Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effects Of Dose, PH, And Osmolarity On Nasal Absorption Of Secretin In Rats.

T. Ohwaki, H. Ando, S. Watanabe, Yasuo Miyake
Published 1985 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The effects of dose, pH, and osmolarity on the nasal absorption of a secretin solution were studied in rats. The nasal absorption of secretin was determined by measuring the increased secretion of pancreatic juice, and this was compared with the same response on intravenous administration. The relative bioavailability of secretin on intranasal administration compared with intravenous administration, as estimated from the pharmacological response, was approximately one-tenth. It was enhanced in acid solution and reached a maximum in a 0.462 M sodium chloride solution.
This paper references



This paper is referenced by
10.1007/978-1-4757-9960-6_15
Biopharmaceutical Aspects on the Intranasal Administration of Peptides
A. Harris (1986)
10.1080/107175499266823
Toxicological Implications of Nasal Formulations
M. Quadir (1999)
10.1016/0378-5173(91)90185-Q
Peptide and protein drugs: II. Non-parenteral routes of delivery
X. Zhou (1991)
10.1016/j.ijpharm.2020.119491
Just How Prevalent are Peptide Therapeutic Products? A Critical Review.
Y. Zhang (2020)
10.3109/10717544.2014.920431
Nasal-nanotechnology: revolution for efficient therapeutics delivery
A. Kumar (2016)
10.1016/0168-3659(92)90018-M
Microspheres as a nasal delivery system for peptide drugs
P. Edman (1992)
10.1371/journal.pone.0045395
Loss of the V-ATPase B1 Subunit Isoform Expressed in Non-Neuronal Cells of the Mouse Olfactory Epithelium Impairs Olfactory Function
T. G. Paunescu (2012)
10.1016/S1359-6446(02)02452-2
Permeability issues in nasal drug delivery.
P. Arora (2002)
10.1517/14712598.1.1.49
Prodrugs in nasal drug delivery
G. Tirucherai (2001)
10.18452/15128
Vergleichende Permeabilitäts- und Penetrationsstudien in vitro an Schweinekornea und Rindernasenmukosa sowie biophysikalische Untersuchungen an potentiellen Formulierungen (Mikroemulsionen)
Telse Erika Richter (2004)
NASAL VACCINE: A NOVEL APPROACH IN NASAL DRUG DELIVERY SYSTEM
S. Raut (2015)
Intranasal drug delivery system- A glimpse to become maestro
S. Upadhyay (2011)
10.1007/978-981-13-3642-3_9
Inhalation Drug Therapy: Emerging Trends in Nasal and Pulmonary Drug Delivery
M. Lalan (2019)
10.1111/j.2042-7158.1989.tb06363.x
Rectal Absorption of E‐2078 (Dynorphin Analogue Peptide) in Rats
N. Murahashi (1989)
10.22377/AJP.V2I4.203
Bioavailability of intranasal drug delivery system
S. B. Bhise (2008)
10.1016/0378-5173(91)90159-L
Nasal absorption in the rat. I: A method to demonstrate the histological effects of nasal formulations
Susan G. Chandler (1991)
10.1002/JPS.2600761206
Effect of bile salts on nasal permeability in vitro.
S. Hersey (1987)
Nasal delivery of recombinant human growth hormone with pheroid technology
J. D. Steyn (2006)
10.1111/j.2042-7158.1987.tb03131.x
Nasal administration of desmopressin by spray and drops
A. Harris (1987)
10.1080/17425247.2020.1762563
Nose-to-brain delivery of antipsychotics using nanotechnology: a review
M. S. Tan (2020)
10.1016/0378-5173(93)90167-E
Effect of absorption promoters on the nasal absorption of drugs with various molecular weights
A. Yamamoto (1993)
10.1016/0378-5173(94)00238-Z
Effects of formulation variables on nasal epithelial cell integrity: Biochemical evaluations
Chetan P. Pujara (1995)
10.1007/978-1-4757-9960-6
Delivery Systems for Peptide Drugs
S. S. Davis (1986)
10.1016/S0378-5173(99)00451-2
Chitosans as nasal absorption enhancers of peptides: comparison between free amine chitosans and soluble salts.
P. Tengamnuay (2000)
10.1002/JPS.2600751113
Intranasal administration of peptides: nasal deposition, biological response, and absorption of desmopressin.
A. Harris (1986)
10.1016/j.otohns.2003.10.007
Techniques of Intranasal Steroid Use
M. Benninger (2004)
A REVIEW ON NASAL DRUG DELIVERY SYSTEM FOR BRAIN TARGETING WITH RECENT ADVANCEMENT
Rohit Sharma (2016)
10.1111/j.2042-7158.1987.tb03398.x
The effect of molecular size on the nasal absorption of water‐soluble compounds in the albino rat
A. Fisher (1987)
10.2174/157488507779422374
Nasal Drug Delivery System-Factors Affecting and Applications
K. Jadhav (2007)
10.1023/A:1015891727080
Model of Disposition of Drugs Administered into the Human Nasal Cavity
I. Gonda (2004)
10.1007/s11094-019-01960-x
Prospects for Intranasal Delivery of Neuropeptides to the Brain
K. Shevchenko (2019)
INTRANASAL DRUG DELIVERY SYSTEM : A REVIEW
Pratikkumar A. Mistri (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar