Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Aging Rat Neuromuscular Junnctions: A Morphometric Study Of Cholinesterase‐stained Whole Mounts And Ultrastructure

C. Cardasis, D. M. Lafontaine
Published 1987 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Previous morphological studies of the adult rat soleus neuromuscular junction (NMJ) indicate that its ultrastructure changes with age, a consequence of a dynamic, ongoing remodeling of pre‐ and postsynaptic elements. With aging, the balance between axonal sprouting and withdrawal appears to shift in favor of denervation. Here we have examined the extent and direction of the remodeling process during the adult life of the rat (5–111 weeks) by quantificatation and morphometry of NMJ structure as seen in electron microscopic composites and in cholinesterase (ChE) stained whole mounts.
This paper references
10.7326/0003-4819-79-4-620_1
Age changes in the neuromuscular system
E. Gutmann (1972)
10.1016/0014-4886(81)90257-0
Axonal sprouting at the neuromuscular junction of adult and aged rats
G. Fagg (1981)
10.1007/BF01181582
Precision of reinnervation of original postsynaptic sites in frog muscle after a nerve crush
M. S. Letinsky (1976)
10.1177/12.3.219
A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES
M. Karnovsky (1964)
10.1016/0165-3806(84)90084-1
Synaptic remodelling during development and maturation: junction differentiation and splitting as a mechanism for modifying connectivity.
S. Dyson (1984)
10.1152/JN.1982.48.1.100
Decreased sprouting and degeneration of nerve terminals of active muscles in aged rats.
D. O. Smith (1982)
10.1002/AR.1092000105
Ultrastructural evidence indicating reorganization at the neuromuscular junction in the normal rat soleus muscle
C. Cardasis (1981)
10.1016/0306-4522(83)90187-2
Muscle reinnervation—I. Restoration of transmitter release mechanisms
G. Carmignoto (1983)
10.1113/jphysiol.1981.sp013960
Age changes in neuromuscular junction morphology and acetylcholine receptor distribution on rat skeletal muscle fibres.
J. Courtney (1981)
10.1016/0022-510X(84)90021-2
Age changes of motor innervation and acetylcholine receptor distribution on human skeletal muscle fibres
K. Oda (1984)
10.1007/BF01181538
Sprouting and regression of the nerve at the frog neuromuscular junction in normal conditions and after prolonged paralysis with curare
A. Wernig (1980)
10.1016/0014-4886(80)90006-0
Effects of aging on nerve sprouting and regeneration
A. Pestronk (1980)
10.1098/rspb.1966.0008
Sprouting and degeneration of mammalian motor axons in normal and de-afferentated skeletal muscle
D. Barker (1966)
10.1159/000211462
Age Changes of Motor Endplates in Muscle Fibres of the Rat
E. Gutmann (1965)
10.1113/jphysiol.1984.sp015207
Light and electron microscopic identification of nerve terminal sprouting and retraction in normal adult frog muscle.
A. Anzil (1984)
10.1016/0022-510X(76)90001-0
Adaptive transformation of rat soleus motor units during growth: Histochemistry and contraction speed
E. Kugelberg (1976)
10.1007/BF01148085
Scanning and light microscopic study of age changes at a neuromuscular junction in the mouse
M. A. Fahim (1983)
10.1083/JCB.11.3.729
SIMPLE METHODS FOR "STAINING WITH LEAD" AT HIGH pH IN ELECTRON MICROSCOPY
M. Karnovsky (1961)
10.1002/AR.1092070303
Ultrastructural evidence of continued reorganization at the aging (11–26 months) rat soleus neuromuscular junction
C. Cardasis (1983)
10.1007/BF01262429
Ultrastructural studies of young and old mouse neuromuscular junctions
M. A. Fahim (1982)
Growth and degeneration of motor end-plates in normal cat hind limb muscles.
Tuffery Ar (1971)
10.1016/0306-4522(84)90227-6
Persistence of nerve sprouting with features of synapse remodelling in soleus muscles of adult mice
A. Wernig (1984)



This paper is referenced by
10.1152/JAPPL.1997.83.1.59
Endurance exercise modulates neuromuscular junction of C57BL/6NNia aging mice.
M. Fahim (1997)
10.1002/CNE.903210406
Progressive morphological abnormalities observed in rat spinal motor neurons at extended intervals after axonal regeneration
C. Bowe (1992)
10.1016/0896-6273(89)90236-5
Motor nerve terminal loss from degenerating muscle fibers
M. Rich (1989)
10.1016/S0072-9752(07)01502-3
Reliability of neuromuscular transmission and how it is maintained.
C. Slater (2008)
Progressive die-back and death of motoneurons in a transgenic mouse model of amyotrophic lateral sclerosis
T. Gordon (2005)
10.1002/cne.22764
Active zone density is conserved during synaptic growth but impaired in aged mice
J. Chen (2012)
10.1371/journal.pone.0093140
The Role of Muscle microRNAs in Repairing the Neuromuscular Junction
Gregorio Valdez (2014)
10.1016/0306-4522(90)90069-G
Ultraterminal sprouting in innervated and partially denervated adult and aged rat muscle
J. Rosenheimer (1990)
10.1007/BF01474549
Reorganization of intrinsic components in the distal motor axon during outgrowth
K. Alderson (1989)
10.1002/MUS.880121206
Denervated single myofibers: Neurite interactions and synaptic molecules
J. C. Jay (1989)
10.1016/j.resp.2015.10.001
Functional impact of sarcopenia in respiratory muscles
Jonathan E Elliott (2016)
10.1016/0022-510X(90)90138-D
Quantitative and qualitative morphological properties of the soleus motor nerve and the L5 ventral root in young and old rats: Relation to the number of soleus muscle fibres
T. Ansved (1990)
10.1007/s10741-016-9549-4
Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology
Rachel C. Kelley (2016)
10.1152/PHYSIOLGENOMICS.00210.2004
Comparison of gene expression of 2-mo denervated, 2-mo stimulated-denervated, and control rat skeletal muscles.
T. Kostrominova (2005)
10.1111/J.1439-0442.1990.TB00914.X
Neuromuscular transmission in the gastrocnemius muscle of young domestic and wild pigs.
L. Szentkuti (1990)
10.1016/S1569-2590(08)60179-2
Remodeling and Elimination of Neuromuscular Synapses
A. Herrera (1997)
10.1073/pnas.1002220107
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise
G. Valdez (2010)
10.1016/S0248-4900(99)80078-1
Physiological activity‐dependent ultrastructural plasticity in normal adult rat neuromuscular junctions
J. Tomas (1997)
10.1016/B978-012088387-5/50020-0
Differential Aging Among Skeletal Muscles
R. McCarter (2005)
10.1016/S0301-0082(00)00055-1
Safety factor at the neuromuscular junction
S. J. Wood (2001)
10.1002/(SICI)1097-4598(199903)22:3<307::AID-MUS3>3.0.CO;2-M
Inactivity‐induced remodeling of neuromuscular junctions in rat diaphragmatic muscle
Y. Prakash (1999)
10.1016/j.exger.2018.01.021
Age-related remodelling of the myotendinous junction in the mouse soleus muscle
K. Nielsen (2018)
10.1016/0047-6374(89)90100-0
Maintenance of neurite contacts at junctional regions of cultured individual muscle fibers from aged rats is correlated with the presence of a synapse-associated protein, gelasmin
J. C. Jay (1989)
10.1093/GERONA/51A.2.B117
Complexity of age-related change in skeletal muscle.
M. Brown (1996)
10.1186/2046-2395-2-13
Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses
G. Gouspillou (2013)
10.1080/09553009214551301
Effect of ionizing radiation on neuromuscular junctions in mouse tongues.
R. Gorodetsky (1992)
10.1016/S0065-1281(11)80372-7
Variations of collateral branching in the motor nerve fibers in the skeletal muscle of adult rats.
M. Kawabuchi (1993)
Effects of Beta-Hydroxy-Beta-Methylbutyrate (HMB) on Body Composition, Functionality, MR-Determined Myofiber Dimensions, and Transcript Factors Inovolved in Myofiber Growth in Young and Old Fisher 344 Rats
J. Wilson (2010)
Muscle loss in aging population
M. Nikolić (2013)
10.1002/AR.1092230209
Perisynaptic satellite cells in human external intercostal muscle: A quantitative and qualitative study
J. Wokke (1989)
MYOSIN LIGHT CHAIN 1 ISOFORM EXPRESSION REMAINS CONSTANT
Andrea L. Dunathan (1991)
10.1179/016164104225013806
Adaptive and maladaptive motor axonal sprouting in aging and motoneuron disease
T. Gordon (2004)
See more
Semantic Scholar Logo Some data provided by SemanticScholar