Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Molecular Understanding And Design Of Zwitterionic Materials.
Q. Shao, S. Jiang
Published 2015 · Materials Science, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Zwitterionic materials have moieties possessing cationic and anionic groups. This molecular structure leads to unique properties that can be the solutions of various application problems. A typical example is that zwitterionic carboxybetaine (CB) and sulfobetaine (SB) materials resist nonspecific protein adsorption in complex media. Considering the vast number of cationic and anionic groups in the current chemical inventory, there are many possible structural variations of zwitterionic materials. The diversified structures provide the possibility to achieve many desired properties and urge a better understanding of zwitterionic materials to provide design principles. Molecular simulations and modeling are a versatile tool to understand the structure-property relationships of materials at the molecular level. This progress report summarizes recent simulation and modeling studies addressing two fundamental questions regarding zwitterionic materials and their applications as biomaterials. First, what are the differences between zwitterionic and nonionic materials? Second, what are the differences among zwitterionic materials? This report also demonstrates a molecular design of new protein-resistant zwitterionic moieties beyond conventional CB and SB based on design principles developed from these simulation studies.
This paper references
Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials.
S. Chen (2005)
Effect of carbon spacer length on zwitterionic carboxybetaines.
Q. Shao (2013)
Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production
W. Yang (2014)
Structure of water at zwitterionic copolymer film-liquid water interfaces as examined by the sum frequency generation method.
Takuya Kondo (2014)
Counteraction of urea-induced protein denaturation by trimethylamine N-oxide: a chemical chaperone at atomic resolution.
B. Bennion (2004)
Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications.
S. Jiang (2010)
Strong repulsive forces between protein and oligo (ethylene glycol) self-assembled monolayers: a molecular simulation study.
J. Zheng (2005)
Carbon dioxide capture in metal-organic frameworks.
K. Sumida (2012)
Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins.
S. Jayaraman (2004)
Pursuing "zero" protein adsorption of poly(carboxybetaine) from undiluted blood serum and plasma.
W. Yang (2009)
Molecular dynamics simulations of peptide adsorption on self-assembled monolayers
Y. Xie (2012)
Opportunities and challenges for a sustainable energy future
S. Chu (2012)
Differences in cationic and anionic charge densities dictate zwitterionic associations and stimuli responses.
Q. Shao (2014)
Integrated antimicrobial and nonfouling zwitterionic polymers.
L. Mi (2014)
The high-throughput highway to computational materials design.
S. Curtarolo (2013)
Platelet adhesion to radiofrequency glow-discharge-deposited fluorocarbon polymers preadsorbed with selectively depleted plasmas show the primary role of fibrinogen
W. Tsai (2004)
Difference of carboxybetaine and oligo(ethylene glycol) moieties in altering hydrophobic interactions: a molecular simulation study.
Q. Shao (2014)
Effect of the intramolecular charge separation distance on the solution properties of betaines and sulfobetaines
J. Weers (1991)
Ultralow fouling and functionalizable surface chemistry based on a zwitterionic polymer enabling sensitive and specific protein detection in undiluted blood plasma.
Hana Vaisocherová (2008)
Zwitteration: Coating Surfaces with Zwitterionic Functionality to Reduce Nonspecific Adsorption
J. Schlenoff (2014)
Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity.
Andrew J. Keefe (2011)
Reversibly switchable polymer with cationic/zwitterionic/anionic behavior through synergistic protonation and deprotonation
Harihara S. Sundaram (2014)
SYNTHETIC ELECTRICAL ANALOG OF PROTEINS1
T. Alfrey (1950)
Molecular dynamics simulation study of ion interactions with zwitterions.
Q. Shao (2011)
The Impact of PEGylation on Biological Therapies
F. Veronese (2012)
Modification of polysulfone with phospholipid polymer for improvement of the blood compatibility. Part 1. Surface characterization.
K. Ishihara (1999)
Divalent cation-mediated polysaccharide interactions with zwitterionic surfaces.
L. Mi (2012)
Protein interactions with polymer coatings and biomaterials.
Q. Wei (2014)
Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles
Z. Cao (2012)
Two-layer architecture using atom transfer radical polymerization for enhanced sensing and detection in complex media.
Norman D. Brault (2012)
Local and bulk hydration of zwitterionic glycine and its analogues through molecular simulations.
A. White (2011)
Synthesis and solution properties of zwitterionic polymers.
A. B. Lowe (2002)
Difference in hydration between carboxybetaine and sulfobetaine.
Q. Shao (2010)
Mesoscopic coarse-grained simulations of lysozyme adsorption.
G. Yu (2014)
Theory of polyzwitterion conformations
R. Kumar (2009)
Influence of Charged Groups on the Properties of Zwitterionic Moieties: A Molecular Simulation Study.
Q. Shao (2014)
Review and analysis of molecular simulations of methane, hydrogen, and acetylene storage in metal-organic frameworks.
Rachel B Getman (2012)
Mammalian plasma membranes
M. Bretscher (1975)
Kosmotropes Form the Basis of Protein-Resistant Surfaces
R. Kane (2003)
Decoding nonspecific interactions from nature
A. D. White (2012)
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
UCST wetting transitions of polyzwitterionic brushes driven by self-association.
O. Azzaroni (2006)
Molecular simulation studies of protein interactions with zwitterionic phosphorylcholine self-assembled monolayers in the presence of water.
Yi He (2008)
Different effects of zwitterion and ethylene glycol on proteins.
Q. Shao (2012)
An New Avenue to Nonfouling Materials
S. Chen (2008)
Zwitterionic hydrogels implanted in mice resist the foreign-body reaction
Lei Zhang (2013)
Zwitterionic poly(carboxybetaine) hydrogels for glucose biosensors in complex media.
W. Yang (2011)
Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma.
J. Ladd (2008)
Membrane lipids: where they are and how they behave
G. V. Meer (2008)
Dry film refractive index as an important parameter for ultra-low fouling surface coatings.
Norman D. Brault (2012)
Free energy of ligand binding to protein: evaluation of the contribution of water molecules by computational methods.
P. Cozzini (2004)
Phase behaviour and solution properties of sulphobetaine polymers
D. Schulz (1986)
The role of hydrophobic interactions in initiation and propagation of protein folding
H. Dyson (2006)
Improved mechanical properties of zwitterionic hydrogels with hydroxyl groups.
Yi He (2012)
Ion pairing in molecular simulations of aqueous alkali halide solutions.
C. Fennell (2009)
Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses
P. Yancey (2005)
This paper is referenced by
Ion-Specific Modulation of Interfacial Interaction Potentials between Solid Substrates and Cell-Sized Particles Mediated via Zwitterionic, Super-Hydrophilic Poly(sulfobetaine) Brushes.
Y. Higaki (2017)
MDMS: Software Facilitating Performing Molecular Dynamics Simulations
S. Żaczek (2020)
Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment
Lihua Lu (2018)
Constructing zwitterionic surface of nanofiltration membrane for high flux and antifouling performance
Yifang Mi (2017)
One-pot synthesis of silica–titania binary nanoparticles with acid–base pairs via biomimetic mineralization to fabricate highly proton-conductive membranes
Yongheng Yin (2017)
Molecular Interactions of Protein with TiO2 by the AFM-Measured Adhesion Force.
Yihui Dong (2017)
Proton conductive and low methanol permeable PVA-based zwitterionic membranes
L. Gao (2016)
Self-healing fluoropolymer brushes as highly polymer-repellent coatings
Zhanhua Wang (2016)
Zwitterionic Polymer Brush Grafted on Polyvinylidene Difluoride Membrane Promoting Enhanced Ultrafiltration Performance with Augmented Antifouling Property
Y. Chiao (2020)
Biocompatible zwitterionic polymer chemistries and hydrogels for gene therapy, drug delivery, and regenerative medicine
A. Sinclair (2016)
Design and regulation of the surface and interfacial behavior of protein molecules
Qianqian Hou (2020)
Progress and perspectives on nanoplatforms for drug delivery to the brain
Y. Xu (2020)
Incorporation of carboxybetaine methacrylate into poly(methyl methacrylate) to prevent multi-species biofilm formation
Jie Jin (2020)
The effect of zwitterionic surface content on blood circulation time of nanocapsule
X. Han (2020)
Understanding the Role of Shape and Composition of Star-Shaped Polymers and their Ability to Both Bind and Prevent Bacteria Attachment on Oral Relevant Surfaces
Hamid Mortazavian (2019)
Superior Antifouling Performance of a Zwitterionic Peptide Compared to an Amphiphilic, Non-Ionic Peptide.
Huijun Ye (2015)
Dual water-healable zwitterionic polymer coatings for anti-biofouling surfaces.
Zhanhua Wang (2018)
Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management.
Da Huo (2019)
Outstanding antifouling performance of poly(vinylidene fluoride) membranes: Novel amphiphilic brushlike copolymer blends and one‐step surface zwitterionization
Jianxiu Wang (2019)
Zwitterionic materials for antifouling membrane surface construction.
Mingrui He (2016)
Functionalization of Polydopamine via the Aza-Michael Reaction for Antimicrobial Interfaces.
Chia-yu Liu (2016)
Self-Healing Zwitterionic Microgels as a Versatile Platform for Malleable Cell Constructs and Injectable Therapies.
A. Sinclair (2018)
Molecular Dynamics Study of the Correlation between the Solvation Structures and the Antifouling Properties of Three Types of Betaine Moieties
Ryo Nagumo (2017)
Effect of end-groups on sulfobetaine homopolymers with the tunable upper critical solution temperature (UCST)
Z. Li (2020)
Ultrafast water‐selective permeation through graphene oxide membrane with water transport promoters
F. Liang (2020)
Interplays of Interfacial Forces Modulate Structure and Function of Soft and Biological Matters in Aquatic Environments
M. Tanaka (2020)
Establishment of a Physical Model for Solute Diffusion in Hydrogel: Understanding the Diffusion of Proteins in Poly(sulfobetaine methacrylate) Hydrogel.
Yu-hang Zhou (2017)
Highly Specific Binding on Antifouling Zwitterionic Polymer-Coated Microbeads as Measured by Flow Cytometry
E. van Andel (2017)
Hoch fluoreszierende Pyridiniumbetaine für die Lichtsammlung
J. Xu (2017)
Mitigation of Inflammatory Immune Responses with Hydrophilic Nanoparticles.
B. Li (2018)
A novel biocompatible zwitterionic polyurethane with AIE effect for cell imaging in living cells
Junhuai Xu (2018)
Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs.
S. H. Ye (2015)See more