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Microwave-assisted Aza-Baylis-Hillman Reaction. Preparation Of Poly(ethylene Glycol) Supported α-methylene-β-Aminoester

P. Ribière, N. Yadav-Bhatnagar, Jean Martínez, F. Lamaty
Published 2004 · Chemistry

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The aza-Baylis Hillman is a practical method for the preparation of a-methylene-β-aminoesters. A soluble polymer supported version of this reaction has been developed. The reaction was shown to proceed in the absence of solvent under microwave activation. In the presence of 3-hydroxyquinuclidine, the reaction time was reduced from 3-12 h under thermal conditions to 30 min under microwave irradiation. A small library of PEG-supported aminoesters was generated.
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