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Preparation And Properties Of Ionically Cross‐linked Chitosan Nanoparticles
H. Liu, C. Gao
Published 2009 · Materials Science
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Chitosan nanoparticles were fabricated by a method of tripolyphosphate (TPP) cross-linking. The influence of fabrication conditions on the physical properties and drug loading and release properties was investigated by transmission electron microscopy (TEM), dynamic light scattering (DLS), and UV–vis spectroscopy. The nanoparticles could be prepared only within a zone of appropriate chitosan and TPP concentrations. The particle size and surface zeta potential can be manipulated by variation of the fabrication conditions such as chitosan/TPP ratio and concentration, solution pH and salt addition. TEM observation revealed a core–shell structure for the as-prepared nanoparticles, but a filled structure for the ciprofloxacin (CH) loaded particles. Results show that the chitosan nanoparticles were rather stable and no cytotoxicity of the chitosan nanoparticles was found in an in vitro cell culture experiment. Loading and release of CH can be modulated by the environmental factors such as solution pH and medium quality. Copyright © 2008 John Wiley & Sons, Ltd.
This paper references
Chitosan nanoparticles as delivery systems for doxorubicin.
K. Janes (2001)
Novel method for the preparation of controlled-release theophylline granules coated with a polyelectrolyte complex of sodium polyphosphate-chitosan.
Y. Kawashima (1985)
Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines
P. Calvo (2004)
Influence of ultrasonic stimulation on the growth and proliferation of Oryza sativa Nipponbare callus cells
Yiyao Liu (2003)
Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres
I. Genta (1998)
Novel hydrophilic chitosan‐polyethylene oxide nanoparticles as protein carriers
P. Calvo (1997)
Preparation and characterization of chitosan microparticles intended for controlled drug delivery.
J. A. Ko (2002)
Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo.
Yan Pan (2002)
Chitosan/β-lactoglobulin core–shell nanoparticles as nutraceutical carriers
L. Chen (2005)
Chitosan microspheres prepared by spray drying.
P. He (1999)
Controlled release of indomethacin by chitosan-polyelectrolyte complex: optimization and in vivo/in vitro evaluation
S. Shiraishi (1993)
Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior.
T. López-León (2005)
Preformed microcapsules for loading and sustained release of ciprofloxacin hydrochloride.
Z. Mao (2005)
The effects of thickness and hardness of the coating film on the drug release rate of theophylline granules coated with chitosan-sodium tripolyphosphate complex.
Y. Kawashima (1985)
Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery.
Quan Gan (2005)
A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery.
X. Shu (2000)
Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.
J. Berger (2004)
Design of biodegradable particles for protein delivery.
A. Vila (2002)
Chitosan beads for the delivery of salmon calcitonin : preparation and release characteristics
Z. Aydin (1996)
Cross‐linked Chitosan Microspheres: Preparation and Evaluation as a Matrix for the Controlled Release of Pharmaceuticals
B. C. Thanoo (1992)
Effects of preparative parameters on the properties of chitosan hydrogel beads containing Candida rugosa lipase.
I. Alsarra (2004)
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Nanodispersion-loaded mucoadhesive polymeric inserts for prolonged treatment of post-operative ocular inflammation
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M. Kotb (2018)
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D. Honarmand (2016)
Development and Characterization of Chitosan Cross-Linked With Tripolyphosphate as a Sustained Release Agent in Tablets, Part I: Design of Experiments and Optimization.
C. A. Pinto (2018)
Surface-modified solid lipid nanoparticulate formulation for ifosfamide: development and characterization.
A. A. Pandit (2011)
A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles.
Y. Wang (2010)
Nanoparticle preparation and characterization of Haruan fish ( Channa striata ) exctract contains albumin from south Kalimantan with ionic gelation method
D. Rahmawanty (2017)
Optimization of production parameters for fabrication of thymol-loaded chitosan nanoparticles.
M. A. Çakır (2020)
Formulation development and characterization of silybin loaded nanoparticles
S. Anandam (2016)
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A. I. Flores-Rojas (2020)
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K. Konecsni (2011)
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U. A. Hassan (2017)
Zeolite molecular sieve 5A acts as a reinforcing filler, altering the morphological, mechanical, and thermal properties of chitosan
A. Ghosh (2013)
Physicochemical and morphological properties of size-controlled chitosan–tripolyphosphate nanoparticles
J. Antoniou (2015)
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