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Peripheral Nerve Injury: A Review And Approach To Tissue Engineered Constructs

G. Evans
Published 2001 · Medicine

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Eleven thousand Americans each year are affected by paralysis, a devastating injury that possesses associated annual costs of $7 billion (American Paralysis Association, 1997). Currently, there is no effective treatment for damage to the central nervous system (CNS), and acute spinal cord injury has been extraordinarily resistant to treatment. Compared to spinal cord injury, damage to peripheral nerves is considerably more common. In 1995, there were in excess of 50,000 peripheral nerve repair procedures performed. (National Center for Health Statistics based on Classification of Diseases, 9th Revision, Clinical Modification for the following categories: ICD‐9 CM Code: 04.3, 04.5, 04.6, 04.7). These data, however, probably underestimate the number of nerve injuries appreciated, as not all surgical or traumatic lesions can be repaired. Further, intraabodominal procedures may add to the number of neurologic injuries by damage to the autonomic system through tumor resection. For example, studies assessing the outcome of impotency following radical prostatectomy demonstrated 212 of 503 previously potent men (42%) suffered impotency when partial or complete resection of one or both cavernosal nerve(s). This impotency rate decreased to 24% when the nerves were left intact (Quinlan et al., J. Urol. 1991 ;145:380–383; J. Urol. 1991 ;145:998–1002). Anat Rec 263:396–404, 2001. © 2001 Wiley‐Liss, Inc.
This paper references
10.2106/00004623-195840040-00029
Peripheral Nerve Regeneration. A Follow-up Study of 3,656 World War II Injuries. Edited by Barnes Woodhall, M.D., and Gilbert W. Beebe, Ph.D. Washington, United States Government Printing Office, 1956
E. A. Kahn (1958)
10.1002/JBM.820290514
Hydrogel-based three-dimensional matrix for neural cells.
R. Bellamkonda (1995)
10.1002/CNE.903060410
A collagen‐based nerve guide conduit for peripheral nerve repair: An electrophysiological study of nerve regeneration in rodents and nonhuman primates
S. Archibald (1991)
10.1163/156856200744011
In vitro evaluation of the biofunctionality of osteoblasts cultured on DegraPol-foam
B. Saad (2000)
10.1016/0142-9612(96)85568-2
Neural tissue engineering: from polymer to biohybrid organs.
S. Woerly (1996)
10.1023/A:1015410023132
Basic Fibroblast Growth Factor Promotes Extension of Regenerating Axons of Peripheral Nerve. In Vivo Experiments Using a Schwann Cell Basal Lamina Tube Model
E. Fujimoto (1997)
10.1016/0032-3861(94)90953-9
Preparation and characterization of poly(l-lactic acid) foams
A. Mikos (1994)
10.1006/exnr.1994.1136
Point Sources of Schwann Cells Result in Growth into a Nerve Entubulation Repair Site in the Absence of Axons: Effects of Freeze-Thawing
R. Madison (1994)
10.1016/0304-3940(87)90233-3
Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia
D. Otto (1987)
10.1097/00006534-198012000-00065
Nerve regeneration through preformed pseudosynovial tubes
J. Chong (1980)
10.1007/BF01795309
Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury
K. Rich (1987)
10.1002/(SICI)1097-4636(199605)31:1<105::AID-JBM13>3.0.CO;2-M
Light-microscopic and electron-microscopic evaluation of short-term nerve regeneration using a biodegradable poly(DL-lactide-epsilon-caprolacton) nerve guide.
W. D. den Dunnen (1996)
10.1002/CNE.902640211
Exogenous matrix precursors promote functional nerve regeneration across a 15‐mm gap within a silicone chamber in the rat
L. Williams (1987)
Nerve repair and grafting
S E Mackinnon (1988)
10.2106/00004623-197658020-00008
Further experience with interfascicular grafting of the median, ulnar, and radial nerves.
H. Millesi (1976)
Insulin - like growth factor ( IGF - I ) as a stimulator of regeneration in the freeze - injured rat sciatic nerve
GD Sterne (1989)
10.1016/0014-4886(87)90247-0
Collagen- and laminin-containing gels impede peripheral nerve regeneration through semipermeable nerve guidance channels
R. Valentini (1987)
10.1016/0142-9612(95)93851-4
Peripheral nerve repair using a poly(organo)phosphazene tubular prosthesis.
F. Langone (1995)
Nuova selva di cirurgia divisia in tre parti venice
G Ferrara (1608)
10.1016/0014-4886(89)90135-0
Preservation of sensory cells by placing stumps of transected nerve in an impermeable tube
S. Melville (1989)
10.1002/CNE.903610203
Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts II. Tenascin‐C
Y. Zhang (1995)
10.1016/0006-8993(89)90671-9
Insulin-like growth factor (IGF-1) as a stimulator of regeneration in the freeze-injured rat sciatic nerve
Jacob Sjöberg (1989)
10.1016/S0006-8993(96)01012-8
Peripheral nerve regeneration through short- and long-term degenerated nerve transplants
A. Gulati (1996)
10.1098/rstl.1850.0021
Experiments on the Section of the Glosso-Pharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres
A. Waller (1850)
10.1002/JBM.820270207
Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation.
A. Mikos (1993)
10.1006/exnr.1997.6650
Influence of Collagen and Laminin Gels Concentration on Nerve Regeneration after Resection and Tube Repair
R. Labrador (1998)
10.1097/BLO.0b013e31803df02c
THE CLASSIC: Gunshot Wounds and Other Injuries of Nerves
S. W. Mitchell (1982)
10.1007/3540587888_17
Tissue regeneration templates based on collagen-glycosaminoglycan copolymers
I. Yannas (1995)
10.1002/JNR.490410409
Laminin oligopeptide derivatized agarose gels allow three‐dimensional neurite extension in vitro
R. Bellamkonda (1995)
10.1016/S0142-9612(98)00099-4
Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration.
M. Widmer (1998)
10.1111/j.1460-9568.1997.tb01493.x
Neurotrophin‐3 Delivered Locally via Fibronectin Mats Enhances Peripheral Nerve Regeneration
G. D. Sterne (1997)
10.2106/00004623-195537040-00041
Peripheral Nerve Injuries By the Nerve Injuries Committee of the Medical Research Council. Edited by H. J. Seddon. (Privy Council. Medical Research Council Special Report Series. No. 282.) London, Her Majesty's Stationery Office, 1954. 2 pounds, 15 shillings
S. Bunnell (1955)
Nerve growth factor enhances expression of neuron - glia cell adhesion molecule in PC 12 cells
DR Friedlander (1986)
10.1163/156856200744066
Clinical long-term in vivo evaluation of poly(L-lactic acid) porous conduits for peripheral nerve regeneration
G. Evans (2000)
10.1016/S0142-9612(01)00190-9
Bioactive poly(L-lactic acid) conduits seeded with Schwann cells for peripheral nerve regeneration.
G. Evans (2002)
10.1089/10763270152044161
Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering.
C. Patrick (2001)
10.1073/PNAS.91.7.2795
Nerve growth factor and its low-affinity receptor promote Schwann cell migration.
E. Anton (1994)
10.1016/S1044-5765(05)80010-7
Regeneration and repair of the peripheral nervous system
D. Tonge (1993)
Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injry
CE Schmidt (1987)
10.1002/CNE.903610202
Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts I. Neural cell adhesion molecules
Y. Zhang (1995)
Contain On Lifting Bodies which Two-Dimensional Supersonic By L . H ' TOWNEND Flows LONDON : HER MAJESTY ' S STATIONERY OFFICE
By L. H. TOWNEND (2002)
Experiments on the glossopharyngeal and hypoglossal nerves of the frog and observations produced thereby in the structure of their primative fibres
KK Wang (1850)
10.1523/JNEUROSCI.04-12-02986.1984
The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia
H. Yip (1984)
10.1016/0142-9612(96)84669-2
Effectiveness of a bioabsorbable conduit in the repair of peripheral nerves.
