Online citations, reference lists, and bibliographies.

Central Pain Mechanisms In The Rheumatic Diseases: Future Directions.

K. Phillips, D. Clauw
Published 2013 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Pain is a prominent component of many rheumatologic conditions, and is the result of a complex physiologic interaction of central and peripheral nervous system signaling that results in a highly individualized symptom complex. Pain is frequently categorized as acute or chronic (generally greater than three months duration). Chronic pain is not simply acute pain that has lasted longer, and is more likely to be influenced by input from the central nervous system, whereas acute pain is often attributable primarily to inflammation and/or damage in peripheral structures (i.e., nociceptive input). The prominent role of central factors in chronic pain is highlighted by the fact that there is currently no chronic pain condition in which the degree of tissue inflammation or damage alone (e.g., as measured by radiographs, magnetic resonance imaging (MRI), or endoscopy) accurately predicts the presence or severity of pain. Central factors alter pain processing by setting the “gain”, such that when peripheral input is present, it is processed against a background of central factors that can enhance or diminish the experience of pain. There are very large inter-individual differences in these central nervous system factors that influence pain perception, such that some individuals with significant peripheral nociceptive input (e.g. from joint damage or inflammation) will feel little or no pain, whereas others are very pain sensitive, and they can experience pain with minimal or no identifiable abnormal peripheral nociceptive input. This emerging knowledge has important implications for pain management in individuals with chronic rheumatologic disorders.
This paper references
10.1007/s11926-010-0114-1
Quality-of-Life Measurements Versus Disease Activity in Systemic Lupus Erythematosus
A. Kiani (2010)
10.1007/S11916-007-0216-2
Sensitization, glutamate, and the link between migraine and fibromyalgia
P. Sarchielli (2007)
Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Arthritis ResTher 2007;9:R110
G Vargas-Alarcon (2007)
: results from the 1958 British Birth Cohort Study
BI Nicholl (2010)
10.1002/1529-0131(199902)12:1<3::AID-ART2>3.0.CO;2-K
The relationship of anxiety and depression with self-reported knee pain in the community: data from the Baltimore Longitudinal Study of Aging.
P. Creamer (1999)
10.1016/j.jpain.2009.06.001
Understanding fibromyalgia: lessons from the broader pain research community.
D. Williams (2009)
10.1017/S0033291708003784
A population-based twin study of functional somatic syndromes.
K. Kato (2009)
10.1016/j.rdc.2009.06.006
From fibrositis to functional somatic syndromes to a bell-shaped curve of pain and sensory sensitivity: evolution of a clinical construct.
K. Ablin (2009)
10.1038/nm.2710
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
R. E. Sorge (2012)
10.3109/07853890008995932
Evidence-based data on pain relief with antidepressants
D. Fishbain (2000)
10.1016/S0022-3956(96)00051-9
The relationship between fibromyalgia and interstitial cystitis.
D. Clauw (1997)
10.1177/0961203309345784
Work disability in systemic lupus erythematosus is prevalent and associated with socio-demographic and disease related factors
K. Baker (2009)
Severe rheumatoid arthritis (RA), worse outcomes, comorbid illness, and sociodemographic disadvantage characterize ra patients with fibromyalgia.
F. Wolfe (2004)
10.1016/j.pain.2007.10.033
Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk
D. Yarnitsky (2008)
Co-morbidities of patients with knee osteoarthritis.
K. W. Chan (2009)
10.1016/j.pain.2009.05.020
Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: A randomized, double-blind, placebo-controlled study
R. Staud (2009)
10.1016/j.jpain.2010.01.004
How neuroimaging studies have challenged us to rethink: is chronic pain a disease?
D. Doleys (2010)
hypersensitivity states
DJ Clauw (1991)
processing of fibromyalgia patients is maintained by muscle afferent input : a randomized , double - blind , placebo - controlled study
G Affaitati (2009)
Learning from discordance in patient and physician global assessments of systemic lupus erythematosus disease activity.
