Online citations, reference lists, and bibliographies.

A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia.

Wen Lv, Zhang Zhang, Kenneth Yin Zhang, Huiran Yang, Shujuan Liu, Aqiang Xu, Song Guo, Qiang Zhao, Wei Huang
Published 2016 · Chemistry, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Organelle-targeted photosensitizers have been reported to be effective photodynamic therapy (PDT) agents. In this work, we designed and synthesized two iridium(III) complexes that specifically stain the mitochondria and lysosomes of living cells, respectively. Both complexes exhibited long-lived phosphorescence, which is sensitive to oxygen quenching. The photocytotoxicity of the complexes was evaluated under normoxic and hypoxic conditions. The results showed that HeLa cells treated with the mitochondria-targeted complex maintained a slower respiration rate, leading to a higher intracellular oxygen level under hypoxia. As a result, this complex exhibited an improved PDT effect compared to the lysosome-targeted complex, especially under hypoxia conditions, suggestive of a higher practicable potential of mitochondria-targeted PDT agents in cancer therapy.
This paper references



This paper is referenced by
10.3390/molecules25051127
Influence of Polymer Charge on the Localization and Dark- and Photo-Induced Toxicity of a Potential Type I Photosensitizer in Cancer Cell Models
Mikael Lindgren (2020)
10.3762/bjnano.11.15
Rational design of block copolymer self-assemblies in photodynamic therapy
Maxime Demazeau (2020)
10.1016/j.ejmech.2019.06.045
Guanidine-modified cyclometalated iridium(III) complexes for mitochondria-targeted imaging and photodynamic therapy.
Xing-Dong Song (2019)
10.1002/chem.201803452
Exploitation of Environment-Sensitive Luminophores in the Design of Sydnone-Based Bioorthogonal Imaging Reagents.
Lawrence Cho-Cheung Lee (2018)
Metal-NHC complexes for anti-cancer applications : gold(I) for antimitochondrial activity and iridium(III) for photodynamic therapy
Chen Zhang (2018)
10.1021/acsami.8b05944
Phosphorescent Starburst Pt(II) Porphyrins as Bifunctional Therapeutic Agents for Tumor Hypoxia Imaging and Photodynamic Therapy.
Zhuang Lv (2018)
10.1039/c8cs00660a
Dinuclear metal complexes: multifunctional properties and applications.
Guangfu Li (2020)
10.1039/c9nj05093k
A highly sensitive Ru(II) complex-based phosphorescent probe for thiophenol detection with aggregation-induced emission characteristics
Linlin Yang (2020)
10.1039/c9cc06411g
Mitochondrial heat shock protein-guided photodynamic therapy.
Ajesh P Thomas (2019)
10.1002/cnma.201900507
Mitochondria‐Targeted Nanoscale MOFs for Improved Photodynamic Therapy
Ming Gong (2020)
Targeted photosensitizers and controlled singlet oxygen generation for therapeutic applications
Esma Uçar (2019)
10.1039/c9pp00142e
Neutral iridium(iii) complexes bearing BODIPY-substituted N-heterocyclic carbene (NHC) ligands: synthesis, photophysics, in vitro theranostic photodynamic therapy, and antimicrobial activity.
Bingqing Liu (2019)
10.1002/advs.201802050
AIE Multinuclear Ir(III) Complexes for Biocompatible Organic Nanoparticles with Highly Enhanced Photodynamic Performance
Liping Zhang (2019)
10.1038/s41467-019-11082-3
Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
Da Huo (2019)
10.1002/smll.201804969
Recent Progress in Time-Resolved Biosensing and Bioimaging Based on Lanthanide-Doped Nanoparticles.
Qinqin Ma (2019)
10.1016/j.dyepig.2019.108105
Electrostatic self-assembled Iridium(III) nano-photosensitizer for selectively disintegrated and mitochondria targeted photodynamic therapy
Yongfeng Deng (2020)
10.2147/IJN.S196959
Hypoxia-active nanoparticles used in tumor theranostic
Yaqin Wang (2019)
10.1039/c8dt00720a
Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes.
Yun Ma (2018)
10.1039/C9QI00081J
Mitochondria-targeting cyclometalated iridium(III) complexes for tumor hypoxic imaging and therapy
Jia Peng Li (2019)
10.1002/asia.201801221
Photodynamic Therapy Based on Nanoscale Metal-Organic Frameworks: From Material Design to Cancer Nanotherapeutics.
Qun Guan (2018)
10.1039/C8TB01805G
Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy.
Caixia Huang (2018)
10.1002/chem.201705561
Cancer-Targeting Functionalization of Selenium-Containing Ruthenium Conjugate with Tumor Microenvironment-Responsive Property to Enhance Theranostic Effects.
Zhennan Zhao (2018)
10.1016/j.biomaterials.2019.05.030
A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy.
Tong Qi (2019)
10.3390/molecules23113016
Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
Fengming Lin (2018)
10.1039/c9nr10453d
Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy.
Ying Lan (2020)
10.1039/c8dt00887f
Phosphorescent iridium(iii) complexes: a versatile tool for biosensing and photodynamic therapy.
Tianci Huang (2018)
10.1002/anie.202003895
GSH and H2O2 Co-Activatable Mitochondria-Targeted Photodynamic Therapy under Normoxia and Hypoxia.
Jian Sun (2020)
10.1039/d0dt00180e
Cyclometalated iridium(iii) complexes for mitochondria-targeted combined chemo-photodynamic therapy.
Weiwei Qin (2020)
10.1002/adma.202001862
A Porous Au@Rh Bimetallic Core-Shell Nanostructure as an H2 O2 -Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy.
Jinping Wang (2020)
10.1002/ADFM.201804317
“Wax‐Sealed” Theranostic Nanoplatform for Enhanced Afterglow Imaging–Guided Photothermally Triggered Photodynamic Therapy
Gongyuan Liu (2018)
10.1002/adma.201802006
Aggressive Man-Made Red Blood Cells for Hypoxia-Resistant Photodynamic Therapy.
Wenlong Liu (2018)
10.1002/smll.202000363
Iridium(III) Complex-Derived Polymeric Micelles with Low Dark Toxicity and Strong NIR Excitation for Phototherapy and Chemotherapy.
Jian Zhao (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar