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Antimicrobial Enzymes: An Emerging Strategy To Fight Microbes And Microbial Biofilms
Barbara Thallinger, E. Prasetyo, G. Nyanhongo, G. Guebitz
Published 2013 · Biology, Medicine
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Time to take this seriously.
With the increasing prevalence of antibiotic resistance, antimicrobial enzymes aimed at the disruption of bacterial cellular machinery and biofilm formation are under intense investigation. Several enzyme‐based products have already been commercialized for application in the healthcare, food and biomedical industries. Successful removal of complex biofilms requires the use of multi‐enzyme formulations that contain enzymes capable of degrading microbial DNA, polysaccharides, proteins and quorum‐sensing molecules. The inclusion of anti‐quorum sensing enzymes prevents biofilm reformation. The development of effective complex enzyme formulations is urgently needed to deal with the problems associated with biofilm formation in manufacturing, environmental protection and healthcare settings. Nevertheless, advances in synthetic biology, enzyme engineering and whole DNA‐Sequencing technologies show great potential to facilitate the development of more effective antimicrobial and anti‐biofilm enzymes.
This paper references
Inactivation of Escherichia coli O157:H7 in biofilm on stainless steel by treatment with an alkaline cleaner and a bacteriophage
M. Sharma (2005)
Resistance to hydrogen peroxide in Helicobacter pylori: role of catalase (KatA) and Fur, and functional analysis of a novel gene product designated 'KatA-associated protein', KapA (HP0874).
A. G. Harris (2002)
Dispersing biofilms with engineered enzymatic bacteriophage
Timothy K. Lu (2007)
Genetically Engineered Alginate Lyase-PEG Conjugates Exhibit Enhanced Catalytic Function and Reduced Immunoreactivity
J. W. Lamppa (2011)
Combinations of Lysostaphin with β-Lactams Are Synergistic against Oxacillin-Resistant Staphylococcus epidermidis
Nandini Kiri (2002)
Postgenomic strategies in antibacterial drug discovery.
Heike Brötz-Oesterhelt (2010)
“Escherichia coli‐milk” biofilm removal from stainless steel surfaces: Synergism between ultrasonic waves and enzymes
N. Oulahal-Lagsir (2003)
Lactoperoxidase: From catalytic mechanism to practical applications
J.-W. Boots (2006)
Proteolytic enzymes as adjuncts to antimicrobial prophylaxis of contaminated wounds.
G. Rodeheaver (1975)
Uber die keimtötende und entwicklungshemmende Wirkung von Hühnereiweiß
P. Laschtschenko (2005)
Quantitative Immunological Comparison of Bird Lysozymes
N. Arnheim (1967)
Lactoperoxidase. New recognition of an "old" enzyme in airway defenses.
A. Ratner (2000)
Multiple Enzymatic Activities of the Murein Hydrolase from Staphylococcal Phage φ11
W. Navarre (1999)
Bacteriophage Endolysins as a Novel Class of Antibacterial Agents
J. Borysowski (2006)
Lysostaphin-Coated Catheters Eradicate Staphylococccus aureus Challenge and Block Surface Colonization
A. Shah (2004)
Functional properties of antimicrobial lysozyme-chitosan composite films
Su-il Park (2004)
Enzymatic treatment for preventing biofilm formation in the paper industry
Claudia Esperanza Torres (2011)
On hydrogen peroxide decomposition; ferric salt catalysis.
Andersen Vs (1948)
An antioxidant regenerating system for continuous quenching of free radicals in chronic wounds.
G. Nyanhongo (2013)
Lysostaphin Treatment of Experimental Methicillin-Resistant Staphylococcus aureus Aortic Valve Endocarditis
M. Climo (1998)
Hydrogen peroxide for prevention of bacterial growth on polymer biomaterials.
E. Alt (1999)
Lyso staphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications
J. Miao (2011)
Lysostaphin: an antistaphylococcal agent
J. K. Kumar (2008)
Microbicidal efficacy of thiocyanate hydrogen peroxide after adding lactoperoxidase under saliva loading in the quantitative suspension test.
A. Welk (2011)
Glucose oxidase from Aspergillus niger: the mechanism of action with molecular oxygen, quinones, and one-electron acceptors.
V. Leskovac (2005)
Antibacterial Activity of the Glucose Oxidase/Glucose System in Liquid Whole Egg.
