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Regio- And Chemoselective Metalation Of Arenes And Heteroarenes Using Hindered Metal Amide Bases.

B. Haag, M. Mosrin, H. Ila, V. Malakhov, P. Knochel
Published 2011 · Chemistry, Medicine

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The preparation of highly functionalized organometallic compounds can be achieved by direct C-H activation of a broad range of unsaturated substrates using lithium chloride solubilized 2,2,6,6-tetramethylpiperidide bases (TMP(n)MX(m)⋅p LiCl). These are excellent reagents for converting a wide range of aromatic and heterocyclic substrates into valuable organometallic reagents with broad applications in organic synthesis.
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