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Ectodermal And Mesodermal Cell Death Patterns In 6-mercaptopurine Riboside-induced Digital Deformities.

W. J. Scott, E. Ritter, J. Wilson
Published 1980 · Biology, Medicine

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Intravenous injection of 5–20 mg/kg of 6-mercaptopurine riboside on the 11th day of rat gestation resulted in a high percentage of preaxial polydactyly of the hindlimb. The pathogenesis of this deformity was similar to that of other polydactyly-inducing drugs such as cytosine arabinoside and 5-fluorodeoxyuridine. Following drug induced cell death in the limb bud mesoderm, the normal pattern of physiological necrosis in the apical ectodermal ridge was disrupted. Subsequently, a zone of physiological necrosis within the preaxial mesoderm thought to be instrumental in controlling preaxial digitation was abolished. A speculative causal connection between these events is discussed.
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