D. Dobbenie (1995)
Molecular Mechanisms of Antibacterial Multidrug Resistance
M. Alekshun (2007)
A bacteriolytic enzyme that detects and kills Bacillus anthracis
R Schuch. (2002)
Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium.
P. Yoong (2004)
The dearth of new antibiotic development: why we should be worried and what we can do about it
P. Charles (2004)
Multidrug resistance in bacteria.
H. Nikaido (2009)
The Biofilm Matrix
D. Allison (2003)
Antimicrobial and antibiofilm efficacy of triclosan and DispersinB combination.
R. Darouiche (2009)
An in vitro evaluation of hydrolytic enzymes as dental plaque control agents.
R. Ledder (2009)
Cellulose oxidation and bleaching processes based on recombinant Myriococcum thermophilum cellobiose dehydrogenase.
Annemarie Flitsch (2013)
Preventing Biofilm Formation Using Microbes and Their Enzymes
A. Leslie (2011)
Chitinase production by endophytic Streptomyces aureofaciens CMUAc130 and its antagonism against phytopathogenic fungi
T. Taechowisan (2003)
Mono- and multilayer active films containing lysozyme as antimicrobial agent
G. Buonocore (2005)
Structural investigation of the cofactor-free chloroperoxidases.
B. Hofmann (1998)
A proposed unified mechanism of action for the lyases and epimerases
Peter Gacesa (2001)
Candida Biofilms on Oral Biomaterials
P. Courtois (2011)
Assessment of enzymatic cleaning agents and disinfectants against bacterial biofilms.
M. Augustin (2004)
Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci
J. Kaplan (2012)
Transgenic potato plants resistant to the phytopathogenic bacterium Erwinia carotovora
K. Duering (1993)
Removal of microbial multi-species biofilms from the paper industry by enzymatic treatments
C. Marcato-Romain (2012)
Immobilization of glucose oxidase in electrospun nanofibrous membranes for food preservation
Ling Ge (2012)
AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora.
Y. Dong (2000)
Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi11. Identification of a D-alanyl-glycine endopeptidase activity.
W. Navarre (1999)
The chemistry of lysozyme and its use as a food preservative and a pharmaceutical.
V. A. Proctor (1988)
Mechanism and Suppression of Lysostaphin Resistance in Oxacillin-Resistant Staphylococcus aureus
M. Climo (2001)
Peroxidase-thiocyanate inhibition of streptococci in raw milk
B. Reiter (1963)
Protease treatment affects both invasion ability and biofilm formation in Listeria monocytogenes.
C. Longhi (2008)
The targets of currently used antibacterial agents: lessons for drug discovery.
Roland Lange (2007)
The addition of lysostaphin dramatically improves survival, protects porcine biomesh from infection, and improves graft tensile shear strength.
I. Belyansky (2011)
Antibacterial effect of myeloperoxidase against Streptococcus mutans.
J. Tenovuo (1988)
Elucidation of the Antibacterial Mechanism of the Curvularia Haloperoxidase System by DNA Microarray Profiling
E. H. Hansen (2004)
Free radicals and antioxidants in normal physiological functions and human disease.
M. Valko (2007)
Effect of environmental and physiological factors on the antibacterial activity of Curvularia haloperoxidase system against Escherichia coli
E. H. Hansen (2005)
Lysozyme: antigen, enzyme and antibacterial agent.
A. Glynn (1968)
Synthesis of multifunctional bioresponsive polymers for the management of chronic wounds.
G. Nyanhongo (2013)
Hybrid antimicrobial enzyme and silver nanoparticle coatings for medical instruments.
D. Matthew Eby (2009)
Effects of commercial enzymes on the adhesion of a marine biofilm-forming bacterium
C. Leroy (2008)
Efficacy of enzymatic mouth rinses for immobilisation of protective enzymes in the in situ pellicle.
C. Hannig (2010)
Bacterial biofilms in patients with indwelling urinary catheters
D. Stickler (2008)
Oxidative Stress and Oxidative Damage in Carcinogenesis
J. Klaunig (2010)
Serine protease mechanism and specificity.
L. Hedstrom (2002)
Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans.
P. Recsei (1987)
Cellobiose dehydrogenase: a versatile catalyst for electrochemical applications.
R. Ludwig (2010)
Rapid Killing of Streptococcus pneumoniae with a Bacteriophage Cell Wall Hydrolase
J. Loeffler (2001)
A review of current and emergent biofilm control strategies
M. Simões (2010)
Immobilization of lysozyme-cellulose amide-linked conjugates on cellulose I and II cotton nanocrystalline preparations
J. Edwards (2011)
Antimicrobial Activity of Vanadium Chloroperoxidase on Planktonic Streptococcus mutans Cells and Streptococcus mutans Biofilms
M.A. Hoogenkamp (2009)
Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase
R. Nijland (2010)
Myeloperoxidase Exerts Microbicidal Activity against Mycobacterium tuberculosis
V. Borelli (1999)
Polyurethane-based leukocyte-inspired biocidal materials.
Gabriel Amitai (2009)
Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
Y. Dong (2001)
Characterization of Fish-Skin Gelatin Gels and Films Containing the Antimicrobial Enzyme Lysozyme
C. Bower (2006)
Antimicrobial activity of glucose oxidase‐immobilized plasma‐activated polypropylene films
J. Vartiainen (2005)
Verdoperoxidase, A ferment isolated from leucocytes
K. Agner (1941)
Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model.
I. Jado (2003)
Curvularia Haloperoxidase: Antimicrobial Activity and Potential Application as a Surface Disinfectant
E. H. Hansen (2003)
The new toothpastes.
I. Mandel (1998)
Quorum sensing in biofilms
J. Prosser (1999)
Bacterial biofilms: a common cause of persistent infections.
J. Costerton (1999)
The Use of Commercially Available Alpha-Amylase Compounds to Inhibit and Remove Staphylococcus aureus Biofilms
Bradford Craigen (2011)
A bacteriolytic agent that detects and kills Bacillus anthracis
Investigation into the resistance of lactoperoxidase tolerant Escherichia coli mutants to different forms of oxidative stress.
P. De Spiegeleer (2005)
Removal of Microbial Biofilms from Dispense Equipment: The Effect of Enzymatic Pre-digestion and Detergent Treatment
S. Walker (2007)
Quorum sensing and quorum-quenching enzymes.
Y. Dong (2005)
Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition
P. Chaignon (2007)
Novel Method to Control Pathogenic Bacteria on Human Mucous Membranes
V. Fischetti (2003)
Gene cloning and expression and secretion of Listeria monocytogenes bacteriophagelytic enzymes in Lactococcus lactis
S. Gaeng (2000)
Origins and evolution of antibiotic resistance. Microbiol
J Davies (2010)
Genetically enhanced cows resist intramammary Staphylococcus aureus infection
R. Wall (2005)
Growth Inhibition by Glucose Oxidase of Selected Organisms Associated With the Microbial Spoilage of Shrimp ( Pandalus jordani ): In Vitro Model Studies.
C. A. Kantt (1993)
Quorum sensing in biofilms Anaerobe
V Lazar (2011)
B. Schuller (2015)
Efficacy of enzymatic toothpastes for immobilisation of protective enzymes in the in situ pellicle.
C. Hannig (2010)
Recombinant bacteriophage lysins as antibacterials
Mark Fenton (2010)
Lysostaphin Cream Eradicates Staphylococcus aureus Nasal Colonization in a Cotton Rat Model
J. Kokai-Kun (2003)
Industrial-scale production and purification of a heterologous protein in Lactococcus lactis using the nisin-controlled gene expression system NICE: The case of lysostaphin
I. Mierau (2005)
Antibacterial effect of the glucose oxidase-glucose system on food-poisoning organisms.
M. Tiina (1989)
Evaluation of whole lysosomal enzymes directly immobilized on titanium (IV) oxide used in the development of antimicrobial agents.
S. H. Bang (2011)
Antibacterial functionalization of wool fabric via immobilizing lysozymes
Q. Wang (2009)
Bacteriophage endolysins--current state of research and applications.
M. Loessner (2005)
Significance of the lactoperoxidase system in the dairy industry and its potential applications: a review
E. Seifu (2005)
Oxidation von Glukose mit Extrakten aus Aspergillus niger
D. Müller (1928)
Lactoperoxidase: physico-chemical properties, occurrence, mechanism of action and applications
K. Kussendrager (2000)
Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms.
