Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Molecular Understanding And Design Of Zwitterionic Materials.

Q. Shao, S. Jiang
Published 2015 · Materials Science, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Zwitterionic materials have moieties possessing cationic and anionic groups. This molecular structure leads to unique properties that can be the solutions of various application problems. A typical example is that zwitterionic carboxybetaine (CB) and sulfobetaine (SB) materials resist nonspecific protein adsorption in complex media. Considering the vast number of cationic and anionic groups in the current chemical inventory, there are many possible structural variations of zwitterionic materials. The diversified structures provide the possibility to achieve many desired properties and urge a better understanding of zwitterionic materials to provide design principles. Molecular simulations and modeling are a versatile tool to understand the structure-property relationships of materials at the molecular level. This progress report summarizes recent simulation and modeling studies addressing two fundamental questions regarding zwitterionic materials and their applications as biomaterials. First, what are the differences between zwitterionic and nonionic materials? Second, what are the differences among zwitterionic materials? This report also demonstrates a molecular design of new protein-resistant zwitterionic moieties beyond conventional CB and SB based on design principles developed from these simulation studies.
This paper references
10.1021/JA054169U
Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials.
S. Chen (2005)
10.1021/jp3094534
Effect of carbon spacer length on zwitterionic carboxybetaines.
Q. Shao (2013)
10.1016/J.NANTOD.2014.02.004
Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production
W. Yang (2014)
10.1016/j.colsurfb.2013.08.051
Structure of water at zwitterionic copolymer film-liquid water interfaces as examined by the sum frequency generation method.
Takuya Kondo (2014)
10.1073/PNAS.0308633101
Counteraction of urea-induced protein denaturation by trimethylamine N-oxide: a chemical chaperone at atomic resolution.
B. Bennion (2004)
10.1002/adma.200901407
Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications.
S. Jiang (2010)
10.1529/BIOPHYSJ.105.059428
Strong repulsive forces between protein and oligo (ethylene glycol) self-assembled monolayers: a molecular simulation study.
J. Zheng (2005)
10.1021/cr2003272
Carbon dioxide capture in metal-organic frameworks.
K. Sumida (2012)
10.1021/BI036274R
Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins.
S. Jayaraman (2004)
10.1021/la9015788
Pursuing "zero" protein adsorption of poly(carboxybetaine) from undiluted blood serum and plasma.
W. Yang (2009)
10.1016/J.APSUSC.2012.05.013
Molecular dynamics simulations of peptide adsorption on self-assembled monolayers
Y. Xie (2012)
10.1038/nature11475
Opportunities and challenges for a sustainable energy future
S. Chu (2012)
10.1021/jp503473u
Differences in cationic and anionic charge densities dictate zwitterionic associations and stimuli responses.
Q. Shao (2014)
10.1002/anie.201304060
Integrated antimicrobial and nonfouling zwitterionic polymers.
L. Mi (2014)
10.1038/nmat3568
The high-throughput highway to computational materials design.
S. Curtarolo (2013)
10.1163/1568562041271093
Platelet adhesion to radiofrequency glow-discharge-deposited fluorocarbon polymers preadsorbed with selectively depleted plasmas show the primary role of fibrinogen
W. Tsai (2004)
10.1021/jp410224w
Difference of carboxybetaine and oligo(ethylene glycol) moieties in altering hydrophobic interactions: a molecular simulation study.
Q. Shao (2014)
10.1021/LA00053A008
Effect of the intramolecular charge separation distance on the solution properties of betaines and sulfobetaines
J. Weers (1991)
10.1021/ac8015888
Ultralow fouling and functionalizable surface chemistry based on a zwitterionic polymer enabling sensitive and specific protein detection in undiluted blood plasma.
Hana Vaisocherová (2008)
10.1021/la500057j
Zwitteration: Coating Surfaces with Zwitterionic Functionality to Reduce Nonspecific Adsorption
J. Schlenoff (2014)
10.1038/nchem.1213
Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity.
Andrew J. Keefe (2011)
10.1039/C3SC52233D
Reversibly switchable polymer with cationic/zwitterionic/anionic behavior through synergistic protonation and deprotonation
Harihara S. Sundaram (2014)
10.1021/JA01160A532
SYNTHETIC ELECTRICAL ANALOG OF PROTEINS1
T. Alfrey (1950)
10.1021/jp204046f
Molecular dynamics simulation study of ion interactions with zwitterions.
Q. Shao (2011)
10.2165/00063030-200822050-00004
The Impact of PEGylation on Biological Therapies
F. Veronese (2012)
10.1016/S0142-9612(99)00052-6
Modification of polysulfone with phospholipid polymer for improvement of the blood compatibility. Part 1. Surface characterization.
