Online citations, reference lists, and bibliographies.

Central Pain Mechanisms In The Rheumatic Diseases: Future Directions.

Kristine Phillips, Daniel J. Clauw
Published 2013 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Pain is a prominent component of many rheumatologic conditions, and is the result of a complex physiologic interaction of central and peripheral nervous system signaling that results in a highly individualized symptom complex. Pain is frequently categorized as acute or chronic (generally greater than three months duration). Chronic pain is not simply acute pain that has lasted longer, and is more likely to be influenced by input from the central nervous system, whereas acute pain is often attributable primarily to inflammation and/or damage in peripheral structures (i.e., nociceptive input). The prominent role of central factors in chronic pain is highlighted by the fact that there is currently no chronic pain condition in which the degree of tissue inflammation or damage alone (e.g., as measured by radiographs, magnetic resonance imaging (MRI), or endoscopy) accurately predicts the presence or severity of pain. Central factors alter pain processing by setting the “gain”, such that when peripheral input is present, it is processed against a background of central factors that can enhance or diminish the experience of pain. There are very large inter-individual differences in these central nervous system factors that influence pain perception, such that some individuals with significant peripheral nociceptive input (e.g. from joint damage or inflammation) will feel little or no pain, whereas others are very pain sensitive, and they can experience pain with minimal or no identifiable abnormal peripheral nociceptive input. This emerging knowledge has important implications for pain management in individuals with chronic rheumatologic disorders.
This paper references
10.1002/1529-0131(199902)12:1<3::AID-ART2>3.0.CO;2-K
The relationship of anxiety and depression with self-reported knee pain in the community: data from the Baltimore Longitudinal Study of Aging.
P Creamer (1999)
: results from the 1958 British Birth Cohort Study
BI Nicholl (2010)
10.1007/s11916-007-0216-2
Sensitization, glutamate, and the link between migraine and fibromyalgia
Paola Sarchielli (2007)
10.1007/s11926-010-0114-1
Quality-of-Life Measurements Versus Disease Activity in Systemic Lupus Erythematosus
Adnan N. Kiani (2010)
10.1016/j.rdc.2009.06.006
From fibrositis to functional somatic syndromes to a bell-shaped curve of pain and sensory sensitivity: evolution of a clinical construct.
Kobby Ablin (2009)
10.1016/j.jpain.2009.06.001
Understanding fibromyalgia: lessons from the broader pain research community.
David G A Williams (2009)
10.1017/S0033291708003784
A population-based twin study of functional somatic syndromes.
Kenji Mitsubishi-Kasei-Ta Kato (2009)
10.1001/archinte.160.2.221
Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.
Leslie A. Aaron (2000)
10.1080/03009740601153790
Regional cerebral blood flow between primary and concomitant fibromyalgia patients: a possible way to differentiate concomitant fibromyalgia from the primary disease
Jiunn-Horng Chen (2007)
10.1093/brain/awq195
Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
Michael L. Costigan (2010)
10.1016/j.jpain.2010.01.004
How neuroimaging studies have challenged us to rethink: is chronic pain a disease?
Daniel M. Doleys (2010)
Learning from discordance in patient and physician global assessments of systemic lupus erythematosus disease activity.
Carolyn Neville (2000)
hypersensitivity states
DJ Clauw (1991)
processing of fibromyalgia patients is maintained by muscle afferent input : a randomized , double - blind , placebo - controlled study
G Affaitati (2009)
10.1159/000097332
Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms.
Daniel J. Clauw (1997)
Osteoarthritis and sleep: the Johnston County Osteoarthritis Project.
Kelli D. Allen (2008)
10.1016/j.pain.2010.04.003
Sensitization in patients with painful knee osteoarthritis
Lars Arendt-Nielsen (2010)
10.1186/1471-2474-5-48
Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain
James N. Baraniuk (2004)
10.1177/0961203309345784
Work disability in systemic lupus erythematosus is prevalent and associated with socio-demographic and disease related factors
Kim Baker (2009)
10.3109/07853890008995932
Evidence-based data on pain relief with antidepressants
David A. Fishbain (2000)
10.1016/S0022-3956(96)00051-9
The relationship between fibromyalgia and interstitial cystitis.
Daniel J. Clauw (1997)
10.1038/nm.2710
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
Robert E. Sorge (2012)
Fatigue in lupus is not correlated with disease activity.
Bin-jiang Wang (1998)
10.1002/art.23710
The impact of momentary pain and fatigue on physical activity in women with osteoarthritis.
Susan L Murphy (2008)
10.1002/art.24326
Pain and rheumatology: thinking outside the joint.
Daniel J. Clauw (2009)
10.1002/art.24175
A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain.
Joyce B. J. van Meurs (2009)
10.1097/JCP.0000000000000323
A 13-week, randomized double-blind, placebo-controlled, cross-over trial of ziprasidone in bipolar spectrum disorder.
Ashwin A Patkar (2015)
10.1016/S0304-3959(96)03295-2
Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects
Eva Kosek (1997)
10.1016/j.eurpsy.2007.02.002
Role of the COMT gene Val158Met polymorphism in mental disorders: a review.
Ladislav Hosák (2007)
Number of fibromyalgia tender points is associated with health status in patients with systemic lupus erythematosus
Dedra Buchwald
Severe rheumatoid arthritis (RA), worse outcomes, comorbid illness, and sociodemographic disadvantage characterize ra patients with fibromyalgia.
Frederick Wolfe (2004)
10.1016/j.pain.2007.10.033
Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk
David Yarnitsky (2008)
10.1016/j.pain.2009.05.020
Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: A randomized, double-blind, placebo-controlled study
Roland Staud (2009)
Co-morbidities of patients with knee osteoarthritis.
Kim Weng Chan (2009)
10.1002/art.1790110110
The relationship between psychosocial variables and pain reporting in osteoarthritis of the knee.
Paul M. Creamer (1998)
Enhanced central
R Staud
Fibromyalgianess [editorial
F. Wolfe (2009)
10.1186/ar2316
Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
Gilberto Vargas-Alarcón (2007)
10.1016/j.pain.2006.05.024
Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
Luda Diatchenko (2006)
10.1097/00124743-199512000-00004
The Overlap Between Fibromyalgia and Inflammatory Rheumatic Disease: When and Why Does it Occur?
Daniel J. Clauw (1995)
10.1016/0304-3959(91)90100-C
The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states
Clifford J Woolf (1991)
10.1016/S0022-3956(96)00046-5
An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome.
Keiji Fukuda (1997)
10.1186/ar3024
The role of stress in rheumatic diseases
Afton L Hassett (2010)
10.1016/j.pain.2009.06.024
Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: A 13-week, randomized, placebo-controlled trial
Amy S. Chappell (2009)
10.1002/art.1780350509
Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis.
Irwin Jon Russell (1992)
10.1016/j.jpain.2009.02.002
Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera.
Lars Arendt-Nielsen (2009)
10.1093/hmg/ddi013
Genetic basis for individual variations in pain perception and the development of a chronic pain condition.
Luda Diatchenko (2005)
10.1001/jama.280.11.981
Chronic multisymptom illness affecting Air Force veterans of the Gulf War.
Keiji Fukuda (1998)
10.1002/art.33339
Reduced insular γ-aminobutyric acid in fibromyalgia.
Bradley R. Foerster (2012)
Prediction of chronic post - operative
D Yarnitsky
10.1177/096120339400300310
Fibromyalgia Syndrome and Disease Activity in Systemic Lupus Erythematosus
Eric F Morand (1994)
10.1016/j.ejpain.2010.09.002
Effects of treatment of peripheral pain generators in fibromyalgia patients.
Giannapia Affaitati (2011)
10.1185/03007990802429627
The relationship between antidepressant and analgesic responses: findings from six placebo-controlled trials assessing the efficacy of duloxetine in patients with major depressive disorder.
David A. Fishbain (2008)
10.1016/j.rdc.2012.10.004
Epidemiology of osteoarthritis.
Tuhina Neogi (2013)
10.1053/eujp.2001.0312
Somatosensory perception in a remote pain-free area and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from long-term trapezius myalgia.
A S Leffler (2002)
10.1016/j.autrev.2008.07.023
Etiology of fibromyalgia: the possible role of infection and vaccination.
Dan Buskila (2008)
10.1016/0304-3959(94)90198-8
Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome
Stephen J. Gibson (1994)
10.1016/j.amjmed.2009.09.006
Fibromyalgia: an overview.
Daniel J. Clauw (2009)
10.1523/JNEUROSCI.4015-06.2006
The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity
Fumimasa Amaya (2006)
10.1016/j.pain.2010.04.028
Corrigendum to “Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: Results from the 1958 British Birth Cohort Study” [Pain 149 (2010) 143–151]
Lynne J. Hocking (2010)
10.1186/ar3311
Distinguishing fibromyalgia from rheumatoid arthritis and systemic lupus in clinical questionnaires: an analysis of the revised Fibromyalgia Impact Questionnaire (FIQR) and its variant, the Symptom Impact Questionnaire (SIQR), along with pain locations
Ronald Friend (2011)
10.1016/j.jpsychores.2008.08.004
Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome.
Roseanne Armitage (2009)
10.1097/01.AOG.0000129238.49397.4e
Quantitative sensory testing in vulvodynia patients and increased peripheral pressure pain sensitivity.
Jutta Giesecke (2004)
10.1186/ar2842
The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study
Yvonne C Lee (2009)
Fatigue in systemic lupus erythematosus: contributions of disordered sleep, sleepiness, and depression.
Andrea Iaboni (2006)
disorders — pathways of vulnerability
K Kato (2006)
10.1016/j.pain.2006.04.015
Idiopathic pain disorders – Pathways of vulnerability
Luda Diatchenko (2006)
Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome
H D Wilder (2007)
10.1136/ard.2009.126086
No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
Barbara I. Nicholl (2010)
10.1016/j.jpain.2007.05.002
Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome.
Paola Sarchielli (2007)
10.1007/BF02032098
Measurement of pain threshold in patients with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and healthy controls
E. M. Gerecz-Simon (2005)
10.1002/art.27585
Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study.
Stephen E. Gwilym (2010)
10.1016/j.jpain.2010.05.008
Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision.
Samuel A McLean (2011)
10.1016/0304-3959(95)00061-5
Increased pressure pain sensibility in fibromyalgia patients is located deep to the skin but not restricted to muscle tissue
Eva Kosek (1995)
10.1016/j.pain.2009.02.015
The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans
Dorit Pud (2009)
10.1002/art.24837
Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients.
Stephen E. Gwilym (2009)
10.1016/j.ejpain.2004.11.001
Human brain mechanisms of pain perception and regulation in health and disease.
A. Vania Apkarian (2005)
10.1002/art.1780370812
The prevalence and clinical impact of fibromyalgia in systemic lupus erythematosus.
Gregory D Middleton (1994)
10.1016/j.genhosppsych.2008.12.006
Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews.
Kurt Kroenke (2009)
10.1016/j.pain.2004.12.032
Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition
Nancy Julien (2005)
10.1016/S0167-8760(00)00087-8
Peripheral and central nervous changes in patients with rheumatoid arthritis in response to repetitive painful stimulation.
Thomas Hummel (2000)
10.1146/annurev.neuro.23.1.777
Pain genes?: natural variation and transgenic mutants.
Jeffrey S. Mogil (2000)
10.1002/art.1780400310
Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury.
Dan Buskila (1997)
erythem - atosus
R Friend (1994)
10.4088/JCP.08m04969blu
Pain inhibition is deficient in chronic widespread pain but normal in major depressive disorder.
Edith Normand (2011)
10.1016/S0959-4388(03)00090-4
Interoception: the sense of the physiological condition of the body
Ad Craig (2003)
Fibromyalgia is a major contributor to quality of life in lupus.
Dafna D Gladman (1997)
Functional imaging of pain in patients with primary fibromyalgia.
Dane B. Cook (2004)
10.1016/j.urology.2008.06.031
Antecedent nonbladder syndromes in case-control study of interstitial cystitis/painful bladder syndrome.
John W. Warren (2009)
10.1002/art.20063
Evidence of augmented central pain processing in idiopathic chronic low back pain.
Thorsten Giesecke (2004)
10.1002/art.10225
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia.
Richard H. Gracely (2002)
10.1016/0304-3959(95)00068-2
Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain
William Maixner (1995)
, fatigue , and sleep disturbance and improves functionality in fibromyalgia : results from a 14 - week , randomized , double - blind , placebo - controlled study
DJ Clauw (2011)
10.1016/0016-5085(90)90332-U
Tolerance for rectosigmoid distention in irritable bowel syndrome.
William E. Whitehead (1990)
10.1016/j.mayocp.2012.02.010
A framework for fibromyalgia management for primary care providers.
Lesley M. Arnold (2012)
10.1016/j.pain.2003.09.005
Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables
Robert R. Edwards (2003)
10.1016/j.pain.2010.12.022
Sodium oxybate reduces pain, fatigue, and sleep disturbance and improves functionality in fibromyalgia: Results from a 14-week, randomized, double-blind, placebo-controlled study
Irwin Jon Russell (2011)
10.1136/bmj.327.7428.1357
The health consequences of the first Gulf war
Daniel Clauw (2003)
10.1016/j.jpain.2011.08.005
Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study.
Shad B. Smith (2011)
10.3928/01477447-20090301-21
Comparison of hip and knee arthroplasty outcomes at early and intermediate follow-up.
S. O'brien (2009)
10.1016/j.nurt.2009.07.009
Preclinical and early clinical investigations related to monoaminergic pain modulation
Kirsty Bannister (2011)
10.1016/j.pain.2010.09.027
The development of fibromyalgia – I: Examination of rates and predictors in patients with rheumatoid arthritis (RA)
Frederick Wolfe (2011)
10.1007/s10165-009-0185-x
The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus
P. Chandrasekhara (2009)
10.1186/ar3306
The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia
Yvonne C Lee (2011)
10.1111/j.1365-2710.2009.01144.x
Gabapentin and pregabalin in the treatment of fibromyalgia: a systematic review and a meta-analysis.
Thrasivoulos George Tzellos (2010)
10.1136/aim.9.2.47
Diffuse Noxious Inhibitory Controls (DNIC) in Animals and in Man
Daniel Le Bars (1991)
10.1002/art.21798
Importance of genetic influences on chronic widespread pain.
Kenji Kato (2006)
10.1097/00006842-200105000-00006
Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation.
Bruce D. Naliboff (2001)
10.1097/01.jom.0000091693.43121.2f
Unexplained symptoms after terrorism and war: an expert consensus statement.
Daniel J. Clauw (2003)
10.1073/pnas.1430684100
Neural correlates of interindividual differences in the subjective experience of pain
Robert C. Coghill (2003)
10.1136/bmj.b2844
Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
Tuhina Neogi (2009)
10.3899/jrheum.100759
Pain Mechanisms in Osteoarthritis: Understanding the Role of Central Pain and Current Approaches to Its Treatment
Philip J. Mease (2011)
10.1001/archinte.163.20.2433
Depression and pain comorbidity: a literature review.
Matthew J. Bair (2003)
10.1371/journal.pone.0006016
Increased Sensitivity to Thermal Pain Following a Single Opiate Dose Is Influenced by the COMT val158met Polymorphism
Karin Jensen (2009)
Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee.
Marian T Hannan (2000)
10.1016/j.pain.2007.06.029
Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: Do conditioning stimulus painfulness, gender and personality variables matter?
Michal Granot (2008)
10.1016/S0950-3579(98)80027-7
Measures of disease activity and damage in SLE.
Murray B Urowitz (1998)
10.1002/art.1780371106
Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome.
Irwin Jon Russell (1994)
10.1080/08869634.1999.11746100
Increased pain sensitivity of the upper extremities of TMD patients with myalgia to experimentally-evoked noxious stimulation: possibility of worsened endogenous opioid systems.
Koji Kashima (1999)
10.3899/jrheum.080897
Outcome and Predictor Relationships in Fibromyalgia and Rheumatoid Arthritis: Evidence Concerning the Continuum versus Discrete Disorder Hypothesis
Frederick Wolfe (2009)
10.1002/acr.20005
Report of the American College of Rheumatology Pain Management Task Force.
David Borenstein (2010)
10.1016/S0304-3959(00)00310-9
Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief
Eva Kosek (2000)
10.1126/science.1078546
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
Jon-Kar Zubieta (2003)
10.1093/rheumatology/36.7.726
Why does osteoarthritis of the knee hurt--sometimes?
Paul M. Creamer (1997)
10.1016/j.pain.2010.09.030
Central sensitization: Implications for the diagnosis and treatment of pain
Clifford J Woolf (2011)
10.1001/archpsyc.60.11.1145
Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission.
Jon-Kar Zubieta (2003)
10.1523/JNEUROSCI.2849-07.2007
Decreased Central μ-Opioid Receptor Availability in Fibromyalgia
Richard Edmund Harris (2007)
10.1016/S0987-7053(00)00227-6
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Roland Peyron (2000)
10.1002/art.21008
The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort.
Thorsten Giesecke (2005)
thresholds and cerebral event - related potentials following painful CO 2 laser stimulation in subjects with fibromyalgia syndrome
E Kosek (1994)
10.1038/nm1490
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
Irmgard Tegeder (2006)



This paper is referenced by
10.3109/03009742.2015.1046484
Concomitant fibromyalgia in rheumatoid arthritis is associated with the more frequent use of biological therapy: a cross-sectional study
Philip Rask Lage-Hansen (2016)
10.1515/sjpain-2019-0088
Changes in inflammatory plasma proteins from patients with chronic pain associated with treatment in an interdisciplinary multimodal rehabilitation program – an explorative multivariate pilot study
Björn Gerdle (2019)
10.1016/j.cgh.2013.03.011
Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome.
Jeffrey M Lackner (2013)
10.3109/03009742.2015.1052553
Association of rheumatic diseases with symptom severity, quality of life, and treatment outcome in patients with fibromyalgia
Juan Jiao (2016)
10.2217/pmt.13.30
Reflecting on pain management for patients with osteoarthritis and other rheumatic disorders: there's more to pain management than managing pain.
Danielle Perret (2013)
10.1080/24740527.2019.1620097
Evaluating the psychometric properties of the Widespread Pain Index and the Symptom Severity Scale in youth with painful conditions
Joanne Dudeney (2019)
10.1016/j.neubiorev.2016.04.001
Functional reorganisation in chronic pain and neural correlates of pain sensitisation: A coordinate based meta-analysis of 266 cutaneous pain fMRI studies
Radu Tanasescu (2016)
Dysfunctional syndromes and fibromyalgia: a 2012 critical digest.
Piercarlo Sarzi-Puttini (2012)
Facteurs émotionnels, cognitifs et comportementaux dans la fibromyalgie
Emmanuel Fontaine (2015)
10.1111/JABR.12137
The neurobiology of central sensitization
Steven E. Harte (2018)
10.1016/j.mayocp.2015.03.014
Fibromyalgia and related conditions.
Daniel J. Clauw (2015)
10.1007/978-3-319-74698-2_142-1
Pathophysiology, Assessment, and Treatment of Chronic Cancer Pain in Critically Ill Patients
Christina Le-Short (2019)
10.1016/j.ejphar.2018.05.005
Nociceptin/orphanin FQ opioid peptide (NOP) receptor and &mgr;‐opioid peptide (MOP) receptors both contribute to the anti‐hypersensitive effect of cebranopadol in a rat model of arthritic pain
Klaus Schiene (2018)
Drug and Non-drug Treatment Options of Fibromyalgia
Abdul Kader Mohiuddin (2020)
10.1002/art.38271
Involvement of peripheral and spinal tumor necrosis factor α in spinal cord hyperexcitability during knee joint inflammation in rats.
Christian Koenig (2014)
10.1016/j.jpain.2014.01.487
Effect of estrogen depletion on pain sensitivity in aromatase inhibitor-treated women with early-stage breast cancer.
N Lynn Henry (2014)
10.4103/jfmpc.jfmpc_7_17
Musculoskeletal manifestations of tuberculosis: An observational study
Nikhil Gupta (2018)
10.1038/s41584-020-0375-7
Reflections on ‘older’ drugs: learning new lessons in rheumatology
S. A. Kerrigan (2020)
10.1016/j.autrev.2017.11.010
Physical activity and autoimmune diseases: Get moving and manage the disease.
Kassem Sharif (2017)
10.1097/j.pain.0000000000000707
Towards a neurophysiological signature for fibromyalgia
Marina López-Solà (2017)
10.1002/ejp.856
Central sensitization as the mechanism underlying pain in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.
Giulia Di Stefano (2016)
10.1093/rheumatology/kex419
Osteoarthritis: the genesis of pain
Kai Fu (2018)
10.1002/art.39051
Characteristics of Fibromyalgia Independently Predict Poorer Long‐Term Analgesic Outcomes Following Total Knee and Hip Arthroplasty
Chad M Brummett (2015)
Development and psychometric validation of pain scales in feline osteoarthritis
Mary P. Klinck (2018)
10.1093/bjaed/mkw010
Common functional pain syndromes
David C. Crabtree (2016)
10.2174/1573397114666180806142814
The Effect of Neuropathic Pain Symptoms on Remission in Patients with Early Rheumatoid Arthritis.
Fausto Salaffi (2019)
10.1002/acr.22967
Prevalence of Axial Spondyloarthritis Among Patients With Fibromyalgia: A Magnetic Resonance Imaging Study With Application of the Assessment of SpondyloArthritis International Society Classification Criteria.
Jacob N Ablin (2017)
10.1177/1759720X13508508
Clinical experience with duloxetine in the management of chronic musculoskeletal pain. A focus on osteoarthritis of the knee
Jacques P Brown (2013)
Associations of widespread pain sensitivity, comorbid chronic pain and psychological distress with Irritable Bowel Syndrome and abdominal pain
Niklas Stabell (2014)
10.1080/09540261.2017.1320982
The management of fibromyalgia from a psychosomatic perspective: an overview
Federica Sancassiani (2017)
Avaliação dos efeitos da imersão diária em água termomineral de Caldas da Imperatriz-SC na inflamação periférica em camundongos
Fernanda Madeira (2016)
10.2174/1573397113666170502152955
Work Ability in Fibromyalgia: An Update in the 21st Century
Annie Palstam (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar