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Synthesis Of Poly(Alkyl Cyanoacrylates) As Biodegradable Polymers For Drug Delivery Applications

M. Dossi, G. Storti, D. Moscatelli
Published 2010 · Materials Science

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Poly(alkyl cyanoacrylates) are biodegradable and biocompatible polymers. Ethyl, n-butyl and octyl cyanoacrylate have been approved in the last decades by the US Food and Drug Administration (FDA) and novel applications are continuously appearing. Recently, such polymers have been proposed as raw materials for the synthesis of nanoparticles aimed to drug delivery. In the literature, such nanoparticles have been always produced through heterogeneous polymerization processes in water. In this work, the anionic polymerization of ethyl, n-butyl and octyl-cyanoacrylate in water is systematically investigated. Optimum conditions for the process are identified by changing reaction temperature and solution pH. It is found that an aqueous dispersion medium at pH around 5 and 6 5 °C gives the best results in terms of polymer molecular weight for all monomers, even if the process exhibits the dominant production of low molecular weight (LMW) polymer. On the other hand, the amount of high molecular weight polymer becomes noticeable at room temperature.
This paper references
10.1016/0021-9797(84)90015-8
Particle size and size distribution of poly(butyl-2-cyanoacrylate) nanoparticles: I. Influence of physicochemical factors
S. J. Douglas (1984)
10.1016/S0142-9612(00)00286-6
Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation.
N. Behan (2001)
10.1016/J.AMJSURG.2003.11.017
A review of the literature on octylcyanoacrylate tissue adhesive.
A. Singer (2004)
10.1111/j.2042-7158.1979.tb13510.x
Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties
P. Couvreur (1979)
10.1055/S-2002-35312
Cyanoacrylate glue in gastric variceal bleeding.
S. Seewald (2002)
Dominant-hemisphere arteriovenous malformations: therapeutic embolization with isobutyl-2-cyanoacrylate.
F. Viñuela (1983)
10.1007/BF00387334
Experimental osteosynthesis with liquid ethyl cyanaerylate polymerized with ultrasound
H. Forssell (2004)
10.1002/MARC.1996.030170404
Novel sub‐ceiling temperature rapid depolymerization‐repolymerization reactions of cyanoacrylate polymers
B. Ryan (1996)
10.1007/s00405-007-0454-2
The use of cyanoacrylates for wound closure in head and neck surgery
M. K. Bozkurt (2007)
10.1016/J.DET.2004.09.003
Cyanoacrylates for skin closure.
W. Eaglstein (2005)
10.1134/S181123820703006X
Cyanoacrylate-based adhesives
N. G. Senchenya (2007)
10.1046/j.1442-9071.2000.00351.x
Cyanoacrylate glue for corneal perforations: a description of a surgical technique and a review of the literature
B. Vote (2000)
10.1016/j.ajem.2007.05.015
The cyanoacrylate topical skin adhesives.
A. Singer (2008)
10.1016/J.POLYMDEGRADSTAB.2008.04.012
Synthesis and degradation behavior of poly(ethyl cyanoacrylate)
M. G. Han (2008)
10.1016/J.IJPHARM.2006.06.008
Core-shell type of nanoparticles composed of poly[(n-butyl cyanoacrylate)-co-(2-octyl cyanoacrylate)] copolymers for drug delivery application: synthesis, characterization and in vitro degradation.
C. Huang (2006)



This paper is referenced by
10.1039/C4PY01423E
Pulsed-laser and quantum mechanics study of n-butyl cyanoacrylate and methyl methacrylate free-radical copolymerization
Thomas R. Rooney (2015)
10.1007/978-94-007-1248-5_9
Poly(Alkyl Cyanoacrylate) Nanosystems
J. Nicolas (2011)
Caracterización fisicoquímica de diferentes adhesivos basados en cianoacrilato de etilo
Gabriel Estañ Cerezo (2015)
10.1016/B978-0-08-100262-9.00001-X
Introduction to bioresorbable polymers for biomedical applications
G. Pertici (2017)
10.1557/OPL.2012.1014
Microencapsulation of Liquid Cyanoacrylate via In situ Polymerization for Self-Healing
Vineela D. Gandham (2011)
10.1016/B978-1-4557-3149-7.00013-9
Chapter 13 – Cyanoacrylates
J. Fink (2013)
10.1016/J.SNB.2013.03.109
Fabrication of graphene/poly(ethyl 2-cyanoacrylate) composite electrode for amperometric detection in capillary electrophoresis
Junchao Xu (2013)
10.1080/01694243.2018.1509502
Structural and adhesion properties of poly(ethyl 2-cyanoacrylate) post-cured at different temperatures and times
G. Estan-Cerezo (2019)
Functionalised dextran nanoparticles for drug delivery to the brain
Daniel Madu Ibegbu (2015)
10.1002/MACP.201700380
HPMA‐PEG Surfmers and Their Use in Stabilizing Fully Biodegradable Polymer Nanoparticles
M. Sponchioni (2017)
10.4172/2157-7099.1000395
Comparative Effectiveness of Cyanoacrylate Bioadhesives and MonofilamentSuture in Wound Healing: A Histopathological and Physicochemical Study inNew Zealand White Rabbit
A. Angulo (2015)
10.1002/ADEM.201080088
Polymers in Drug Delivery—State of the Art and Future Trends
Stefan Grund (2011)
10.1016/j.clindermatol.2016.10.003
Understanding the role of Propionibacterium acnes in acne vulgaris: The critical importance of skin sampling methodologies.
Hélène Omer (2017)
10.1016/J.CEJ.2019.122400
Controllable polymerization of n-butyl cyanoacrylate using a high-gravity rotating packed bed
Xingzheng Liu (2020)
10.1016/J.COMPCHEMENG.2014.07.015
Identifying polymer structures for oral drug delivery - A molecular design approach
Naresh Pavurala (2014)
10.1002/chem.201101758
Facile preparation of carbon nanotube/poly(ethyl 2-cyanoacrylate) composite electrode by water-vapor-initiated polymerization for enhanced amperometric detection.
Q. Chen (2011)
10.1016/J.POLYMDEGRADSTAB.2017.08.024
Poly(α-hydroxy acid) based polymers: A review on material and degradation aspects
Kishore Ginjupalli (2017)
10.1007/978-1-4614-4328-5_5
Comparative Properties of Ethyl, n-Butyl, and n-Octyl Cyanoacrylate Bioadhesives Intended for Wound Closure
Ana María Villarreal-Gómez (2013)
10.1533/9780857096517.1.3
Types of bioresorbable polymers for medical applications
T. Casalini (2012)
10.3390/molecules23020465
Radical Polymerization of Alkyl 2-Cyanoacrylates
Cormac Duffy (2018)
10.1080/01694243.2013.852784
Use of cyanoacrylate adhesives in dermal lesions: a review
Antonio B. Martín-Ballester (2014)
10.1517/17425247.2016.1156671
Biodegradable polymers for targeted delivery of anti-cancer drugs
Sindhu Doppalapudi (2016)
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