C. Neville (2000)
10.1159/000097332
Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms.
D. Clauw (1997)
10.1016/j.pain.2010.04.003
Sensitization in patients with painful knee osteoarthritis
L. Arendt-Nielsen (2010)
10.1186/1471-2474-5-48
Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain
J. Baraniuk (2004)
Osteoarthritis and sleep: the Johnston County Osteoarthritis Project.
K. Allen (2008)
10.1080/03009740601153790
Regional cerebral blood flow between primary and concomitant fibromyalgia patients: a possible way to differentiate concomitant fibromyalgia from the primary disease
J. Chen (2007)
10.1016/j.pain.2010.01.023
Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: Results from the 1958 British Birth Cohort Study
L. Hocking (2010)
10.1093/brain/awq195
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
M. Costigan (2010)
10.1001/ARCHINTE.160.2.221
Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.
L. Aaron (2000)
FibroCollective. A framework for fibromyalgia management for primary care providers
LM Arnold (2012)
10.1002/art.24175
A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain.
J. V. van Meurs (2009)
Fatigue in lupus is not correlated with disease activity.
B. Wang (1998)
10.1002/art.23710
The impact of momentary pain and fatigue on physical activity in women with osteoarthritis.
S. Murphy (2008)
10.1002/art.24326
Pain and rheumatology: thinking outside the joint.
D. Clauw (2009)
10.1097/JCP.0000000000000323
A 13-Week, Randomized Double-Blind, Placebo-Controlled, Cross-Over Trial of Ziprasidone in Bipolar Spectrum Disorder
A. Patkar (2015)
10.1016/J.EURPSY.2007.02.002
Role of the COMT gene Val158Met polymorphism in mental disorders: a review.
L. Hosák (2007)
Number of fibromyalgia tender points is associated with health status in patients with systemic lupus erythematosus
D. Buchwald
10.1016/S0304-3959(96)03295-2
Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects
E. Kosek (1997)
10.1002/ART.1790110110
The relationship between psychosocial variables and pain reporting in osteoarthritis of the knee.
P. Creamer (1998)
10.1186/ar2316
Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
G. Vargas-Alarcón (2007)
Fibromyalgianess [editorial
F. Wolfe (2009)
Enhanced central
R Staud
10.1016/j.pain.2006.05.024
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
L. Diatchenko (2006)
10.1001/JAMA.280.11.981
Chronic multisymptom illness affecting Air Force veterans of the Gulf War.
K. Fukuda (1998)
Prediction of chronic post - operative
D Yarnitsky
10.1002/art.1780350509
Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis.
I. J. Russell (1992)
10.1002/art.33339
Reduced insular γ-aminobutyric acid in fibromyalgia.
B. Foerster (2012)
10.1016/j.jpain.2009.02.002
Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera.
L. Arendt-Nielsen (2009)
10.1093/HMG/DDI013
Genetic basis for individual variations in pain perception and the development of a chronic pain condition.
L. Diatchenko (2005)
European Male Ageing Study Group. No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
BI Nicholl (2009)
10.1016/j.pain.2009.06.024
Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: A 13-week, randomized, placebo-controlled trial
A. Chappell (2009)
10.1097/00124743-199512000-00004
The Overlap Between Fibromyalgia and Inflammatory Rheumatic Disease: When and Why Does it Occur?
D. Clauw (1995)
10.1016/S0022-3956(96)00046-5
An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome.
K. Fukuda (1997)
10.1016/0304-3959(91)90100-C
The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states
C. Woolf (1991)
10.1186/ar3024
The role of stress in rheumatic diseases
A. Hassett (2010)
10.1186/ar2842
The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study
Y. Lee (2009)
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 2002;46:1333–43
RH Gracely (2002)
10.1016/j.pain.2006.04.015
Idiopathic pain disorders – Pathways of vulnerability
L. Diatchenko (2006)
disorders — pathways of vulnerability
K Kato (2006)
Fatigue in systemic lupus erythematosus: contributions of disordered sleep, sleepiness, and depression.
A. Iaboni (2006)
Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome
H. Wilder (2007)
10.1136/ard.2009.126086
No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
B. Nicholl (2010)
10.1016/j.jpain.2010.05.008
Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision.
S. McLean (2011)
A functional polymorphism in the catechol-Omethyltransferase gene is associated with osteoarthritis-related pain. Arthritis Rheum 2009;60:628–9
JB Van Meurs (2009)
10.1007/BF02032098
Measurement of pain threshold in patients with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and healthy controls
E. Gerecz-Simon (2005)
10.1016/j.pain.2009.02.015
The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans
D. Pud (2009)
10.1016/0304-3959(95)00061-5
Increased pressure pain sensibility in fibromyalgia patients is located deep to the skin but not restricted to muscle tissue
E. Kosek (1995)
10.1002/art.27585
Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study.
S. Gwilym (2010)
10.1016/J.JPAIN.2007.05.002
Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome.
P. Sarchielli (2007)
10.1097/01.AOG.0000129238.49397.4e
Quantitative Sensory Testing in Vulvodynia Patients and Increased Peripheral Pressure Pain Sensitivity
Jutta Giesecke (2004)
10.1016/J.PAIN.2010.04.028
Corrigendum to “Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: Results from the 1958 British Birth Cohort Study” [Pain 149 (2010) 143–151]
Lynne J. Hocking (2010)
10.1016/0304-3959(94)90198-8
Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome
S. Gibson (1994)
10.1016/j.amjmed.2009.09.006
Fibromyalgia: an overview.
D. Clauw (2009)
10.1523/JNEUROSCI.4015-06.2006
The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity
F. Amaya (2006)
10.1016/j.jpsychores.2008.08.004
Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome.
R. Armitage (2009)
10.1186/ar3311
Distinguishing fibromyalgia from rheumatoid arthritis and systemic lupus in clinical questionnaires: an analysis of the revised Fibromyalgia Impact Questionnaire (FIQR) and its variant, the Symptom Impact Questionnaire (SIQR), along with pain locations
Ronald Friend (2011)
The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum 2005;52:1577–84
T Giesecke (2005)
10.1016/j.urology.2008.06.031
Antecedent nonbladder syndromes in case-control study of interstitial cystitis/painful bladder syndrome.
J. Warren (2009)
Functional imaging of pain in patients with primary fibromyalgia.
D. Cook (2004)
10.1016/0304-3959(95)00068-2
Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain
W. Maixner (1995)
, fatigue , and sleep disturbance and improves functionality in fibromyalgia : results from a 14 - week , randomized , double - blind , placebo - controlled study
DJ Clauw (2011)
10.1002/ART.20063
Evidence of augmented central pain processing in idiopathic chronic low back pain.
T. Giesecke (2004)
10.1002/ART.10225
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia.
R. Gracely (2002)
10.1146/ANNUREV.NEURO.23.1.777
Pain genes?: natural variation and transgenic mutants.
J. Mogil (2000)
10.4088/JCP.08m04969blu
Pain inhibition is deficient in chronic widespread pain but normal in major depressive disorder.
Edith Normand (2011)
10.1016/S0959-4388(03)00090-4
Interoception: the sense of the physiological condition of the body
A. Craig (2003)
Fibromyalgia is a major contributor to quality of life in lupus.
D. Gladman (1997)
erythem - atosus
R Friend (1994)
10.1002/ART.1780400310
Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury.
D. Buskila (1997)
10.1136/bmj.b2844
Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
T. Neogi (2009)
10.1001/ARCHINTE.163.20.2433
Depression and pain comorbidity: a literature review.
M. Bair (2003)
10.1073/pnas.1430684100
Neural correlates of interindividual differences in the subjective experience of pain
R. Coghill (2003)
10.3899/jrheum.100759
Pain Mechanisms in Osteoarthritis: Understanding the Role of Central Pain and Current Approaches to Its Treatment
P. Mease (2011)
10.1371/journal.pone.0006016
Increased Sensitivity to Thermal Pain Following a Single Opiate Dose Is Influenced by the COMT val158met Polymorphism
K. Jensen (2009)
10.1097/00006842-200105000-00006
Cerebral Activation in Patients With Irritable Bowel Syndrome and Control Subjects During Rectosigmoid Stimulation
B. Naliboff (2001)
10.1097/01.jom.0000091693.43121.2f
Unexplained Symptoms After Terrorism and War: An Expert Consensus Statement
D. Clauw (2003)
10.1016/j.pain.2010.09.027
The development of fibromyalgia – I: Examination of rates and predictors in patients with rheumatoid arthritis (RA)
F. Wolfe (2011)
10.1016/j.nurt.2009.07.009
Preclinical and early clinical investigations related to monoaminergic pain modulation
K. Bannister (2011)
10.1136/aim.9.2.47
Diffuse Noxious Inhibitory Controls (DNIC) in Animals and in Man
D. Le Bars (1991)
10.1007/s10165-009-0185-x
The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus
P. Chandrasekhara (2009)
10.1186/ar3306
The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia
Y. Lee (2011)
10.1002/ART.21798
Importance of genetic influences on chronic widespread pain.
Kenji Kato (2006)
10.1111/j.1365-2710.2009.01144.x
Gabapentin and pregabalin in the treatment of fibromyalgia: a systematic review and a meta‐analysis
T. Tzellos (2010)
10.1016/j.genhosppsych.2008.12.006
Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews.
K. Kroenke (2009)
10.1002/art.24837
Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients.
S. Gwilym (2009)
10.1016/j.pain.2004.12.032
Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition
Nancy Julien (2005)
10.1016/j.ejpain.2004.11.001
Human brain mechanisms of pain perception and regulation in health and disease
A. Apkarian (2005)
10.1016/S0167-8760(00)00087-8
Peripheral and central nervous changes in patients with rheumatoid arthritis in response to repetitive painful stimulation.
T. Hummel (2000)
10.1002/ART.1780370812
The prevalence and clinical impact of fibromyalgia in systemic lupus erythematosus.
G. D. Middleton (1994)
10.1185/03007990802429627
The relationship between antidepressant and analgesic responses: findings from six placebo-controlled trials assessing the efficacy of duloxetine in patients with major depressive disorder.
D. Fishbain (2008)
10.1177/096120339400300310
Fibromyalgia Syndrome and Disease Activity in Systemic Lupus Erythematosus
E. Morand (1994)
10.1016/j.autrev.2008.07.023
Etiology of fibromyalgia: the possible role of infection and vaccination.
D. Buskila (2008)
10.1016/j.rdc.2012.10.004
Epidemiology of osteoarthritis.
T. Neogi (2013)
10.1053/eujp.2001.0312
Somatosensory perception in a remote pain‐free area and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from long‐term trapezius myalgia
A. Leffler (2002)
10.1016/j.ejpain.2010.09.002
Effects of treatment of peripheral pain generators in fibromyalgia patients
G. Affaitati (2011)
10.3899/jrheum.080897
Outcome and Predictor Relationships in Fibromyalgia and Rheumatoid Arthritis: Evidence Concerning the Continuum versus Discrete Disorder Hypothesis
F. Wolfe (2009)
10.1016/S0304-3959(00)00310-9
Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief
E. Kosek (2000)
Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee.
M. Hannan (2000)
10.1016/j.pain.2007.06.029
Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: Do conditioning stimulus painfulness, gender and personality variables matter?
M. Granot (2008)
10.1016/S0950-3579(98)80027-7
Measures of disease activity and damage in SLE.
M. Urowitz (1998)
10.1080/08869634.1999.11746100
Increased pain sensitivity of the upper extremities of TMD patients with myalgia to experimentally-evoked noxious stimulation: possibility of worsened endogenous opioid systems.
K. Kashima (1999)
10.1002/acr.20005
Report of the American College of Rheumatology Pain Management Task Force
D. Borenstein (2010)
10.1002/ART.1780371106
Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome.
I. J. Russell (1994)
10.1016/j.jpain.2011.08.005
Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study.
S. Smith (2011)
10.1016/j.mayocp.2012.02.010
A framework for fibromyalgia management for primary care providers.
L. Arnold (2012)
10.1016/j.pain.2003.09.005
Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables
R. Edwards (2003)
10.1136/bmj.327.7428.1357
The health consequences of the first Gulf war
D. Clauw (2003)
10.1016/0016-5085(90)90332-U
Tolerance for rectosigmoid distention in irritable bowel syndrome.
W. E. Whitehead (1990)
10.1016/j.pain.2010.12.022
Sodium oxybate reduces pain, fatigue, and sleep disturbance and improves functionality in fibromyalgia: Results from a 14-week, randomized, double-blind, placebo-controlled study
I. J. Russell (2011)
10.3928/01477447-20090301-21
Comparison of hip and knee arthroplasty outcomes at early and intermediate follow-up.
S. O'brien (2009)
10.1016/j.pain.2010.09.030
Central sensitization: Implications for the diagnosis and treatment of pain
C. Woolf (2011)
10.1126/SCIENCE.1078546
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
J. Zubieta (2003)
10.1001/ARCHPSYC.60.11.1145
Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission.
J. Zubieta (2003)
10.1038/nm1490
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
I. Tegeder (2006)
10.1523/JNEUROSCI.2849-07.2007
Decreased Central μ-Opioid Receptor Availability in Fibromyalgia
R. Harris (2007)
10.1016/S0987-7053(00)00227-6
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
R. Peyron (2000)
10.1016/j.pain.2007.02.011
Comment on Diatchenko et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006;125:216–24
H. Kim (2007)
thresholds and cerebral event - related potentials following painful CO 2 laser stimulation in subjects with fibromyalgia syndrome
E Kosek (1994)
10.1002/ART.21008
The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort.
T. Giesecke (2005)
Co-morbidities of patients with knee osteoarthritis.
Chan Kw (2009)
10.1093/RHEUMATOLOGY/36.7.726
Why does osteoarthritis of the knee hurt--sometimes?
P. Creamer (1997)



This paper is referenced by
10.1016/j.cgh.2013.03.011
Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome.
J. Lackner (2013)
10.1016/j.neubiorev.2016.04.001
Functional reorganisation in chronic pain and neural correlates of pain sensitisation: A coordinate based meta-analysis of 266 cutaneous pain fMRI studies
R. Tanasescu (2016)
10.1080/24740527.2019.1620097
Evaluating the psychometric properties of the Widespread Pain Index and the Symptom Severity Scale in youth with painful conditions
Joanne Dudeney (2019)
10.3109/03009742.2015.1052553
Association of rheumatic diseases with symptom severity, quality of life, and treatment outcome in patients with fibromyalgia
Juan Jiao (2016)
10.2217/pmt.13.30
Reflecting on pain management for patients with osteoarthritis and other rheumatic disorders: there's more to pain management than managing pain.
Danielle Perret (2013)
10.1515/sjpain-2019-0088
Changes in inflammatory plasma proteins from patients with chronic pain associated with treatment in an interdisciplinary multimodal rehabilitation program – an explorative multivariate pilot study
B. Gerdle (2019)
10.3109/03009742.2015.1046484
Concomitant fibromyalgia in rheumatoid arthritis is associated with the more frequent use of biological therapy: a cross-sectional study
P. R. Lage-Hansen (2016)
10.1016/B978-0-323-40196-8.00026-7
Fibromyalgia and Centralized Pain States
Chad M Brummett (2018)
10.1016/j.ejphar.2018.05.005
Nociceptin/orphanin FQ opioid peptide (NOP) receptor and &mgr;‐opioid peptide (MOP) receptors both contribute to the anti‐hypersensitive effect of cebranopadol in a rat model of arthritic pain
Klaus Schiene (2018)
Drug and Non-drug Treatment Options of Fibromyalgia
Abdul Kader Mohiuddin (2020)
10.1002/art.38271
Involvement of Peripheral and Spinal Tumor Necrosis Factor α in Spinal Cord Hyperexcitability During Knee Joint Inflammation in Rats
C. Koenig (2014)
10.1038/s41584-020-0375-7
Reflections on ‘older’ drugs: learning new lessons in rheumatology
S. Kerrigan (2020)
10.4103/jfmpc.jfmpc_7_17
Musculoskeletal manifestations of tuberculosis: An observational study
Nikhil Gupta (2018)
10.1016/j.jpain.2014.01.487
Effect of estrogen depletion on pain sensitivity in aromatase inhibitor-treated women with early-stage breast cancer.
N. Henry (2014)
10.1007/s10067-020-05304-z
Two sides on the fibromyalgia coin: physical pain and social pain (invalidation)
Banafsheh Ghavidel-Parsa (2020)
10.1080/09540261.2017.1320982
The management of fibromyalgia from a psychosomatic perspective: an overview
F. Sancassiani (2017)
Avaliação dos efeitos da imersão diária em água termomineral de Caldas da Imperatriz-SC na inflamação periférica em camundongos
Fernanda Madeira (2016)
10.2174/1573397113666170502152955
Work Ability in Fibromyalgia: An Update in the 21st Century
A. Palstam (2017)
10.1002/art.38659
Editorial: Fibromyalgia: A Never‐Ending Story of Central and Peripheral Pain Mechanisms
P. Sarzi-Puttini (2014)
10.1111/sms.13579
Diclofenac attenuates inflammation through TLR4 pathway and improves exercise performance after exhaustive swimming.
F. M. Steckling (2019)
10.1186/s12891-015-0715-y
Patient-Reported Outcomes Measurement Information System (PROMIS) instruments among individuals with symptomatic knee osteoarthritis: a cross-sectional study of floor/ceiling effects and construct validity
J. Driban (2015)
10.1016/j.jpain.2017.08.004
Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention.
A. Schrepf (2017)
10.4081/reumatismo.2014.766
The sources of pain in osteoarthritis: a pathophysiological review.
F. Salaffi (2014)
Chronic widespread pain and fibromyalgia from the perspective of rehabilitation Aspects of clinical assessment and management
U. Wewer (2016)
10.2217/9781780844350
Novel Insights into the Pathophysiology and Treatment of Fibromyalgia
Bente Danneskiold-Samsøe (2014)
10.1186/s41927-019-0100-9
Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae
Daniel F. McWilliams (2019)
10.5041/RMMJ.10239
Attitudes of Israeli Rheumatologists to the Use of Medical Cannabis as Therapy for Rheumatic Disorders
Jacob N Ablin (2016)
10.1038/srep14648
Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice
A. U. Quadros (2015)
10.1097/01.NPR.0000490394.96969.0d
Fibromyalgia: Timely diagnosis and treatment options.
Yvonne Dʼarcy (2016)
10.1097/AJP.0000000000000354
Fibromyalgia and Chronic Pain Syndromes
L. Arnold (2016)
10.1097/j.pain.0000000000001215
Temporal dynamics of pain: an application of regime-switching models to ecological momentary assessments in patients with rheumatic diseases
Stefan Schneider (2018)
10.3390/jcm8081118
Fibromyalgia-Like Syndrome Associated with Parkinson’s Disease—A Cohort Study
Ran Abuhasira (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar