
12–0‐tetradecanoylphorbol‐13‐acetatea and concanavalin a enhance glucose uptake in thymocytes by different mechanisms
J. Nordenberg (1983)
Increased ouabain‐sensitive glycolysis of lymphocytes treated with phytohemagglutinin: Relationship to potassium transport
G. Segel (1978)
Phosphorylation of the glucose transporter in vitro and in vivo by protein kinase C
L. Witters (1985)
Stimulation of hematopoiesis in vivo by recombinant bacterial murine interleukin 3.
V. Kindler (1986)
The role of protein kinase C in cell surface signal transduction and tumour promotion
Y. Nishizuka (1984)
Necessary and sufficient conditions for recruitment of macrophages into the cell cycle.
S. Dienstman (1978)
Bone marrow-derived macrophages: development and regulation of differentiation markers by colony-stimulating factor and interferons.
M. K. Warren (1985)
The regulation of macrophage protein turnover by a colony stimulating factor (CSF‐1)
R. Tushinski (1983)
CSF-1 stimulates glucose uptake in murine bone marrow-derived macrophages.
J. Hamilton (1986)
Haemopoietic cell growth factor mediates cell survival via its action on glucose transport.
A. Whetton (1984)
Production of macrophage-activating factor by T lymphocyte clones and correlation with other lymphokine activities.
A. Kelso (1982)
In vitro actions on hemopoietic cells of recombinant murine GM‐CSF purified after production in Escherichia coli: Comparison with purified native GM‐CSF
D. Metcalf (1986)
The cell biology of macrophage activation.
D. Adams (1984)
Purification of two forms of colony-stimulating factor from mouse L-cell-conditioned medium.
A. Burgess (1985)
Tumor promoter-stimulated translocation of glucose transport system in mouse embryo fibroblast Swiss 3T3 cell.
K. Kitagawa (1985)
Stimulatory effects of purified macrophage colony-stimulating factor on murine resident peritoneal macrophages.
N. Ampel (1986)
Insulin stimulation of glucose transport and metabolism in a human Wilms' tumor‐derived myoblast‐like cell Line: Modulation of hormone effects by glucose deprivation
Sandra K. Lemmon (1985)
Stimulation of macrophage plasminogen activator activity by colony‐stimulating factors
J. Hamilton (1980)
Studies on the relationship between glycolysis and (Na+ + K+)-ATPase in cultured cells.
R. Balaban (1984)
Control of Macrophage Stimulation and Proliferation
J. Hamilton (1981)
Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1).
E. R. Stanley (1981)
Identification of the stereospecific hexose transporter from starved and fed chicken embryo fibroblasts.
J. Pessin (1982)
Effect of anoxia, 2,4-dinitrophenol and salicylate on xylose transport by isolated rat soleus muscle.
G. P. Korbl (1977)
Activation and proliferation signals in murine macrophages: Stimulation of Na+, K+‐ATPase activity by hemopoietic growth factors and other agents
G. Vairo (1988)
Growth of factor-dependent hemopoietic precursor cell lines
T. Dexter (1980)
Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages
J. Kurland (1978)
The hemopoietic colony stimulating factors
D. Metcalf (1984)
Dissociation by cytochalasin B of movement, DNA synthesis and transport in 3T3 cells
Barbara L. Brownstein (1975)
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1
C. Sherr (1985)
Stimulation of hexose transport by human polymorphonuclear leukocytes: a possible role for protein kinase C.
C. McCall (1985)
Stimulation of hexose uptake in rat thymic lymphocytes by phorbol ester. A role for Ca2+ and Na+/H+ exchange?
A. Klip (1984)
Control mechanisms of adenine nucleotide metabolism of ascites tumor cells.
W. D. Yushok (1971)
Hemopoietic colony-stimulating factors.
N. Nicola (1984)
Effect of protein kinase C activation and Ca2+ mobilization on hexose transport in Swiss 3T3 cells.
K. Kitagawa (1986)
The regulation of mononuclear phagocyte entry into S phase by the colony stimulating factor CSF-1.
Tushinski Rj (1985)
Haemopoietic cell growth factor and glucose transport. Its role in cell survival and the relevance of this in normal haemopoiesis and leukaemia.
T. Dexter (1984)
Dissociation of increased hexose transport from initiation of fibroblast proliferation
CORNELIA R. Thrash (1974)
Early signals in the mitogenic response.
E. Rozengurt (1986)
Production of lymphocyte-activating factor (Interleukin 1) by macrophages activated with colony-stimulating factors.
R. N. Moore (1980)
Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy
R. Tushinski (1982)
Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor.
N. Nicola (1983)
Stimulation of phagocytosis in bone marrow-derived mouse macrophages by bacterial lipopolysaccharide: correlation with biochemical and functional parameters.
P. Cooper (1984)
CSF-1 stimulates Na+K+-ATPase mediated 86Rb+ uptake in mouse bone marrow-derived macrophages.
G. Vairo (1985)

This paper is referenced by
Genetic modifiers of response to glucose–insulin–potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial
K. Ellis (2015)
ester for DNA synthesis interactions between the hematopoietic growth factors and with phorbol Activation and proliferation signals in murine macrophages: synergistic
J. Hamilton (2011)
Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents.
J. Hamilton (1991)
Hematopoietins: biology, pathophysiology, and potential as therapeutic agents.
R. Mertelsmann (1991)
In vivo metabolic response of hepatic nonparenchymal cells and leukocytes to granulocyte‐macrophage colony‐stimulating factor
Z. Spolarics (1992)
High-capacity redox control at the plasma membrane of mammalian cells: trans-membrane, cell surface, and serum NADH-oxidases.
M. Berridge (2000)
Glycolytic control of adjuvant‐induced macrophage survival: role of PI3K, MEK1/2, and Bcl‐2
Margaret M. Chang (2009)
Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin.
Ji-Biao Huang (2002)
The Florey Lecture, 1991. The colony-stimulating factors: discovery to clinical use.
D. Metcalf (1991)
Garanulocyte-macrophage colony-stimulating factor
S. Devereux (1990)
Cytokine Modulation of Glucose Metabolism
G. Bagby (1993)
Augmented 18 F-FDG Uptake in Activated Monocytes Occurs During the Priming Process and Involves Tyrosine Kinases and Protein Kinase C
Jin-Young Paik (2003)
Regulation of mononuclear phagocyte proliferation by colony-stimulating factor-1.
C. Sherr (1990)
Colony stimulating factor‐1 Is a negative regulator of the macrophage respiratory burst
W. Phillips (1990)
Colony stimulating factor‐1 stimulates diacylglycerol generation in murine bone marrow‐derived macrophages, but not in resident peritoneal macrophages
N. Veis (1991)
M-CSF Signals through the MAPK/ERK Pathway via Sp1 to Induce VEGF Production and Induces Angiogenesis In Vivo
Jennifer M. Curry (2008)
Evidence against a requirement for Na+/H+ exchange activity for proliferation or differentiation of HL60 leukemic cells.
G. Vairo (1993)
Evidence that cell survival is controlled by interleukin‐3 independently of cell proliferation
M. Berridge (1995)
Expression and modulation of IL‐3 and GM‐CSF receptors in human growth factor dependent leukaemic cells
M. Brizzi (1990)
Correlations between 18F-FDG uptake by bone marrow and hematological parameters: measurements by PET/CT.
Y. Murata (2006)
Regulation of human monocyte DNA synthesis by colony-stimulating factors, cytokines, and cyclic adenosine monophosphate.
D. L. Cheung (1992)
Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents.
J. Hamilton (1991)
GM-CSF and IL-3 stimulate diacylglycerol generation in murine bone marrow-derived macrophages.
N. Veis (1991)
Use of granulocyte colony-stimulating factor for fluorine-18-fluorodeoxyglucose labeling in human leukocytes
S. Moon (2011)
Activation and proliferation signals in murine macrophages: synergistic interactions between the hematopoietic growth factors and with phorbol ester for DNA synthesis
J. Hamilton (1988)
Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating-Factor)
C. Sherr (1991)
Correlación de los parámetros hematológicos con la captación de FDG en médula ósea y bazo en la PET
R. Nuñez (2005)
Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells.
R. Datta (1992)
Developmental Expression of Magmas in Murine Tissues and Its Co-expression with the GM-CSF Receptor
P. Jubinsky (2003)
This information is current as Aerobic Conditions Associated with Their Maturation under Survival and Enhanced Glycolysis Is Hypoxia Prolongs Monocyte / Macrophage
John Roiniotis (2009)
Control of lipoprotein lipase secretion in mouse macrophages.
R. Goldman (1989)
Granulocyte-Macrophage Colony-stimulating Factor Signals for Increased Glucose Transport via Phosphatidylinositol 3-Kinase- and Hydrogen Peroxide-dependent Mechanisms*
Manya Dhar-Mascareño (2003)
See more
Semantic Scholar Logo Some data provided by SemanticScholar