K. Ishihara (1999)
10.1016/j.biomaterials.2011.11.071
Divalent cation-mediated polysaccharide interactions with zwitterionic surfaces.
L. Mi (2012)
10.1002/anie.201400546
Protein interactions with polymer coatings and biomaterials.
Q. Wei (2014)
10.1016/J.NANTOD.2012.08.001
Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles
Z. Cao (2012)
10.1021/bm301335r
Two-layer architecture using atom transfer radical polymerization for enhanced sensing and detection in complex media.
Norman D. Brault (2012)
10.1021/jp1067654
Local and bulk hydration of zwitterionic glycine and its analogues through molecular simulations.
A. White (2011)
10.1021/CR020371T
Synthesis and solution properties of zwitterionic polymers.
A. B. Lowe (2002)
10.1021/jp107272n
Difference in hydration between carboxybetaine and sulfobetaine.
Q. Shao (2010)
10.1021/jp409326f
Mesoscopic coarse-grained simulations of lysozyme adsorption.
G. Yu (2014)
10.1063/1.3216107
Theory of polyzwitterion conformations
R. Kumar (2009)
10.1021/jp5027114
Influence of Charged Groups on the Properties of Zwitterionic Moieties: A Molecular Simulation Study.
Q. Shao (2014)
10.1021/cr200217c
Review and analysis of molecular simulations of methane, hydrogen, and acetylene storage in metal-organic frameworks.
Rachel B Getman (2012)
10.1038/258043A0
Mammalian plasma membranes
M. Bretscher (1975)
10.1021/LA020737X
Kosmotropes Form the Basis of Protein-Resistant Surfaces
R. Kane (2003)
10.1039/C2SC21135A
Decoding nonspecific interactions from nature
A. D. White (2012)
10.1038/nmat3776
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
10.1002/ANIE.200503264
UCST wetting transitions of polyzwitterionic brushes driven by self-association.
O. Azzaroni (2006)
10.1021/la8013046
Molecular simulation studies of protein interactions with zwitterionic phosphorylcholine self-assembled monolayers in the presence of water.
Yi He (2008)
10.1063/1.4726135
Different effects of zwitterion and ethylene glycol on proteins.
Q. Shao (2012)
10.1002/ADMA.200701164
An New Avenue to Nonfouling Materials
S. Chen (2008)
10.1038/nbt.2580
Zwitterionic hydrogels implanted in mice resist the foreign-body reaction
Lei Zhang (2013)
10.1016/j.bios.2010.10.031
Zwitterionic poly(carboxybetaine) hydrogels for glucose biosensors in complex media.
W. Yang (2011)
10.1021/bm701301s
Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma.
J. Ladd (2008)
10.1038/nrm2330
Membrane lipids: where they are and how they behave
G. V. Meer (2008)
10.1021/bm3001217
Dry film refractive index as an important parameter for ultra-low fouling surface coatings.
Norman D. Brault (2012)
10.2174/0929867043363929
Free energy of ligand binding to protein: evaluation of the contribution of water molecules by computational methods.
P. Cozzini (2004)
10.1016/0032-3861(86)90269-7
Phase behaviour and solution properties of sulphobetaine polymers
D. Schulz (1986)
10.1073/pnas.0605504103
The role of hydrophobic interactions in initiation and propagation of protein folding
H. Dyson (2006)
10.1021/jp300205m
Improved mechanical properties of zwitterionic hydrogels with hydroxyl groups.
Yi He (2012)
10.1021/jp809782z
Ion pairing in molecular simulations of aqueous alkali halide solutions.
C. Fennell (2009)
10.1242/jeb.01730
Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses
P. Yancey (2005)



This paper is referenced by
10.1021/acs.jpcb.6b11540
Ion-Specific Modulation of Interfacial Interaction Potentials between Solid Substrates and Cell-Sized Particles Mediated via Zwitterionic, Super-Hydrophilic Poly(sulfobetaine) Brushes.
Y. Higaki (2017)
10.1002/jcc.26090
MDMS: Software Facilitating Performing Molecular Dynamics Simulations
S. Żaczek (2020)
10.1016/J.SNB.2017.11.047
Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment
Lihua Lu (2018)
10.1016/J.MEMSCI.2017.06.091
Constructing zwitterionic surface of nanofiltration membrane for high flux and antifouling performance
Yifang Mi (2017)
10.1039/C7TA03513F
One-pot synthesis of silica–titania binary nanoparticles with acid–base pairs via biomimetic mineralization to fabricate highly proton-conductive membranes
Yongheng Yin (2017)
10.1021/acs.langmuir.7b02024
Molecular Interactions of Protein with TiO2 by the AFM-Measured Adhesion Force.
