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Direct Electrophilic N-trifluoromethylation Of Azoles By A Hypervalent Iodine Reagent.

Katrin Niedermann, N. Frueh, R. Senn, Barbara Czarniecki, R. Verel, A. Togni
Published 2012 · Chemistry, Medicine

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Effective CF(3) transfer: Various electron-rich nitrogen heterocycles (pyrazoles, triazoles, and tetrazoles) can be directly N-trifluoromethylated by a hypervalent iodine reagent in an efficient manner. The optimized procedure, which includes an in situ silylation of the substrate followed by an acid-catalyzed CF(3) transfer, provides ready access to a series of new and previously challenging or inaccessible NCF(3) compounds.
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