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Optimal Ferric Hydroxamate Method For Determination Of Intact Pilocarpine.

I. Gibbs, M. M. Tuckerman
Published 1970 · Chemistry, Medicine

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The ferric hydroxamate colorimetric method for lactones has been optimized for the determination of pilocarpine in the presence of its degradation product by careful control of pH, reagent concentration, and time to yield a method which has the following advantages of similar methods previously proposed: (a) direct sampling of the usual 1 or 2% solutions without dilution; (b) a stable blank with relatively low absorbance; and (c) production of a color with a minimal rate of fading, suitable for quantitative determination. Analysis of 20 independent sets of calibrations by linear regression analysis yields a regression coefficient of 0.98, an absorbance (y) intercept of -0.007, and a slope of 0.51.
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