Online citations, reference lists, and bibliographies.
← Back to Search

Severe Generalised Dystonia Associated With A Mosaic Pattern Of Striatal Gliosis

W. Gibb, L. Kilford, C. Marsden
Published 1992 · Psychology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
A mosaic pattern of striatal pathology is described in a male who developed severe generalised dystonia from the age of 10 years, and died at the age of 18 years. There was no family history of dystonia, and extensive investigations during his life failed to identify a cause for the dystonia. The caudate nucleus and putamen showed a network of cell loss and gliosis surrounding islands of preserved striatum. Dorsal parts showed confluent gliosis, and ventral parts were spared. The pattern suggested a correlation with patch‐matrix organisation, but there was no correlation with the distribution of calbindin immunoreactive cells, which are present in the matrix of the classical striosome‐matrix organisation. The pathological findings were unlike those in status marmoratus, perinatal hypoxia‐ischaemia, Huntington's disease, and neuroacanthocytosis, but similar to those reported in a 44‐year‐old man with predominantly cranial dystonia.
This paper references
10.1212/WNL.20.11_Part_2.79
Pathology of the torsion dystonias (dystonia musculorum deformans)
W. Zeman (1970)
10.1002/ANA.410270606
Selective sparing of NADPH‐diaphorase–somatostatin–neuropeptide Y neurons in ischemic gerbil striatum
Y. Uemura (1990)
Biochemical findings in symptomatic dystonias.
J. D. de Yébenes (1988)
10.1136/jnnp.33.4.457
On the problem of the pathology of spasmodic torticollis in man
E. Tarlov (1970)
10.1002/ANA.410220615
Neurological syndrome following bilateral damage to the head of the caudate nuclei
E. Richfield (1987)
10.1016/S0140-6736(71)92148-9
Neocortical death after cardiac arrest: A clinical, neurophysiological, and neuropathological report of two cases
J. Brierley (1971)
10.1136/jnnp.43.9.789
Delayed-onset dystonia in patients with "static" encephalopathy.
R. Burke (1980)
10.1016/0006-8993(90)90866-A
Calbindin D28K as a marker for the degeneration of the striatonigral pathway in Huntington's disease
H. Kiyama (1990)
10.1002/ANA.410270113
Quantitative morphological analysis of striatal cholinergic neurons in perinatal asphyxia
R. Burke (1990)
10.1136/jnnp.44.5.437
Brueghel's syndrome, report of a case with postmortem studies
E. García-Albea (1981)
10.1136/jnnp.10.1.12
ÉTAT MARBRÉ OF THE CORPUS STRIATUM FOLLOWING BIRTH INJURY
R. Norman (1947)
10.1002/MDS.870030305
Pathological report of four patients presenting with cranial dystonias
W. Gibb (1988)
10.1001/ARCHNEUR.1976.00500030052011
Delayed encephalopathy after strangling.
E. Dooling (1976)
10.1212/WNL.33.6.802
Spontaneous oral‐facial dyskinesia
P. Altrocchi (1983)
10.1002/MDS.870030209
Meige syndrome: Neuropathology of a case
J. Kulisevsky (1988)
10.1001/ARCHNEUR.1972.00490120046004
Spontaneous oral-facial dyskinesia.
P. Altrocchi (1972)
10.1002/ANA.410030312
Familial degeneration of the basal ganglia with acanthocytosis: A clinical, neuropathological, and neurochemical study
T. Bird (1978)
10.1212/WNL.38.5.702
Pathology in brainstem regions of individuals with primary dystonia
R. Zweig (1988)
10.2169/INTERNALMEDICINE1962.23.118
Neuropathological study of chorea-acanthocytosis.
M. Iwata (1984)
10.1056/NEJM199005033221807
Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease.
R. Albin (1990)
10.1056/NEJM198608073150602
Brain neurotransmitters in dystonia musculorum deformans.
O. Hornykiewicz (1986)
10.1093/BRAIN/108.2.463
The anatomical basis of symptomatic hemidystonia.
C. Marsden (1985)



