Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effects Of Dose, PH, And Osmolarity On Nasal Absorption Of Secretin In Rats. II: Histological Aspects Of The Nasal Mucosa In Relation To The Absorption Variation Due To The Effects Of PH And Osmolarity.

T. Ohwaki, H. Ando, F. Kakimoto, K. Uesugi, S. Watanabe, Yasuo Miyake, M. Kayano
Published 1987 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Nasal absorption of secretin in rats was enhanced in an acid solution, and the maximum absorption was observed at a sodium chloride solution molarity of 0.462. In order to examine reasons for the variation of absorbability caused by the change of pH and osmolarity in secretin preparations, both a pretreatment study, in which the nasal mucosa was treated with placebo prior to the administration of a secretin preparation, and a histological study were conducted in rats. The nasal absorption of secretin was determined by measuring the increased secretin of pancreatic juice. Similar profiles of nasal absorption, both after intranasal administration of secretin preparations and as a result of pretreatment effects, were obtained in studies of the effects of pH and osmolarity. However, in the pH-effect study, the absorption with the use of active preparations was observed to be significantly larger than that with the pretreatment effect below a pH of 4.79, and significantly smaller than that with the pretreatment effect at a pH of 7 to 8. The results of histological studies revealed structural changes of the epithelial cells of the nasal mucosa at pH 2.94, and shrinkage of epithelial cells was observed at a sodium chloride solution molarity of 0.462.
This paper references
10.2337/diab.27.3.296
Nasal Absorption of Insulin in Dogs
Shin-Ichiro Hirai (1978)
10.1248/CPB.29.1470
Influence of osmotic pressure and viscosity on intestinal drug absorption. II Quinine concentration profile in plasma after oral administration of various quinine solutions to rats.
Y. Sakiya (1981)
10.1111/j.2042-7158.1979.tb13603.x
The effects of some sweetening agents and osmotic pressure on the intestinal absorption of sulfafurazole in the rat
M. Marvola (1979)
10.1111/j.1365-2265.1976.tb03827.x
A RE‐EXAMINATION OF THE CONFORMATION OF SECRETIN IN WATER
M. Bodanszky (1976)
10.1021/MA60017A612
Proton Nuclear Magnetic Resonance Study of Sccretin
D. Patel (1970)
10.1254/JJP.21.325
The bioassay of secretin in the rat.
S. Tachibana (1971)
10.1002/JPS.2600740406
Nasal delivery of polypeptides I: nasal absorption of enkephalins in rats.
K. S. Su (1985)
10.1002/JPS.2600730915
Nasal drug delivery system of a quaternary ammonium compound: clofilium tosylate.
K. S. Su (1984)
10.1136/gut.14.11.842
Inhibition by secretin of the gastric acid responses to meals and to pentagastrin in duodenal ulcer patients
S. Konturek (1973)
10.1002/JPS.2600740511
Effects of dose, pH, and osmolarity on nasal absorption of secretin in rats.
T. Ohwaki (1985)
10.1016/S0016-5085(66)80024-0
Treatment of duodenal ulcer with secretin: a speculative proposal.
M. Grossman (1966)
10.1002/JPS.2600730523
Nasal absorption of nafarelin acetate, the decapeptide [D-Nal(2)6)]LHRH, in rhesus monkeys. I.
S. T. Anik (1984)
10.1002/JPS.2600691215
Nasal absorption of propranolol from different dosage forms by rats and dogs.
A. Hussain (1980)
10.1021/JA01032A026
Synthesis of secretin. IV. Secondary structure in a miniature protein.
A. Bodanszky (1969)



This paper is referenced by
10.1023/A:1011952804479
Nasal Absorption Kinetic Behavior of Azetirelin and Its Enhancement by Acylcarnitines in Rats
S. Kagatani (2004)
Development of osmotically active liposomes for nose-to-brain drug delivery
I. Wu (2019)
10.1023/A:1015862603939
Effects of Proteolytic Enzyme Inhibitors on the Nasal Absorption of Vasopressin and an Analogue
K. Morimoto (2004)
10.1016/S0378-5173(02)00345-9
The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal mucosa.
K. Asai (2002)
10.22270/JDDT.V2I3.163
NASAL CAVITY, A PROMISING TRANSMUCOSAL PLATFORM FOR DRUG DELIVERY AND RESEARCH APPROACHES FROM NASAL TO BRAIN TARGETTING
A. Singh (2012)
10.1080/107175400455155
Development and evaluation of nasal formulations of ketorolac.
M. Quadir (2000)
10.1016/S0378-5173(03)00090-5
Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-beta-cyclodextrins.
Prapasri Sinswat (2003)
10.1016/j.ejps.2019.105026
Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes.
I. Wu (2019)
10.1371/journal.pone.0045395
Loss of the V-ATPase B1 Subunit Isoform Expressed in Non-Neuronal Cells of the Mouse Olfactory Epithelium Impairs Olfactory Function
T. G. Paunescu (2012)
10.1016/J.CARBPOL.2012.01.051
Freeze-drying of nanostructure lipid carriers by different carbohydrate polymers used as cryoprotectants
J. Varshosaz (2012)
10.1023/A:1015894910416
Effects of Viscous Hyaluronate–Sodium Solutions on the Nasal Absorption of Vasopressin and An Analogue
K. Morimoto (2004)
10.22377/AJP.V2I4.203
Bioavailability of intranasal drug delivery system
S. B. Bhise (2008)
10.1016/0378-5173(95)04115-X
Bioadhesive and formulation parameters affecting nasal absorption
P. Dondeti (1996)
10.1016/0378-5173(91)90159-L
Nasal absorption in the rat. I: A method to demonstrate the histological effects of nasal formulations
Susan G. Chandler (1991)
10.1016/0169-409X(89)90018-5
Penetration and enzymatic barriers to peptide and protein absorption
V. Lee (1989)
10.4155/TDE.12.12
Drug development of intranasally delivered peptides.
C. Campbell (2012)
INTRANASAL DRUG DELIVERY-NEW CONCEPT OF THERAPEUTIC IMPLICATIONS FOR EFFECTIVE TREATMENT OF CNS DISORDERS
M. Singh (2017)
10.1016/j.xphs.2019.03.006
The Hypotonic Environmental Changes Affect Liposomal Formulations for Nose-to-Brain Targeted Drug Delivery.
I. Wu (2019)
10.1111/vaa.12183
Comparison of intranasal and intramuscular ketamine-midazolam combination in cats.
M. Marjani (2015)
10.1080/107175400455155
Development and Evaluation of Nasal Formulations of Ketorolac
Muhammad Quadir, Hossein Zia, Thomas E. Needham (2000)
10.1016/S0378-5173(96)04750-3
In vitro nasal transport across rabbit mucosa: Effect of oxygen bubbling, pH and hypertonic pressure on permeability of lucifer yellow, diazepam and 17 β-estradiol
Y. Maitani (1997)
10.1016/0378-5173(91)90081-X
PREPARATION AND CHARACTERIZATION OF HSA - PROPRANOLOL MICROSPHERES FOR NASAL ADMINISTRATION
S. P. Vyas (1991)
10.1016/B978-0-12-384964-9.00009-8
Protein and Peptide Delivery through Respiratory Pathway
H. Tandel (2011)
10.1016/S1359-6446(02)02452-2
Permeability issues in nasal drug delivery.
P. Arora (2002)
10.1016/0378-5173(94)00238-Z
Effects of formulation variables on nasal epithelial cell integrity: Biochemical evaluations
Chetan P. Pujara (1995)
10.1016/S0378-5173(99)00442-1
Determination of baseline human nasal pH and the effect of intranasally administered buffers.
N. Washington (2000)
INTRANASAL DRUG DELIVERY SYSTEM : A REVIEW
Pratikkumar A. Mistri (2012)
10.1016/S0378-5173(99)00451-2
Chitosans as nasal absorption enhancers of peptides: comparison between free amine chitosans and soluble salts.
P. Tengamnuay (2000)
10.14232/phd.10508
DEVELOPMENT AND CHARACTERIZATION OF LORATADINE NANOSYSTEMS FOR INTRANASAL DELIVERY USING QUALITY BY DESIGN APPROACH
I. Csóka (2020)
10.1007/s12247-018-9343-z
Lamotrigine Lipid Nanoparticles for Effective Treatment of Epilepsy: a Focus on Brain Targeting via Nasal Route
Puja K. Gangurde (2018)
10.2174/157488511795304930
Pulmonary Drug Delivery System: A Novel Approach for Drug Delivery
Anupama Singh (2011)
10.1016/j.vaccine.2012.06.035
Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristics.
M. Tafaghodi (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar