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Solvent‐free Synthesis Of 2,6‐Dihydroxy‐9H‐purin And Pteridine Derivatives

Navabeh Nami, Mozhgan Tizkar, Mohammad Reza Zardost
Published 2017 · Chemistry
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5,6-Diaminopyrimidin-2,4-diol 1 was reacted with 1,4-d-gluconolactone 2, 6-chloro-4-cyclopropyl-7-floro-1,4-dihydro-1-oxonaphthalen-2-carboxilic acid 4, (3S)-9,10-difloro-3,7-dihydro-3-methyl-7-oxo-2H-[1,4]oxazino[2,3,4-ij]quinolin-6-carboxylic acid 6, and dimethylacetylendicarboxylate to afford 1-(2,6-dihydroxy-9H-purin-8-yl)-sorbitol 3, 7-chloro-1-cyclopropyl-6-flouro-3-(2,6-dihydroxy-9H-purin-8-yl)quinoline-4(1H)-one 5, 9,10-difluoro-2,3-dihydro-6-(2,6-dihydroxy-9H-purin-8-yl)-3-methyl-[1,4]oxazine[2,3,4-ij]quinoline-7-one 7, and (2,4-dihydroxy-6-oxo-5,8-dihydro-6H-pteridine-7-yiliden)-acetic acid methyl ester 9, respectively. The synthesized compounds characterized by IR, 1H-NMR, 13C-NMR, GC-mass, and elemental analysis.
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