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Highly Selective Trifluoromethylation Of 1,3-disubstituted Arenes Through Iridium-catalyzed Arene Borylation.

Tianfei Liu, Xinxin Shao, Y. Wu, Q. Shen
Published 2012 · Chemistry, Medicine

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The old one two: A sequential iridium-catalyzed borylation and copper-catalyzed trifluoromethylation of arenes is described (see scheme; Pin = pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. The advantages of this tandem procedure are demonstrated by the late-stage trifluoromethylation of a number of biologically active molecules.
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