Online citations, reference lists, and bibliographies.

A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia.

Wen Lv, Z. Zhang, K. Zhang, H. Yang, S. Liu, Aqiang Xu, S. Guo, Q. Zhao, W. Huang
Published 2016 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Organelle-targeted photosensitizers have been reported to be effective photodynamic therapy (PDT) agents. In this work, we designed and synthesized two iridium(III) complexes that specifically stain the mitochondria and lysosomes of living cells, respectively. Both complexes exhibited long-lived phosphorescence, which is sensitive to oxygen quenching. The photocytotoxicity of the complexes was evaluated under normoxic and hypoxic conditions. The results showed that HeLa cells treated with the mitochondria-targeted complex maintained a slower respiration rate, leading to a higher intracellular oxygen level under hypoxia. As a result, this complex exhibited an improved PDT effect compared to the lysosome-targeted complex, especially under hypoxia conditions, suggestive of a higher practicable potential of mitochondria-targeted PDT agents in cancer therapy.
This paper references
10.1016/j.biomaterials.2013.06.028
Mitochondria-targeting cyclometalated iridium(III)-PEG complexes with tunable photodynamic activity.
S. Li (2013)
10.1021/IC0005893
Oxygen atom transfer from nitrogenous ReVO reagents to diphosphines and subsequent transformations. Rhenium(III) products and reaction models.
S. Bhattacharyya (2001)
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.angewandte.org These are not the final page numbers! Communications Photodynamic Therapy
D. R. Green (2004)
10.1002/anie.201507800
Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy.
Huaiyi Huang (2015)
10.1039/c3cs60131e
Biological detection by optical oxygen sensing.
D. Papkovsky (2013)
10.1021/ja408426z
Exploitation of long-lived 3IL excited states for metal-organic photodynamic therapy: verification in a metastatic melanoma model.
R. Lincoln (2013)
10.1002/ANGE.201204933
Durch rotes Licht aktivierbare multifunktionelle Agentien für die photodynamische Therapie
Samantha L. H. Higgins (2012)
In vitro cell viability of HeLa cells. The cells
J. Tian (2013)
10.1126/SCIENCE.1099320
The Pathophysiology of Mitochondrial Cell Death
D. Green (2004)
10.1002/advs.201500107
A Phosphorescent Iridium(III) Complex‐Modified Nanoprobe for Hypoxia Bioimaging Via Time‐Resolved Luminescence Microscopy
Wen Lv (2015)
10.1002/adhm.201300533
Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticles with polyethylenimine coat as simple, safe, and versatile vehicles for cell targeting: population characteristics, cell uptake, and intracellular trafficking.
Linping Wu (2014)
10.1021/ja3009677
Strained ruthenium complexes are potent light-activated anticancer agents.
B. Howerton (2012)
10.1002/chem.201504800
New Ru(II) Complex for Dual Activity: Photoinduced Ligand Release and (1)O2 Production.
Lauren M Loftus (2016)
10.1021/ic301310q
Design and synthesis of a luminescent cyclometalated iridium(III) complex having N,N-diethylamino group that stains acidic intracellular organelles and induces cell death by photoirradiation.
Shinsuke Moromizato (2012)
10.1038/nrc3064
Targeting hypoxia in cancer therapy
W. Wilson (2011)
10.1038/nrm2745
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
P. Saftig (2009)
10.1021/acs.inorgchem.5b00369
Photochemical Properties of Red-Emitting Tris(cyclometalated) Iridium(III) Complexes Having Basic and Nitro Groups and Application to pH Sensing and Photoinduced Cell Death.
Aya Kando (2015)
10.1021/ic402387b
Synthesis and photochemical properties of pH responsive tris-cyclometalated iridium(III) complexes that contain a pyridine ring on the 2-phenylpyridine ligand.
Akihiro Nakagawa (2014)
10.1016/S0098-2997(00)00007-8
The molecular biology of cancer.
J. Bertram (2000)
10.1016/j.biomaterials.2014.09.012
Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions.
X. Li (2015)
10.1002/ADFM.201500590
Dual‐Stage‐Light‐Guided Tumor Inhibition by Mitochondria‐Targeted Photodynamic Therapy
K. Han (2015)
10.1039/c4sc03759f
Combination of Ru(ii) complexes and light: new frontiers in cancer therapy
C. Mari (2015)
10.1158/0008-5472.CAN-11-3744
Tumor vascular microenvironment determines responsiveness to photodynamic therapy.
Amanda L. Maas (2012)
10.1039/c4cs00039k
Optical methods for sensing and imaging oxygen: materials, spectroscopies and applications.
Xu-Dong Wang (2014)
10.1039/b917753a
Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine.
N. J. Farrer (2009)
Angewandte Chemie Communications
D. R. Green (2004)
10.1038/nrc1738
Lysosomes and autophagy in cell death control
G. Kroemer (2005)
10.1016/J.CCR.2014.05.018
Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy.
J. Knoll (2015)
10.1021/cr900300p
Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.
J. Celli (2010)
10.1039/c5cc01978h
A multifunctional phosphorescent iridium(III) complex for specific nucleus staining and hypoxia monitoring.
S. Liu (2015)
10.1002/chem.201402796
DNA intercalating Ru(II) polypyridyl complexes as effective photosensitizers in photodynamic therapy.
C. Mari (2014)
10.1021/ja408286k
Cell-specific and pH-activatable rubyrin-loaded nanoparticles for highly selective near-infrared photodynamic therapy against cancer.
Jiangwei Tian (2013)
10.1021/ja508272h
Marked improvement in photoinduced cell death by a new tris-heteroleptic complex with dual action: singlet oxygen sensitization and ligand dissociation.
B. A. Albani (2014)
10.1038/ncomms9785
Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy
Yuhao Cheng (2015)
10.1038/nrd3137
Targeting mitochondria for cancer therapy
S. Fulda (2010)
10.1002/anie.201204933
Designing red-light-activated multifunctional agents for the photodynamic therapy.
S. H. Higgins (2012)