Yihui Dong (2017)
10.1016/J.IJHYDENE.2016.08.048
Proton conductive and low methanol permeable PVA-based zwitterionic membranes
L. Gao (2016)
10.1039/C5TA09209D
Self-healing fluoropolymer brushes as highly polymer-repellent coatings
Zhanhua Wang (2016)
10.3390/polym12061303
Zwitterionic Polymer Brush Grafted on Polyvinylidene Difluoride Membrane Promoting Enhanced Ultrafiltration Performance with Augmented Antifouling Property
Y. Chiao (2020)
Biocompatible zwitterionic polymer chemistries and hydrogels for gene therapy, drug delivery, and regenerative medicine
A. Sinclair (2016)
10.1016/j.cjche.2020.05.035
Design and regulation of the surface and interfacial behavior of protein molecules
Qianqian Hou (2020)
10.1016/j.jddst.2020.101636
Progress and perspectives on nanoplatforms for drug delivery to the brain
Y. Xu (2020)
10.1016/j.jiec.2020.03.003
Incorporation of carboxybetaine methacrylate into poly(methyl methacrylate) to prevent multi-species biofilm formation
Jie Jin (2020)
10.1177/0885328220935381
The effect of zwitterionic surface content on blood circulation time of nanocapsule
X. Han (2020)
10.3390/jfb10040056
Understanding the Role of Shape and Composition of Star-Shaped Polymers and their Ability to Both Bind and Prevent Bacteria Attachment on Oral Relevant Surfaces
Hamid Mortazavian (2019)
10.1021/acsami.5b06500
Superior Antifouling Performance of a Zwitterionic Peptide Compared to an Amphiphilic, Non-Ionic Peptide.
Huijun Ye (2015)
10.1039/C8TB01863D
Dual water-healable zwitterionic polymer coatings for anti-biofouling surfaces.
Zhanhua Wang (2018)
10.1002/adma.201904337
Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management.
Da Huo (2019)
10.1002/APP.47637
Outstanding antifouling performance of poly(vinylidene fluoride) membranes: Novel amphiphilic brushlike copolymer blends and one‐step surface zwitterionization
Jianxiu Wang (2019)
10.1016/j.actbio.2016.03.038
Zwitterionic materials for antifouling membrane surface construction.
Mingrui He (2016)
10.1021/acs.langmuir.6b00990
Functionalization of Polydopamine via the Aza-Michael Reaction for Antimicrobial Interfaces.
Chia-yu Liu (2016)
10.1002/adma.201803087
Self-Healing Zwitterionic Microgels as a Versatile Platform for Malleable Cell Constructs and Injectable Therapies.
A. Sinclair (2018)
10.1252/JCEJ.16WE373
Molecular Dynamics Study of the Correlation between the Solvation Structures and the Antifouling Properties of Three Types of Betaine Moieties
Ryo Nagumo (2017)
10.1016/j.eurpolymj.2020.109704
Effect of end-groups on sulfobetaine homopolymers with the tunable upper critical solution temperature (UCST)
Z. Li (2020)
10.1002/aic.16812
Ultrafast water‐selective permeation through graphene oxide membrane with water transport promoters
F. Liang (2020)
10.3389/fchem.2020.00165
Interplays of Interfacial Forces Modulate Structure and Function of Soft and Biological Matters in Aquatic Environments
M. Tanaka (2020)
10.1021/acs.jpcb.6b10355
Establishment of a Physical Model for Solute Diffusion in Hydrogel: Understanding the Diffusion of Proteins in Poly(sulfobetaine methacrylate) Hydrogel.
Yu-hang Zhou (2017)
10.1021/acsami.7b09725
Highly Specific Binding on Antifouling Zwitterionic Polymer-Coated Microbeads as Measured by Flow Cytometry
E. van Andel (2017)
10.1002/ANGE.201704832
Hoch fluoreszierende Pyridiniumbetaine für die Lichtsammlung
J. Xu (2017)
10.1002/anie.201710068
Mitigation of Inflammatory Immune Responses with Hydrophilic Nanoparticles.
B. Li (2018)
10.1039/C7RA13238G
A novel biocompatible zwitterionic polyurethane with AIE effect for cell imaging in living cells
Junhuai Xu (2018)
10.1021/la504907m
Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs.
S. H. Ye (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar