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Physical, Chemical, And Biological Structures Based On ROS-Sensitive Moieties That Are Able To Respond To Oxidative Microenvironments.

C. Tapeinos, A. Pandit
Published 2016 · Materials Science, Medicine

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Reactive oxygen species (ROS) (H2 O2 , OCl(-) , (•) OH, O2 (-) ) are a family of reactive molecules that are generated intracellularly and are engaged in many biological processes. In physiological concentrations, ROS act as signaling molecules to a number of metabolic pathways; however, in excess they can be harmful to living organisms. Overproduction of ROS has been related to many pathophysiological conditions and a number of studies have been reported in elucidating their mechanism in these conditions. With the aim of harnessing this role, a number of imaging tools and therapeutic compounds have been developed. Here these imaging and therapeutic tools are reviewed and particularly those structures with ROS-sensitivity based on their biomedical applications and their functional groups. There is also a brief discussion about the method of preparation as well as the mechanism of action.
This paper references
10.1073/pnas.1012864107
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
G. C. Van de Bittner (2010)
10.1021/ja2073824
Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs.
Yunyan Kuang (2011)
10.1039/B820044K
Thermo- and photo-responsive polymeric systems
S. Dai (2009)
10.1021/nn501135m
Heterogeneous assembled nanocomplexes for ratiometric detection of highly reactive oxygen species in vitro and in vivo.
E. Ju (2014)
10.1038/nrd4333
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
V. Torchilin (2014)
10.1021/bm4002574
Therapeutic nanocarriers with hydrogen peroxide-triggered drug release for cancer treatment.
J. Liu (2013)
10.1021/JA063308K
A FRET-based approach to ratiometric fluorescence detection of hydrogen peroxide.
Aaron E Albers (2006)
10.1039/C5PY00257E
Hydrogen peroxide-responsive anticancer hyperbranched polymer micelles for enhanced cell apoptosis
Bing Liu (2015)
10.1074/jbc.M209264200
Development of Novel Fluorescence Probes That Can Reliably Detect Reactive Oxygen Species and Distinguish Specific Species* 210
Ken-ichi Setsukinai (2003)
10.1021/bm201328k
Physiologically relevant oxidative degradation of oligo(proline) cross-linked polymeric scaffolds.
Shann S. Yu (2011)
10.1021/ja100117u
Organelle-targetable fluorescent probes for imaging hydrogen peroxide in living cells via SNAP-Tag protein labeling.
Duangkhae Srikun (2010)
10.1002/cmdc.201402290
Stimuli‐Responsive Polymeric Nanoparticles for Nanomedicine
Carina Crucho (2015)
10.1039/C3PY00406F
Oxidation responsive mono-cleavable amphiphilic di-block polymer micelles labeled with a single diselenide
Tongbing Sun (2013)
10.1039/c0cc01560a
Lanthanide-based luminescent probes for selective time-gated detection of hydrogen peroxide in water and in living cells.
A. Lippert (2010)
10.1038/nchembio.607
Chemistry and biology of reactive oxygen species in signaling or stress responses.
Bryan C. Dickinson (2011)
10.1039/c5cc01779c
Ultra-sensitive ROS-responsive tellurium-containing polymers.
W. Cao (2015)
10.1016/j.biomaterials.2015.05.007
Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer.
Yi-Ting Chiang (2015)
10.1021/ja507626y
Cell protective, ABC triblock polymer-based thermoresponsive hydrogels with ROS-triggered degradation and drug release.
M. Gupta (2014)
10.1038/NCHEMBIO871
Molecular imaging of hydrogen peroxide produced for cell signaling
Evan W. Miller (2007)
10.1039/C1SM06673K
Side-chain selenium-containing amphiphilic block copolymers: redox-controlled self-assembly and disassembly†
Huifeng Ren (2012)
10.1021/ja802355u
A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells.
Bryan C. Dickinson (2008)
10.1016/j.jinorgbio.2011.05.023
Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.
Marina G. D. Leed (2011)
10.1021/la102837a
Oxidation-responsive micelles based on a selenium-containing polymeric superamphiphile.
P. Han (2010)
10.1039/c1cc12526e
Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.
Jody Jourden (2011)
10.1021/nn4058787
Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications.
Hsiao-Lan Pu (2014)
10.1039/c1cc13583j
A two-photon fluorescent probe for ratiometric imaging of hydrogen peroxide in live tissue.
C. Chung (2011)
10.1002/1521-3773(20021202)41:23<4495::AID-ANIE4495>3.0.CO;2-I
A europium-ion-based luminescent sensing probe for hydrogen peroxide.
O. Wolfbeis (2002)
10.1021/nn3014905
Dye/peroxalate aggregated nanoparticles with enhanced and tunable chemiluminescence for biomedical imaging of hydrogen peroxide.
Yongdeok Lee (2012)
10.1002/adhm.201400299
Biocompatible reactive oxygen species (ROS)-responsive nanoparticles as superior drug delivery vehicles.
Dinglin Zhang (2015)
10.1021/bc200141h
Inflammation responsive logic gate nanoparticles for the delivery of proteins.
E. Mahmoud (2011)
10.1016/j.addr.2010.07.009
Nanoparticle-based theranostic agents.
J. Xie (2010)
10.1002/anie.201209633
A reactive oxygen species (ROS)-responsive polymer for safe, efficient, and targeted gene delivery in cancer cells.
M. Shim (2013)
10.1039/C3TB21725F
Oxidation-responsive polymers for biomedical applications.
Chengcheng Song (2014)
10.1021/nn201477y
Encapsulation and enzyme-mediated release of molecular cargo in polysulfide nanoparticles.
B. L. Allen (2011)
10.1002/cbic.200900597
A Prochelator Activated by Hydrogen Peroxide Prevents Metal‐Induced Amyloid β Aggregation
Marina G. Dickens (2010)
10.1098/rstb.2008.0151
Inflammation and oxidative stress in vertebrate host–parasite systems
G. Sorci (2008)
10.1039/C4PY01156B
Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release
C. Xiao (2015)
10.1021/JA01578A020
Electrophilic Displacement Reactions. IX. Effects of Substituents on Rates of Reactions between Hydrogen Peroxide and Benzeneboronic Acid1-3
H. Kuivila (1957)
10.1039/C5PY00050E
Reactive oxygen species (ROS)-responsive tellurium-containing hyperbranched polymer
Ruochen Fang (2015)
10.1021/acsnano.5b02937
Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies.
C. Brubaker (2015)
10.1039/C3PY01192E
Redox-responsive polymers for drug delivery: from molecular design to applications
Meng Huo (2014)
10.1002/anie.201003819
Hydrogen peroxide activated matrix metalloproteinase inhibitors: a prodrug approach.
Jody L Major Jourden (2010)
10.1002/HLCA.200900184
Tetracycline)europium(III) Complex as Luminescent Probe for Hydrogen Peroxide Detection
Geert Dehaen (2009)
10.1021/ja1014103
A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells.
Bryan C. Dickinson (2010)
2016, DOI: 10.1002/adma.201505376 www.advmat.de www.MaterialsViews.com
b L.K. Charkoudian (2006)
10.1039/C2TB00186A
Red light responsive diselenide-containing block copolymer micelles.
P. Han (2013)
10.1016/j.bmcl.2008.08.035
A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells.
Aaron E Albers (2008)
10.1038/NMAT1983
In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles.
D. Lee (2007)
10.1021/ja309078t
Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation.
G. C. Van de Bittner (2013)
10.1039/C5RA03423J
Novel multi-sensitive pseudo-poly(amino acid) for effective intracellular drug delivery
Yanjuan Wu (2015)
10.7150/thno.7101
ROS-Responsive Activatable Photosensitizing Agent for Imaging and Photodynamic Therapy of Activated Macrophages
H. Kim (2013)
10.1021/nn204899m
Fluorescent polymer nanoparticle for selective sensing of intracellular hydrogen peroxide.
Wan-Kyu Oh (2012)
10.1002/MACP.201200502
Oxidation‐Responsive Polymers: Which Groups to Use, How to Make Them, What to Expect From Them (Biomedical Applications)
E. Lallana (2013)
10.1038/nchembio.497
Nox2 redox signaling maintains essential cell populations in the brain
Bryan C. Dickinson (2011)
10.1021/jm2014937
Aminoferrocene-based prodrugs activated by reactive oxygen species.
Helen Hagen (2012)
10.1038/nmeth866
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide
V. Belousov (2006)
10.1172/JCI25102
Inflammation, stress, and diabetes.
K. Wellen (2005)
10.1039/C0PY00144A
Selenium-containing block copolymers and their oxidation-responsive aggregates
N. Ma (2010)
10.1002/MACP.201300579
Post-Assembly of Oxidation-Responsive Amphiphilic Triblock Polymer Containing a Single Diselenide
Tongbing Sun (2013)
10.2147/IJN.S33065
Nanotheranostics – a review of recent publications
L. Wang (2012)
10.1016/j.biomaterials.2014.03.084
Therapeutic use of H2O2-responsive anti-oxidant polymer nanoparticles for doxorubicin-induced cardiomyopathy.
Seunggyu Park (2014)
10.1021/ja110468v
A biocompatible oxidation-triggered carrier polymer with potential in therapeutics.
Kyle E. Broaders (2011)
10.1021/JA054474F
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide.
Evan W. Miller (2005)
10.1021/JA01001A025
Chemiluminescence from reactions of electronegatively substituted aryl oxalates with hydrogen peroxide and fluorescent compounds
M. Rauhut (1967)
10.1002/PPSC.201300222
A ROS Eliminating Nanocomposite Film Fabricated from Diselenide-Containing Polymer Micelles
Shaobo Ji (2013)
10.1039/c2cs35191a
Temperature- and light-responsive smart polymer materials.
F. Jochum (2013)
10.1021/ja908124g
Dual redox responsive assemblies formed from diselenide block copolymers.
N. Ma (2010)
10.1038/nmat2859
Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines.
D. S. Wilson (2010)
10.1039/b921187j
A highly specific ferrocene-based fluorescent probe for hypochlorous acid and its application to cell imaging.
S. Chen (2010)
10.1016/j.jconrel.2012.07.042
Poly(PS-b-DMA) micelles for reactive oxygen species triggered drug release.
M. Gupta (2012)
10.1021/JA0441716
A selective, cell-permeable optical probe for hydrogen peroxide in living cells.
M. Chang (2004)
10.1021/ja203145v
A unique paradigm for a Turn-ON near-infrared cyanine-based probe: noninvasive intravital optical imaging of hydrogen peroxide.
Naama Karton-Lifshin (2011)
10.1038/NMAT1081
Oxidation-responsive polymeric vesicles
A. Napoli (2004)
10.1021/MA102608A
Stimuli-Triggered Off/On Switchable Complexation between a Novel Type of Charge-Generation Polymer (CGP) and Gold Nanoparticles for the Sensitive Colorimetric Detection of Hydrogen Peroxide and Glucose
Changhua Li (2011)
10.1039/B821363A
Multi-membrane hydrogel fabricated by facile dynamic self-assembly
Hongjun Dai (2009)
10.1039/C3PY00880K
Multi-stimuli responsive polymers – the all-in-one talents
Philipp Schattling (2014)
10.1021/ja411547j
In Vivo Targeting of Hydrogen Peroxide by Activatable Cell-Penetrating Peptides
Roy Weinstain (2014)
10.1007/s00726-003-0011-2
Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
E. Stadtman (2003)
10.1021/ja711480f
An ICT-based approach to ratiometric fluorescence imaging of hydrogen peroxide produced in living cells.
Duangkhae Srikun (2008)
10.1038/srep02233
H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents
D. Lee (2013)
10.1002/ADFM.201000780
Chemiluminescence‐Generating Nanoreactor Formulation for Near‐Infrared Imaging of Hydrogen Peroxide and Glucose Level in vivo
Chang-Keun Lim (2010)
10.1021/bm5000554
Oxidation-responsive OEGylated poly-L-cysteine and solution properties studies.
Xiaohui Fu (2014)
10.1038/nmat3776
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
10.1021/JA064806W
A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation.
Louise K. Charkoudian (2006)
10.1021/ja3007484
Glycopolypeptides with a redox-triggered helix-to-coil transition.
Jessica R. Kramer (2012)
10.1021/LA0478043
Oxidation-sensitive polymeric nanoparticles.
A. Rehor (2005)
10.1039/B705199A
Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.
Louise K. Charkoudian (2007)
10.1021/ar200126t
Boronate oxidation as a bioorthogonal reaction approach for studying the chemistry of hydrogen peroxide in living systems.
A. Lippert (2011)
10.1007/S00604-003-0090-5
Reversible Optical Sensor Membrane for Hydrogen Peroxide Using an Immobilized Fluorescent Probe, and its Application to a Glucose Biosensor
O. Wolfbeis (2003)
10.1039/C4TB01094A
ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.
S. Lee (2014)
10.4330/wjc.v6.i6.462
Antioxidants, inflammation and cardiovascular disease.
H. Mangge (2014)
10.1021/bc200449k
Scavenging ROS: superoxide dismutase/catalase mimetics by the use of an oxidation-sensitive nanocarrier/enzyme conjugate.
P. Hu (2012)
10.1021/acsami.5b04419
Ultrasensitive ROS-Responsive Coassemblies of Tellurium-Containing Molecules and Phospholipids.
L. Wang (2015)
10.1021/MA401656T
Oxidation-Responsive Poly(amino ester)s Containing Arylboronic Ester and Self-Immolative Motif: Synthesis and Degradation Study
Chengcheng Song (2013)
10.2147/IJN.S3728
Detection of hydrogen peroxide with chemiluminescent micelles
D. Lee (2008)
10.1002/adhm.201200423
Current progress in Reactive Oxygen Species (ROS)-Responsive materials for biomedical applications.
S. Lee (2013)
10.1016/j.biomaterials.2014.11.016
ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease.
K. Poole (2015)
10.1073/pnas.1005776107
Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling
Evan W. Miller (2010)
10.1039/b309393j
Development of highly selective and sensitive probes for hydrogen.
L. Lo (2003)
10.1038/nature05485
Inflammation and metabolic disorders
G. Hotamisligil (2006)
10.1002/ANIE.200604859
Hydrogen peroxide triggered prochelator activation, subsequent metal chelation, and attenuation of the fenton reaction.
Yibin Wei (2007)



This paper is referenced by
10.1039/C7TB01689A
Antioxidant nanomaterials in advanced diagnoses and treatments of ischemia reperfusion injuries.
HaMeD aMaNi (2017)
10.7150/jca.31166
The role of Wnt signaling pathway in tumor metabolic reprogramming
Yongzhen Mo (2019)
10.1002/advs.201801155
Biodegradable 2D Fe–Al Hydroxide for Nanocatalytic Tumor‐Dynamic Therapy with Tumor Specificity
Zhenbang Cao (2018)
10.3390/ijms18010120
The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles
Ahmed Abdal Dayem (2017)
10.1016/j.biomaterials.2018.12.004
A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy.
X. Sun (2019)
10.1016/j.biomaterials.2017.03.010
A positive feedback strategy for enhanced chemotherapy based on ROS-triggered self-accelerating drug release nanosystem.
Jing-jing Hu (2017)
10.1016/j.jconrel.2017.04.043
Smart chemistry-based nanosized drug delivery systems for systemic applications: A comprehensive review.
T. Ramasamy (2017)
10.1039/C9PY00575G
Reactive oxygen species-responsive nanoparticles based on a thioketal-containing poly(β-amino ester) for combining photothermal/photodynamic therapy and chemotherapy
Bowei Chen (2019)
10.1016/j.jconrel.2017.08.033
Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases
C. Tapeinos (2017)
10.7150/thno.39412
A cancer-specific activatable theranostic nanodrug for enhanced therapeutic efficacy via amplification of oxidative stress
Xie-an Yu (2020)
10.1016/J.SCIB.2018.05.008
Enhanced catalysis of ultrasmall Au-MoS 2 clusters against reactive oxygen species for radiation protection
Peixian Bian (2018)
10.1002/cphc.201900899
Theoretical investigation of cyano-chalcogen dimers and their importance in molecular recognition.
Viola Previtali (2019)
10.1039/d0tb00636j
Glutathione- and light-controlled generation of singlet oxygen for triggering drug release in mesoporous silica nanoparticles.
Roy C. H. Wong (2020)
10.1039/C7PY00915A
Synthesis of a phenylboronic ester-linked PEG-lipid conjugate for ROS-responsive drug delivery
Tianhui Zhang (2017)
10.1039/C8TB00308D
Near infrared light triggered reactive oxygen species responsive nanoparticles for chemo-photodynamic combined therapy.
X. Zhang (2018)
10.1039/c7bm00334j
Serum-resistant, reactive oxygen species (ROS)-potentiated gene delivery in cancer cells mediated by fluorinated, diselenide-crosslinked polyplexes.
Qiurong Deng (2017)
10.1039/C6CS00271D
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy.
Zijian Zhou (2016)
10.1002/advs.201903525
Near‐Infrared Chemiluminescent Carbon Nanodots and Their Application in Reactive Oxygen Species Bioimaging
C. Shen (2020)
10.1021/acsomega.9b00384
Synthesis of Stimuli-Responsive Heterofunctional Dendrimer by Passerini Multicomponent Reaction
N. Patil (2019)
10.1002/adma.202000013
A Multistage Cooperative Nanoplatform Enables Intracellular Co-Delivery of Proteins and Chemotherapeutics for Cancer Therapy.
P. Zhang (2020)
10.1039/d0na00286k
Role of inorganic nanoparticle degradation in cancer therapy
Christy Maksoudian (2020)
10.1002/adfm.201906283
Advanced Functional Materials and Cell-Based Therapies for the Treatment of Ischemic Stroke and Postischemic Stroke Effects
C. Tapeinos (2020)
10.1016/j.addr.2018.02.008
Responsive triggering systems for delivery in chronic wound healing
Mangesh Morey (2018)
10.1016/j.actbio.2017.12.014
Antioxidant functionalized polymer capsules to prevent oxidative stress.
A. Larrañaga (2018)
10.1016/j.nano.2017.03.022
Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS.
C. Tapeinos (2018)
10.1016/j.biomaterials.2017.08.008
Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice.
G. Chen (2017)
10.1155/2019/7072917
The Differential Expression of Mitochondrial Function-Associated Proteins and Antioxidant Enzymes during Bovine Herpesvirus 1 Infection: A Potential Mechanism for Virus Infection-Induced Oxidative Mitochondrial Dysfunction
X. Fu (2019)
10.1039/C9TB00847K
Reactive oxygen species (ROS)-responsive biomaterials mediate tissue microenvironments and tissue regeneration.
Y. Yao (2019)
10.1142/s1793292019501418
Novel Thioacetal-Bridged Hollow Mesoporous Organosilica Nanoparticles with ROS-Responsive Biodegradability for Smart Drug Delivery
Zeyang Lin (2019)
10.1016/j.cbi.2019.108820
Piperlongumine analogue L50377 induces pyroptosis via ROS mediated NF-κB suppression in non-small-cell lung cancer.
Q. Li (2019)
10.1002/adbi.201800086
Scavenging Nanoreactors that Modulate Inflammation
D. Pereira (2018)
10.1021/acsami.7b12297
Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release.
Yongbeom Seo (2017)
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