This paper is referenced by
10.1212/WNL.44.5.846
Prolonged MRI T2 times of the lentiform nucleus in idiopathic spasmodic torticollis
S. Schneider (1994)
10.1002/MDS.870130611
1H Magnetic resonance spectroscopy of the lentiform nucleus in primary focal hand dystonia
M. Naumann (1998)
Neurobiology of Disease
D. A. Peterson (2010)
10.1016/S0006-8993(03)03164-0
Distribution and ultrastructural localization of torsinA immunoreactivity in the human brain
S. Augood (2003)
10.1093/BRAIN/AWF090
The genetics of primary dystonias and related disorders.
A. Nemeth (2002)
10.1002/mds.20267
A novel family with an unusual early‐onset generalized dystonia
G. Fabbrini (2005)
10.1016/S0967-5868(99)90593-3
Dystonia: recent advances
D. Thyagarajan (1999)
10.1007/978-3-7091-6472-3_35
Motorische Störungen aus neurologischer Sicht: Dystonien
M. Schwarz (1998)
10.1016/S0006-8993(99)02232-5
Immunohistochemical localization and distribution of torsinA in normal human and rat brain
P. Shashidharan (2000)
10.3109/9781420019988.003
Genetic Evaluation in Primary Dystonia
C. Klein (2006)
10.1016/B978-0-444-52014-2.00037-9
Adult-onset dystonia.
M. Evatt (2011)
10.1007/978-3-7091-9415-7_112
Verlängerte T2-Zeiten des Nucleus Lentiformis bei idiopathischem Torticollis Spasmodicus im Hochfeld-MRT
S. Schneider (1995)
10.1212/WNL.47.5.1284
Lenticular nucleus lesion in idiopathic dystonia detected by transcranial sonography
M. Naumann (1996)
10.1002/MDS.870130218
Increased activation of frontal areas during arm movement in idiopathic torsion dystonia
E. Diane Playford (1998)
10.1002/1531-8249(199911)46:5<761::AID-ANA12>3.0.CO;2-Z
Distribution of the mRNAs encoding torsinA and torsinB in the normal adult human brain
S. Augood (1999)
10.1016/B978-0-12-802206-1.00047-7
Pathophysiology of dystonia.
M. Hallett (1998)
10.1007/s00401-002-0609-6
Clinico-pathological study of a case of familial parkinsonism with striatal degeneration
M. Sakai (2002)
10.1016/S0035-3787(04)71031-0
Athétose ou dystonie
F. Turny (2004)
10.1007/s11910-011-0202-2
Differential Diagnosis of Chorea
R. Walker (2011)
10.1016/B978-1-4377-2369-4.00012-3
Chapter 12 – Dystonia: Phenomenology, classification, etiology, pathology, biochemistry, and genetics
S. Fahn (2011)
10.1016/S0193-953X(05)70347-6
Dystonia and dyskinesia.
F. Cardoso (1997)
10.1016/S1353-8020(02)00031-7
The role of anatomical pathology in understanding human movement disorders.
C. Robinson (2002)
10.1007/978-1-4613-0485-2_3
Myeloarchitectonics of the Primate Caudate-Putamen
Bruce Quinn (1994)
10.1007/s100480050025
Clinical and molecular genetics of primary dystonias
U. Müller (1998)
10.1034/j.1600-0404.2000.90339.x
Elevated plasma levels of homocysteine in dystonia
T. Müller (2000)
10.1002/MDS.870080328
Neuropathology of lubag (x‐linked dystonia parkinsonism)
C. Waters (1993)
10.1002/MDS.870130217
X‐linked dystonia‐deafness syndrome
M. Hayes (1998)
10.3389/fncir.2016.00090
Contribution of TMS and rTMS in the Understanding of the Pathophysiology and in the Treatment of Dystonia
P. Lozeron (2016)
10.1002/ANA.410370313
Overactive prefrontal and underactive motor cortical areas in idiopathic dystonia
A. O. Ceballos-Baumann (1995)
10.1177/19714009980110S204
Proton Magnetic Resonance Spectroscopy of the Basal Ganglia in Idiopathic Focal Hand Dystonia
M. Warmuth-Metz (1998)
10.1016/S1474-4422(04)00905-6
PINK, PANK, or PARK? A clinicians' guide to familial parkinsonism
D. Healy (2004)
10.1016/j.nicl.2017.10.011
Loss of inhibition in sensorimotor networks in focal hand dystonia
C. Gallea (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar