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Mitochondrial DNA Depletion In Respiratory Chain–Deficient Parkinson Disease Neurons

A. Grünewald, K. Rygiel, P. Hepplewhite, C. Morris, M. Picard, D. Turnbull
Published 2016 · Medicine, Biology

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To determine the extent of respiratory chain abnormalities and investigate the contribution of mtDNA to the loss of respiratory chain complexes (CI–IV) in the substantia nigra (SN) of idiopathic Parkinson disease (IPD) patients at the single‐neuron level.
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