Michelle Finnegan (2010)
Phage Lytic Enzyme Cpl-1 as a Novel Antimicrobial for Pneumococcal Bacteremia
J. Loeffler (2003)
Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: efficacy and safety.
J. Tenovuo (2002)
Egg-white lysozyme as a food preservative: an overview
F. E. Cunningham (1991)
Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil.
A. Kumar (2008)
Biology of Human Milk
Nigel Meadows (1989)
Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia.
Carlene K Chun (2004)
L(+)-Mandelate dehydrogenase from Rhodotorula graminis: purification, partial characterization and identification as a flavocytochrome b.
M. Yasin (1993)
In Vitro Antifungal Activity of Strains of Trichoderma harzianum
Ç. Küçük (2004)
A ferment isolated from leucocytes
K Agner (1941)
Evaluation of the Antimicrobial Activity of Lysostaphin-Coated Hernia Repair Meshes
R. Satishkumar (2011)
Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus.
A. Strandén (1997)
Degradation of pathogen quorum-sensing molecules by soil bacteria: a preventive and curative biological control mechanism.
L. Molina (2003)
Infection and removal of L-forms of Listeria monocytogenes with bred bacteriophage.
A. Hibma (1997)
Gene Cloning and Expression and Secretion ofListeria monocytogenes Bacteriophage-Lytic Enzymes inLactococcus lactis
S. Gaeng (2000)
Antistaphylococcal nanocomposite films based on enzyme-nanotube conjugates.
Ravindra C. Pangule (2010)
Alginate lyase enhances antibiotic killing of mucoid Pseudomonas aeruginosa in biofilms
M. Alkawash (2006)
Staphylococcus aureus resistant to vancomycin
Bacterial biofilms: an emerging link to disease pathogenesis.
M. Parsek (2003)
Regulation and measurement of oxidative stress in apoptosis.
James F Curtin (2002)
Virucidal effect of myeloperoxidase on human immunodeficiency virus type 1-infected T cells.
J. Chochola (1994)
Candidacidal activities of the glucose oxidase-mediated lactoperoxidase system.
H. Kho (2012)
Bacterial biofilm removal using fungal enzymes
B. Orgaz (2006)
Recent advances in animal feed additives such as metabolic modifiers, antimicrobial agents, probiotics, enzymes and highly available minerals - review.
C. Wenk (2000)
Biology of Human Milk, Nestlé Nutrition Workshop Series, vol. 15, L. Hanson (Ed.). Raven Press, 1185 Ave. of the Americas, New York, NY 10036 (1988), 231 pp; hardcover, $65
N. I. Huyck (1989)
Lysostaphin as a treatment for systemic Staphylococcus aureus infection in a mouse model.
J. Kokai-Kun (2007)
Antibacterial discovery and development—the failure of success?
P. Fernandes (2006)
Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications.
Jianjun Miao (2011)
Effect of vanadium chloroperoxidase on Enterococcus faecalis biofilms.
I. Persoon (2012)
Degradation of N-acylhomoserine lactones, the bacterial quorum-sensing molecules, by acylase.
F. Xu (2003)
ALGINATE LYASE: review of major sources and enzyme characteristics, structure-function analysis, biological roles, and applications.
T. Y. Wong (2000)
Microbiology and Industrial Biotechnology of Food-Grade Proteases: A Perspective
Alagarsamy Sumantha (2006)
Origins and Evolution of Antibiotic Resistance
J. Davies (2010)
Degradation of fungal cell walls of phytopathogenic fungi by lytic enzyme of Streptomyces griseus.
A. Anitha (2010)
Strategies for decreasing multidrug antibiotic resistance: role of ototopical agents for treatment of middle ear infections.
J. Klein (2002)
Taking aim on bacterial pathogens: from phage therapy to enzybiotics.
J. Hermoso (2007)
Selection of commercial hydrolytic enzymes with potential antifouling activity in marine environments.
G. Zanaroli (2011)
Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals.
J. P. Pearson (1999)
Myeloperoxidase: friend and foe
S. Klebanoff (2005)
Preparation and characterization of immobilized lysozyme and evaluation of its application in edible coatings
Zixuan Lian (2012)
Treatment of Methicillin-Resistant Staphylococcus aureus in Neonatal Mice: Lysostaphin Versus Vancomycin
F. Placencia (2009)
A novel extracellular subtilisin-like protease from the hyperthermophile Aeropyrum pernix K1: biochemical properties, cloning, and expression
G. Catara (2003)
Lysostaphin: an enzymatic approach to staphylococcal disease. 3. Combined lysostaphin-methicillin therapy of established staphylococcal abscesses in mice.
R. Dixon (1968)
Protease and amylase enzymes for biofilm removal and degradation of extracellular polymeric substances (EPS) produced by Pseudomonas fluorescens bacteria
I. Molobela (2010)
This paper is referenced by
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Emtenan M. Hanafi (2019)
Molecular characterization of alkaline protease-coding gene from Bacillus licheniformis MK90 mutants with biofilm inhibitory activity
A. Hamed (2019)
RIR-MAPLE deposition of multifunctional films combining biocidal and fouling release properties.
Qian Yu (2014)
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Jeng Yeong Chow (2013)
Rotibot: Use of Rotifers as Self‐Propelling Biohybrid Microcleaners
F. Soto (2019)
Innovative Modifications for Preventing Mesh Infections
K. Aydınuraz (2017)
Surface modifications for antimicrobial effects in the healthcare setting: a critical overview.
C. Adlhart (2018)
Fast preparation of biopassive nonfouling coatings on cellulose
Alexander S Münch (2018)
Biomimetic polymeric superhydrophobic surfaces and nanostructures: from fabrication to applications.
G. Wen (2017)
Nanopatterned smart polymer surfaces for controlled attachment, killing, and release of bacteria.
Q. Yu (2013)
Nanostructured coatings for controlling bacterial biofilms and antibiotic resistance
Kristina Ivanova (2017)
Targeting microbial biofilms using Ficin, a nonspecific plant protease
Diana R. Baidamshina (2017)
Polyethyleneimine brushes effectively inhibit encrustation on polyurethane ureteral stents both in dynamic bioreactor and in vivo.
Merve Gultekinoglu (2017)
Laccase immobilization on bacterial nanocellulose membranes: Antimicrobial, kinetic and stability properties.
Liliana M. P. Sampaio (2016)
The current knowledge on the application of anti-biofilm enzymes in the food industry
A. Meireles (2016)
Biofilm matrix-degrading enzymes.
J. Kaplan (2014)
Functional-modified polyurethanes for rendering surfaces antimicrobial: An overview.
C. Wang (2020)
Functionalization of titanium implants with phase-transited lysozyme for gentle immobilization of antimicrobial lysozyme
L. Diaz-Gomez (2018)
Cellobiose dehydrogenase functionalized urinary catheter as novel antibiofilm system.
Barbara Thallinger (2016)
Disruption of Biofilm Formation by the Human Pathogen Acinetobacter baumannii Using Engineered Quorum-Quenching Lactonases
J. Y. Chow (2013)
Bacteriophage : Clinical Applications
A. Attama (2017)
Effects of surface properties on biofilm formation and the related applications
XIONG Fu-Zhong (2018)
Antibacterial enzymes from the functional screening of metagenomic libraries hosted in Ralstonia metallidurans.
Hala A Iqbal (2014)
Antibiofilm Strategies in the Food Industry
P. Teixeira (2014)
Antimicrobial activity as a potential factor influencing the predominance of Bacillus subtilis within the constitutive microflora of a whey reverse osmosis membrane biofilm.
Pratishtha Verma (2020)
New Trends in the Prevention of Biofilm Formation in Health Care Premises
Iveta Danilová (2017)
Enzymes from Marine Polar Regions and Their Biotechnological Applications
S. Bruno (2019)
Prevention and Control of Biofilms in the Food Industry and Bio‐Nanotechnology Approaches
Eric Birkenhauer (2015)
The Complex Relationship between Virulence and Antibiotic Resistance
M. Schroeder (2017)
Assessment of control strategies against Staphylococcus aureus biofilms potentially present in the fishery industry
Daniel Vázquez-Sánchez (2014)
Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part II: Active, Combined Active and Passive, and Smart Bacteria-Responsive Antibiofilm Nanocoatings
P. Balaure (2020)
The Japanese Fermented Food Natto Inhibits Sucrose-dependent Biofilm Formation by Cariogenic Streptococci
A. Iwamoto (2018)See more