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Thermosensitive Micelles Self-assembled By Novel N-isopropylacrylamide Oligomer Grafted Polyphosphazene
J. Zhang, Liyan Qiu, K. J. Zhu, Yi Jin
Published 2004 · Chemistry
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A novel thermosensitive amphiphilic copolymer of PNIPAm grafted polyphosphazene (PNIPAm-g-PPP) has been synthesized through a co-substitution reaction of poly(dichlorophosphazene) with amino terminated NIPAm oligomer and glycine ethyl ester (GlyEt). The polymer obtained had a molar ratio of 1:5.25 PNIPAm to GlyEt and had a lower critical solution temperature (LCST) near 30 °C. The formation of polymeric micelles was confirmed by fluorescence, dynamic light scattering and transmission electron microscopy measurements.
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