N. Nicoli Aldini (1996)
10.1083/JCB.86.1.156
Rapid retraction of neurites by sensory neurons in response to increased concentrations of nerve growth factor
C. Griffin (1980)
10.1002/MICR.1920140914
Inside‐out vein graft promotes improved nerve regeneration in rats
K. Wang (1993)
10.1523/JNEUROSCI.15-11-07226.1995
Impaired peripheral nerve regeneration in a mutant strain of mice (Enr) with a Schwann cell defect
E. M. Rath (1995)
10.1002/MUS.880050110
Regeneration of peripheral nerve through a polyglactin tube
H. Molander (1982)
10.1007/BF01189813
Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves
R. Martini (1994)
In peripheral nerve regeneration: A follow-up study of 3,656 World War II injuries. VA Medical Monograph
B Woodall (1956)
10.1016/0896-6273(92)90213-W
The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons
P. Distefano (1992)
10.1016/S0363-5023(80)80041-4
Nerve regeneration through preformed pseudosynovial tubes. A preliminary report of a new experimental model for studying the regeneration and reorganization capacity of peripheral nerve tissue.
G. Lundborg (1980)
10.1002/JNR.490400305
Hyaluronic acid through a new injectable nerve guide delivery system enhances peripheral nerve regeneration in the rat
B. Seckel (1995)
4-Methylcatechol, an inducer of nerve growth factor synthesis, enhances peripheral nerve regeneration across nerve gaps.
K. Kaechi (1995)
Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerve
S Melville (1994)
10.1111/j.1460-9568.1996.tb01237.x
Interleukin 6 in Intact and Injured Mouse Peripheral Nerves
F. Reichert (1996)
10.1016/S0142-9612(99)00010-1
In vivo evaluation of poly(L-lactic acid) porous conduits for peripheral nerve regeneration.
G. Evans (1999)
10.1523/JNEUROSCI.14-03-01309.1994
The functional characteristics of Schwann cells cultured from human peripheral nerve after transplantation into a gap within the rat sciatic nerve
A. Levi (1994)
10.1016/S0022-5347(17)38512-9
Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles.
D. Quinlan (1991)
Poly ( DL - lactic - co - glycolic acid ) ( PLGA ) biodegradable tissue engineered nerve conduits : Their use in peripheral nerve regeneration
Evans GRD (1998)
10.1073/PNAS.94.17.8948
Stimulation of neurite outgrowth using an electrically conducting polymer.
C. Schmidt (1997)
10.1083/JCB.102.2.413
Nerve growth factor enhances expression of neuron-glia cell adhesion molecule in PC12 cells
D. R. Friedlander (1986)
10.1001/ARCHOTOL.124.10.1081
A tissue-engineered conduit for peripheral nerve repair.
T. Hadlock (1998)
10.1016/S0022-5347(17)38348-9
Cavernous nerve grafts restore erectile function in denervated rats.
D. Quinlan (1991)
10.1016/0006-8993(88)91135-3
Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses
R. Madison (1988)
10.1016/0006-8993(85)91130-8
An in vivo model to quantify motor and sensory peripheral nerve regeneration using bioresorbable nerve guide tubes
C. D. Silva (1985)
Peripheral nerve injury and regeneration.
G. Terenghi (1995)
10.1002/MUS.880181009
Regeneration across preserved peripheral nerve grafts
P. Evans (1995)
10.1016/S0030-5898(05)70166-8
Engineering strategies for peripheral nerve repair.
T. W. Hudson (1999)
Schwann cell proliferation
De Vries (1993)
Classification of nerve injuries as the basis for treatment
S E Mackinnon (1988)
Dermal fibroblasts genetically engineered to release NGF
CW Patrick



This paper is referenced by
10.7936/K7HT2M9D
Evalulating Environmental Cues that Affect Schwann Cell Gene Expression to Enhance Peripheral Nerve Regeneration
N. Jesuraj (2012)
Comparison of the effects of PRP and hyaluronic acid in promoting peripheral nerve regeneration An experimental study with vascular conduit model in rats'.
C. Fırat (2016)
10.1016/J.INJURY.2008.05.010
Siatic nerve regeneration in rats stimulated by fibrin glue containing nerve growth factor: an experimental study.
G. Chun-zheng (2008)
10.1111/j.1743-6109.2010.01730.x
Erectile function restoration after repair of excised cavernous nerves by autologous vein graft in rats.
W. Hu (2010)
10.1002/JBM.A.30683
Porous chitosan tubular scaffolds with knitted outer wall and controllable inner structure for nerve tissue engineering.
Aijun Wang (2006)
10.1007/B136241
BioMEMS and Biomedical Nanotechnology
M. Ferrari (2006)
10.4015/S1016237212002974
METHYL CELLULOSE ENHANCE GELATIN MEMBRANE AS GUIDANCE CHANNELS FOR PERIPHERAL NERVE REGENERATION
Kuo-Chi Chang (2012)
10.1039/d0tb00779j
Reduced graphene oxide-GelMA-PCL hybrid nanofibers for peripheral nerve regeneration.
X. Fang (2020)
10.3390/ijms17122101
Peripheral Nerve Injury: Stem Cell Therapy and Peripheral Nerve Transfer
R. Sullivan (2016)
10.1109/IEMBS.2005.1615821
Nanofunctionalisation for the treatment of peripheral nervous system injuries.
L. Pastorino (2005)
10.2147/IJN.S11883
Types of neural guides and using nanotechnology for peripheral nerve reconstruction
E. Biazar (2010)
10.1523/JNEUROSCI.0648-19.2019
The Cofilin/Limk1 Pathway Controls the Growth Rate of Both Developing and Regenerating Motor Axons
M. Frendo (2019)
10.1002/jbm.a.36497
Xenogeneic acellular nerve scaffolds supplemented with autologous bone marrow-derived stem cells promote axonal outgrowth and remyelination but not nerve function.
B. Hou (2018)
10.1002/jnr.10560
Regeneration of sciatic nerves of adult rats induced by extracts from distal stumps of pre‐degenerated peripheral nerves
W. Marcol (2003)
10.2174/1874325001206010103
Recent Advances and Developments in Neural Repair and Regeneration for Hand Surgery
M. Chimutengwende-Gordon (2012)
10.1002/bdrc.21006
Organ repair and regeneration: an overview.
Joëlle A Baddour (2012)
10.4252/wjsc.v12.i10.1196
Neurotrophic effects of dental pulp stem cells in repair of peripheral nerve after crush injury
D. Wang (2020)
10.3389/fsurg.2020.609638
Reviving Matrix for Nerve Reconstruction in Rabbit Model of Chronic Peripheral Nerve Injury With Massive Loss Defect
S. Rochkind (2020)
10.2176/nmc.oa2012-0330
Acetyl Salicylic Acid Locally Enhances Functional Recovery after Sciatic Nerve Transection in Rat
R. Mohammadi (2013)
Electrophysiological and histopathological effects of mesenchymal stem cells in treatment of experimental rat model of sciatic nerve injury.
Ercan Yarar (2015)
10.3171/2017.8.JNS163020
Therapeutic electrical stimulation of injured peripheral nerve tissue using implantable thin-film wireless nerve stimulators.
Matthew MacEwan (2018)
10.7936/K79C6WV2
Functional Electrical Stimulation of Peripheral Nerve Tissue Via Regenerative Sieve Microelectrodes
Matthew MacEwan (2018)
No synergistic effect of mesenchymal stem cells and exercise on functional recovery following sciatic nerve transection.
J. Wang (2010)
10.1002/MICR.20290
Effect of oblique nerve grafting on peripheral nerve regeneration in rats
K. Kotulska (2006)
10.1111/j.1473-2165.2011.00582.x
Factors influencing postoperative hyperesthesia in hair restoration surgery
Carlos K Wesley (2011)
10.1007/s00580-014-1976-9
Effect of local administration of fibroblastic growth factor with chitosan conduit on peripheral nerve regeneration: a rat sciatic nerve transection model
R. Mohammadi (2014)
10.1016/j.jmbbm.2014.10.002
Decellularized grafts with axially aligned channels for peripheral nerve regeneration.
R. Sridharan (2015)
10.1088/0957-4484/20/1/015101
Process entanglement as a neuronal anchorage mechanism to rough surfaces.
R. Sorkin (2009)
10.1101/654723
Tissue Engineered Axon Tracts Serve as Living Scaffolds to Accelerate Axonal Regeneration and Functional Recovery Following Peripheral Nerve Injury in Rats
Kritika S. Katiyar (2019)
10.1016/j.cxom.2010.11.007
Advances in bioengineered conduits for peripheral nerve regeneration.
M. Steed (2011)
10.1002/jbm.b.31118
Fabrication, characterization, and biocompatibility of single-walled carbon nanotube-reinforced alginate composite scaffolds manufactured using freeform fabrication technique.
E. D. Yildirim (2008)
10.1007/S11930-005-0007-X
Neuromodulatory therapy with applications for the radical pelvic surgery patient
A. Burnett (2005)
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