Online citations, reference lists, and bibliographies.

Antibacterial, SOD Mimic And Nuclease Activities Of Copper(II) Complexes Containing Ofloxacin And Neutral Bidentate Ligands

M. Patel, P. Parmar, Deepen S. Gandhi
Published 2011 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
Drug-based mixed-ligand copper(II) complexes of type [Cu(OFL)(An)Cl]·5H2O (OFL = ofloxacin, A1 = pyridine-2-carbaldehyde, A2 = 2,2′-bipyridylamine, A3 = thiophene-2-carbaldehyde, A4 = 2,9-dimethyl-1,10-phenanthroline, A5 = 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline, A6 = 4,5-diazafluoren-9-one, A7 = 1,10-phenanthroline-5,6-dione and A8 = 5-nitro-1,10-phenanthroline) were synthesized and characterized. Spectral investigations of complexes revealed square pyramidal geometry. Viscosity measurement and absorption titration were employed to determine the mode of binding of complexes with DNA. DNA cleavage study showed better cleaving ability of the complexes compared with metal salt and standard drug by conversion of a supercoiled form of pUC19 DNA to linear via circular. From the SOD mimic study, concentration of complexes ranging from 0.415 to 1.305 µM is enough to inhibit the reduction rate of NBT by 50% (IC50) in the NADH-PMS system. Antibacterial activity was assayed against selective Gram-negative and Gram-positive microorganisms using the doubling dilution technique. Copyright © 2010 John Wiley & Sons, Ltd.
This paper references
10.1016/S0020-1693(00)81179-2
Synthesis and characterization of mixed ligand complexes of copper with nalidixic acid and (NN) donors. Crystal structure of [Cu(Phen)(Nal)-(H2O)]NO3·3H2O
G. Mendoza-Díaz (1987)
10.1016/J.POLY.2006.09.041
Synthesis, characterization and superoxide dismutase activity of some octahedral nickel(II) complexes
R. Patel (2007)
10.1039/B509690A
Recognition of guanines at a double helix-coil junction in DNA by a trinuclear copper complex.
T. Itô (2005)
10.1021/jm00329a015
Compounds affecting the central nervous system. I. 4-Piperidones and related compounds.
C. R. Ganellin (1965)
10.1016/J.JINORGBIO.2006.10.004
DNA-binding and cleavage studies of novel binuclear copper(II) complex with 1,1'-dimethyl-2,2'-biimidazole ligand.
Y. Li (2007)
10.1080/14756360310001624948
Metal binding and antibacterial activity of ciprofloxacin complexes
Z. Chohan (2005)
10.1016/S0010-8545(00)80537-8
Study of the relation between the structural data and magnetic interaction in oxo-bridged binuclear copper(II) compounds
M. Mel'nik (1982)
10.1007/S11243-007-0246-Y
Synthesis, characterization and DNA binding studies of ruthenium(II) complexes: [Ru(bpy)2(dtmi)]2+ and [Ru(bpy)2(dtni)]2+
Y. Liu (2007)
10.1021/ja00536a063
Cleavage of DNA by coordination complexes. Superoxide formation in the oxidation of 1,10-phenanthroline-cuprous complexes by oxygen - relevance to DNA-cleavage reaction
D. R. Graham (1980)
10.1016/0162-0134(95)00022-G
COORDINATION BEHAVIOR OF SULFATHIAZOLE. CRYSTAL STRUCTURE OF CU(SULFATHIAZOLE) (PY)3CL SUPEROXIDE DISMUTASE ACTIVITY
J. Casanova (1995)
10.1021/ja01474a026
Intramolecular H-Bonds. I. A Spectroscopic Study of the Hydrogen Bond between Hydroxyl and Nitrogen
H. Freedman (1961)
10.1021/jo01170a007
The improved synthesis of 5-nitro-1,10-phenanthroline.
G. F. Smith (1947)
10.1007/S10973-007-8542-5
Coordination chain polymeric assemblies of trivalent lanthanides with multidentate Schiff base synthetic, spectral investigation and thermal aspects
S. Patel (2008)
10.1016/J.SAA.2005.04.030
Synthesis, characterization and biological activity of ternary copper(II) complexes containing polypyridyl ligands.
R. N. Patel (2006)
10.1016/J.SAA.2006.09.041
Spectrophotometric determination of gatifloxacin in pure form and in pharmaceutical formulation.
A. Amin (2007)
10.1016/J.POLY.2004.02.028
Solid state coordination chemistry of mononuclear mixed-ligand complexes of Ni(II), Cu(II) and Zn(II) with α-hydroxycarboxylic acids and imidazole
R. Carballo (2004)
10.1023/A:1007132408648
Ruthenium(II) complexes containing bidentate Schiff bases and their antifungal activity
N. Dharmaraj (2001)
10.1021/bi00260a005
Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: equilibrium binding studies on interaction of daunomycin with deoxyribonucleic acid.
J. Chaires (1982)
10.1081/SIM-120037516
Synthesis and EPR Spectral Studies of Mono- and Binuclear Cobalt(II) and Nickel(II) Complexes with New 20‐Membered Dithiatetraazamacrocyclic [N4S2] Ligand
S. Chandra (2004)
10.1016/0731-7085(95)01598-1
Spectral characterization of fluconazole.
T. Cyr (1996)
10.1016/j.bmcl.2008.10.068
Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: synthesis, spectral, antimicrobial, and DNA interaction approach.
M. Patel (2008)
10.1021/bi00394a013
Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA.
A. Wolfe (1987)
10.1021/bi00061a015
Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: mode and specificity of binding.
S. Satyanarayana (1993)
10.1021/ja00332a020
Selective perturbation of ligand field excited states in polypyridine ruthenium(II) complexes
Leslie J. Henderson (1984)
10.1016/S0162-0134(97)00004-4
Synthesis and DNA binding studies of cobalt (III) mixed-polypyridyl complex.
L. Jin (1997)
10.1016/S0162-0134(99)00206-8
DNA binding of iron(II) mixed-ligand complexes containing 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline.
Mudasir (1999)
10.1016/S0162-0134(96)00218-8
Crystal structure and characterization of the bismuth(III) compound with quinolone family member (ciprofloxacin). Antibacterial study.
I. Turel (1997)
10.1021/JM000038M
Synthesis and biological evaluation of certain α, β-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents
H. El-Subbagh (2000)
10.1007/S11243-009-9200-5
Synthesis, characterization, and bioactivities of copper complexes with N-substituted Di(picolyl)amines
L. Wang (2009)
10.1016/S0162-0134(00)00132-X
DNA-binding and photocleavage studies of cobalt(III) polypyridyl complexes: [Co(phen)2IP]3+ and [Co(phen)2PIP]3+
Qian-ling Zhang (2001)
10.1016/J.ICA.2005.11.003
Crystal structure and DNA-binding studies of a new Cu(II) complex involving benzimidazole
Q. Zhou (2006)
10.1021/IC010232E
Synthesis and DNA binding of novel water-soluble cationic methylcobalt porphyrins.
J. Trommel (2001)
10.1023/A:1012037312390
Synthesis, characterization and interaction of mixed polypyridyl ruthenium(II) complexes with calf thymus DNA
J. Liu (2001)
10.1016/S0162-0134(02)00591-3
High nuclearity nickel compounds with three, four or five metal atoms showing antibacterial activity.
M. Alexiou (2003)
10.1016/j.bmc.2009.06.023
Interaction of drug based binuclear mixed-ligand complexes with DNA.
Mohan N. Patel (2009)
10.1016/S0020-1693(00)00080-3
Superoxide dismutase activity of ternary copper complexes of sulfathiazole and imidazole derivatives. Synthesis and properties of [CuL2(R-Him)2] [HL=4-amino-N-(thiazol-2-yl)benzenesulfonamide, R-Him=4-methylimidazole, 4,4-dimethylimidazoline or 1,2-dimethylimidazole]. Crystal structure of [CuL2(4,4-
J. Casanova (2000)
10.1021/ja00062a007
DNA-BINDING OF DELTA- RU(PHEN)2DPPZ 2+ AND LAMBDA- RU(PHEN)2DPPZ 2+
C. Hiort (1993)
10.1016/J.ICA.2007.08.026
Dinuclear fumarato- and terephthalato-bridged copper(II) complexes: Structural characterization and magnetic properties
F. Mautner (2008)
10.1080/00958970500443144
Synthesis, structure and SOD-like activity of a ternary Cu(II) complex with 1,10-phenanthroline and L-valinate
Xueyi Le (2006)
10.1002/bip.1969.360080105
Viscosity and sedimentation study of sonicated DNA–proflavine complexes
G. Cohen (1969)
10.1016/S0010-8545(00)80455-5
Relationships between the carbon-oxygen stretching frequencies of carboxylato complexes and the type of carboxylate coordination
G. Deacon (1980)
10.1007/BF02173735
Über einige heterozyklische Thiosemicarbazone
R. E. Hagenbach (2005)
10.1080/00958970412331272403
Synthesis, characterization and magnetochemical studies of dicopper(II) complexes derived from bis(N-salicylidene)dicarboxylic acid dihydrazides
M. Iskander (2005)
10.1007/S11243-004-4576-8
Bis(2,2′-bipyridine)cobalt(III) complexes containing asymmetric ligands: Synthesis, DNA-binding and photocleavage studies
X. Wang (2005)
10.1016/0009-2797(78)90090-X
Studies on the reduction of nitroblue tetrazolium chloride mediated through the action of NADH and phenazine methosulphate.
V. Ponti (1978)
10.1021/ja00365a069
Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)
R. Hertzberg (1982)
10.1002/prac.19853270418
Potential anticancer agents. XXVI. Spin Labelled Nitrosoureas
I. Baracu (1985)
10.1016/S0010-8545(02)00027-9
The interactions of metal ions with quinolone antibacterial agents
I. Turel (2002)
10.1016/S0010-8545(00)80504-4
Mono-, bi-, tetra- and polynuclear copper(II) halogenocarboxylates
M. Melnik (1981)
10.1016/S0031-9422(00)00451-9
Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications.
A. Watson (2001)



This paper is referenced by
10.2174/1568026616666161003143333
The Antibacterial Activity of Metal Complexes Containing 1,10- phenanthroline: Potential as Alternative Therapeutics in the Era of Antibiotic Resistance.
Lívia Viganor (2017)
10.1016/j.ijantimicag.2014.03.007
A high-throughput small-molecule screen to identify a novel chemical inhibitor of Clostridium difficile.
David S. Katzianer (2014)
10.1007/s10895-016-1788-1
The Zn(II) nanocomplex: Sonochemical synthesis, characterization, DNA- and BSA-binding, cell imaging, and cytotoxicity against the human carcinoma cell lines
Marzieh Anjomshoa (2016)
10.1080/15533174.2013.818020
Ofloxacin Metal Complexes: Synthesis, Characterization, Analytical Properties, and DNA Binding Studies
Ayşegül Gölcü (2014)
10.1016/J.POLY.2014.06.001
Variable coordination modes of an active ligand periphery in 1,3-bis(2-pyridylimino)isoindolato copper(II) complexes
Désirée C. Sauer (2014)
10.1016/j.saa.2015.05.076
In vitro DNA and BSA-binding, cell imaging and anticancer activity against human carcinoma cell lines of mixed ligand copper(II) complexes.
Marzieh Anjomshoa (2015)
10.1007/s00044-013-0576-6
Thermal, kinetic, spectroscopic studies and anti-microbial, anti-tuberculosis, anti-oxidant properties of clioquinol and benzo-coumarin derivatives mixed complexes with copper ion
H. Dholariya (2013)
10.2174/13895575113136660092
Copper complexes of bioactive ligands with superoxide dismutase activity.
Huma Khalid (2013)
10.1016/J.ICA.2016.10.034
Synthesis, spectral, magnetic properties, electrochemical evaluation and SOD mimetic activity of four mixed-ligand Cu(II) complexes
Miroslava Puchoňová (2017)
Semantic Scholar Logo Some data provided by SemanticScholar