← Back to Search
Subarachnoid Blood And Headache: Altered Trigeminal Tachykinin Gene Expression
M. D. Linnik, D. Sakas, G. Uhl, M. Moskowitz
Published 1989 · Medicine
Download PDFAnalyze on Scholarcy
Sensory axons from the trigeminal ganglion (V) innervate cephalic blood vessels and use the preprotachykinin gene products, substance P (SP) and neurokinin A (NKA), as putative neurotransmitters conveying nociceptive information. Blood in the subarachnoid space is accompanied by severe headache. We now report that this painful stimulus, which should enhance activity in V, specifically alters tachykinin peptide and mRNA levels in V and perivascular axons. Marked reductions in SP levels were observed in basilar artery segments within 4 hours after intracisternal blood injection which persisted for 48 hours and recovered by 7 days. SP peptide levels in V were elevated by 49% two days after blood injection. The changes in SP peptide levels were accompanied by increases in ganglionic content of the preprotachykinin mRNA that codes for the peptide. Blood‐induced peptide depletion in arteries and subsequent increases in peptide and mRNA in V are consistent with increased neuronal activity and enhanced neuropeptide release. These results implicate the tachykinin‐utilizing trigeminovascular neurons in the sequelae of subarachnoid hemorrhage.
This paper references
Ultrastructural evidence of arterial denervation following experimental subarachnoid hemorrhage.
T. Duff (1986)
Response of brainstem trigeminal neurons to electrical stimulation of the dura
A. Strassman (1986)
Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.
J. Krause (1987)
Sequence analysis of cloned cDNA for rat substance P precursor: existence of a third substance P precursor.
Y. Kawaguchi (1986)
Electrophoretic transfer of proteins and nucleic acids from slab gels to diazobenzyloxymethyl cellulose or nitrocellulose sheets.
M. Bittner (1980)
Co‐localization of retrogradely transported wheat germ agglutinin and the putative neurotransmitter substance P within trigeminal ganglion cells projecting to cat middle cerebral artery
L. Y. Liu-Chen (1984)
Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain.
W. Young (1986)
Depolarizing influences regulate preprotachykinin mRNA in sympathetic neurons.
A. Roach (1987)
Perivascular meningeal projections from cat trigeminal ganglia: possible pathway for vascular headaches in man.
M. Mayberg (1981)
Cerebral perivascular nerves in subarachnoid hemorrhage. A histochemical and immunohistochemical study.
H. Hara (1986)
Origin and distribution of cerebral vascular innervation from superior cervical, trigeminal and spinal ganglia investigated with retrograde and anterograde WGA-HRP tracing in the rat
M. A. Arbab (1986)
Changes of neuropeptide immunoreactivity in cerebrovascular nerve fibers after experimentally produced SAH. Immunohistochemical study in the dog.
Y. Uemura (1987)
Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks.
F. Tang (1983)
Activation of trigeminal brain-stem nociceptive neurons by dural artery stimulation
K. Davis (1986)
Striatonigral Tachykinin Biosynthesis
P. J. Elliott (1987)
Co-localization of corticotropin releasing factor and vasopressin mRNA in neurones after adrenalectomy
B. Wolfson (1985)
Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range
S. Udenfriend (1972)
Trigeminal origin of β-preprotachykinin products in feline pial blood vessels
K. Saito (1987)
Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing
H. Nawa (1984)
Angiographic evidence of basilar artery constriction in the rabbit: a new model of vasospasm.
K. Baker (1987)
Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor
H. Nawa (1983)
Pia arachnoid contains substance P originating from trigeminal neurons
L. -. Liu-Chen (1983)
Headache in acute cerebrovascular disease
P. Gorelick (1986)
Development and regulation of substance P in sensory neurons in vitro.
J. Adler (1984)
Substance P and the sensory innervation of intracranial and extracranial feline cephalic arteries. Implications for vascular pain mechanisms in man.
T. Norregaard (1985)
Substance P in principal sympathetic neurons: regulation by impulse activity.
J. Kessler (1981)
Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons.
M. Bannon (1986)
In vitro release of immunoreactive substance P from putative afferent nerve endings in bovine pia arachnoid
M. Moskowitz (1983)
Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs
P. Valenzuela (1981)
Headache and other head pain
H. Wolff (1972)
Suprachiasmatic nucleus vasopressin messenger RNA: circadian variation in normal and Brattleboro rats.
G. Uhl (1986)
This paper is referenced by
Receptive properties of pial afferents
W. Jänig (1991)
Sumatriptan and Sensory Neuropeptide Activity in Subarachnoid Haemorrhage: An Hypothesis
L. White (1995)
Advent of a New Generation of Antimigraine Medications
A. Recober (2007)
Peptidergic and serotoninergic innervation of the rat dura mater
J. Keller (1991)
Effect of pre- and postganglionic lesioning of the trigeminal nerve on cerebral blood flow and glucose metabolism following a subarachnoid haemorrhage in the squirrel monkey.
Y. Shiokawa (1992)
Cerebral Vasoconstriction: Physiology, Pathophysiology and Occurrence in Selected Cerebrovascular Disorders
M. Sloan (1995)
Dural neuropeptide changes after subarachnoid hemorrhage in rats
J. Keller (1993)
Chapter 6 – Pharmacology
R. Macdonald (2001)
Alterations in perivascular dilatory neuropeptides (CGRP, SP, VIP) in the external jugular vein and in the cerebrospinal fluid following subarachnoid haemorrhage in man
R. Juul (2005)
Neuronal Pathophysiology of Migraine as a Basis for Acute Treatment with 5-HT Receptor Ligands
M. Moskowitz (2000)
Cerebrovascular sensory innervation involved in the development of cerebral vasospasm following a subarachnoid hemorrhage.
Y. Shiokawa (1994)
Experimental microneurosurgery of the trigeminal nerve: surgical technique for ganglionectomy and rhizotomy in the cat
D. Sakas (1996)
Expression of c-fos-like immunoreactivity in brainstem after meningeal irritation by blood in the subarachnoid space
K. Nozaki (1992)
Trigeminal sensory innervation on perforators of the circle of Willis in rabbits by wheat germ agglutinin-conjugated horseradish peroxidase anterograde tracing.
Q. J. Zhang (1994)
Referred Headache of Rhinogenic Origin in the Absence of Sinusitis
D. M. Clerico (1994)
The Innervation of Pial Blood Vessels and their Role in Cerebrovascular Regulation
R. Macfarlane (1995)
Chapter 19 – Perivascular Peptides in Subarachnoid Hemorrhage
R. Juul (1993)
Effect of subarachnoid haemorrhage on trigeminovascular calcitonin-gene-related peptide and substance P of the rat dura mater versus cerebral vasculature
A. G. Arand (2005)
Pathophysiology of Headaches with a Prominent Vascular Component
J. Pareja (1996)
Identification of immunoreactive substance P in human and other mammalian endothelial cells
M. D. Linnik (1989)
Effect of unilateral pre- and postganglionic lesioning of the trigeminal nerve on the development of cerebral vasospasm in the squirrel monkey: angiographic findings.
Y. Shiokawa (1992)
Role of endothelin in mediating neurogenic plasma extravasation in rat dura mater
P. Brändli (1996)
Involvement of Perivascular Sensory Fibers in the Pathophysiology of Cerebral Vasospasm following Subarachnoid Hemorrhage
L. Edvinsson (1990)
Perivascular neuropeptides (NPY, VIP, CGRP and SP) in human brain vessels after subarachnoid haemorrhage
L. Edvinsson (1994)
Experimental models of migraine.
M. G. Buzzi (2010)
Abstracts of Citations
S. Solomon (1989)
Experimental models of migraine.
U. Reuter (2000)