← Back to Search
Preparation Of Controlled-release Microspheres Of Ibuprofen With Acrylic Polymers By A Novel Quasi-emulsion Solvent Diffusion Method.
Y. Kawashima, T. Niwa, T. Handa, H. Takeuchi, T. Iwamoto, K. Itoh
Published 1989 · Materials Science, Medicine, Chemistry
Download PDFAnalyze on Scholarcy
A novel quasi-emulsion solvent diffusion method to prepare the controlled-release microspheres of ibuprofen with acrylic polymers has been developed. An ethanol solution of ibuprofen and acrylic resin was poured into aqueous medium with stirring. The finely dispersed ethanolic droplet-like coacervates formed in aqueous medium were gradually solidified and transformed into microspheres during agitation. The size of microspheres was determined by the concentrations of drug and polymer and the agitation speed of the system. The flowability, the packability, and the compressibility of the resultant microspheres were much improved compared with the raw crystals of the drug. The drug release rate from the microspheres could be controlled by the type and the concentration of polymer formulated. A unique principle of the present method and the resultant microspheres, having a matrix- or sponge-like texture, can provide characteristic advantages compared with a conventional reservoir-type device drug, like a microcapsule.
This paper references
[Damage of the microcapsule wall during compression].
A. Hasegawa (1984)
Spherical Crystallization: Direct Spherical Agglomeration of Salicylic Acid Crystals During Crystallization
Y. Kawashima (1982)
Preparation of spherically agglomerated crystals of aminophylline.
Y. Kawashima (1984)
Formation of encapsulated hydrophilic polymer beads by combined techniques of bead polymerization and phase separation
H. Suryakusuma (1984)
[Role of metal stearates in preparation of Eudragit RS-microcapsules containing sulfamethizole by evaporation process in water phase].
S. Goto (1986)
Studies on dissolution mechanism of drugs from ethylcellulose microcapsules.
Y. Koida (1987)
MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.
T. Higuchi (1963)
Studies on microcapsules. IV. Influence of properties of drugs on microencapsulation and dissolution behavior.
Y. Koida (1986)
Microencapsulation and related drug processes
P. Deasy (1984)
Some considerations on powder compression equations
K. Kawakita (1971)
Preparations of agglomerated crystals of polymorphic mixtures and a new complex of indomethacin-epirizole by the spherical crystallization technique.
Y. Kawashima (1985)
[Effect of magnesium stearate in preparation of eudragit RS-microcapsules containing drugs].
S. Goto (1985)
The Effects of Interfacial Physical Properties on the Cohesive Forces of Moist Powder in Air and in Liquid
H. Takenaka (1981)
This paper is referenced by
Development and Preliminary In vitro Evaluation of Nanomicelles Laden In situ Gel of Dexamethasone for Ophthalmic Delivery
P. Chowdhury (2015)
Preparation of Bitter Taste Masked Ibuprofen Microspheres by Spherical Crystallization Technique and Their Tabletting
M. Kameyama (2004)
In vitro and in vivo studies of ibuprofen-loaded biodegradable alginate beads
B. Arıca (2005)
Microspheres based on herbal actives: the less-explored ways of disease treatment
S. Gupta (2015)
Hollow microspheres for use as a floating controlled drug delivery system in the stomach.
Y. Kawashima (1992)
Optimization of process variables for the preparation of ibuprofen coprecipitates with Eudragit S100
M. A. Khan (1994)
Targeted Delivery of Protein Drugs by Nanocarriers
R. Solaro (2010)
Development of a new colloidal drug carrier from chemically-modified cyclodextrins: Nanospheres and influence of physicochemical and technological factors on particle size
M. Skiba (1996)
Modelling drug delivery mechanisms for microencapsulated substances applied on textile substracts
N. Parera (2012)
MİKROSÜNGER TAŞIYICI SİSTEMLER : MICROSPONGE DELIVERY SYSTEMS
T. Çomoğlu (2000)
Studies on Mefenamic Acid Microparticles: Formulation, In Vitro Release, and In Situ Studies in Rats
F. Sevgi (2008)
Razvoj i vrednovanje dvoslojnih tableta propranolol hidroklorida
C. N. Patra (2007)
The Effect of Microfluidic Geometry for in situ Generating Monodispersed Hydrogels
C. Choi (2008)
Development and Evaluation of a Floating Multiparticulate Gastroretentive System for Modified Release of AZT
Valquíria Miwa Hanai Yoshida (2011)
Enhanced Ocular Anti-Inflammatory Activity of Ibuprofen Carried by an Eudragit RS100® Nanoparticle Suspension
C. Bucolo (2002)
Polymeric Microsphere Formulation for Colon Targeted Delivery of 5-Fluorouracil Using Biocompatible Natural Gum Katira
S. Karan (2019)
Effects of selected formulation parameters on the entrapment of diclofenac sodium in ethyl cellulose microspheres
G. Jani (1997)
Chapter 8 Polymer Nanoparticles for Smart Drug Delivery
D. Bennet (2018)
Naproxen-eudragit RS100 nanoparticles: preparation and physicochemical characterization.
Khosro Adibkia (2011)
Uniform double wall microspheres/microcapsules for protein delivery
Yujie Xia (2012)
Fabrication of electrospun poly(vinyl alcohol)/dextran nanofibers via emulsion process as drug delivery system: Kinetics and in vitro release study.
A. M. Moydeen (2018)
Physical characterization and dissolution properties of ibuprofen: Eudragit coprecipitates.
M. Kislalioglu (1991)
Preparation of sustained-release nitrendipine microspheres with Eudragit RS and Aerosil using quasi-emulsion solvent diffusion method.
M. S. Yang (2003)
A novel formulation design about water-insoluble oily drug: preparation of zedoary turmeric oil microspheres with self-emulsifying ability and evaluation in rabbits.
Jian You (2005)
Preparation and characterization of ibuprofen microspheres
N. Bolourtchian (2005)
Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges.
M. Orlu (2006)
Sustained Release Spherical Agglomerates of Tiaprofenic Acid Prepared by Quasi-emulsion Solvent Diffusion Method
Kishorkumar R. Sorathia (2016)
Solvent and plasticizer influences on ethylcellulose-microcapsules.
M. E. Palomo (1996)
Quasi-emulsion precipitation of pharmaceuticals. 1. Conditions for formation and crystal nucleation and growth behavior
X. Wang (2006)
Effect of adding non-volatile oil as a core material for the floating microspheres prepared by emulsion solvent diffusion method
J.-H. Lee, T. G. Park, Y.-B. Lee, S.-C. Shin, H.-K (2001)
“ETHYL CELLULOSE BASED MICROSPONGE DELIVERY SYSTEM FOR ANTI-FUNGAL VAGINAL GELS OF TIOCONAZOLE”
R. S. Kalkotwar (2013)
Preparation and in-vitro evaluation of sustained-release metoclopramide hydrochloride microspheres.
S. Khidr (1995)See more