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N‐Acylbenzotriazole As Efficient Ligand In Copper‐Catalyzed O‐Arylation Leading To Diverse Benzoxazoles

Anoop S. Singh, M. Singh, N. Mishra, S. Mishra, A. K. Agrahari, V. K. Tiwari
Published 2017 · Chemistry

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An establishment of (1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)methanone as ligand was attained in intramolecular C-O cross-coupling of N-(2-halophenyl)aryl/alkylamide derivatives to form 2-Aryl/alkyl benzoxazole derivatives using CuI/K2CO3 as catalytic system. A series of benzoxazoles was developed using this protocol and synthesized compounds were characterized using spectroscopic analysis (IR, MS, 1H & 13C NMR). Salient advantages associated with this pathway include easily available starting materials, cheap catalyst, highly stable ligand, wide substrate scope, smooth reaction, easy work-up and high product yield.
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