Online citations, reference lists, and bibliographies.
← Back to Search

Activation And Proliferation Signals In Murine Macrophages: Stimulation Of Glucose Uptake By Hemopoietic Growth Factors And Other Agents

J. Hamilton, G. Vairo, S. Lingelbach
Published 1988 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Purified colony‐stimulating factor (CSF‐1) (or macrophage colony stimulating factor [M‐CSF]) stimulated the glucose uptake of murine bone marrow‐derived macrophages (BMM) and resident peritoneal macrophages (RPM) as measured by 3H‐2‐deoxyglucose (2‐DOG) uptake. Similar concentrations of CSF‐1 stimulated the 2‐DOG uptake and DNA synthesis in BMM. Other purified hemopoietic growth factors, granulocyte‐macrophage CSF (GM‐CSF) and interleukin‐3 (IL‐3) (or multi‐CSF), and the tumor promoter, 12‐O‐tetrade‐canoyl‐phorbol‐13‐acetate (TPA), even though differing in their mitogenic capabilities on BMM, were also stimulators of 2‐DOG uptake in BMM and RPM. The nonmitogenic agents, lipopolysaccharide (LPS) and concanavalin A (Con A), were also active. The inhibition by cytochalasin B and by high concentrations of D‐glucose suggest that the basal and stimulated 2‐DOG uptake occurred via a carrier‐facilitated D‐glucose transport system. The responses of the two macrophage populations to the hemopoietic growth factors and to the other agents were quite similar, suggesting that events that are important for the induction of DNA synthesis are not tightly coupled to the earlier rise in glucose uptake. For the BMM, the ability of a particular agent to stimulate glucose uptake did not parallel its ability to promote cell survival. However, stimulation of glucose uptake could still be a necessary but insufficient early macrophage response for cell survival and subsequent DNA synthesis.
This paper references
10.1016/S0074-7696(08)60238-7
The roles of transport and phosphorylation in nutrient uptake in cultured animal cells.
R. Wohlhueter (1980)
10.1016/0003-9861(77)90403-9
Changes in glycolytic enzyme levels and isozyme expression in human lymphocytes during blast transformation.
M. Kester (1977)
10.1002/JCP.1041170208
12–0‐tetradecanoylphorbol‐13‐acetatea and concanavalin a enhance glucose uptake in thymocytes by different mechanisms
J. Nordenberg (1983)
10.1002/JCP.1040970315
Increased ouabain‐sensitive glycolysis of lymphocytes treated with phytohemagglutinin: Relationship to potassium transport
G. Segel (1978)
10.1038/315777a0
Phosphorylation of the glucose transporter in vitro and in vivo by protein kinase C
L. Witters (1985)
10.1073/PNAS.83.4.1001
Stimulation of hematopoiesis in vivo by recombinant bacterial murine interleukin 3.
V. Kindler (1986)
10.1038/308693A0
The role of protein kinase C in cell surface signal transduction and tumour promotion
Y. Nishizuka (1984)
10.1016/0014-4827(78)90416-0
Necessary and sufficient conditions for recruitment of macrophages into the cell cycle.
S. Dienstman (1978)
Bone marrow-derived macrophages: development and regulation of differentiation markers by colony-stimulating factor and interferons.
M. K. Warren (1985)
10.1002/JCP.1041160111
The regulation of macrophage protein turnover by a colony stimulating factor (CSF‐1)
R. Tushinski (1983)
10.1016/0006-291X(86)90301-3
CSF-1 stimulates glucose uptake in murine bone marrow-derived macrophages.
J. Hamilton (1986)
10.1002/j.1460-2075.1984.tb01821.x
Haemopoietic cell growth factor mediates cell survival via its action on glucose transport.
A. Whetton (1984)
Production of macrophage-activating factor by T lymphocyte clones and correlation with other lymphokine activities.
A. Kelso (1982)
10.1002/JCP.1041280311
In vitro actions on hemopoietic cells of recombinant murine GM‐CSF purified after production in Escherichia coli: Comparison with purified native GM‐CSF
D. Metcalf (1986)
10.1146/ANNUREV.IY.02.040184.001435
The cell biology of macrophage activation.
D. Adams (1984)
Purification of two forms of colony-stimulating factor from mouse L-cell-conditioned medium.
A. Burgess (1985)
10.1016/0006-291X(85)91082-4
Tumor promoter-stimulated translocation of glucose transport system in mouse embryo fibroblast Swiss 3T3 cell.
K. Kitagawa (1985)
10.1016/0008-8749(86)90405-3
Stimulatory effects of purified macrophage colony-stimulating factor on murine resident peritoneal macrophages.
N. Ampel (1986)
10.1002/JCP.1041250314
Insulin stimulation of glucose transport and metabolism in a human Wilms' tumor‐derived myoblast‐like cell Line: Modulation of hormone effects by glucose deprivation
Sandra K. Lemmon (1985)
10.1002/JCP.1041030309
Stimulation of macrophage plasminogen activator activity by colony‐stimulating factors
J. Hamilton (1980)
10.1016/0167-4889(84)90069-7
Studies on the relationship between glycolysis and (Na+ + K+)-ATPase in cultured cells.
R. Balaban (1984)
10.1159/000406107
Control of Macrophage Stimulation and Proliferation
J. Hamilton (1981)
10.1016/0022-1759(81)90156-3
Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1).
E. R. Stanley (1981)
10.1073/PNAS.79.7.2286
Identification of the stereospecific hexose transporter from starved and fed chicken embryo fibroblasts.
J. Pessin (1982)
10.1016/0005-2736(77)90358-3
Effect of anoxia, 2,4-dinitrophenol and salicylate on xylose transport by isolated rat soleus muscle.
G. P. Korbl (1977)
10.1002/JCP.1041340103
Activation and proliferation signals in murine macrophages: Stimulation of Na+, K+‐ATPase activity by hemopoietic growth factors and other agents
G. Vairo (1988)
10.1084/JEM.152.4.1036
Growth of factor-dependent hemopoietic precursor cell lines
T. Dexter (1980)
10.1084/JEM.147.3.952
Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages
J. Kurland (1978)
10.1007/978-3-642-67986-5_12
The hemopoietic colony stimulating factors
D. Metcalf (1984)
10.1002/JCP.1040850309
Dissociation by cytochalasin B of movement, DNA synthesis and transport in 3T3 cells
Barbara L. Brownstein (1975)
10.1016/S0092-8674(85)80047-7
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1
C. Sherr (1985)
10.1016/0006-291X(85)90626-6
Stimulation of hexose transport by human polymorphonuclear leukocytes: a possible role for protein kinase C.
C. McCall (1985)
10.1016/0006-291X(84)90909-4
Stimulation of hexose uptake in rat thymic lymphocytes by phorbol ester. A role for Ca2+ and Na+/H+ exchange?
A. Klip (1984)
Control mechanisms of adenine nucleotide metabolism of ascites tumor cells.
W. D. Yushok (1971)
10.1016/0167-5699(84)90170-1
Hemopoietic colony-stimulating factors.
N. Nicola (1984)
10.1016/0167-4889(86)90128-X
Effect of protein kinase C activation and Ca2+ mobilization on hexose transport in Swiss 3T3 cells.
K. Kitagawa (1986)
10.1002/JCP.1041220210
The regulation of mononuclear phagocyte entry into S phase by the colony stimulating factor CSF-1.
Tushinski Rj (1985)
10.1111/J.1432-0436.1984.TB01423.X
Haemopoietic cell growth factor and glucose transport. Its role in cell survival and the relevance of this in normal haemopoiesis and leukaemia.
T. Dexter (1984)
10.1038/252045A0
Dissociation of increased hexose transport from initiation of fibroblast proliferation
CORNELIA R. Thrash (1974)
10.1126/SCIENCE.3018928
Early signals in the mitogenic response.
E. Rozengurt (1986)
Production of lymphocyte-activating factor (Interleukin 1) by macrophages activated with colony-stimulating factors.
R. N. Moore (1980)
10.1016/0092-8674(82)90376-2
Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy
R. Tushinski (1982)
Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor.
N. Nicola (1983)
Stimulation of phagocytosis in bone marrow-derived mouse macrophages by bacterial lipopolysaccharide: correlation with biochemical and functional parameters.
P. Cooper (1984)
10.1016/0006-291X(85)91040-X
CSF-1 stimulates Na+K+-ATPase mediated 86Rb+ uptake in mouse bone marrow-derived macrophages.
G. Vairo (1985)



This paper is referenced by
10.1038/tpj.2015.10
Genetic modifiers of response to glucose–insulin–potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial
K. Ellis (2015)
ester for DNA synthesis interactions between the hematopoietic growth factors and with phorbol Activation and proliferation signals in murine macrophages: synergistic
J. Hamilton (2011)
10.1182/blood.v77.3.616.616
Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents.
J. Hamilton (1991)
10.1093/OXFORDJOURNALS.ANNONC.A057932
Hematopoietins: biology, pathophysiology, and potential as therapeutic agents.
R. Mertelsmann (1991)
10.1002/jlb.51.4.360
In vivo metabolic response of hepatic nonparenchymal cells and leukocytes to granulocyte‐macrophage colony‐stimulating factor
Z. Spolarics (1992)
10.1089/ARS.2000.2.2-231
High-capacity redox control at the plasma membrane of mammalian cells: trans-membrane, cell surface, and serum NADH-oxidases.
M. Berridge (2000)
10.1189/jlb.0908522
Glycolytic control of adjuvant‐induced macrophage survival: role of PI3K, MEK1/2, and Bcl‐2
Margaret M. Chang (2009)
10.1016/S0008-8749(02)00582-8
Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin.
Ji-Biao Huang (2002)
10.1098/RSTB.1991.0065
The Florey Lecture, 1991. The colony-stimulating factors: discovery to clinical use.
D. Metcalf (1991)
10.1007/BF02170080
Garanulocyte-macrophage colony-stimulating factor
S. Devereux (1990)
10.1007/978-3-642-76736-4_43
Cytokine Modulation of Glucose Metabolism
G. Bagby (1993)
Augmented 18 F-FDG Uptake in Activated Monocytes Occurs During the Priming Process and Involves Tyrosine Kinases and Protein Kinase C
Jin-Young Paik (2003)
10.1002/STEM.5530080706
Regulation of mononuclear phagocyte proliferation by colony-stimulating factor-1.
C. Sherr (1990)
10.1002/JCP.1041440203
Colony stimulating factor‐1 Is a negative regulator of the macrophage respiratory burst
W. Phillips (1990)
10.1002/JCP.1041470215
Colony stimulating factor‐1 stimulates diacylglycerol generation in murine bone marrow‐derived macrophages, but not in resident peritoneal macrophages
N. Veis (1991)
10.1371/journal.pone.0003405
M-CSF Signals through the MAPK/ERK Pathway via Sp1 to Induce VEGF Production and Induces Angiogenesis In Vivo
Jennifer M. Curry (2008)
Evidence against a requirement for Na+/H+ exchange activity for proliferation or differentiation of HL60 leukemic cells.
G. Vairo (1993)
10.1002/JCP.1041630306
Evidence that cell survival is controlled by interleukin‐3 independently of cell proliferation
M. Berridge (1995)
10.1111/j.1365-2141.1990.tb07872.x
Expression and modulation of IL‐3 and GM‐CSF receptors in human growth factor dependent leukaemic cells
M. Brizzi (1990)
10.1016/J.NUCMEDBIO.2006.09.005
Correlations between 18F-FDG uptake by bone marrow and hematological parameters: measurements by PET/CT.
Y. Murata (2006)
10.1182/blood.v79.8.1972.1972
Regulation of human monocyte DNA synthesis by colony-stimulating factors, cytokines, and cyclic adenosine monophosphate.
D. L. Cheung (1992)
10.1182/BLOOD.V77.3.616.BLOODJOURNAL773616
Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents.
J. Hamilton (1991)
10.1016/0006-291X(91)91411-5
GM-CSF and IL-3 stimulate diacylglycerol generation in murine bone marrow-derived macrophages.
N. Veis (1991)
10.1097/MNM.0b013e328342dea1
Use of granulocyte colony-stimulating factor for fluorine-18-fluorodeoxyglucose labeling in human leukocytes
S. Moon (2011)
10.1182/BLOOD.V71.6.1574.BLOODJOURNAL7161574
Activation and proliferation signals in murine macrophages: synergistic interactions between the hematopoietic growth factors and with phorbol ester for DNA synthesis
J. Hamilton (1988)
10.1007/978-1-4612-3210-0_15
Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating-Factor)
C. Sherr (1991)
10.1157/13071686
Correlación de los parámetros hematológicos con la captación de FDG en médula ósea y bazo en la PET
R. Nuñez (2005)
10.1182/BLOOD.V79.4.904.BLOODJOURNAL794904
Functional expression of the macrophage colony-stimulating factor receptor in human THP-1 monocytic leukemia cells.
R. Datta (1992)
10.1177/002215540305100504
Developmental Expression of Magmas in Murine Tissues and Its Co-expression with the GM-CSF Receptor
P. Jubinsky (2003)
This information is current as Aerobic Conditions Associated with Their Maturation under Survival and Enhanced Glycolysis Is Hypoxia Prolongs Monocyte / Macrophage
John Roiniotis (2009)
10.1016/0005-2760(89)90137-9
Control of lipoprotein lipase secretion in mouse macrophages.
R. Goldman (1989)
10.1074/jbc.M212541200
Granulocyte-Macrophage Colony-stimulating Factor Signals for Increased Glucose Transport via Phosphatidylinositol 3-Kinase- and Hydrogen Peroxide-dependent Mechanisms*
Manya Dhar-Mascareño (2003)
See more
Semantic Scholar Logo Some data provided by SemanticScholar