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Direct Binding To NLRP3 Pyrin Domain As A Novel Strategy To Prevent NLRP3‐Driven Inflammation And Gouty Arthritis

G. Yang, H. E. Lee, Su-Jin Moon, K. M. Ko, J. Koh, J. K. Seok, J. Min, T. Heo, H. C. Kang, Yongyeon Cho, H. E. Lee, K. Fitzgerald, J. Lee
Published 2020 · Medicine

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The NLRP3 inflammasome is closely linked to the pathophysiology of a wide range of inflammatory diseases. This study was undertaken to identify small molecules that directly bind to NLRP3 in order to develop pharmacologic interventions for NLRP3‐related diseases.
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