This paper is referenced by
10.3762/bjnano.11.15
Rational design of block copolymer self-assemblies in photodynamic therapy
Maxime Demazeau (2020)
10.1016/j.ejmech.2019.06.045
Guanidine-modified cyclometalated iridium(III) complexes for mitochondria-targeted imaging and photodynamic therapy.
Xing-Dong Song (2019)
10.1039/c7cc01320e
Novel hypoxia-targeting Pt(iv) prodrugs.
Zi-chen Xu (2017)
10.1021/jacs.7b05019
Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy.
Wen Xiang Piao (2017)
10.3390/molecules25051127
Influence of Polymer Charge on the Localization and Dark- and Photo-Induced Toxicity of a Potential Type I Photosensitizer in Cancer Cell Models
Mikael Lindgren (2020)
10.1039/c8dt00887f
Phosphorescent iridium(iii) complexes: a versatile tool for biosensing and photodynamic therapy.
Tianci Huang (2018)
10.3390/molecules23113016
Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria
Fengming Lin (2018)
10.1039/c9nr10453d
Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy.
Ying Lan (2020)
10.1039/c7nr06130g
Redox-triggered activation of nanocarriers for mitochondria-targeting cancer chemotherapy.
Wei Zhou (2017)
10.1002/anie.202003895
GSH and H2O2 Co-Activatable Mitochondria-Targeted Photodynamic Therapy under Normoxia and Hypoxia.
Jian Sun (2020)
10.1002/advs.201802050
AIE Multinuclear Ir(III) Complexes for Biocompatible Organic Nanoparticles with Highly Enhanced Photodynamic Performance
L. Zhang (2019)
10.1039/c7cc01229b
Silica-encapsulated gold nanoparticle dimers for organelle-targeted cellular delivery.
Vu Thanh Cong (2017)
10.1038/s41467-019-11082-3
Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
Da Huo (2019)
10.1039/c9pp00142e
Neutral iridium(iii) complexes bearing BODIPY-substituted N-heterocyclic carbene (NHC) ligands: synthesis, photophysics, in vitro theranostic photodynamic therapy, and antimicrobial activity.
Bingqing Liu (2019)
Targeted photosensitizers and controlled singlet oxygen generation for therapeutic applications
E. Uçar (2019)
10.1002/smll.201702299
Recent Progress in Near Infrared Light Triggered Photodynamic Therapy.
Kerong Deng (2017)
10.1002/CPTC.201700046
Blue‐Emitting Electron‐Donor/Acceptor Dyads for Naked‐Eye Fluorescence Detection of Singlet Oxygen
Reiko Kohara (2017)
10.1021/acsami.8b05944
Phosphorescent Starburst Pt(II) Porphyrins as Bifunctional Therapeutic Agents for Tumor Hypoxia Imaging and Photodynamic Therapy.
Zhuang Lv (2018)
Metal-NHC complexes for anti-cancer applications : gold(I) for antimitochondrial activity and iridium(III) for photodynamic therapy
Chen Zhang (2018)
10.1002/chem.201803452
Exploitation of Environment-Sensitive Luminophores in the Design of Sydnone-Based Bioorthogonal Imaging Reagents.
L. C. Lee (2018)
10.1002/anie.201704458
Hybrid TiO2 -Ruthenium Nano-photosensitizer Synergistically Produces Reactive Oxygen Species in both Hypoxic and Normoxic Conditions.
Rebecca C. Gilson (2017)
10.1039/d0sc00757a
A multifunctional nanoprobe for targeting tumors and mitochondria with singlet oxygen generation and monitoring mitochondrion pH changes in cancer cells by ratiometric fluorescence imaging
Jingjin Zhao (2020)
10.1007/s11426-019-9583-4
Mitochondria-localized iridium(III) complexes with anthraquinone groups as effective photosensitizers for photodynamic therapy under hypoxia
Song Guo (2019)
10.1039/c9cc05998a
A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells.
C. Zhang (2019)
10.1002/ANGE.201805138
Innovative Strategien für die photodynamische Therapie hypoxischer Tumore
X. Li (2018)
10.1002/adma.201706090
A Magnetofluorescent Carbon Dot Assembly as an Acidic H2 O2 -Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy.
Qingyan Jia (2018)
10.1186/s11671-018-2445-1
Novel Dual Mitochondrial and CD44 Receptor Targeting Nanoparticles for Redox Stimuli-Triggered Release
Kaili Wang (2018)
10.3390/ph12040163
Fighting Hypoxia to Improve PDT
Ludivine Larue (2019)
10.1021/acsami.8b10339
In Situ Growth of CuS/SiO2-Based Multifunctional Nanotherapeutic Agents for Combined Photodynamic/Photothermal Cancer Therapy.
Xiangmei Liu (2018)
10.1039/c8sc02984a
Phosphorescent iridium(iii) complexes capable of imaging and distinguishing between exogenous and endogenous analytes in living cells† †Electronic supplementary information (ESI) available: Synthesis, characterization, experimental information, and additional figures. See DOI: 10.1039/c8sc02984a
K. Zhang (2018)
10.1002/cbic.201800182
Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy
Huaiyi Huang (2018)
10.1039/c8cs00660a
Dinuclear metal complexes: multifunctional properties and applications.
Guangfu Li (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar